Salvatore Nesci | Bioenergetics | Best Researcher award

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Salvatore Nesci | Bioenergetics| Best Researcher Award

 

šŸ‘Øā€šŸ« šŸŒ¾ Assoc Prof Dr. is an esteemed Associate Professor of Biochemistry at the University of Bologna, showcasing a remarkable academic journey. Holding a Ph.D. in Biochemistry and an illustrious postdoctoral tenure at renowned institutions in Spain and the UK,Ā  has established expertise in mitochondrial bioenergetics and metabolism. His extensive contributions include structural analyses of respiratory complexes, lipid studies, and proteomic techniques for mitochondrial protein characterization. As an Editor and Board member for prestigious journals, Dr. [Name] significantly shapes the discourse in biochemistry and molecular biology. With ongoing research projects exploring mitochondrial dysfunction in various health contexts, he continues to advance our understanding of fundamental cellular processes. šŸ”¬šŸ§¬šŸ“š

šŸŒ Professional Profiles

šŸŽ“ Education

B. Sc. in Biology University of Calabria Year of Beginning: 2001 Achievement Date: 28-07-2004 Thesis Title: “Lipoprotein: Electrophoretic Analysis Techniques and Risk Factors Associated with Diseases” Thesis Supervisor: Prof. C. Quagliariello M. Sc. in Biology University of Calabria Year of Beginning: 2004 Achievement Date: 26-07-2006 Thesis Title: “Effect of Omeprazole on the Carnitine Transporter OCTN2” Thesis Supervisor: Prof. C. Indiveri

šŸ” Ā Undergraduate Training

Stage: Use of the Confocal Microscope “Institute on Membrane Technology” (ITM-CNR), Rende, Italy Training: Analysis of Plasma Proteins of Membrane-Grown Hepatic Cells “Institute on Membrane Technology” (ITM-CNR), Rende, Italy

šŸ“š Ā Post Graduate and Training

2007: Qualification to the Biologist Profession 2007 – 2009: PhD in Biochemistry Department of Biochemistry “G. Moruzzi”, University of Bologna September 2008 – March 2009: Visiting Scientist Environmental Chemistry Department of IDAEAā€“CSIC (Barcelona, Spain) Supervisor: Dr. Cinta Porte March 2012 – May 2012: Visiting Scientist Medical Research Council: Mitochondrial Biology Unit (Cambridge, UK) Supervisor: Dr. Michael P. Murphy July 2017: Associate Professor Qualification Disciplinary Scientific Sector BIO/10 – Biochemistry February 2022: National Scientific Qualification as Full Professor Disciplinary Field of 05/E1 – General Biochemistry March 2023: Eligibility for Full Professor Position Disciplinary Field of 05/E1 – General Biochemistry

šŸ‘©ā€šŸ« Position

July 2010 – June 2012: Postdoctoral Research Associate Department of Veterinary Medical Sciences, University of Bologna December 2012 – November 2017: Junior Assistant Professor (Scientific Disciplinary Sector BIO/10 – Biochemistry) Department of Veterinary Medical Sciences, University of Bologna November 2017 – November 2020: Senior Assistant Professor – Tenure Track (RTDb) (Scientific Disciplinary Sector BIO/10 – Biochemistry) Department of Veterinary Medical Sciences, University of Bologna November 2020 – Present: Associate Professor (Scientific Disciplinary Sector BIO/10 – Biochemistry) Department of Veterinary Medical Sciences, University of Bologna

šŸ‘„ Ā Memberships

2013 – Present: Member of the Italian Society of Biochemistry and Molecular Biology (SIB) 2017 – Present: Italian Group of Biomembranes and Bioenergetics (GIBB) 2018 – Present: Member of the Council of the PhD Program in Veterinary Sciences, University of Bologna 2021 – Present: Member of ABCD (Associazione di Biologia Cellulare e del Differenziamento) 2022 – Present: Tutor of the “Collegio Superiore” of the University of Bologna

šŸ† Prizes, Awards, and Ongoing Research Projects

2008: Marco Polo Fellowship IDAEAā€“CSIC (Barcelona, Spain) 2012: Marco Polo Fellowship MRC-Mitochondrial Biology Unit (Cambridge, UK) 2013: Young SIB (Italian Biochemical Society) Researchers Award 2017: Travel Fellowship Membrane Group of SIB (Italian Biochemical Society) 2018: PI of the One-Year Project “Mitochondrial Permeability and F-ATPase: Implications in High Impact Diseases in Emilia-Romagna” (CARISBO Foundation, 2017-0313) 2018: Participant in the Two-Year Project “Hydrogen Sulphide as Modulator of Mitochondrial Bioenergetics in Cell Function: Effects under Physio-Pathological Conditions and in Phylogenetically Distinct Species” (University of Bologna Almaidea Senior Grant 2017) 2018: PI of the Funding for Basic Research (FFABR 2017) 2019: Participant in the One-Year Project “Mitochondrial Permeability, Aging, and Related Diseases in Emilia-Romagna” (CARISBO Foundation, 2018-0375) 2020: PI of the One-Year Project “Mitochondrial Permeability Transition Pore Modulation as a Therapy for Cardiovascular Diseases of Great Impact in Emilia-Romagna” (CARISBO Foundation, 2019/0534) 2021: PI of the One-Year Project “Effects of Bergamot Polyphenols on Human Murine Lipodystrophic Adipocytes with LMNA Gene Mutations Linked to Aging Diseases” (CARISBO Foundation, 2021/0173) 2022: PI of the One-Year Project “Molecular Strategies in Mitochondria to Limit Cardiovascular Damage in a Porcine Preclinical Model of DCD (Donation After Cardiac Death): Mitochondrial Permeability Transition Pore and F1FO-ATPase as Biological Targets” (Almaidea Grant 2022 ā€“ University of Bologna) 2023: PI of the Two-Year Project “Dissecting a Molecular Mechanism for Cardiac Hypertrophy in Hypertension: Roles of Mitochondrial NDUFC2-dependent Complex I Dysfunction and of Mitochondrial Permeability Transition” (PRIN Under40 2022, nĀ° 2022E75TWB), Italian Ministry of University and Research 2023: Co-PI of the Two-Year Project “Mitochondrial Dysfunction Associated with Permeability Transition Pore Phenomenon in Lung Inflammation Controls Mitochondria-Derived Vesicles Biogenesis and Release in Cystic Fibrosis” (PRIN 2022 PNRR, nĀ° P202242AFC), Italian Ministry of University and Research

šŸ”¬ Ā Research Interests Skills

Main interest in mitochondrial bioenergetics and metabolism, especially on the F1FO-ATPase catalytic mechanism and the mitochondrial permeability transition pore opening. Acquired scientific expertise: Mitochondrial F1FO-ATPase activity and kinetics and mitochondrial respiration analysis. Proteomic techniques for the characterization of modified protein thiols in mitochondria. Structural analysis of respiratory complexes and supercomplexes. Lipid

 

šŸ“šTop Noted Publication

Toxicity of organotin compounds: shared and unshared biochemical targets and mechanisms in animal cells Paper Published in 2013 Cited by 80

Sperm function and mitochondrial activity: An insight on boar sperm metabolism Paper Published in 2020 Cited by 49

Molecular and supramolecular structure of the mitochondrial oxidative phosphorylation system: Implications for pathology Paper Published in 2021 Cited by 44

Opposite Rotation Directions in the Synthesis and Hydrolysis of ATP by the ATP Synthase: Hints fromĀ a Subunit Asymmetry Paper Published in 2015 Cited by 44

TheĀ c-Ring of the F1FO-ATP Synthase: Facts and Perspectives Paper Published in 2016 Cited by 43

The mitochondrial permeability transition pore in cell death: A promising drug binding bioarchitecture Paper Published in 2020 Cited by 43

Tributyltin (TBT) and dibutyltin (DBT) differently inhibit the mitochondrial Mg-ATPase activity in mussel digestive gland Paper Published in 2011 Cited by 40

A Therapeutic Role for the F1FO-ATP Synthase Paper Published in 2019 Cited by 34

Tributyltin (TBT) inhibition of oligomycin-sensitive Mg-ATPase activity in mussel mitochondria Paper Published in 2008 Cited by 33

Mercury and protein thiols: Stimulation of mitochondrial F1FO-ATPase and inhibition of respiration Paper Published in 2016 Cited by 32

Modifiers of the oligomycin sensitivity of the mitochondrial F1F0-ATPase Paper Published in 2013 Cited by 31

Kinetic properties of the mitochondrial F1FO-ATPase activity elicited by Ca2+ in replacement of Mg2+ Paper Published in 2017 Cited by 30

Tributyltin (TBT) and mitochondrial respiration in mussel digestive gland Paper Published in 2011 Cited by 30