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 Dr . Srinivasan Jayakumar | Organic | Best Researcher Award

👨‍🏫Profile Summary

Dynamic, versatile, and self-motivated Research Scientist with eight years of expertise in Synthetic Organic and Medicinal Chemistry. A pragmatic strategist adept at crafting research strategies aligned with organizational priorities. Proven ability to manage complex research schedules, delivering results on demanding projects.🧪

Passionate about hands-on organic synthesis, possessing extensive knowledge in modern organic chemistry, crystallization techniques, metal-catalyzed reactions, and multi-step synthesis. Proficient in purification using flash column chromatography, Combi Flash, Gilson, Isolera, and spectroscopic characterization of novel compounds. Specialized in Drug discovery, Lead optimization, and Synthesis Characterization of Anti-viral Drugs, focusing on viral infections, macular degeneration, and neuropathic pain🌐

🌐 Professional Profiles

 

🎓 Education

Ph.D. in Organic Chemistry, National Tsing Hua University, Taiwan (2011-2020), Title: Synthesis of Quinolinoquinolines by a New Domino Reaction and Hinged Aromatic Compounds against Enterovirus 71, Masters in Chemistry, Gurunanak College, University of Madras, India (2003-2005) Bachelors in Chemistry, Gurunanak College, University of Madras, India (2000-2003)

🔬 Professional and Research Experience

Rensselaer Polytechnic Institute, Troy, NY (Jan 2022 – Present) Postdoctoral Research Associate (Department of Chemistry and Chemical Biology) Title: Synthesis of GlyT2 inhibitors to treat Neuropathic pain Albany College of Pharmacy and Health Sciences, Albany, NY (July 2020 – Dec 2021) Postdoctoral Research Associate (Department of Basic and Clinical Sciences, Department of Pharmaceutical Sciences) Title: Age-Related Macular Degeneration Syngene International Limited, India (June 2006 – Jan 2011) Research Associate II Job responsibilities include research and development of new synthetic pathways, Suzuki coupling, Grignard reaction, and monitoring reaction progress using analytical techniques.

📚 Editorial Board and Committee (2023-Present)

Editorial board member at the International Journal of Pharmacy and Chemistry, Editorial board member at Online Journal of Chemistry. Editorial board member at the International Journal of Science and Management Studies Editorial board member at Archives of Pharmacy & Pharmacology Research Community associate membership at ACS. Serving as a member of the Selection Committee for Graduate Scholarships and Awards at the University of Ottawa.

🔍Journal Reviewer and Peer- Reviewing

Demonstrated expertise in the organic and medicinal field through service as a reviewer for Eleven reputable organic chemistry journals. Reviewer at Pharmacy & Pharmacology International Journal.

🌟 Research Highlight

Participated in extramurally funded small molecule drug discovery research focusing on indications like dry AMD, neuropathic pain, and viral infections. Key projects include the design and development of novel transthyretin (TTR) tetramer kinetic stabilizers and inhibitors of glycine transporter 2 (GlyT2).

🔬Skillset

Synthesis, purification, and characterization of structurally diverse organic compounds, Broad knowledge of Synthetic Organic and Medicinal chemistry. Experience with using Chem Draw, Chem Sketch, ISIS draw, Beilstein, Reaxys, and SciFinder. Proven experience in synthetic organic chemistry, process optimization, and technology transfer. Purification using reverse-phase preparative HPLC and method development. Expertise in scale-up, product development, mass spectrometry, lead optimization, and peer

 

📚Top Noted Publication

  • “The efficacy of the analgesic GlyT2 inhibitor, ORG25543, is determined by two connected allosteric sites.”
    • Authors: Cantwell Chater, Ryan; Quinn, Ada; Wilson, Katie; Frangos, Zachary; Sutton, Patrick; Jayakumar, Srinivasan; Cioffi, Christopher; O’Mara, Megan; Vandenberg, Robert
    • Published: J. Neurochem. 2023, 00, 1–20
    • DOI: 10.1111/jnc.16028

 

  • “Novel Phenylene Lipids That Are Positive Allosteric Modulators of Glycine Receptors and Inhibitors of Glycine Transporter 2”
    • Authors: Casey I. Gallagher, Zachary J. Frangos, Diba Sheipouri, Susan Shimmon, Meryem-Nur Duman, Srinivasan Jayakumar, Christopher L. Cioffi, Tristan Rawling, Robert J. Vandenberg
    • Published: ACS Chem. Neurosci. 2023, 14, 15, 2634–2647
    • DOI: 10.1021/acschemneuro.3c00167

 

  • “Bis(Benzofuran–1,3-N,N-heterocycle)s as Symmetric and Synthetic Drug Leads against Yellow Fever Virus.”
    • Authors: Nitesh K. Gupta, Srinivasan Jayakumar, Wen-Chieh Huang, Pieter Leyssen, Johan Neyts, Sergey O. Bachurin, Jih Ru Hwu, Shwu-Chen Tsay
    • Published: Int. J. Mol. Sci. 2022, 23, 12675.
    • DOI: 10.3390/ijms232012675

 

  • “Identification of Transthyretin Tetramer Kinetic Stabilizers That Are Capable of Inhibiting the Retinol-Dependent Retinol Binding Protein 4-Transthyretin Interaction: Potential Novel Therapeutics for Macular Degeneration, Transthyretin Amyloidosis, and Their Common Age-Related Comorbidities.”
    • Authors: Christopher L. Cioffi, Arun Raja, Parthasarathy Muthuraman, Aravindan Jayaraman, Srinivasan Jayakumar, Andras Varadi, Boglarka Racz, Konstantin Petrukhin
    • Published: J. Med. Chem. 2021, 64, 13, 9010−9041.
    • DOI: 10.1021/acs.jmedchem.1c00099

 

  • “Enterovirus Inhibition by Hinged Aromatic Compounds with Polynuclei.”
    • Authors: Jih Ru Hwu, Avijit Panja, Srinivasan Jayakumar, Shwu-Chen Tsay, Kui-Thong Tan, WenChieh Huang, Yu-Chen Hu, Pieter Leyssen, Johan Neyts
    • Published: Molecules 2020, 25, 3821.
    • DOI: 10.3390/molecules25173821

 

  • “Synthesis and Human Anticancer Cell Line Studies on Coumarin- −carboline Hybrids as Possible Antimitotic Agents.”
    • Authors: S. Samundeeswari, Manohar V. Kulkarni, Shrinivas D. Joshi, Sheshagiri R. Dixit, Srinivasan Jayakumar, R. M. Ezhilarasi
    • Published: ChemistrySelect 2016, 1, 50195024.
    • DOI: 10.1002/slct.201601020

 

 

Srinivasan Jayakumar | Organic | Best Researcher Award

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