Srinivasan Jayakumar | Organic | Best Researcher Award

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Ā Dr . Srinivasan Jayakumar | Organic | Best Researcher Award

šŸ‘Øā€šŸ«Profile Summary

Dynamic, versatile, and self-motivated Research Scientist with eight years of expertise in Synthetic Organic and Medicinal Chemistry. A pragmatic strategist adept at crafting research strategies aligned with organizational priorities. Proven ability to manage complex research schedules, delivering results on demanding projects.šŸ§Ŗ

Passionate about hands-on organic synthesis, possessing extensive knowledge in modern organic chemistry, crystallization techniques, metal-catalyzed reactions, and multi-step synthesis. Proficient in purification using flash column chromatography, Combi Flash, Gilson, Isolera, and spectroscopic characterization of novel compounds. Specialized in Drug discovery, Lead optimization, and Synthesis Characterization of Anti-viral Drugs, focusing on viral infections, macular degeneration, and neuropathic painšŸŒ

šŸŒ Professional Profiles

 

šŸŽ“ Education

Ph.D. in Organic Chemistry, National Tsing Hua University, Taiwan (2011-2020), Title: Synthesis of Quinolinoquinolines by a New Domino Reaction and Hinged Aromatic Compounds against Enterovirus 71, Masters in Chemistry, Gurunanak College, University of Madras, India (2003-2005) Bachelors in Chemistry, Gurunanak College, University of Madras, India (2000-2003)

šŸ”¬Ā Professional and Research Experience

Rensselaer Polytechnic Institute, Troy, NY (Jan 2022 ā€“ Present) Postdoctoral Research Associate (Department of Chemistry and Chemical Biology) Title: Synthesis of GlyT2 inhibitors to treat Neuropathic pain Albany College of Pharmacy and Health Sciences, Albany, NY (July 2020 ā€“ Dec 2021) Postdoctoral Research Associate (Department of Basic and Clinical Sciences, Department of Pharmaceutical Sciences) Title: Age-Related Macular Degeneration Syngene International Limited, India (June 2006 ā€“ Jan 2011) Research Associate II Job responsibilities include research and development of new synthetic pathways, Suzuki coupling, Grignard reaction, and monitoring reaction progress using analytical techniques.

šŸ“šĀ Editorial Board and Committee (2023-Present)

Editorial board member at the International Journal of Pharmacy and Chemistry, Editorial board member at Online Journal of Chemistry. Editorial board member at the International Journal of Science and Management Studies Editorial board member at Archives of Pharmacy & Pharmacology Research Community associate membership at ACS. Serving as a member of the Selection Committee for Graduate Scholarships and Awards at the University of Ottawa.

šŸ”Journal Reviewer and Peer- Reviewing

Demonstrated expertise in the organic and medicinal field through service as a reviewer for Eleven reputable organic chemistry journals. Reviewer at Pharmacy & Pharmacology International Journal.

šŸŒŸ Research Highlight

Participated in extramurally funded small molecule drug discovery research focusing on indications like dry AMD, neuropathic pain, and viral infections. Key projects include the design and development of novel transthyretin (TTR) tetramer kinetic stabilizers and inhibitors of glycine transporter 2 (GlyT2).

šŸ”¬Skillset

Synthesis, purification, and characterization of structurally diverse organic compounds, Broad knowledge of Synthetic Organic and Medicinal chemistry. Experience with using Chem Draw, Chem Sketch, ISIS draw, Beilstein, Reaxys, and SciFinder. Proven experience in synthetic organic chemistry, process optimization, and technology transfer. Purification using reverse-phase preparative HPLC and method development. Expertise in scale-up, product development, mass spectrometry, lead optimization, and peer

 

šŸ“šTop Noted Publication

  • “The efficacy of the analgesic GlyT2 inhibitor, ORG25543, is determined by two connected allosteric sites.”
    • Authors: Cantwell Chater, Ryan; Quinn, Ada; Wilson, Katie; Frangos, Zachary; Sutton, Patrick; Jayakumar, Srinivasan; Cioffi, Christopher; O’Mara, Megan; Vandenberg, Robert
    • Published: J. Neurochem. 2023, 00, 1ā€“20
    • DOI: 10.1111/jnc.16028

 

  • “Novel Phenylene Lipids That Are Positive Allosteric Modulators of Glycine Receptors and Inhibitors of Glycine Transporter 2”
    • Authors: Casey I. Gallagher, Zachary J. Frangos, Diba Sheipouri, Susan Shimmon, Meryem-Nur Duman, Srinivasan Jayakumar, Christopher L. Cioffi, Tristan Rawling, Robert J. Vandenberg
    • Published: ACS Chem. Neurosci. 2023, 14, 15, 2634ā€“2647
    • DOI: 10.1021/acschemneuro.3c00167

 

  • “Bis(Benzofuranā€“1,3-N,N-heterocycle)s as Symmetric and Synthetic Drug Leads against Yellow Fever Virus.”
    • Authors: Nitesh K. Gupta, Srinivasan Jayakumar, Wen-Chieh Huang, Pieter Leyssen, Johan Neyts, Sergey O. Bachurin, Jih Ru Hwu, Shwu-Chen Tsay
    • Published: Int. J. Mol. Sci. 2022, 23, 12675.
    • DOI: 10.3390/ijms232012675

 

  • “Identification of Transthyretin Tetramer Kinetic Stabilizers That Are Capable of Inhibiting the Retinol-Dependent Retinol Binding Protein 4-Transthyretin Interaction: Potential Novel Therapeutics for Macular Degeneration, Transthyretin Amyloidosis, and Their Common Age-Related Comorbidities.”
    • Authors: Christopher L. Cioffi, Arun Raja, Parthasarathy Muthuraman, Aravindan Jayaraman, Srinivasan Jayakumar, Andras Varadi, Boglarka Racz, Konstantin Petrukhin
    • Published: J. Med. Chem. 2021, 64, 13, 9010āˆ’9041.
    • DOI: 10.1021/acs.jmedchem.1c00099

 

  • “Enterovirus Inhibition by Hinged Aromatic Compounds with Polynuclei.”
    • Authors: Jih Ru Hwu, Avijit Panja, Srinivasan Jayakumar, Shwu-Chen Tsay, Kui-Thong Tan, WenChieh Huang, Yu-Chen Hu, Pieter Leyssen, Johan Neyts
    • Published: Molecules 2020, 25, 3821.
    • DOI: 10.3390/molecules25173821

 

  • “Synthesis and Human Anticancer Cell Line Studies on Coumarin- āˆ’carboline Hybrids as Possible Antimitotic Agents.”
    • Authors: S. Samundeeswari, Manohar V. Kulkarni, Shrinivas D. Joshi, Sheshagiri R. Dixit, Srinivasan Jayakumar, R. M. Ezhilarasi
    • Published: ChemistrySelect 2016, 1, 5019ļ€­5024.
    • DOI: 10.1002/slct.201601020

 

 

Beom Jin Kim | Organic Chemistry | Best Researcher Award

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Ā Dr. Beom Jin Kim | Organic Chemistry | Best Researcher Award

 

šŸ‘Øā€šŸ«Professional Profile šŸŒŸ

šŸ”¬ With a rich nine-year background in advanced energy storage materials, I specialize in pioneering electrode materials and systems for cutting-edge batteries beyond lithium-ion. My expertise spans the synthesis and modification of electrode materials using diverse chemical and solid-state approaches. Proficient in assessing electrochemical performance through various techniques, I excel in characterizing materials using in-situ and ex-situ spectroscopic methods. Currently immersed in anode-free all-solid-state lithium battery systems, cathode materials, anode materials, and superionic conductors, I am poised to bring my valuable knowledge and skills to elevate any project or position within your esteemed organization. āš”šŸ” #EnergyStorage #MaterialsScience #BatteryInnovation #Electrochemistry.

šŸŒ Professional Profiles

 

šŸŽ“Academic Background

Assistant Professor, Department of Chemistry, University of Ulsan, Ulsan, Republic of Korea (September, 2020- Present), Postdoctoral Fellow, Department of Chemistry, Brandeis University, Waltham, Massachusetts, USA (February, 2019- July, 2020). Advisor: Professor Bing Xu, Postdoctoral Fellow, Department of Chemistry, KAIST, Daejeon, Republic of Korea (March, 2018-January 2019). Advisor: Professor Insung S. Choi, Ph.D. in Organic Chemistry, Department of Chemistry, KAIST, Daejeon, Republic of Korea (February, 2018). Advisor: Professor Insung S. Choi, B.S. in Chemistry, Department of Chemistry, Sungkyunkwan University, Suwon, Republic of Korea (February, 2012)

šŸ†Awards and Honors

Review Editor of Frontiers in Chemistry (March, 2023-Present), Early Career Research (ECR) Board Member of Materials Today Bio (June, 2022-Present), KAIST Best Ph.D. Thesis Award (2018, KAIST), Selected as Rising Researcher (2017, Inter-Academy Seoul Science Forum, KAST), Hyocheon Scholarship (2011, Sungkyunkwan University), Academic Scholarship (2009, 2011; Sungkyunkwan University)

šŸ“šTop Noted Publication

Chemical Degradation of Various Organic Coatings via UV-Generated Sulfate Radicals. Baskoro, G. A.ā€ ; Christstardy, Y. Y.ā€ ; Rho, J.; Kim, B. J.* Chem. Asian J. 2024, accepted.

 

Thermoresponsive Maleimide-Containing Polymers with Tunable Emission for Temperature-Dependent Intracellular Imaging. Sharma, R.; Vijay, N.; Kim, B. J.; Lee, H. Eur. Polym. J. 2023, 201, 112545.

 

An Exploration of Multiple Component Peptide Assemblies by Enzymeā€Instructed Selfā€Assembly. Shy, A. N.; Xu, J.; Kim, B. J.; Xu, B.* ChemSystemsChem 2023, 5, e202200041.

 

Cytoprotection of Probiotic Lactobacillus acidophilus with Artificial Nanoshells of Nature-Derived Eggshell Membrane Hydrolysates and Coffee Melanoidins in Single-Cell Nanoencapsulation. Han, S. Y.; Nguyen, D. T.; Kim, B. J.; Kim, N.; Kang, E. K.; Park, J. H.; Choi, I. S. Polymers 2023, 15, 1104.

 

Hydrogen Bonding-Based Layer-by-Layer Assembly of Nature-Derived Eggshell Membrane Hydrolysates and Coffee Melanoidins in Single-Cell Nanoencapsulation. Han, S. Y.; Yun, G.; Nguyen, D. T.; Kang, E. K.; Lee, H.; Kim, S.; Kim, B. J.; Park, J. H.; Choi, I. S.* ChemNanoMat 2022, 8, e202100535. Cover Article

 

Enzyme-Instructed Self-Assembly of Peptides: From Concept to Representative Applications. Kim, B. J.* Chem. Asian J. 2022, 17, e202200094. Invited Review

 

Enzyme-Mediated Kinetic Control of Fe3+-Tannic Acid Complexation for Interface Engineering. Lee, H.; Nguyen, D. T.; Kim. N.; Han, S. Y.; Hong, Y. J.; Yun, G.; Kim, B. J.; Choi, I. S. ACS Appl. Mater. Interfaces. 2021, 13, 52385-52394.

 

Enzyme-Mediated Film Formation of Melanin-Like Species from orthoDiphenols: Application to Single-Cell Nanoencapsulation. Kim, N.ā€ ; Lee, H. J.ā€ ; Han, S. Y.; Kim, B. J.; Choi, I. S. Appl. Surf. Sci. Adv. 2021, 5, 100098.

 

A Decade of Advances in Single-Cell Nanocoating for Mammalian Cells. Lee, H. J.; Kim, N.; Kim, B. J.; Park, J. H.; Choi, I. S.* Adv. Healthcare Mater. 2021, 10, 2100347.

 

Enzymatically Forming Cell Compatible Supramolecular Assemblies of Tryptophan-Rich Short Peptides. Yang, D.; Kim, B. J.; He, H.; Xu, B.* Pept. Sci. 2021, 113, e24173.

 

Peptide Assemblies Mimicking Chaperones for Protein Trafficking. Yang, D.; He, H.; Kim, B. J.; Xu, B.* Bioconjugate Chem. 2021, 32, 502-506.

 

Trypsin-Instructed Self-Assembly on Endoplasmic Reticulum for Selectively Inhibiting Cancer Cells. Kim, B. J.; Fang, Y.; He, H.; Xu, B.* Adv. Healthcare Mater. 2021, 10, 2000416.

 

The Ratio of Hydrogelator and Precursor Controls Enzymatic Hydrogelation of a Branched Peptide. Guo, J.; He. H.; Kim, B. J.; Wang, J.; Yi, M.; Xu, B.* Soft Matter, 2020, 16, 10101-10105.