Angelika Długosz-Pokorska | cancer research | Women Researcher Award

 Dr. Angelika Długosz-Pokorska | cancer research |Women Researcher Award

 Dr at Medical University of Łódź,  Poland

A dedicated researcher and project leader at the Medical University of Lodz, Poland, with expertise in pharmacological characterization and anticancer drug development. As Principal Investigator and Co-investigator, led projects funded by prestigious grants like OPUS and SONATA, focusing on opioid peptide analogs and alpha-methylidene-delta-lactones. Supervising international student exchanges and engaging in expert activities, workshops, and editorial work. Recognized with numerous awards for scientific excellence, including Rector’s Awards and IF=8.638 for publication series on opioid mimetics and glutathione peroxidase. Committed to advancing medical science through innovative research and academic leadership.

Profile

  1. Scopus

 

  1. Orcid

📜 Employment History:

Research Associate (2017-present) Medical University of Lodz, Poland; Faculty of Medicine. Co-investigator (2016-2021)
Project: Rational design and pharmacological characterization of chimeric cyclic opioid peptide analogs targeting multiple receptors
Grant: OPUS 9, project ID 2015/17/B/ST5/00153. Principal Investigator (2016-2021) Project: Analysis of the anticancer activity of new synthetic alpha-methylidene-delta-lactones in selected cell lines Grant: SONATA, project ID 2015/17/D/NZ3/02226. Supervisor, Project Manager, and Principal Investigator (2018-present) Project: Analysis of the anticancer activity and molecular mechanism of action of new hybrid molecules containing uracil skeleton with an exo-cyclic methylene group Grant: PRELUDIUM13, project ID UMO-2017/25/N/NZ3/01039

📚 Short Research Training:

University of Rouen, France (2014) Laboratoire de Neuropsychopharmacologie Expérimentale

🌍 Activities:

  • Expert Activity/Reviewer (2024)
    Platform: Qeios
  • International Student Exchanges and ERASMUS Supervision (2024)
    Engaging in initiatives and participating in European Union programs, overseeing ERASMUS students.
  • Participation in Scientific Workshops and Research Teams (2024)
    Engaging in workshops aimed at exchanging experiences, self-improvement, and organization.
  • Editorial Work (2023-present)
    Journal: Reviewer for Breast Cancer-Tokyo, ISSN 1340-6868, eISSN 1880-4233.

🏆 Awards and Distinctions:

2022: First-level Special Award for Outstanding Didactic Work by Academic Teachers Medical University of Lodz.

2020: Team Distinction from the Faculty of Chemistry Nicolaus Copernicus University in Toruń Rector’s Award Medical University of Lodz Second-degree scientific award for a series of publications titled: ‘Investigation of the Anticancer Properties of Synthetic Analogues of Compounds Isolated from Plants’. (Impact Factor – 8.034). Polish Intelligent Development Award – Nomination.

2019: Investigation of Anticancer Activity of Synthetic Analogues of Methylenolactones”, IF=4.026PTBioch Bursary Scholarship 44th FEBS Congress “From Molecules to Living Systems”. Rector’s Award Medical University of Lodz Second Prize for Publication: ‘Synthetic Analogues of Coumarin as Novel Agents with Anticancer Activity’. (Impact Factor = 4.173). Rector’s Award Medical University of Lodz Team Second award for Publication Series:

2017: Rector’s Award Medical University of Lodz First Prize for Publication Series: “Synthesis and Investigation of Biological Activity of Opioid Mimetics and Glutathione Peroxidase”. (IF=8.638). Rector’s Award Medical University of Lodz Team First Prize for Publication Series: “Anticancer Properties of Novel Synthetic Dicoumarins”. (IF=6.221) “Investigation of Anticancer Activity of Sesquiterpene Lactones”. (IF=4.994)

2016: Rector’s Award Medical University of Lodz First Prize for Publication Series: “Anticancer Properties of Novel Synthetic Lactones in Combination with Known Anticancer Drugs”. (IF = 8.835)

Publications Top Notes 📝

  • Title: Synthesis of New Chiral β-Carbonyl Selenides with Antioxidant and Anticancer Activity Evaluation-Part I
    • Authors: Laskowska, A., Pacuła-Miszewska, A.J., Obieziurska-Fabisiak, M., et al.
    • Journal: Materials
    • Year: 2024
    • Volume: 17
    • Pages: 1–15
    • Summary: This study focuses on the synthesis of new chiral β-carbonyl selenides and evaluates their antioxidant and anticancer activities, providing valuable insights into potential therapeutic agents.

 

  • Title: New Uracil Analog with Exocyclic Methylidene Group Can Reverse Resistance to Taxol in MCF7 Cancer Cells
    • Authors: Długosz-Pokorska, A., Perlikowska, R., Janecki, T., et al.
    • Journal: Biologics: Targets and Therapy
    • Year: 2023
    • Volume: 17
    • Pages: 69–83
    • Summary: This article presents a novel uracil analog with potential to reverse resistance to Taxol in MCF7 cancer cells, indicating its promising role as an anticancer agent.

 

  • Title: New Uracil Analog- U-359 can Reverse Resistance to Taxol in MCF-7 cancer cells
    • Authors: Długosz-Pokorska, A., Perlikowska, R., Janecki, T., et al.
    • Journal: Acta Biochimica Polonica
    • Year: 2023
    • Volume: 70
    • Pages: 56
    • Summary: This study explores another uracil analog’s potential to reverse resistance to Taxol in MCF-7 cancer cells, indicating a promising avenue for further research.

 

  • Title: The Influence of Long Carbon Chains on the Antioxidant and Anticancer Properties of N-Substituted Benzisoselenazolones and Corresponding Diselenides
    • Authors: Pacuła-Miszewska, A.J., Obieziurska-Fabisiak, M., Jastrzębska, A., et al.
    • Journal: Pharmaceuticals
    • Year: 2023
    • Volume: 16
    • Pages: 1–11
    • Summary: This research investigates the impact of long carbon chains on the antioxidant and anticancer properties of N-substituted benzisoselenazolones and corresponding diselenides, providing valuable insights into structure-activity relationships.

 

  • Title: Attachment of Chiral Functional Groups to Modify the Activity of New GPx Mimetics
    • Authors: Laskowska, A., Pacuła-Miszewska, A., Długosz-Pokorska, A., et al.
    • Journal: Materials
    • Year: 2022
    • Volume: 16
    • Pages: 1–14
    • Summary: This study explores the modification of GPx mimetics’ activity through the attachment of chiral functional groups, offering potential strategies for enhancing therapeutic effects.

 

Faiyaz Shakeel |Pharmaceutical sciences | Best Researcher Award

 Prof Dr. Faiyaz Shakeel | Pharmaceutical sciences |Best Researcher Award

Prof Dr. King Saud University, Saudi Arabia

👩‍🔬Highly accomplished in pharmaceutics, holds a Ph.D. and M. Pharm. from Jamia Hamdard University, India. With extensive experience as a Professor and Associate Professor at King Saud University, Riyadh, Saudi Arabia, and previous roles in academia and research, he excels in formulation research and development. His expertise spans nanoemulsions and transdermal dosage forms, contributing significantly to the field. Driven by a passion for innovation, he led groundbreaking projects, optimizing drug delivery systems for enhanced therapeutic outcomes. Eager to leverage his skills and knowledge, he seeks to join a renowned research organization, fostering growth and advancement in pharmaceutical sciences.🌟

 

Profile

 

Scholar

 

🎓  Objectives

Seeking association with a renowned research organization in formulation research and development to upgrade knowledge, research, and management skills in line with the latest trends. Eager to be part of a dynamic team contributing to organizational growth.

📚  Qualification Overview

Doctor of Philosophy (Ph.D.) in Pharmaceutics, Jamia Hamdard University, New Delhi, India, 2004-2007. Master of Pharmacy (M. Pharm.) in Pharmaceutics, Jamia Hamdard University, New Delhi, India, 2002-2004. Bachelor of Pharmacy (B. Pharm.), Jamia Hamdard University, New Delhi, India, 1998-2002.

👨‍🏫 Professional Experience

Professor, King Saud University, Riyadh, Saudi Arabia (Feb 2022 – Present) Associate Professor, King Saud University, Riyadh, Saudi Arabia (Mar 2016 – Feb 2022) Assistant Professor, King Saud University, Riyadh, Saudi Arabia (Nov 2011 – Mar 2016) Lecturer, Garyounis University, Benghazi, Libya (Nov 2007 – Nov 2011) Senior Lecturer, Bhawani Shankar Anangpuria Institute of Pharmacy, Faridabad, India (Aug 2006 – Oct 2007) Guest Lecturer, Shri Gopichand College of Pharmacy, Baghpat, India (Jul 2004 – Jun 2006)

🏅  Professional Qualification

Ph.D. Title: Formulation and development of transdermal dosage form (Nanoemulsions) for antirheumatoid drug, Jamia Hamdard University, New Delhi, India, 2004-2007. M. Pharm. Title: Development and evaluation of bioadhesive transdermal gels of diclofenac diethylamine, Jamia Hamdard University, New Delhi, India, 2002-2004. B. Pharm., Jamia Hamdard University, New Delhi, India, 1998-2002.

🔬 Practical Experience

Master’s Research Project: Developed bioadhesive transdermal gels for diclofenac diethylamine. Ph.D. Thesis: Developed nanoemulsion and nanoemulsion gel formulations of celecoxib and aceclofenac for arthritis.

🔍Conclusion of Research Projects

Master’s Project: Optimized gel showed controlled drug release and significant anti-inflammatory effects. Ph.D. Thesis: Developed nanoemulsion formulations with controlled release, higher absorption, and significant pharmacodynamic effects.

Publications Top Notes 📝

  • Development and bioavailability assessment of ramipril nanoemulsion formulation
    • Authors: S Shafiq, F Shakeel, S Talegaonkar, FJ Ahmad, RK Khar, M Ali
    • Journal: European journal of pharmaceutics and biopharmaceutics
    • Year: 2007
    • Volume: 66
    • Issue: 2
    • Pages: 227-243
    • Citations: 1006

 

  • Nanoemulsions as vehicles for transdermal delivery of aceclofenac
    • Authors: F Shakeel, S Baboota, A Ahuja, J Ali, M Aqil, S Shafiq
    • Journal: Aaps Pharmscitech
    • Year: 2007
    • Volume: 8
    • Pages: 191-199
    • Citations: 427

 

  • Formulation development and optimization using nanoemulsion technique: a technical note
    • Authors: S Shafiq-un-Nabi, F Shakeel, S Talegaonkar, J Ali, S Baboota, A Ahuja, …
    • Journal: AAPS pharmscitech
    • Year: 2007
    • Volume: 8
    • Pages: E12-E17
    • Citations: 420

 

  • Design, development and evaluation of novel nanoemulsion formulations for transdermal potential of celecoxib
    • Authors: S Baboota, F Shakeel, A Ahuja, J Ali, S Shafiq
    • Journal: Acta pharmaceutica
    • Year: 2007
    • Volume: 57
    • Issue: 3
    • Pages: 315-332
    • Citations: 397

 

  • A review on the strategies for oral delivery of proteins and peptides and their clinical perspectives
    • Authors: A Muheem, F Shakeel, MA Jahangir, M Anwar, N Mallick, GK Jain, …
    • Journal: Saudi Pharmaceutical Journal
    • Year: 2016
    • Volume: 24
    • Issue: 4
    • Pages: 413-428
    • Citations: 384

 

Annesha Chakraborty| Bioinformatics | Women Researcher Award

 Dr. Annesha Chakraborty | Bioinformatics | Women Researcher Award

 Dr. SASTRA DEEMED UNIVERSITY

👩‍🔬 A highly motivated Ph.D. candidate at SASTRA Deemed University, specializing in Bioinformatics and Biomolecular Crystallography, with hands-on experience in molecular docking, dynamics, and laboratory techniques. Possessing an M.Sc. in Microbiology and B.Sc. (Hons.) in Microbiology, Chemistry, and Botany, I excel in research and academic achievements. As a Research Intern at MEAB LAB and Lab Tech. Intern at Suraksha Diagnostic Pvt. Ltd., I contributed to multiple publications and gained expertise in DNA/RNA extraction and PCR. Currently engaged in molecular dynamics studies on COVID Mpro, biomass production, and A.baumannii’s efflux pump research. Passionate about advancing scientific knowledge and addressing real-world challenges.🌟

 

Profile

Orcid

Scholar

 

🎓 Education

Doctor of Philosophy (2023-Ongoing) SASTRA Deemed University, India Bioinformatics Center and Biomolecular Crystallography Lab, under the supervision of Dr. S. Thamotharan and co-supervision of Dr. Vigneshwer R. Currently pursuing research funded by DBT-govt. of India. M.Sc in Microbiology (2020-2022) Grade: A+ (80%) [Ranked 4th] B.Sc (Hons.) in Microbiology (2017-2020) Optional subjects: Chemistry and Botany Grade: B+ 12th (High School) (2015-2017) Science stream

🔬 Key Skills

  • Molecular Docking
  • Molecular Dynamics
  • Schrodinger
  • Pymol
  • MegaAUTODOCK
  • Agarose Gel Electrophoresis
  • ELISA
  • qPCR
  • RT-PCR
  • Flow Cytometry
  • Online tools for nucleic acid or protein sequence-based analysis (Expasy, Clustal Omega, NCBI)

💼 Work Experience

Research Intern at MEAB LAB (08/2021-09/2022) JIS University (Hybrid mode) Responsibilities: Worked on current research projects with PhD scholars as a Project Associate Intern. Co-authored 3 review articles and 1 book chapter, and contributed to 3 research projects. Previously worked here for Master’s thesis paper. Lab Tech Intern at Suraksha Diagnostic Pvt. Ltd. (12.08.2022-24.08.2022) Responsibilities: Conducted DNA and RNA extraction for PCR to detect HLA, hepatitis B, hepatitis C, and Covid-19 virus. Performed RT-PCR and real-time PCR to detect RNA and DNA viruses.

Publications Top Notes 📝

  1. Title: Lignocellulolytic Microbial Systems and its Importance in Dye Decolourization: A Review

 

  1. Title: Microbial electrolysis cells for effective biohydrogen biogenesis from biowastes

 

  1. Title: Algae educed industrial enzymes production: a sustainable way forward?
    • Book: Industrial Microbiology
    • ISBN: 978-93-5461-997-7
    • Publisher: Astral International Pvt. Ltd. (Scopus)

Somayeh Hashemi Sheikhshabani | Human Genetics | Best Researcher Award

Dr. Somayeh Hashemi Sheikhshabani | Human Genetics | Best Researcher Award

👨‍🏫Profile Summary

I am a highly skilled researcher specializing in Medical Genetics with a focus on Cancer Biology, Cancer Drug Resistance, Noncoding RNAs, Computational Biology, and Genetics of Rare Diseases. With a Ph.D. from Shahid Beheshti University of Medical Sciences, Tehran, Iran, and a strong background in Cellular and Molecular Biology, I’ve conducted extensive research on genetic analysis of male infertility, identification of genes involved in various cancers, and prediction of regulatory networks using bioinformatics tools. Proficient in a wide range of experimental techniques and software applications, I am dedicated to advancing knowledge in genetics and contributing to the development of innovative therapies.

 

🌐 Professional Profiles

Education 📚

PhD in Medical Genetics Shahid Beheshti University of Medical Sciences, Tehran, Iran September 23, 2019 – October 7, 2023 PhD Thesis: Genetic investigation of non-obstructive azoospermia families with cytogenetic and molecular genetic tests, and determining the relationship between genetic and clinical findings of patients.M.Sc. in Cellular and Molecular Biology National Institute of Genetic Engineering and Biotechnology, Tehran, Iran September 23, 2010 – October 27, 2012 Master Thesis: Alkaloid extract of Peganum harmala L. seed on the expression of Bax and Bcl-2 genes involved in mitochondrial apoptosis pathway in cancer cells.B.Sc. in Molecular Genetics Shahrekord University, Shahrekord, Iran September 23, 2005 – October 7, 2009

Research Interests 🔬

  • Cancer Biology
  • Cancer Drug Resistance
  • Noncoding RNAs
  • Computational Biology
  • Genetics of Rare Diseases

Research Projects 🧬

Genetic analysis of male infertility in a family using Whole Exome Sequencing. (Student Research Committee, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2024)In silico prediction of non-coding RNA-gene regulatory network in primary gonad failure defects. (Student Research Committee, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2024)In silico identification of functional single nucleotide polymorphisms of azoospermia genes. (Student Research Committee, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2024)In silico prediction of coagulation system functional polymorphisms. (Student Research Committee, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2024)Identification of genes involved in Imatinib resistance in chronic myeloid leukemia (CML). (Student Research Committee, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2024)Genetic analysis of families with non-obstructive azoospermia by Whole Exome Sequencing. (Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2024)Genetic investigation of infertility in an Iranian family with infertility in both sexes. (Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2023)Prediction of tissue-specific inflammatory LncRNAs in COVID-19 patients. (Student Research Committee, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2021-2024)Identification of inflammatory miRNAs associated with COVID-19 and determination of their potential target genes using bioinformatics tools. (Student Research Committee, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2021-2023)Identification of genes involved in the development of chemotherapy resistance in lung cancer. (Student Research Committee, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2021-2024)Identification of common polymorphisms in the host antioxidant pathway against viruses and prediction of their effects. (Student Research Committee, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2021-2024)Identification of genes involved in the development of chemotherapy resistance in ovarian cancer. (Student Research Committee, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2021-2023)Investigation of the effect of oleuropein on miR-125b and miR-34a expression in ovarian cancer cell lines. (Cellular and Molecular Research Center, Shahrekord University of Medical Sciences; 2019-2020)Investigation of the effect of oleuropein on miR-181b and miR-21 expression in breast cancer cell line. (Cellular and Molecular Research Center, Shahrekord University of Medical Sciences; 2019-2020)Investigation of the effect of oleuropein on the expression of genes involved in apoptosis in cisplatin-resistant ovarian cell line. (Cellular and Molecular Research Center, Shahrekord University of Medical Sciences; 2019-2020)Study of the effect of nanoparticles containing altretiamine and arstin on ferroptosis in ovarian cancer cell line. (Cellular and Molecular Research Center, Shahrekord University of Medical Sciences; 2016-2020)Study of the effect of nanoparticles containing altretamine on ferroptosis-apoptosis in ovarian cancer cell line. (Cellular and Molecular Research Center, Shahrekord University of Medical Sciences; 2018-2019)Genetic etiology determination of non-syndromic hearing loss families using Whole Exome Sequencing. (Cellular and Molecular Research Center, Shahrekord University of Medical Sciences; 2018-2019)

Skills 🛠️

A. Experimental Techniques:Human cell cultureMTT assay (Drugs, Natural products, Nanoparticles)DNA and RNA extractionApoptosis assayROS assayElectrophoresisQuantitative PCRConventional PCRSonicationNanodropKaryotypingSanger sequencingWhole exome sequencingB. Software Ability:Various microRNA databases (TargetScan, miRBase, miRWalk, etc.)Various lncRNA databases (starBase, LncBase, etc.)Pathway databases (KEGG, WikiPathways, Reactome)Variant prediction tools (SIFT, Mutation Taster, Polyphen, CADD, etc.)Genome browsers (NCBI, Ensembl, UCSC)Primer design software and tools (AlleleID, Primer3, Oligo 7, etc.)Sequence analysis software (QIAGEN CLC Genomics Workbench, Mutation Surveyor, FinchTV, etc.)STRINGDBCytoscapeGene RunnerGenome expression databases (GEO, GTEx, etc.)

Workshops 📚

 

  • Various workshops covering topics such as predicting LncRNAs, the role of biological systems in cancer, electronic resource investigation, Next Generation sequencing, molecular techniques, article writing, PCR, and bioinformatics.

📚Top Noted Publication

  1. Title: The effect of oleuropein on apoptotic pathway regulators in breast cancer cells
    • Journal: European Journal of Pharmacology
    • Year: 2020
    • Volume: 886
    • Pages: 173509
    • Citations: 43

 

  1. Title: Peganum harmala L.’s anti-growth effect on a breast cancer cell line
    • Journal: Biotechnology reports
    • Year: 2015
    • Volume: 8
    • Pages: 138-143
    • Citations: 39

 

  1. Title: Oleuropein reduces cisplatin resistance in ovarian cancer by targeting apoptotic pathway regulators
    • Journal: Life Sciences
    • Year: 2021
    • Volume: 278
    • Pages: 119525
    • Citations: 26

 

  1. Title: Growth inhibitory impact of Peganum harmala L. on two breast cancer cell lines
    • Journal: Iranian journal of biotechnology
    • Year: 2014
    • Volume: 12
    • Issue: 1
    • Pages: 8-14
    • Citations: 23

 

  1. Title: The impact of oleuropein on miRNAs regulating cell death signaling pathway in human cervical cancer cells
    • Journal: Biotechnology and Applied Biochemistry
    • Year: 2024
    • Volume: 71
    • Issue: 1
    • Pages: 61-71
    • Citations: 1

 

  1. Title: In Silico Prediction of Functional SNPs Interrupting Antioxidant Defense Genes in Relation to COVID-19 Progression
    • Journal: Biochemical Genetics
    • Year: 2024
    • Pages: 1-27

 

  1. Title: Meta-analysis of microarray data to determine gene indicators involved in the cisplatin resistance in ovarian cancer
    • Journal: Cancer Reports
    • Year: 2023
    • Volume: 6
    • Issue: 12
    • Pages: e1884