Hesham El-Beshbishy | toxicology Award | Best Researcher Award

Prof. Hesham El-Beshbishy | toxicology Award |Best Researcher Award

šŸ‘Øā€šŸ«Profile Summary

Hesham El-Beshbishy is a highly accomplished biochemist and molecular biologist with a distinguished academic and professional background. Holding a Ph.D. from the University of Manchester, UK, their research expertise spans TPR-mediated protein interactions, anaphase-promoting complex (APC), and molecular aspects of diseases. As a Professor of Biochemistry and Molecular Biology, they have significantly contributed to medical sciences education at Fakeeh College and Taibah University in Saudi Arabia. Their commitment extends to various academic committees and research projects, showcasing a versatile skill set in laboratory techniques, genomics, and teaching. With honors, awards, and a robust publication record, Hesham El-Beshbishy is an influential figure in the field, focusing on oxidative stress, metal toxicity, and molecular diagnostics.

šŸŒ Professional Profiles

 

 

šŸŽ“University Degrees:

Bachelor of Pharmaceutical Sciences, Faculty of Pharmacy, Al-Azhar University at Cairo, May 1989 (First degree of excellence with honor). Master of Biochemistry, Biochemistry Department, Faculty of Pharmacy, Al-Azhar University at Cairo, June 1994 (Thesis: Studies on some metabolic effects of calcium channel blockers in diabetic rabbits). Master Philosophy (M.Phil.) in Biochemistry, Molecular Biology, and Genetics, Biomolecular Sciences Department, University of Manchester, United Kingdom, 1999. Doctor of Philosophy (Ph.D.) in Biochemistry, Molecular Biology, and Genetics, Biomolecular Sciences Department, The University of Manchester, United Kingdom, March 2001 (Thesis: Investigation of TPR-mediated protein interactions within the anaphase-promoting complex (APC)).

šŸ‘Øā€šŸ«Occupational Background:

Professor of Biochemistry and Molecular Biology, Medical Laboratory Sciences, Fakeeh College for Medical Sciences, Jeddah, Saudi Arabia (July 2016 – Present). Professor of Biochemistry and Molecular Biology, Faculty of Medical Applied Sciences, Taibah University, Saudi Arabia (Nov 2012 – June 2016). Academic and Educational Affairs Coordinator, Faculty of Applied Medical Sciences, Taibah University, Saudi Arabia (2010 – Present). Associate Professor of Biochemistry and Molecular Biology, Faculty of Medical Applied Sciences, Taibah University, Saudi Arabia (Jun 2007 – Present). Assistant Professor of Biochemistry, Chemistry Department, Faculty of Science, Taibah University, Saudi Arabia (Oct 2004 – May 2007). Lecturer of Biochemistry, Faculty of Pharmacy, Al-Azhar University, Egypt (Dec 2001 – Oct 2004). Assistant Lecturer of Biochemistry, Faculty of Pharmacy, Al-Azhar University, Egypt (Jun 1994 – Dec 2001). Demonstrator of Biochemistry and Molecular Biology, Biomolecular Sciences Department, University of Manchester, UK (Sept 1997 – Jul 2001). Demonstrator of Biochemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt (May 1992 – Sept 1994).

Experiences šŸ§Ŗ:

Routine and advanced medical laboratory instrumentation. Animal experimentation (induction of liver injury, diabetes, hyperlipidemia, tumors, kidney damage, etc.). Effect of drugs and certain diseases on several biochemical parameters. Genotyping and phenotyping. Autoanalysers (chemistry). Spectrophotometry. Gene cloning into E. coli and yeast strains. Polymerase Chain Reaction (PCR) types. Automated DNA sequencing. Gene expression in bacterial and yeast systems. Yeast two hybrid assay. Ion exchange chromatography (IEC). Protein purification and interaction. In vitro translation and RNA transcription. Western blotting and electroblotting. Protein-protein interaction assays. Flow cytometry. Mass spectroscopy (MS). Enzymatic immunoradio assays and chemiluminescence. Enzyme-linked immunosorbent assay (ELISA). Electrophoresis (DNA, RNA, and Protein). Ultracentrifugation and separation of cell contents. High-performance liquid chromatography (HPLC). Liquid chromatography with mass spectroscopy (LC-MS). Gas chromatography (GC). Atomic absorption. Computer programs (PrismPad software, InStat, Plasp102, MS Office, and Chemidraw) and internet.

šŸ… Honours:

Honorary medal and a Prime Minister certificate during the annual Egyptian Pharmacists meeting, Cairo (Oct 1989). Full granted Ph.D. scholarship – Biomolecular Sciences Department, University of Manchester, UK; awarded by the Egyptian Ministry of Higher Education (Sept 1996 – Mar 2001). Peter Allen’s travel award fellowship for postgraduate students, University of Manchester (Aug 2000). Nominated by the Who’s Who encyclopedia for scientists (2007-2010). Nominated as the best-cited and H-indexed author among Taibah University staff by the Deanship of Scientific Research (2016-2023). Awarded the prize for excellence in Scientific research from the Deanship of Scientific Research, Taibah University. Awarded the prize for excellence in Scientific research from the Dean, Fakeeh College for Medical Sciences.

Summary of Ph.D.:

Investigation of TPR-mediated protein interactions within the anaphase-promoting complex (APC). The study aimed to map TPR-mediated interaction between Cdc23 and Cdc27 proteins, two components of APC in Saccharomyces cerevisiae.

šŸ“šAcademic Committees Memberships (2016 – Present):

Reviewer for staff promotion in Taibah University, Taif University, Tabuk University, and Um AlQura University, Saudi Arabia. Member in all steering committees in Fakeeh College for Medical Sciences (FCMS), Saudi Arabia. Head and member of standard 4 (teaching and Learning) of the Education Evaluation Commission EEC (formerly NCAAA) for the organizational accreditation of the FCMS. Head of the Scientific Research Review Committee inside the FCMS. Member in the students’ scientific committee, Faculty of Science, Taibah University, Saudi Arabia. Member of the demonstrators committee, Faculty of Applied Medical Sciences, Taibah University, Saudi Arabia. Member of the students’ punishment committee, Faculty of Applied Medical Sciences, Taibah University, Saudi Arabia. Head of laboratories supplies committee, Faculty of Applied Medical Sciences, Taibah University, Saudi Arabia. Head of sports committee, Faculty of Applied Medical Sciences, Taibah University, Saudi Arabia. Member of the educational committee, Faculty of Applied Medical Sciences, Taibah University, Saudi Arabia. Member in the Faculty main committee, Faculty of Applied Medical Sciences, and Faculty of Pharmacy, Taibah University, Saudi Arabia. Member in the curriculum committee, Faculty of Applied Medical Sciences, Taibah University, Saudi Arabia. Member of the academic accreditation committee, Faculty of Applied Medical Sciences, Taibah University, Saudi Arabia. Head of the cultural committee and sports committee, Faculty of Science, Taibah University, Saudi Arabia.

šŸ§ŖResearch Projects (Examples):

Role of dietary antioxidants in alleviating liver injury and oxidative stress induced by the anti-breast cancer drug tamoxifen (June 2008). Application of touch-down PCR and sequencing techniques to study the occurrence and fate of antibiotic-resistance bacteria escaping from hospitals’ wastewater to drinking water resources (Jun. 2009).Ā  Dengue mosquito, Aedes prevalence, and dengue virus molecular & immunologic detection in Al-Madinah (Feb. 2010). Antioxidant and biochemical studies on some plants growing in Al-Madinah (June 2010). Molecular diagnosis of Leishmaniasis in Al-Madinah (Strategic Project, started from Oct. 2009, ended Aug. 2013). Clinical and molecular study of hypothyroidism among pregnant Saudi women in Al-Madinah and its health effects (Dec. 2011). Relation between C-reactive protein levels with dental diseases among cardiovascular patients in Al-Madinah Al-Munawwarrah (June 2012). Biochemical and molecular study on the adverse effects of beryllium chloride and the possible protective role of crocin of saffron (July 2012). Biochemical and pharmacological effects of di-pentyl phthalate present in personal care products in adult rats testis (Dec 2013). Alleviation of doxorubicin cardiotoxicity by some natural products (Oct. 2013). Anti-tumour and antioxidant effects of some plants in Madinah (Dec 2013). Targeting synaptic mitochondria and mitochondrial biogenesis of rat brains for the treatment of psychiatric disorders (End: 5-2015). The association between Vitamin D Receptor BsmI and FokI polymorphisms and gestational diabetes mellitus among Saudi pregnant women: A case-control study (End: 5-2015). The effect of lipoic acid in spermatogenesis in STZ-diabetic rats (End: 6-2015).

Thesis Evaluation šŸ“š:

Evaluated the Ph.D. thesis for the Saudi Commission for Health Specialties of Mr. Ismail M. Al-Turkestany from Glaxo University, UK, 5-11-2007. Title: Interaction of Bordetella bronchiseptica and different Bordetella factors with sheep bone marrow mast cells and other cell types. Evaluated the Ph.D. thesis submitted by Mr. Hasan Al-Ghamdi, Biology Dept., Faculty of Science, King AbdulAziz University, Jeddah, Saudi Arabia, 21-7-2009. Title: Study on the toxicological effects of Retama raetam (medicinal plant) growing in northwestern Saudi Arabia. Evaluated the Ph.D. thesis submitted by Mrs. Aziza Badawood, Biochemistry Dept., Faculty of Science, King AbdulAziz University, Jeddah, Saudi Arabia, 21-12-2019. Title: Effect of some hypocholesterolemic drugs on the expression of genetic markers in diabetic rats. Evaluated the Ph.D. thesis submitted by Mrs. Saeeda Sadaat, Biochemistry Dept., Faculty of Science, King AbdulAziz University, Jeddah, Saudi Arabia, 21-7-2009. Title: Effect of the use of antifungal agents in the liver of rats.

Teaching Activities šŸ“–:

Taught various courses, including Basic Biochemistry, Advanced Biochemistry, Clinical and Laboratory Biochemistry, Molecular Biology, Gene Cloning and Expression, Organic Chemistry, Medicinal Chemistry, and many more. Coordinated and supervised students’ research projects and field training. Conducted Biostatistics and Computer in Chemistry (Postgraduate course). Served as a member of the teaching staff of biochemistry and clinical biochemistry in different universities.

Research Interests šŸ”¬:

  • Reactive oxygen species and tissue injury.
  • Molecular basis of diseases.
  • Molecular biology and genetics techniques.
  • Chemical-induced toxicity.
  • Oxidative stress-mediated cellular injury and protective antioxidant assessment.
  • Metal toxicity.
  • Biochemical screening of natural compounds.
  • Molecular diagnosis of diseases.

šŸ“šTop Noted Publication

 

  1. Title: The effects of diltiazem and cinnarzine on carbohydrate metabolic parameters and plasma regulatory hormones in rabbits.
    • Journal: Al-Azhar Journal of Pharmaceutical Sciences
    • Year: 1995
    • Volume: 15
    • Pages: 205-222
    • Location: Egypt

 

  1. Title: Cloning and expression of tetratricopeptide proteins of anaphase promoting complex (APC).
    • Conference: The 18th International Congress of Biochemistry and Molecular Biology
    • Year: 2000
    • Location: Birmingham, UK

 

  1. Title: Expression and purification of TPR containing proteins of the anaphase promoting complex.
    • Conference: The 14th Symposium of Protein Society
    • Year: 2000
    • Location: San Diego, USA

 

  1. Title: Study on the immunoglobulin status in patients with delayed or unresolving pneumonia.
    • Journal: Al-Azhar Journal of Pharmaceutical and Biological Sciences
    • Year: 2003
    • Volume: 1
    • Pages: 23-31
    • Location: Egypt

 

  1. Title: Protective effect of alpha ketoglutarate and vitamin E against aluminum-induced toxicity in rats’ brain: A comparative study.
    • Journal: Al-Azhar Journal of Pharmaceutical Sciences
    • Year: 2003
    • Volume: 31
    • Pages: 24-39
    • Location: Egypt

 

  1. Title: Proinflammatory cytokines IL-6, TNF-Ī± and oxidative stress in nonalcoholic fatty liver.
    • Journal: The Egyptian Journal of Biochemistry and Molecular Biology
    • Year: 2004
    • Volume: 22
    • Pages: 403-417
    • Location: Egypt

 

  1. Title: Effect of aminoguanidine on lipid peroxidation and reduced glutathione in hepatic and renal tissues of mice.
    • Journal: Biomedical Sciences
    • Year: 2004
    • Volume: 15
    • Pages: 124-131
    • Location: Egypt

 

  1. Title: Green tea extract attenuates cyclosporine A-induced oxidative stress in rats.
    • Journal: Pharmacological Research
    • Year: 2005
    • Volume: 51
    • Issue: 1
    • Pages: 51-57
    • Location: Italy

 

  1. Title: Acrylonitrile-induced toxicity and oxidative stress in isolated rat colonocytes.
    • Journal: Environmental Toxicology and Pharmacology
    • Year: 2005
    • Volume: 19
    • Issue: 2
    • Pages: 371-377
    • Location: Italy

 

  1. Title: The effect of dimethyl dimethoxy biphenyl dicarboxylate (DDB) against tamoxifen-induced liver injury in rats: DDB use is curative or protective.
    • Journal: Journal of Biochemistry and Molecular Biology
    • Year: 2005
    • Volume: 38
    • Issue: 3
    • Pages: 300-306
    • Location: Korea