Angelika Długosz-Pokorska | Molecular biochemistry | Women Researcher Award

Dr. Angelika Długosz-Pokorska | Molecular biochemistry | Women Researcher Award

Dr at Medical University of ÅĆ³dÅŗ, Poland

Angelika Długosz-Pokorska, born on January 15, 1990, in ÅĆ³dÅŗ, Poland, is a Research Associate at the Medical University of ÅĆ³dÅŗ, specializing in medicinal chemistry and cancer research. She leads projects on anticancer compounds, opioid analogs, and their pharmacological effects, contributing to multiple EU-funded research initiatives.

Profile

Scopus

orcid

Education šŸŽ“

Angelika holds a Ph.D. in Medicinal Chemistry from the Medical University of ÅĆ³dÅŗ, Poland, and has undergone research training at the University of Rouen, France, in neuropsychopharmacology.

Experience šŸ§‘ā€šŸ«

With over 7 years of research experience, Angelika has served as Principal Investigator and Co-investigator for numerous projects, including anticancer activity studies and pharmacological analysis of synthetic peptides and compounds. She has also supervised and mentored young researchers and students.

Awards and Honors šŸ†

Angelika has received multiple accolades, including “Skuteczna Kobieta Roku 2021” (Effective Woman of the Year) in the Science category, Rector’s Awards for outstanding publications, and a First-level Special Award for Didactic Excellence.

Research Focus šŸ”

Angelikaā€™s research focuses on the development of new hybrid anticancer agents, including those with uracil skeletons and methylene groups. Her work also explores the role of endomorphin analogs in neuroprotection and cancer treatment.

Publications šŸ“š

 

  • “Synthesis of New Chiral Ī²-Carbonyl Selenides with Antioxidant and Anticancer Activity Evaluationā€”Part I”
    • Journal: Materials
    • Date: February 15, 2024
    • DOI: 10.3390/ma17040899
    • ISSN: 1996-1944
    • Contributors: Anna Laskowska, Agata Pacuła-Miszewska, Magdalena Obieziurska-Fabisiak, Jastrzebska, Angelika Długosz-Pokorska, Katarzyna Gach-Janczak, Jacek Scianowski

 

  • “The Influence of Long Carbon Chains on the Antioxidant and Anticancer Properties of N-Substituted Benzisoselenazolones and Corresponding Diselenides”
    • Journal: Pharmaceuticals
    • Date: November 4, 2023
    • DOI: 10.3390/ph16111560
    • ISSN: 1424-8247
    • Contributors: Agata Pacuła-Miszewska, Magdalena Obieziurska-Fabisiak, Jastrzebska, Angelika Długosz-Pokorska, Katarzyna Gach-Janczak, Jacek Scianowski

 

  • “New Uracil Analog with Exocyclic Methylidene Group Can Reverse Resistance to Taxol in MCF-7 Cancer Cells”
    • Journal: Biologics: Targets and Therapy
    • Date: May 2023
    • DOI: 10.2147/btt.s405080
    • ISSN: 1177-5491
    • Contributors: Angelika Długosz-Pokorska, Renata Perlikowska, Tomasz Janecki, Anna Janecka

 

  • “Attachment of Chiral Functional Groups to Modify the Activity of New GPx Mimetics”
    • Journal: Materials
    • Date: March 11, 2022
    • DOI: 10.3390/ma15062068
    • ISSN: 1996-1944
    • Contributors: Anna Laskowska, Agata Joanna Pacuła-Miszewska, Angelika Długosz-Pokorska, Anna Janecka, Andrzej Wojtczak, Jacek Scianowski

 

  • “A New Hybrid Ī“-Lactone Induces Apoptosis and Potentiates Anticancer Activity of Taxol in HL-60 Human Leukemia Cells”
    • Journal: Molecules
    • Date: 2020
    • DOI: 10.3390/molecules25071479
    • ISSN: 1420-3049
    • Contributors: Katarzyna Gach-Janczak, Joanna Drogosz-Stachowicz, Angelika Długosz-Pokorska, Rafał Jakubowski, Tomasz Janecki, Jacek Szymański, Anna Janecka

 

  • “New Uracil Analog U-332 is an Inhibitor of NF-ĪŗB in 5-Fluorouracil-Resistant Human Leukemia HL-60 Cell Line”
    • Journal: BMC Pharmacology & Toxicology
    • Date: 2020
    • DOI: 10.1186/s40360-020-0397-4
    • ISSN: 1471-2210
    • Contributors: Angelika Długosz-Pokorska, Marlena Pięta, Jacek Kędzia, Tomasz Janecki, Anna Janecka

 

  • “New Uracil Analogs with Exocyclic Methylidene Group as Potential Anticancer Agents”
    • Journal: Anti-Cancer Agents in Medicinal Chemistry
    • Date: 2020
    • DOI: 10.2174/1871520619666191211104128
    • ISSN: 1871-5206
    • PMID: 31823706
    • Contributors: Angelika Długosz-Pokorska, Joanna Drogosz-Stachowicz, Marlena Pięta, Tomasz Janecki, Urszula Krajewska, Marek Mirowski, Anna Janecka

 

  • “Seleninic Acid Potassium Salts as Water-Soluble Biocatalysts with Enhanced Bioavailability”
    • Journal: Materials
    • Date: 2020
    • DOI: 10.3390/ma13030661
    • ISSN: 1996-1944
    • PMID: 32024274
    • Contributors: Magdalena Obieziurska, Agata J. Pacuła, Anna Laskowska, Angelika Długosz-Pokorska, Anna Janecka, Jacek Ścianowski

 

  • “Molecular Mechanisms of Apoptosis Induced by a Novel Synthetic Quinolinone Derivative in HL-60 Human Leukemia Cells”
    • Journal: Chemico-Biological Interactions
    • Date: April 2020
    • DOI: 10.1016/j.cbi.2020.109005
    • ISSN: 0009-2797
    • Contributors: Joanna Drogosz-Stachowicz, Angelika Długosz-Pokorska, Katarzyna Gach-Janczak, Agata Jaskulska, Tomasz Janecki, Anna Janecka

 

  • “Anticancer Activity of New Ī±-Methylene-Ī“-Lactone DL-247 in Selected Cancer Cell Lines”
    • Type: Conference Paper
    • Date: 2019
    • ISBN: 978-80-907442-0-2
    • Contributors: Katarzyna Gach-Janczak, Angelika Długosz-Pokorska, Joanna Drogosz, R. Jakubowski, Jacek Szymański, Tomasz Janecki, Anna Janecka

 

 

 

Biochemistry

Introduction ofĀ  Biochemistry

Biochemistry research is at the forefront of understanding the intricate chemical processes that underlie the living world. This interdisciplinary field bridges the gap between biology and chemistry, unraveling the molecular mechanisms that govern life. From the complexities of cellular metabolism to the structure and function of biomolecules, biochemistry plays a pivotal role in advancing our knowledge of life’s fundamental processes.

Enzyme Kinetics and Mechanisms

Enzymes are the molecular catalysts that drive biochemical reactions. Researchers in this subfield investigate the kinetics and mechanisms by which enzymes facilitate chemical transformations within cells.

Protein Structure and Function

The study of protein structure elucidates the three-dimensional arrangements of these biomolecules and their roles in various cellular processes, including signaling, transport, and catalysis.

Metabolic Pathways and Regulation

Biochemists delve into the intricate web of metabolic pathways, exploring how cells generate and utilize energy, synthesize molecules, and maintain homeostasis through metabolic regulation.

Molecular Genetics and DNA Replication

Research in this area focuses on the molecular basis of genetic information transfer, DNA replication, repair, and the regulation of gene expression, providing insights into heredity and disease.

Biochemical Pharmacology and Drug Development

Biochemists contribute to the development of new drugs and therapies by studying the interactions between drugs and biological molecules, identifying potential targets, and elucidating mechanisms of action.

These subtopics within biochemistry represent key areas of research where scientists delve deep into the molecular intricacies of life. By studying these fundamental processes, biochemists make significant contributions to fields such as medicine, biotechnology, and environmental science, ultimately advancing our understanding of the biological world and its applications.

Biochemistry

Introduction ofĀ  Biochemistry

Biochemistry research is at the forefront of understanding the intricate chemical processes that underlie the living world. This interdisciplinary field bridges the gap between biology and chemistry, unraveling the molecular mechanisms that govern life. From the complexities of cellular metabolism to the structure and function of biomolecules, biochemistry plays a pivotal role in advancing our knowledge of life’s fundamental processes.

Enzyme Kinetics and Mechanisms

Enzymes are the molecular catalysts that drive biochemical reactions. Researchers in this subfield investigate the kinetics and mechanisms by which enzymes facilitate chemical transformations within cells.

Protein Structure and Function

The study of protein structure elucidates the three-dimensional arrangements of these biomolecules and their roles in various cellular processes, including signaling, transport, and catalysis.

Metabolic Pathways and Regulation

Biochemists delve into the intricate web of metabolic pathways, exploring how cells generate and utilize energy, synthesize molecules, and maintain homeostasis through metabolic regulation.

Molecular Genetics and DNA Replication

Research in this area focuses on the molecular basis of genetic information transfer, DNA replication, repair, and the regulation of gene expression, providing insights into heredity and disease.

Biochemical Pharmacology and Drug Development

Biochemists contribute to the development of new drugs and therapies by studying the interactions between drugs and biological molecules, identifying potential targets, and elucidating mechanisms of action.

These subtopics within biochemistry represent key areas of research where scientists delve deep into the molecular intricacies of life. By studying these fundamental processes, biochemists make significant contributions to fields such as medicine, biotechnology, and environmental science, ultimately advancing our understanding of the biological world and its applications.