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Dhurjhoti Saha | Chromatin remodeler | Best Researcher Award

 Dr. Dhurjhoti Saha | Chromatin remodeler | Best Researcher Award

Dr. MD Anderson Cancer Center, United States

👩‍🔬 Dhurjhoti Saha, Ph.D., is an accomplished researcher with expertise in high-throughput Next-Generation Sequencing (NGS) techniques and bioinformatics analysis. With a background in chromatin biology and cancer research, Dr. Saha has made significant contributions to understanding the role of chromatin remodelers in genome organization and cancer progression. Experienced in programming languages like Python and R, she has developed analysis pipelines and tools for genomic data interpretation. Dr. Saha’s strong project management skills have been demonstrated through her leadership in managing research teams and securing NIH grants. With a track record of peer-reviewed publications and scientific presentations, she continues to drive innovation in the field of epigenetics and cancer biology.🌟

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Research Summary 🧬🔬

Proficient in high-throughput Next-Generation Sequencing (NGS) techniques such as ChIP-seq, RNA-seq, PRO-seq, CUT&RUN, Hi-ChIP, and gene editing tools like CRISPR/Cas9.Skilled in NGS data analysis, including ChIP-seq, RIP-seq, ATAC-seq, CUT&RUN, RNA-seq, with established analysis pipelines and genomic analysis tools. Experienced in programming languages Python and R. Expertise in mammalian cell culture, including cancer cell lines, mouse embryonic stem cells, stable cell line generation, and drug/small molecule screening. Demonstrated excellent project management skills, including team management, protocol development, and manuscript writing for publication. Strong track record of research publications in peer-reviewed journals and presentations at international conferences and seminars. Assisted in securing NIH R01 grant.

Employment History 💼

Associate Data Scientist at The University of Texas MD Anderson Cancer Center (June 2023-present)Research Scientist at The University of Texas MD Anderson Cancer Center (August 2021-May 2023)Post-doctoral Fellow at The University of Texas MD Anderson Cancer Center (August 2017-August 2021)Postdoctoral Fellow at CSIR-Institute of Genomics and Integrative Biology (March 2016-June 2017)Senior Research Fellow at CSIR-Institute of Genomics and Integrative Biology (August 2012-February 2016)Research Assistant at CSIR-Institute of Genomics and Integrative Biology (January 2009-July 2012)

Education 🎓

Ph.D. in Life Science from CSIR-Institute of Genomics and Integrative Biology, New Delhi, India (February 2016)M.Sc. in Zoology from University of Kolkata, India (June 2007)B.Sc. in Zoology from [University Name], India (June 2005)

Mentoring and Outreach Activities 🌟

Graduate School

  • Mentored 8 graduate students and project assistants (3 males, 5 females).

Research Scientist and Postdoctoral Fellow

  • Mentored 3 postdoctoral fellows, graduate students, and project assistants.
  • Advised mentees on selecting and planning manageable research topics.
  • Evaluated and monitored research progress, providing guidance and encouragement.
  • Fostered intellectual and scholarly development, offering advice on career opportunities.
  • Mentored a female project assistant to secure a Ph.D. position based on her research interests.
  • Guided an international female Ph.D. student from China in completing research work at MDACC.

Outreach

  • Served as elected Chairperson of the Postdoctoral Association (PDAEC) at MDACC for three years (2018-2021).
  • Led outreach programs including Career Development, Internal Communications, Responsible Conduct of Research, Teaching Opportunities, and Policy Making.

Honors and Other Scientific Recognitions 🏆

Received travel awards from MD Anderson Cancer Center to present at Keystone Conference Center, Epigenetics Meeting in Denver (January 2020), and Penn State Conference, Epigenetics Meeting in Pennsylvania (August 2019).Awarded the Center of Cancer Epigenetics (CCE) postdoctoral fellowship (2019-20).Recognized with a poster award at Genome Meet Conference, New Delhi, India (December 2012).Nationally recognized for scientific work in India by The Hindu newspaper.Awarded Senior Research Fellowship by CSIR, Dept. of Life Science, Govt. Of India (2012).Acknowledged for Best Performance in M.Sc. (Zoology) by Rishi Bankim Chandra College, Kolkata University, India (2005).

 

Publications Top Notes 📝

  1. Title: Zinc-finger transcription factors are associated with guanine quadruplex motifs in human, chimpanzee, mouse and rat promoters genome-wide
    • Authors: P Kumar, VK Yadav, A Baral, P Kumar, D Saha, S Chowdhury
    • Journal: Nucleic acids research
    • Volume: 39
    • Issue: 18
    • Pages: 8005-8016
    • Year: 2011
    • Citations: 71

 

  1. Title: MRN complex-dependent recruitment of ubiquitylated BLM helicase to DSBs negatively regulates DNA repair pathways
    • Authors: V Tripathi, H Agarwal, S Priya, H Batra, P Modi, M Pandey, D Saha, …
    • Journal: Nature communications
    • Volume: 9
    • Issue: 1
    • Pages: 1016
    • Year: 2018
    • Citations: 64

 

  1. Title: Epigenetic suppression of human telomerase (hTERT) is mediated by the metastasis suppressor NME2 in a G-quadruplex–dependent fashion
    • Authors: D Saha, A Singh, T Hussain, V Srivastava, S Sengupta, A Kar, P Dhapola, …
    • Journal: Journal of Biological Chemistry
    • Volume: 292
    • Issue: 37
    • Pages: 15205-15215
    • Year: 2017
    • Citations: 61

 

  1. Title: Telomere length-dependent transcription and epigenetic modifications in promoters remote from telomere ends
    • Authors: AK Mukherjee, S Sharma, S Sengupta, D Saha, P Kumar, T Hussain, …
    • Journal: PLoS genetics
    • Volume: 14
    • Issue: 11
    • Pages: e1007782
    • Year: 2018
    • Citations: 57

 

  1. Title: Transcription regulation of CDKN1A (p21/CIP1/WAF1) by TRF2 is epigenetically controlled through the REST repressor complex
    • Authors: T Hussain, D Saha, G Purohit, A Kar, A Kishore Mukherjee, S Sharma, …
    • Journal: Scientific reports
    • Volume: 7
    • Issue: 1
    • Pages: 11541
    • Year: 2017
    • Citations: 52

 

  1. Title: Non-metastatic 2 (NME2)-mediated suppression of lung cancer metastasis involves transcriptional regulation of key cell adhesion factor vinculin
    • Authors: RK Thakur, VK Yadav, A Kumar, A Singh, K Pal, L Hoeppner, D Saha, …
    • Journal: Nucleic acids research
    • Volume: 42
    • Issue: 18
    • Pages: 11589-11600
    • Year: 2014
    • Citations: 48

 

  1. Title: Telomere repeat–binding factor 2 binds extensively to extra-telomeric G-quadruplexes and regulates the epigenetic status of several gene promoters
    • Authors: AK Mukherjee, S Sharma, S Bagri, R Kutum, P Kumar, A Hussain, P Singh, …
    • Journal: Journal of Biological Chemistry
    • Volume: 294
    • Issue: 47
    • Pages: 17709-17722
    • Year: 2019
    • Citations: 38

 

  1. Title: Metastases suppressor NME2 associates with telomere ends and telomerase and reduces telomerase activity within cells
    • Authors: A Kar, D Saha, G Purohit, A Singh, P Kumar, VK Yadav, P Kumar, …
    • Journal: Nucleic acids research
    • Volume: 40
    • Issue: 6
    • Pages: 2554-2565
    • Year: 2012
    • Citations: 34

 

  1. Title: ATF3 negatively regulates cellular antiviral signaling and autophagy in the absence of type I interferons
    • Authors: V Sood, KB Sharma, V Gupta, D Saha, P Dhapola, M Sharma, U Sen, …
    • Journal: Scientific reports
    • Volume: 7
    • Issue: 1
    • Pages: 8789
    • Year: 2017
    • Citations: 30

 

  1. Title: Fluorescent Dansyl‐Guanosine Conjugates that Bind c‐MYC Promoter G‐Quadruplex and Downregulate c‐MYC Expression
    • Authors: Y Pavan Kumar, P Saha, D Saha, I Bessi, H Schwalbe, S Chowdhury, …
    • Journal: ChemBioChem
    • Volume: 17
    • Issue: 5
    • Pages: 388-393
    • Year: 2016
    • Citations: 22

 

Dhurjhoti Saha | Chromatin remodeler | Best Researcher Award
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