Mr. Shivang Shukla l Pharmacy
| Young Researcher Award
Jagannath University | India
The research focuses on advancing pharmacological science through multidisciplinary approaches involving drug discovery, nanotechnology, computational modeling, and translational pharmacology. Current investigations explore the computational identification of skeletal muscle-specific AMPK activators for type-2 diabetes therapy, aiming to enhance metabolic regulation and therapeutic efficacy. Additional studies examine the cardioprotective potential of Artocarpus heterophyllus against isoprenaline-induced myocardial infarction and the neuroprotective role of Coenzyme Q10 as an adjuvant to nanostructured lipid carriers loaded with Adenium obesum in ethanol-induced cognitive impairment models. The work integrates molecular biology, biochemistry, and pharmacokinetic analysis to identify novel therapeutic pathways and biomarker targets. Emphasis is also placed on nanocarrier-based drug delivery for neurological and cardiovascular disorders, focusing on improving bioavailability and site-specific targeting. Parallel research on nanotherapeutics addresses challenges in treating conditions such as Alzheimer’s disease, psoriasis, and Clostridioides difficile infection. The studies utilize a combination of in silico, in vitro, and in vivo methodologies to develop innovative solutions in pharmacology and toxicology. Through experimental validation and advanced modeling, this research contributes to understanding drug mechanisms, enhancing safety profiles, and formulating next-generation therapeutics for complex diseases, thereby supporting the global goal of precision medicine and sustainable healthcare innovation.
Featured Publications
Rai, A., Shukla, S., Gupta, R. K., & Mishra, A. (2025). ALS: A silent slayer of motor neurons. Traditional Chinese herbal medicine as an effective therapy. Current Pharmaceutical Design. https://doi.org/10.2174/0113816128329141241205063352
Singh, V., Ravindranath, S. K., Verma, H., Shukla, S., Rai, A., Patani, T., Mishra, T., Mishra, A., & Gupta, R. K. (2025). Harnessing traditional Chinese medicine for wound healing and modern wound models: An overview. Pharmacological Research: Modern Chinese Medicine. https://doi.org/10.1016/j.prmcm.2025.100664
Pal, R., Shukla, S., Rai, A., & Sharma, A. (2025, September 25). Nano-brain revolution in Alzheimer’s disease: A new era of brain drug delivery. [Book]. https://doi.org/10.70593/978-93-7185-149-7
Pal, R., Shukla, S., Gupta, R. K., Rai, A., & Sharma, P. (2025, September 13). From ancient roots to nano routes: Targeted delivery of Ginkgo and Gastrodia for Parkinson’s disease (PD) treatment. [Book]. https://doi.org/10.70593/978-93-7185-508-2