Angelika Długosz-Pokorska | cancer research | Women Researcher Award

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Ā Dr. Angelika Długosz-Pokorska | cancer research |Women Researcher Award

Ā Dr at Medical University of ÅĆ³dÅŗ,Ā  Poland

A dedicated researcher and project leader at the Medical University of Lodz, Poland, with expertise in pharmacological characterization and anticancer drug development. As Principal Investigator and Co-investigator, led projects funded by prestigious grants like OPUS and SONATA, focusing on opioid peptide analogs and alpha-methylidene-delta-lactones. Supervising international student exchanges and engaging in expert activities, workshops, and editorial work. Recognized with numerous awards for scientific excellence, including Rector’s Awards and IF=8.638 for publication series on opioid mimetics and glutathione peroxidase. Committed to advancing medical science through innovative research and academic leadership.

Profile

  1. Scopus

 

  1. Orcid

šŸ“œ Employment History:

Research Associate (2017-present) Medical University of Lodz, Poland; Faculty of Medicine. Co-investigator (2016-2021)
Project: Rational design and pharmacological characterization of chimeric cyclic opioid peptide analogs targeting multiple receptors
Grant: OPUS 9, project ID 2015/17/B/ST5/00153. Principal Investigator (2016-2021) Project: Analysis of the anticancer activity of new synthetic alpha-methylidene-delta-lactones in selected cell lines Grant: SONATA, project ID 2015/17/D/NZ3/02226. Supervisor, Project Manager, and Principal Investigator (2018-present) Project: Analysis of the anticancer activity and molecular mechanism of action of new hybrid molecules containing uracil skeleton with an exo-cyclic methylene group Grant: PRELUDIUM13, project ID UMO-2017/25/N/NZ3/01039

šŸ“š Short Research Training:

University of Rouen, France (2014) Laboratoire de Neuropsychopharmacologie ExpƩrimentale

šŸŒ Activities:

  • Expert Activity/Reviewer (2024)
    Platform: Qeios
  • International Student Exchanges and ERASMUS Supervision (2024)
    Engaging in initiatives and participating in European Union programs, overseeing ERASMUS students.
  • Participation in Scientific Workshops and Research Teams (2024)
    Engaging in workshops aimed at exchanging experiences, self-improvement, and organization.
  • Editorial Work (2023-present)
    Journal: Reviewer for Breast Cancer-Tokyo, ISSN 1340-6868, eISSN 1880-4233.

šŸ† Awards and Distinctions:

2022: First-level Special Award for Outstanding Didactic Work by Academic Teachers Medical University of Lodz.

2020: Team Distinction from the Faculty of Chemistry Nicolaus Copernicus University in Toruń Rector’s Award Medical University of Lodz Second-degree scientific award for a series of publications titled: ‘Investigation of the Anticancer Properties of Synthetic Analogues of Compounds Isolated from Plants’. (Impact Factor – 8.034). Polish Intelligent Development Award – Nomination.

2019: Investigation of Anticancer Activity of Synthetic Analogues of Methylenolactones”, IF=4.026PTBioch Bursary Scholarship 44th FEBS Congress “From Molecules to Living Systems”. Rector’s Award Medical University of Lodz Second Prize for Publication: ‘Synthetic Analogues of Coumarin as Novel Agents with Anticancer Activity’. (Impact Factor = 4.173). Rector’s Award Medical University of Lodz Team Second award for Publication Series:

2017: Rector’s Award Medical University of Lodz First Prize for Publication Series: “Synthesis and Investigation of Biological Activity of Opioid Mimetics and Glutathione Peroxidase”. (IF=8.638). Rector’s Award Medical University of Lodz Team First Prize for Publication Series: “Anticancer Properties of Novel Synthetic Dicoumarins”. (IF=6.221) “Investigation of Anticancer Activity of Sesquiterpene Lactones”. (IF=4.994)

2016: Rector’s Award Medical University of Lodz First Prize for Publication Series: “Anticancer Properties of Novel Synthetic Lactones in Combination with Known Anticancer Drugs”. (IF = 8.835)

Publications Top Notes šŸ“

  • Title: Synthesis of New Chiral Ī²-Carbonyl Selenides with Antioxidant and Anticancer Activity Evaluation-Part I
    • Authors: Laskowska, A., Pacuła-Miszewska, A.J., Obieziurska-Fabisiak, M., et al.
    • Journal: Materials
    • Year: 2024
    • Volume: 17
    • Pages: 1ā€“15
    • Summary: This study focuses on the synthesis of new chiral Ī²-carbonyl selenides and evaluates their antioxidant and anticancer activities, providing valuable insights into potential therapeutic agents.

 

  • Title: New Uracil Analog with Exocyclic Methylidene Group Can Reverse Resistance to Taxol in MCF7 Cancer Cells
    • Authors: Długosz-Pokorska, A., Perlikowska, R., Janecki, T., et al.
    • Journal: Biologics: Targets and Therapy
    • Year: 2023
    • Volume: 17
    • Pages: 69ā€“83
    • Summary: This article presents a novel uracil analog with potential to reverse resistance to Taxol in MCF7 cancer cells, indicating its promising role as an anticancer agent.

 

  • Title: New Uracil Analog- U-359 can Reverse Resistance to Taxol in MCF-7 cancer cells
    • Authors: Długosz-Pokorska, A., Perlikowska, R., Janecki, T., et al.
    • Journal: Acta Biochimica Polonica
    • Year: 2023
    • Volume: 70
    • Pages: 56
    • Summary: This study explores another uracil analog’s potential to reverse resistance to Taxol in MCF-7 cancer cells, indicating a promising avenue for further research.

 

  • Title: The Influence of Long Carbon Chains on the Antioxidant and Anticancer Properties of N-Substituted Benzisoselenazolones and Corresponding Diselenides
    • Authors: Pacuła-Miszewska, A.J., Obieziurska-Fabisiak, M., Jastrzębska, A., et al.
    • Journal: Pharmaceuticals
    • Year: 2023
    • Volume: 16
    • Pages: 1ā€“11
    • Summary: This research investigates the impact of long carbon chains on the antioxidant and anticancer properties of N-substituted benzisoselenazolones and corresponding diselenides, providing valuable insights into structure-activity relationships.

 

  • Title: Attachment of Chiral Functional Groups to Modify the Activity of New GPx Mimetics
    • Authors: Laskowska, A., Pacuła-Miszewska, A., Długosz-Pokorska, A., et al.
    • Journal: Materials
    • Year: 2022
    • Volume: 16
    • Pages: 1ā€“14
    • Summary: This study explores the modification of GPx mimetics’ activity through the attachment of chiral functional groups, offering potential strategies for enhancing therapeutic effects.

 

Ebru Temiz | cancer research | Best Researcher Award

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Assist Prof Dr . Ebru Temiz | cancer research | Best Researcher Award

šŸ‘Øā€šŸ«Profile Summary

A dedicated academic and researcher in the field of Medical Biology and Genetics, with extensive experience in cancer research and therapeutic investigations. Holds a Ph.D. and Master’s degree from Gaziantep University, specializing in miRNA and lncRNA therapies for cancer treatment. Currently serving as a faculty member at Harran University, contributing to educational programs and leading various research projects. Proficient in project management, molecular biology techniques, and data analysis. Passionate about advancing medical science and making meaningful contributions to cancer therapy.

šŸŒ Professional Profiles

šŸ“š Education Information

šŸŽ“ PhD in Medical Biology and Genetics Institution: Gaziantep University, Medical Faculty Department: Medical Biology and Genetics Thesis Title: Investigation of the Therapeutic Effects of miRNAs Targeting CCT3 Gene in Various Cancer Cell Lines Date: 01 September 2016 – 01 November 2020 (4 Years 3 Months) Thesis Advisor: Professor Emel Şahin šŸŽ“ Master’s Degree in Medical Biology and Genetics Institution: Gaziantep University, Medical Faculty Department: Medical Biology and Genetics Thesis Title: Investigation of the Therapeutic Effect of PINK1-AS lncRNA in HCT116 Colon Cancer Cell Line Date: 01 September 2013 – 01 June 2016 (2 Years 10 Months) Thesis Advisor: Professor Serdar Oztuzcu šŸŽ“ Bachelorā€™s Degree in Biology Institution: Gaziantep University Date: 01 September 2008 – 26 June 2012 (3 Years 10 Months) Cumulative Grade Point Average: 3.21 / 4.0

šŸ“ Experience Information

šŸ‘Øā€šŸ« Faculty Member, Dr. Institution: Harran University Şanlıurfa Health Services Vocational School Department: Medical Services and Techniques, Medical Promotion and Marketing Program Date: 07 September 2022 – Present (11 Months) šŸ‘Øā€šŸ« Faculty Member Institution: Harran University Şanlıurfa Health Services Vocational School Department: Medical Services and Techniques, Medical Promotion and Marketing Program Date: 09 March 2017 – Present (6 Years 5 Months) šŸ‘Øā€šŸ”¬ PhD Fellow Institution: Gaziantep University Date: 01 January 2013 – 01 January 2017 (4 Years 1 Month)

šŸ“š Competency

šŸ“– Books Title: Cancer Genetics Authors: E. Temiz, R. Dikme, A. Sarpkaya, D. Taşdemir, C. Okudu, . Bozgeyik & E. Bozgeyik Publication: Nobel Publication, Turkey Date: 01 December 2021 Chapter In Book

šŸ”¬ Projects

Investigation Of Mmh-1’s Anti-Cancer Effect In 4T1 Breast Cancer Mouse Model Position: Project Manager Institution: Harran University Sponsor Institution: Harran University (Domestic) Status: Ongoing Investigation Of The Protective Effects Of Green Pistachio (Pistacia Vera L.) Shell Extract On The Heart In Rats With Doxorubicin-Induced Cardiac Damage Position: Researcher Institution: Medical Faculty Sponsor Institution: Harran University (Domestic) Status: Ongoing Protective Effects Of Fusilin On Heart Damage Induced By Dobutamine In Rats Position: Researcher Institution: Harran University Sponsor Institution: Harran University (Domestic) Status: Ongoing Effects Of Myo-Inositol And Oxytetracycline Added To The Diluter On Sperm Quality After Thawing Of Frozen Sperm Of Barbus Grypus Position: Researcher Institution: Harran University Sponsor Institution: Harran University (Domestic) Status: Ongoing Investigation Of Therapeutic Effects Of miRNAs Targeting CCT3 Gene In Various Cancer Cell Lines Position: Researcher Institution: Gaziantep University Sponsor Institution: Gaziantep University (Domestic) Date: 01 May 2019 – 01 November 2020 Investigation Of The Potential Use Of Green Antep Pistachio Shell As A Phytotherapeutic And Dietary Supplement Product Position: Researcher Institution: Harran University Sponsor Institution: Development Ministry (Domestic) Date: 01 February 2019 – 01 May 2020 Evaluation Of Polymorphisms In CX3CR1, UQCC And BMP-2 Genes And miR-96 Expression In Patients With Developmental Hip Dysplasia (DHD) Position: Researcher Institution: Harran University Sponsor Institution: Harran University (Domestic) Date: 01 October 2018 – 01 October 2019 Investigation Of The Anticancer Effect Of Haplophyllum Ptilostylum Plant On Liver Cancer (SNU-423) Cells Position: Researcher Institution: Harran University Sponsor Institution: Harran University (Domestic) Date: 01 July 2018 – 01 February 2019 Change In Micro-RNA During Cardiopulmonary Bypass Position: Researcher Institution: Harran University Sponsor Institution: Harran University (Domestic) Date: 01 February 2018 – 01 February 2019 Investigation Of Tissue And Plasma Free Amino Acid And Carnitine Profile In Patients With Pterygium Position: Researcher Institution: Harran University Sponsor Institution: Harran University (Domestic) Date: 01 January 2018 – 01 January 2019 Equation With Three Unknowns In The Pericardial Fluid And Plasma Of Patients Undergoing Open Heart Surgery: Interleukin 33 (IL33), Fetuin A, And Cytokeratin 18 Relationship Position: Researcher Institution: Harran University Sponsor Institution: Harran University (Domestic) Date: 01 February 2017 – 01 April 2018

šŸ“šTop Noted Publication

  1. Title: Cardioprotective Effect Of Pistacia Vera L.(Green Pistachio) Hull Extract In Wistar Albino Rats With Doxorubicin-Induced Cardiac Damage
    • Authors: Ersƶz, M. S., Aydin, Y., Hacanli, N., KankiliƧ, N., Koyuncu, ., GĆ¼ldĆ¼r, M. E., Temiz, E., Ƈakmak, Y., Eč, K., Dikme, R., Padak, M.
    • Journal: Anatolian Journal Of Cardiology
    • Year: 2023
    • Volume: 27
    • Issue: 3
    • Pages: 2149-2263

 

  1. Title: Local Myelin Damage In The Hippocampus Fluctuates Gut Microbiome Profile And Memory
    • Authors: Bostancıoğlu, M., Kaplan, D. S., Temiz, E., Y, G. T.
    • Journal: Journal Of Psychiatric Research
    • Year: 2023
    • Volume: 158
    • Pages: 392-402

 

  1. Title: Novel Zinc Oxide Nanoparticles Of Teucrium Polium Suppress The Malignant Progression Of Gastric Cancer Cells Through Modulating Apoptotic Signaling Pathways And Epithelial To Mesenchymal Transition
    • Authors: Elmastaş, E., Temiz, E., Koyuncu, ., Erdal, B., Koyuncu, ., Tem Z, C., Bozgeyik, E.
    • Journal: Gene
    • Year: 2023
    • Volume: 853
    • Pages: 147091

 

  1. Title: Protective Effects Of Fuziline On Dobutamine-Induced Heart Damage In Mice
    • Authors: Hacanli, Y., Aydin, M. S., Ersƶz, E. K., KankiliƧ, N., Koyuncu, ., GĆ¼ldĆ¼r, M. E., Temiz, E., Dikme, R., Eč, K., Ƈakmak, Y., Padak, M.
    • Journal: Brazilian Journal Of Cardiovascular Surgery
    • Year: 2023
    • Volume: 38
    • Issue: 1
    • Pages: E20220251

 

  1. Title: Asprosin And Oxidative Stress Level In Covid-19 Patients
    • Authors: Seyhanlı, E. S., Koyuncu, I., Yasak, I. H., Dem, H. R., Temiz, E.
    • Journal: Clinical Laboratory
    • Year: 2022
    • Volume: 68
    • Issue: 1
    • Pages: 1-6

 

  1. Title: Cedrus Libani Tar Prompts Reactive Oxygen Species Toxicity And Dna Damage In Colon Cancer Cells
    • Authors: Temiz, E., Eg, K., Koyuncu, I., Yuksekdag, O., Kurt, Y., Ken, M. T., Akmese, S.
    • Journal: Molecular Biology Reports
    • Year: 2022
    • Volume: –
    • Pages: –
    • DOI: 0301-4851

 

  1. Title: Examination Of Carnitine Metabolism In Different Breast Cancer Cell Lines
    • Authors: Akmeşe, Ş., Temiz, E., Koyuncu, ., Taşkıran, H., TĆ¼ysĆ¼z, M. Z.
    • Journal: Harran University Medical Faculty Journal
    • Year: 2022
    • Volume: 19
    • Issue: 1
    • Pages: 1-7

 

  1. Title: Intracellular Ph-Mediated Induction Of Apoptosis In Hela Cells By A Sulfonamide Carbonic Anhydrase Inhibitor
    • Authors: Koyuncu, I., Temiz, E., Durgun, M., Kocy G T, A., Yuksekdag, O., Supuran, C. T.
    • Journal: International Journal Of Biological Macromolecules
    • Year: 2022
    • Volume: 201
    • Pages: 37-46

 

  1. Title: Examination Of The Anticancer Activity Of Pecan (Carya Illinoensis) Shell
    • Authors: Akkafa, F., Hayırlı, Z., Temiz, E., Koyuncu, .
    • Journal: Harran University Medical Faculty Journal
    • Year: 2022
    • Volume: 19
    • Issue: 1
    • Pages: 131-136

 

  1. Title: Silencing Of Tp73-As1 Impairs Prostate Cancer Cell Proliferation And Induces Apoptosis Via Regulation Of Tp73
  • Authors: Arslan, A., Batar, B., Temiz, E., Tozk R, H., Koyuncu, I., Bozgeyik, E.
  • Journal: Molecular Biology Reports
  • Year: 2022
  • Volume: 49
  • Issue: 7
  • Pages: 6859-6869