Jan Tchorz | Physiology Award | Best Researcher Award

Dr. Jan Tchorz | Physiology Award | Best Researcher Award

Associate Director, Biomedical Research,ย Novartis,ย Switzerland

๐Ÿ† Dr. Jan Tchorz, renowned in the field of physiology, has been honored with the prestigious Physiology Award, recognizing his groundbreaking contributions to the field. As Associate Director of Biomedical Research at Novartis in Switzerland, Dr. Tchorz has exhibited exemplary dedication and expertise, leading innovative projects that push the boundaries of scientific understanding. His pioneering work not only advances medical knowledge but also holds significant promise for improving healthcare outcomes globally. With this Best Researcher Award, Dr. Tchorz’s remarkable achievements stand as a testament to his unwavering commitment to excellence in biomedical research, inspiring the next generation of scientists.

Profile

Scopus

Education ๐ŸŽ“

Jan Stephan Tchorz pursued his academic journey with fervor, culminating in a PhD in research physiology from the University of Basel, Switzerland, in 2010, under the mentorship of Prof. Bernhard Bettler. Prior to this, he completed his Master’s in Biology from MLU Halle, Germany, in 2006, with a focus on genetics and complex models. His academic achievements were honored with prestigious awards such as the Swiss Hepatology Prize in 2009 and the Kurt-Mothes Prize in 2006.

Experience ๐Ÿ’ผ

Jan Stephan Tchorz has showcased remarkable expertise and leadership in various roles at Novartis Institutes for Biomedical Research, Basel, Switzerland. Starting as a research assistant, he progressed to become an Associate Director in Basic and Translational Liver Physiology & Gene Therapy. With over a decade of experience, he has led cross-functional international project teams, fostering collaborations between academia and industry. His contributions have been recognized with numerous awards, including the Novartis Select Award and the Global Novartis 3R Award.

Research Interests ๐Ÿงช

Jan Stephan Tchorz’s research interests revolve around cellular physiology, multicellular dynamics, and metabolism in the contexts of regeneration, maladaptive repair, and cancer. His focus includes disease profiling, drug target identification, and the development of complex cellular organoid models. With labs in Basel, Switzerland, and Cambridge, USA, he explores innovative pathways at the intersection of cellular and metabolic physiology, paving the way for advancements in regenerative medicine and cancer research.

Awards ๐Ÿ†

Jan Stephan Tchorz’s exemplary contributions to the field have been acknowledged through various awards and honors. These include the prestigious Halloran Family Foundation Grant, Novartis Select Award, and multiple recognitions from renowned institutions such as the American Association for the Study of Liver Disease (AASLD) and the European Association for the Study of the Liver (EASL). His dedication to scientific excellence is underscored by accolades like the Swiss Hepatology Prize and the Novartis 3R Award.

Publications Top Notes๐Ÿ“š

Bipotent transitional progenitor cells contribute to liver regeneration (2023) – Published in Nature Genetics, this seminal work by Tchorz et al. investigates the role of transitional progenitor cells in liver regeneration.

Spatiotemporal metabolic liver zonation and consequences on pathophysiology (2023) – Martini et al., with Tchorz as a co-author, elucidate the spatiotemporal metabolic zonation in the liver and its implications on pathophysiology in the Annual Reviews of Pathology: Mechanisms of Disease.

ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation (2021) – Published in Cell Stem Cell, this study by Sun et al., featuring Tchorz as a corresponding author, delves into the cooperative role of ZNRF3 and RNF43 in maintaining metabolic liver zonation and regulating hepatocyte proliferation.

Genetic recording of cell proliferation reveals highly regional hepatocyte generation during liver homeostasis and regeneration (2021) – Tchorz et al., in collaboration with Zhou et al., present a groundbreaking study on genetic recording of hepatocyte proliferation in Science.

AXIN2+ Pericentral Hepatocytes Have Limited Contributions to Liver Homeostasis and Regeneration (2019) – Sun et al., led by Tchorz as a corresponding author, investigate the role of AXIN2+ pericentral hepatocytes in liver homeostasis and regeneration in Cell Stem Cell.

Abolfazl Akbari |Physiology Award | Best Researcher Award

Dr. Abolfazl Akbari | Physiology Award | Best Researcher Award

๐Ÿ‘จโ€๐ŸซProfile Summary

As a dedicated physiologist currently serving as a research assistant at the University of Mazandaran in Babolsar, Iran, I am deeply committed to unraveling the fundamental mechanisms underlying physiological processes. My research primarily focuses on understanding the intricate regulation of inhibitory and excitatory neural pathways controlling heart rate and blood pressure within the paraventricular nucleus of the hypothalamus and medulla. Additionally, I am passionate about investigating basic mechanisms such as inflammation, oxidative stress, and autophagy in metabolic disorders such as diabetes and cancer. My goal is to develop innovative approaches, including nanomaterials and herbal remedies, for the treatment of various disorders including reproductive, neurodegenerative, and metabolic diseases.

๐ŸŒ Professional Profiles

๐ŸŽ“Education

PhD in Physiology (2013-2017) from Shiraz University, with a dissertation on the cardiovascular effects of resistin injection into the paraventricular nucleus in male rats. Master of Science in Physiology (2010-2012) from Shiraz University, with research on the prophylactic effects of Vitamin C on oxidative stress induced by radiofrequency waves.

ย ๐Ÿ”ฌExperience

Researcher and lecturer at Mazandaran University since 2019, focusing on projects related to the effects of endurance exercise on cardiac ATP-sensitive potassium channels and the efficacy of a ketogenic diet combined with zinc and selenium nanoparticles for gastric cancer treatment. Previous lecturing positions at Amol University of Special Modern Techniques (2016-2019) and Malayer University (2016-2017).

 

Skill Highlights

Proficient in stereotaxic surgery and microinjections, Experienced in creating animal models for cancers, heart diseases, hypertension, and reproductive disorders, Skilled in molecular techniques such as PCR and Real-time PCR, Competent in statistical analysis and graphical representation of data

๐Ÿ“šTop Noted Publication

  1. Title: The Protective Effect of Hydroalcoholic Extract of Zingiber officinale Roscoe (Ginger) on Ethanol-Induced Reproductive Toxicity in Male Rats
    • Journal: Journal of evidence-based complementary & alternative medicine
    • Volume: 22
    • Issue: 4
    • Pages: 609-617
    • Year: 2017
    • DOI: 10.3390/cancers13112599

 

  1. Title: An overview of the characteristics and function of vitamin C in various tissues: relying on its antioxidant function
    • Journal: Zahedan Journal of Research in Medical Sciences (Tabib-e-Shargh)
    • Volume: 18
    • Issue: 11
    • Pages: 0-0
    • Year: 2016

 

  1. Title: Effects of Citrullus colocynthis L. in a rat model of diabetic neuropathy
    • Journal: Journal of Integrative Medicine
    • Volume: 18
    • Issue: 1
    • Pages: 59-67
    • Year: 2020

 

  1. Title: The prophylactic effect of vitamin C on induced oxidative stress in rat testis following exposure to 900 MHz radio frequency wave generated by a BTS antenna model
    • Journal: Electromagnetic biology and medicine
    • Volume: 32
    • Issue: 3
    • Pages: 409-416
    • Year: 2013

 

  1. Title: Vitamin C protects rat cerebellum and encephalon from oxidative stress following exposure to radiofrequency wave generated by a BTS antenna model
    • Journal: Toxicology mechanisms and methods
    • Volume: 24
    • Issue: 5
    • Pages: 347-352
    • Year: 2014

 

  1. Title: The prophylactic effect of vitamin C on oxidative stress indexes in rat eyes following exposure to radiofrequency wave generated by a BTS antenna model
    • Journal: International journal of radiation biology
    • Volume: 89
    • Issue: 2
    • Pages: 128-131
    • Year: 2013

 

  1. Title: Oil and extract of safflower seed improve fructose induced metabolic syndrome through modulating the homeostasis of trace elements, TNF-ฮฑ and fatty acids metabolism
    • Journal: Journal of ethnopharmacology
    • Volume: 254
    • Pages: 112721
    • Year: 2020

 

  1. Title: Thyme oxymel by improving of inflammation, oxidative stress, dyslipidemia and homeostasis of some trace elements ameliorates obesity induced by high-fructose/fat diet in male rat
    • Journal: Biomedicine & Pharmacotherapy
    • Volume: 126
    • Pages: 110079
    • Year: 2020

 

  1. Title: The effect of oxidative stress and antioxidants on men fertility
    • Journal: Zahedan Journal of Research in Medical Sciences
    • Volume: 15
    • Issue: 7
    • Pages: 0-0
    • Year: 2013

 

  1. Title: Safflower seed oil improves steroidogenesis and spermatogenesis in rats with type II diabetes mellitus by modulating the genes expression involved in steroidogenesis
  • Journal: Journal of Ethnopharmacology
  • Volume: 275
  • Pages: 114139
  • Year: 2021