Elshimaa Abdelhafez | Medicinal Chemistry | Best Researcher Award

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Dr. Elshimaa Abdelhafez | Medicinal Chemistry |Best Researcher Award

šŸ‘Øā€šŸ«Profile Summary

Elshimaa Abdelhafez is an accomplished academician with a strong background in Medicinal Chemistry. Holding a PhD from Minia University, Egypt, earned through the CHANNEL Program with Wake Forest University, USA, their research focuses on the synthesis, molecular modeling, and anticancer activity of organic compounds. With teaching experience since 2002, they have excelled as an Assistant Professor at Minia University, imparting knowledge in Medicinal and Organic Chemistry to undergraduate and postgraduate students. Their research experience spans mechanistic studies, chromatographic techniques, and computer-based drug design. Proficient in Arabic and English,Elshimaa Abdelhafez possesses excellent computer skills, making significant contributions to both academia and research.

šŸŒ Professional Profiles

Academic Qualifications šŸŽ“:

PhD Degree, Pharmaceutical Sciences (Medicinal Chemistry), December 2013, Minia University (Minia, Egypt) (Earned through CHANNEL Program between the School of Art and Science, Chemistry Dep., Wake Forest University, NC, USA, and Faculty of Pharmacy, El-Minia University) Thesis Advisor: Prof. Dr. Bruce King, Prof. of Chemistry, Wake Forest University, NC, USA Thesis entitled “Synthesis, Molecular Modeling and Anticancer Activity of New Reserpine Derivatives as Inducers of Mis-Match Repair Protein” Master Degree: in Pharmaceutical Sciences (Medicinal Chemistry), January 2008, Faculty of Pharmacy, Minia University (Minia, Egypt) Thesis Advisor: Prof. Dr. Hassan H. A, Farag, Prof. of Pharmaceutical Chemistry, former dean, Faculty of Pharmacy, Assiut University. Thesis entitled: “Synthesis and Investigation of Certain Derivatives Pyrazole-3-Carboxylic Acid as Novel Carriers for Nitric Oxide” B.Sc Degree: In Pharmaceutical Sciences, May 2002, Faculty of Pharmacy, El-Minia University Grade: Excellent with honor (88.23%)

Professional Positions šŸ‘©ā€šŸ«:

September 2002-December 2007: Teaching Assistant (demonstrator) at Medicinal Chemistry department, Faculty of Pharmacy, Minia University. January 2008-May 2011: Assistant Lecturer at Medicinal Chemistry department, Faculty of Pharmacy, Minia University. June 2011-June 2013: Research scholar at Prof. S. Bruce King Lab, Wake Forest University, Winston Salem, North Carolina, USA. June 2013-November 2013: Assistant Lecturer at Medicinal Chemistry department, Faculty of Pharmacy, Minia University. December 2013-Current: Assistant Professor at Medicinal Chemistry department, Faculty of Pharmacy, Minia University.

Research Experiences šŸ§Ŗ:

Channel scholarship at Chemistry Department, Prof. Dr. Bruce King laboratory Wake Forest University, North Carolina, USA (June 2011-June 2013) Design and synthesis of organic compounds of potential biological activities Reaction mechanistic study Chromatographic techniques (Flash chromatography, Column Chromatography, and Preparative chromatography). Biological study of the synthesized compounds by the help of other institutions. Prodrug approaches as a tool for enhancing drug properties Structural elucidation of various groups of synthesized products using spectroscopic techniques including IR, NMR (ID and 2D), elemental analysis and MS (HRMS and ESI). Computer-based drug design including the pharmacophore and structure-based designs using MOE version 2014. Postgraduate research student (master and doctoral student), Faculty of Pharmacy, Minia University, Minia, Egypt (October 2002-May 2011) Synthesis of NO releasing compounds using different synthetic and separation technique for NO release measurement Some biological testing like anti-inflammatory and ulcerogenicity Principles of drug design software Good teaching experience for both organic and medicinal chemistry.

Teaching Experience šŸ“š:

Medicinal Chemistry Department, Faculty of Pharmacy, Minia University. Lecturer of Medicinal Chemistry (December 2013-current) Teaching theoretical Medicinal Chemistry courses for undergraduate pharmacy students (ANS, CNS, CVS, Drug Design, ā€¦.) Teaching theoretical Organic Chemistry courses for undergraduate pharmacy students (stereochemistry, spectroscopy, carboxylic acid & derivatives, heterocyclic chemistry, ..) Teaching Organic Spectroscopy for postgraduate pharmacy students (IR, NMR, Mass) Teaching Stereochemistry for clinical Pharmacy students. Teaching Advanced Medicinal Chemistry Course for postgraduate pharmacy students in Master degree of medicinal chemistry (special courses). Teaching Advanced Organic Chemistry Course for postgraduate pharmacy students in Master degree of medicinal chemistry(Special course). Organic Chemistry Department, Faculty of Pharmacy, Deraya University. Lecturer of Organic Chemistry (September 2015-Jan 2019) Teaching Organic Chemistry I & II courses for undergraduate pharmacy students (Introduction, stereochemistry, Heterocyclic Chemistry, Aromatic compounds, ā€¦.) Medicinal Chemistry Department, Faculty of Pharmacy, Minia University. Teaching Assistant. (September 2002-December 2013) Teaching practical Organic Chemistry courses. Teaching practical Medicinal Chemistry courses.

Skills šŸŒ:

  • Languages:
    • Arabic: mother tongue.
    • English: Excellent written and spoken)
  • Computer:
    • Excellent in windows, Word, PowerPoint, Internet, and Endnote
    • Very good in Excel and GraphPad Prism
    • (Passed ICDL exams ā€“ advanced ICTP, course exam)

 

šŸ“šTop Noted Publication

  1. M.G.A. Abd Elhalim, et al.
    • Title: Hemorrhoidectomy versus Hemorrhoidectomy with Internal Anal Sphincterotomy in Management of Hemorrhoids.

 

  1. S. Abdel Hafez, et al.
    • Title: The role of mast cells in accelerating our skin aging.

 

  1. E.-S.M. Abdel-Hafez, et al.
    • Title: Design, synthesis and biological investigation of certain pyrazole-3-carboxylic acid derivatives as novel carriers for nitric oxide.

 

  1. A.M. Abdel-Hakem, E.-S.M. Abdelhafez, et al.
    • Title: Docking Studies Of Some E-2-Phenyl-4-(2-Phenylhydrazineylidene) Oxazol-5 (4H)-One Derivatives As A Potential Caspase-8 Inhibitor.

 

  1. E. Abdelhafez, et al.
    • Title: Comparing Open Preperitoneal Versus Laparoscopic Totally Extra Peritoneal Repair of Inguinal Hernia.

 

  1. E.-S.M.N. Abdelhafez, et al.
    • Title: Apoptotic inhibitors as therapeutic targets for cell survival.

 

  1. E.-S.M. AbdelHafez, et al.
    • Title: Synthesis, Molecular Modeling and Anticancer Activity of New Rescinnamine Derivatives as MMR-Inducers.

 

  1. E.M. AbdelHafez, et al.
    • Title: Computational and synthetic studies towards improving rescinnamine as an inducer of MSH2-dependent apoptosis in cancer treatment.

 

  1. E.M. AbdelHafez, et al.
    • Title: Improving rescinnamine as an inducer of MSH2-dependent apoptosis in cancer treatment.

 

  1. E.M.N. Abdelhafez, et al.
    • Title: Antimicrobial Activity of New Amide/thioamides Derivatives of Ciprofloxacin.

 

  1. E.S.M. AbdelHafez, et al.
    • Title: Lossen rearrangements under Heck reaction conditions.

 

  1. A.M. AbdelHakem, E.-S.M. Abdelhafez, et al.
    • Title: Current trends and future perspectives of antimutagenic agents.

 

  1. M. Abdullah, et al.
    • Title: Fluoroquinolones as urease inhibitors: anti-Proteus mirabilis activity and molecular docking studies.

Eman Nossier | Pharmaceutical Medicinal Chemistry | Best Researcher Award

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Assoc Prof Dr. Eman Nossier |Pharmaceutical Medicinal ChemistryĀ  | Best Researcher Award

 

šŸŒŸ Profile Summary

šŸŽ“ As an accomplished pharmaceutical scientist, I hold a Ph.D. in Pharmaceutical Chemistry (2014) and have been an integral part of Al-Azhar University’s Faculty of Pharmacy since 2012. Currently serving as an Associate Professor, I specialize in Pharmaceutical Medicinal Chemistry & Drug Design. šŸ« My responsibilities include teaching courses like Pharmaceutical Chemistry I and II, as well as guiding postgraduate students.

šŸ‘©ā€šŸ« With a rich educational background, including a Master’s in Pharmaceutical Sciences (2009) and a Bachelor’s in Pharmacy (2002), I have contributed significantly to the academic and research domains. šŸ’Š My prior experience at the National Research Center, focusing on Therapeutic Chemistry, has further enriched my expertise.

šŸ’” Engaging in various activities such as Chemoffice and Scifinder, I continuously strive for excellence. My commitment extends beyond teaching to include supervising practical courses and fostering the academic growth of aspiring pharmaceutical professionals. šŸŒ

 

šŸŒ Professional Profiles

šŸŽ“Qualifications

PhD in Pharmaceutical Science with a focus on Pharmaceutical Chemistry (2014) MSc in Pharmaceutical Science with a specialization in Pharmaceutical Chemistry (2009) BSc in Pharmaceutical Science from Al-Azhar University (2002)

šŸ’¼Work Experience

 

Associate Professor of Pharmaceutical Chemistry (2019 – Present) Ā Main Responsibilities: Teaching courses: Pharmaceutical Chemistry I, Pharmaceutical Chemistry II Supervision of postgraduate students Lecturer of Pharmaceutical Chemistry (2014 – 2019) Ā Main Responsibilities: Teaching courses: Pharmaceutical Chemistry I, Pharmaceutical Chemistry II Supervision of practical courses Supervision of postgraduate students Assistant Lecturer of Pharmaceutical Chemistry (2012 – 2014) Ā Main Responsibilities: Supervision and teaching of practical courses Participation in practical exams Preparing to obtain the PhD degree National Research Center, Pharmaceutical and Drug Industries Division, Therapeutic Chemistry Department: Pharmacist (2003-2006) Researcher Assistant (2006-2009) Assistant Researcher (2009-2012)

šŸ“šEducation History

Doctor of Philosophy (Ph.D.) in Pharmaceutical Chemistry, Al-Azhar University (Girls)- Cairo, Egypt (2014) Master in Pharmaceutical Sciences (Pharmaceutical Chemistry), Al-Azhar University (Girls)- Cairo, Egypt (2009) Bachelor of Pharmacy, Al-Azhar University – Cairo, Egypt (2002)

Other Activities

Proficient in Chemoffice 2016, Scifinder, and Molsoft ICM 3.4-8C program. Ā Completed a Training Course of “Occupational Safety and Health” at Training and Skills Development Center, National Research Centre (Egypt, January 17-21, 2004). Ā Completed a Training Course of “Scientific Writing” at Training and Skills Development Center, National Research Centre (Egypt, May 24-June 2, 2004). Ā Passed the International Computer Driving Licence Exam (ICDL) in 2010. Ā Participation in organizing the 3rd International Conference of Pharmaceutical and Drug Industries Division, National Research Centre under the theme of Research and Development in Drugs (Future Trends) (March 6-8, 2007). Ā Participation as a speaker in the 4th International Conference of Pharmaceutical and Drug Industries Division, National Research Centre under the theme of Research and Development in Drugs (Current Challenges) (March 3-5, 2009). Ā Completed a Training Course of “Computer-aided Drug Design Using MOE Software” at Medicinal Chemistry Department, Faculty of Pharmacy, Assiut University (Egypt, January 26-28, 2013). Ā Participation as a poster presenter in the 5th International Chemistry Conference under the theme “Chemistry for Durable Globe and Society Welfare,” Abha, Saudi Arabia (April 26-29, 2014). Ā Completed a Training Course of “Structure-Based, Ligand-Based Drug Design Using Discovery Studio Software” at Professional Development Program, Faculty of Pharmacy, Misr International University (Egypt, September 2014).

šŸ†Awards

The Best Poster Award at the 4th International Conference on New Horizons in Basic and Applied Sciences (ICNHBAS2019), Faculty of Science, Al-Azhar University, Assuit, Egypt (July 26-29, 2019).Ā The Best Poster Award at the 15th International Conference on Chemistry and its Role in Development (ICCRD ’15), Faculty of Science, Mansoura University, Hurghada, Egypt (August 9-13, 2021).Ā The Best Scientific Production Award at the Faculty of Pharmacy (Girls), Al-Azhar University (2021-2022).

Membership in Scientific Societies

Member of The Egyptian Chemical Society. Member of the Arab Association of Pharmacy Progress. Member of The National Committee of Drugs by the Academy of Scientific Research and Technology (ASRT) for the term 2022-2025. Member of The Organization for Women in Science for the Developing World (OWSD), Trieste, Italy.

Reviewer in Scientific Journals

Reviewer for the Journal of Enzyme Inhibition and Medicinal Chemistry. Reviewer for Springer Nature Applied Sciences. Ā Reviewer for Breast Cancer: Targets and Therapy. Reviewer for Synthetic Communications. Reviewer for the Journal of Molecular Structure Reviewer for the Egyptian Journal of Chemistry. Reviewer for the Egyptian Pharmaceutical Journal. Reviewer for Molecules. Reviewer for Future Medicinal Chemistry.

šŸ§ŖResearch Projects Involvement

Member in project No. 7020103: “Anti-inflammatory agents: new derivatives as cyclooxygenase inhibitors” Funded by NRC, Cairo, Egypt (2004-2007). Member in project No. 9100102: “Oriented synthesis & pharmacological evaluation of novel organic compounds as anticancer agents” Funded by NRC, Cairo, Egypt (2010-2013). Ā Member in project No. P100208: “Synthesis, molecular modeling studies and biological evaluation of novel pyrazole derivatives as antitumor and EGFR inhibitor” Funded by NRC, Cairo, Egypt (2015-2016). Ā Member in project No. P100205: “Oriented synthesis and anticancer evaluation of new organic compounds” Funded by NRC, Cairo, Egypt (2015-2016). Ā Member in project No. 11010312: “Oriented Synthesis and Molecular Modeling Studies of Novel Heterocyclic Derivatives Including Quinazoline, Pyrazole, benzimidazole and/or Pyrimidine Moieties of Expected Anti-Neoplastic Activity” Funded by NRC, Cairo, Egypt (2016-2019). Ā Member in project No. 11010315: “Synthesis and Molecular Modeling of Some Thiopyrimidine-5-carbonitrile Derivatives as Anticancer and Antimicrobial Agents” Funded by NRC, Cairo, Egypt (2016-2019). Ā Member in project No. 12060111: “Oriented synthesis and molecular modeling studies of novel derivatives including different heterocyclic moieties of expected anti-inflammatory, antihypertension, and anticancer activities” Funded by NRC, Cairo, Egypt (2019-2022). Ā Member in project No. 10191-cos-2020-1-3-I: “Design, Synthesis, Anticancer Activity and Molecular Modeling of New Hybrids Containing Triazole and Derived Glycosides” Funded by Qassim University, Qassim, Saudi Arabia (2020-2022). Ā Member in project No. 43327: “Design, synthesis, and anti-cancer evaluation of new pyrido[2,3-d]pyrimidin-4(3H)-one derivatives as potential EGFRWT and EGFRT790M inhibitors and apoptosis inducers” Funded by Science and Technology Development Fund (STDF), Cairo, Egypt (2020-2021). Ā Member in project No. IFPIP: 210-247-1442: “Design, Synthesis, Anticancer Evaluation and Molecular Docking of Novel Thiophene-based derivatives” Funded by King Abdulaziz University, Jeddah, Saudi Arabia (2021-2022). Ā Member in project No. IFPIP: 1237-247-1443: “Synthesis, bioevaluation, and in silico studies of novel pyridine and pyrazole derivatives as selective c-Met kinase inhibitors of potential anticancer activity” Funded by King Abdulaziz University, Jeddah, Saudi Arabia (2022-2023).

šŸ“šTop Noted Publication

Antibacterial evaluation, in silico characters and molecular docking of Schiff bases derived from 5-aminopyrazoles Paper Published in 2017 Cited by 67

 

Design, synthesis, anticancer evaluation, enzymatic assays, and a molecular modeling study of novel pyrazoleā€“indole hybrids Paper Published in 2021 Cited by 65

 

New pyrimidine and pyrazole-based compounds as potential EGFR inhibitors: Synthesis, anticancer, antimicrobial evaluation and computational studies Paper Published in 2021 Cited by 58

 

Design and synthesis of novel pyrazole-substituted different nitrogenous heterocyclic ring systems as potential anti-inflammatory agents Paper Published in 2017 Cited by 57

 

Design, synthesis and molecular docking of new pyrazole-thiazolidinones as potent anti-inflammatory and analgesic agents with TNF-Ī± inhibitory activity Paper Published in 2021Cited by 54

 

Synthesis and molecular docking study of new pyrazole derivatives as potent anti-breast cancer agents targeting VEGFR-2 kinase Paper Published in 2020 Cited by 54

 

Click chemistry based synthesis, cytotoxic activity and molecular docking of novel triazole-thienopyrimidine hybrid glycosides targeting EGFR Paper Published in 2021 Cited by 51

 

Novel phthalimide based analogues: Design, synthesis, biological evaluation, and molecular docking studies Paper Published in 1019 Cited by48

 

Biological Validation of Novel Polysubstituted Pyrazole Candidates withĀ in Vitro Anticancer Activities Paper Published in 2016 Cited by 48

 

 

Ahmed Abu-Dief | Medicinal chemistry| Best Scholar Award

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Ā Prof Dr. Ahmed Abu-Dief | Medicinal chemistry| Best Scholar Award

 

šŸ‘Øā€šŸ« šŸ§ŖšŸ“š Ahmed Mohammed Abu-Dief Mohammed, a distinguished researcher and educator, boasts a rich academic journey with a B.Sc. in Special Chemistry, M.Sc., and Ph.D. from Sohag University, Egypt. With a prolific h-index, his expertise in inorganic and physical chemistry spans diverse areas. His significant postdoctoral stints in Spain underscore a global perspective. Proficient in a myriad of computer skills,Ā  Abu-Dief is not only a researcher but also an adept trainer. Awarded for his research and teaching contributions, he stands among the top scientists globally. His multifaceted skills, from synthesizing nanomaterials to designing nano photo catalysts, showcase a commitment to cutting-edge research. šŸŒšŸ† #Chemistry #Researcher #Education

šŸŒ Professional Profiles

šŸŽ“Education

BSc in Science Part of Special Chemistry (2004) Honors: Excellent with honor degree Centenary Rate: 85.99% MSc in Chemistry, Sohag University, Egypt (2010) Thesis: “Solvent and Temperature Effects on the Kinetic of Reactions and Their Reactivity Trends of Some Coumarin Derivatives” PhD in Chemistry, Sohag University, Egypt (2013) Thesis: “Design, Physicochemical Studies, Interaction with DNA, and Kinetic Investigation of The Reactivity of Some Multifunctional Complexes Containing Schiff Bases

šŸŒPostdoctoral Experience& Skills and Experiences

6 years postdoctorate in Inorganic Chemistry, Faculty of Chemistry, Barcelona University, Spain 10 years postdoctorate in Physical Chemistry, Department of Chemistry, Oviedo University, Spain Inorganic and Physical Chemistry Complex preparation and characterization (UV-Visible spectra, IR, NMR, CHN, conductance, thermal analysis) Magnetic properties of complexes Bonding in transition metal complexes and crystal field theory Kinetics and reactivity trends of indicator and laser dye compounds Thermodynamic and transfer properties of ions Kinetics of DNA interaction with coordination compounds Design and formation of single crystals of multifunctional systems Computer Skills Operating systems and program packages for Microsoft International Computer Driving License (ICDL) Training in statistical program (SPSS) and Photoshop Oracle Database and SQL expertise Experience in GC tool for catalytic reactions Synthesis of nanomaterials via hydrothermal method

šŸ”¬Research Experience and Interests

Study of base-catalyzed hydrolysis of Chromen-2-one derivatives Analysis of solvent effects on reactivity trends of coumarin derivatives Determination of thermodynamic properties of ions Design and characterization of Schiff base-amino acid complexes Investigation of multifunctional systems containing Schiff base ligands and 4f metals Synthesis and functionalization of nanoparticles for various applications

šŸ…Awards and Recognitions, Grade and Appreciation Certificates

Multiple awards for research excellence and contributions to academia, Top 2% of the world’s scientists (Stanford University classification, 2020-2023), International gold medal for outstanding performance in a project, Best Researcher Award in International Scientist Awards on Engineering, Science, and Medicine (2021), State Encouragement Award from the Academy of Scientific Research (2022), Certificates of thanks and appreciation for various contributions to academia, research, and training, Recognition for website management and teaching assistance, Active participation in international conferences and workshops

šŸ”Research Projects

Design and study of multifunctional systems containing Schiff bases,curcuminoid ligands and 4f metals towards the development of nano devicesā€2011-2012, AECID, program 7-PCI-EGIPTE (AP/040924/ 11) BarcelonaUniversity, Spain.o Mesoporous materials, 2014-2016,Spanish Ministerio de EconomĆ­a yCompetitividad (MAT2013-40950-R), Gobierno del Principado de Asturias(GRUPIN14-060) and EDRF funding, Oviedo Universityo Solubility studies and Transfer Chemical Potentials in different organic cosolvent -water mixtures of Cobalt (III)-hydrazone complexes as Antimicrobialand anticancer agents, Grant No. 7679-SCI-2018-3-9-F from the Deanship ofScientific Research at Northern Border University, Arar, K.S.A.o Temperature and salt effects of the Kinetic reactions of substituted 2-pyridylmethylene-8-quinolyl iron (II) complexes as antimicrobial and anti-canceragents with Cyanide ions, Grant No. 1125-SCI-2019-1-10-F from the Deanship ofScientific Research at Northern Border University, Arar, K.S.A.o Eco-friendly synthesis of AgNPs using Delonix regia extract, characterizationand their applications as anticancer and antimicrobial agents, King SaudUniversity, Riyadh, Saudi Arabia Grant No. RSP-2020/79)o Synthesis of Erbium Oxide Supported on Cupper and Tungsten Oxides andTheir Nanocomposites with Polymers for Environmental and EnergyApplications, Sohag University, Egypt, 2019-2020 .

šŸ“šTop Noted Publication

A review on versatile applications of transition metal complexes incorporating Schiff bases Paper Published in 2015 Cited by 720

Metal based pharmacologically active agents: Synthesis, structural characterization, molecular modeling, CT-DNA binding studies and in vitro antimicrobial screening of iron (IIĀ ā€¦Paper Published in 2014 Cited by 215

Some new nano-sized Fe (II), Cd (II) and Zn (II) Schiff base complexes as precursor for metal oxides: Sonochemical synthesis, characterization, DNA interaction, in vitroĀ ā€¦Paper Published in 2016 Cited by 211

Synthesis, characterization, DFT calculations and biological studies of Mn (II), Fe (II), Co (II) and Cd (II) complexes based on a tetradentate ONNO donor Schiff base ligand Paper Published in 2017 Cited by 179

Design, characterization, teratogenicity testing, antibacterial, antifungal and DNA interaction of few high spin Fe (II) Schiff base amino acid complexes Paper Published in 2017 Cited by 171

Sonochemical synthesis, DNA binding, antimicrobial evaluation and in vitro anticancer activity of three new nano-sized Cu (II), Co (II) and Ni (II) chelates based on triĀ ā€¦ Paper Published in 2016 Cited by 167

Development and functionalization of magnetic nanoparticles as powerful and green catalysts for organic synthesis Paper Published in 2018 Cited by 158

Ni (II) and Cu (II) complexes with ONNO asymmetric tetradentate Schiff base ligand: synthesis, spectroscopic characterization, theoretical calculations, DNA interaction andĀ ā€¦ Ā Paper Published in 2017 Cited by 157

Tailoring, physicochemical characterization, antibacterial and DNA binding mode studies of Cu (II) Schiff bases amino acid bioactive agents incorporating 5-bromo-2Ā ā€¦ Paper Published in 2015 Cited by 154