Chandan Shivamalli | Life Sciences | Excellence in Research

Assoc Prof Dr. Chandan Shivamalli | Life Sciences | Excellence in Research

 

Assoc Prof Dr at JSS Academy of Higher Education and Research India

Assoc Prof Dr Chandan S is an accomplished academic and researcher specializing in Biotechnology and Bioinformatics. He holds a Ph.D. from the University of Mysore and currently serves as an Assistant Professor and Coordinator at Jagadguru Sri Shivarathreeshwara University. Assoc Prof Dr. Chandan has extensive research experience, having worked on projects funded by prestigious agencies like DST-SERB and ICMR. He has led various projects, including studies on anti-mucosal inflammatory effects, Alzheimer’s disease therapy, and leptospiral peptidomimetics. Assoc Prof Dr. Chandan’s contributions to the field have earned him awards such as the DST-SERB Young Scientist Award and the ICMR Senior Research Fellowship.

profile

Scholar

📚 Educational Qualification

Bachelor of Science (B.Sc) University / College: University of Mysore, JSS College, Mysore Period: 2002-2005. M.Sc University / College: University of Mysore, JSS College, Mysore Period: 2005-2007 . Master of Philosophy (M.Phil) University / College: Vinayaka Missions University (Deemed), Vinayaka Missions University Period: 2007-2008 . Ph.D University / College: University of Mysore, University of Mysore Period: 2010-2013

💼 Work Experience

1. Project Directorate on Animal Disease Monitoring and Surveillance, ICAR Designation / Department: Post Graduate Research Assistant Period: June 02, 2007 – March 31, 2010 Duration: 2 Years 9 Months. 2. Department of Studies in Biotechnology Designation / Department: Project Fellow Period: May 17, 2010 – May 21, 2011 Duration: 1 Year 0 Months. 3. Indian Council for Medical Research Designation / Department: Senior Research Fellow Period: May 21, 2011 – December 13, 2013 Duration: 2 Years 7 Months. 4. Jagadguru Sri Shivarathreeshwara University Designation / Department: Lecturer, Biotechnology & Bioinformatics Period: December 13, 2013 – January 31, 2016 Duration: 2 Years 1 Month 5. Jagadguru Sri Shivarathreeshwara University Designation / Department: Assistant Professor & Coordinator, Biotechnology & Bioinformatics Period: February 01, 2016 – Till Date Duration: 5 Years 9 Months

🏆 Awards

1. DST-SERB Young Scientist Awarding Agency: DST-SERB, Purpose of Award: Sanction of Project, Award Type: National, Award Date: June 1, 2016 2. Senior Research Fellow Awarding Agency: ICMR, Purpose of Award: To pursue PhD, Award Type: National, Award Date: May 21, 2011

🔬 Projects

1. Evaluation of anti-mucosal inflammatory effect of Acacia fernesiana using Zebra fish as model organism Principal Investigator: Dr. Chandan S Duration: 1 Year(s) Institute: School of Life Sciences – Mysuru Department: Biotechnology & Bioinformatics 2. A prospective study of synergistic effect of combination therapy of FDA approved drugs and in silico characterization against Alzheimer’s disease Principal Investigator: Dr. Chandan S Duration: 2 Year(s) Institute: School of Life Sciences – Mysuru Department: Biotechnology & Bioinformatics 3. Genomic and proteomic analysis of outer membrane vesicles from clinical isolates of Leptospira and development of antileptospiral peptidomimetics Principal Investigator: Dr. Chandan SDuration: 3 Year(s) Institute: Faculty of Life Sciences [FLS] Department: Bioinformatics [BIOINFO]

Publications Top Notes📝

 

  • Title: A systematic review on ethnopharmacology, phytochemistry and pharmacological aspects of Thymus vulgaris Linn.
    Authors: SM Patil, R Ramu, PS Shirahatti, C Shivamallu, RG Amachawadi
    Year: 2021
    Journal: Heliyon
    Volume and Issue: 7(5)
    Article Number: 134

 

  • Title: Antiviral and immunomodulatory activity of curcumin: A case for prophylactic therapy for COVID-19
    Authors: RK Thimmulappa, KK Mudnakudu-Nagaraju, C Shivamallu, …
    Year: 2021
    Journal: Heliyon
    Volume and Issue: 7(2)
    Article Number: 133

 

  • Title: Bioactive compounds effective against type 2 diabetes mellitus: a systematic review
    Authors: C Egbuna, CG Awuchi, G Kushwaha, M Rudrapal, …
    Year: 2021
    Journal: Current Topics in Medicinal Chemistry
    Volume and Issue: 21(12)
    Pages: 1067-1095

 

  • Title: In silico evaluation of flavonoids as effective antiviral agents on the spike glycoprotein of SARS-CoV-2
    Authors: AS Jain, P Sushma, C Dharmashekar, MS Beelagi, SK Prasad, …
    Year: 2021
    Journal: Saudi Journal of Biological Sciences
    Volume and Issue: 28(1)
    Pages: 1040-1051

 

  • Title: Genetic typing of recent classical swine fever isolates from India
    Authors: SS Patil, D Hemadri, BP Shankar, AG Raghavendra, H Veeresh, …
    Year: 2010
    Journal: Veterinary Microbiology
    Volume and Issue: 141(3-4)
    Pages: 367-373

 

  • Title: Genistein: a potent anti-breast cancer agent
    Authors: SS Bhat, SK Prasad, C Shivamallu, KS Prasad, A Syed, P Reddy, CA Cull, …
    Year: 2021
    Journal: Current Issues in Molecular Biology
    Volume and Issue: 43(3)
    Pages: 1502-1517

 

  • Title: Palladium (II) complexes as biologically potent metallo-drugs: Synthesis, spectral characterization, DNA interaction studies and antibacterial activity
    Authors: KS Prasad, LS Kumar, S Chandan, RMN Kumar, HD Revanasiddappa
    Year: 2013
    Journal: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
    Volume: 107
    Pages: 108-116

 

  • Title: Aqueous Extract of Saraca indica Leaves in the Synthesis of Copper Oxide Nanoparticles: Finding a Way towards Going Green
    Authors: KS Prasad, A Patra, G Shruthi, S Chandan
    Year: 2017
    Journal: Journal of Nanotechnology
    Volume and Issue: 2017(1)
    Article Number: 7502610

 

  • Title: Quinazolinones linked amino acids derivatives as a new class of promising antimicrobial, antioxidant and anti-inflammatory agents
    Authors: KP Rakesh, S Ramesh, HMM Kumar, S Chandan, DC Gowda
    Year: 2015
    Journal: European Journal of Chemistry
    Volume and Issue: 6(3)
    Pages: 254-260

 

  • Title: Diorganotin(IV) complexes of biologically potent 4(3H)-quinazolinone derived Schiff bases: Synthesis, spectroscopic characterization, DNA interaction studies and …
    Authors: KS Prasad, LS Kumar, S Chandan, B Jayalakshmi, HD Revanasiddappa
    Year: 2011
    Journal: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
    Volume and Issue: 81(1)

 

Katherine Simbaña Rivera | Biomedicina | Young Scientist Award

Dr. Katherine Simbaña Rivera | Biomedicina | Young Scientist Award

Assistant Professor at Pontificia Universidad Católica del Ecuador, Ecuador

Summary:

Katherine Simbaña Rivera is a medical doctor and researcher dedicated to advancing medical knowledge and public health initiatives through extensive research and collaborative networks. With a background in molecular biomedicine and significant experience in health research management, she has authored numerous articles and co-authored books on critical health topics. Her leadership in national health research and active involvement in student scientific societies underline her commitment to fostering research capabilities and promoting healthcare access in underserved communities across Latin America.

🎓Education:

Katherine Simbaña Rivera earned her medical degree from Universidad Central del Ecuador. She further pursued a Master’s degree in Molecular Biomedicine, specializing in Basic and Translational Cancer Research, from the Universitat de Barcelona, Spain. Currently, she is enrolled in doctoral studies in Applied Health Sciences Research at the University Institute of Biomedical and Health Research (IUIBS) at Universidad de Las Palmas de Gran Canaria, Spain.

🏥👨‍🏫Professional Experience:

From 2021 to 2022, Katherine served as the National Director of Health Research at the Ecuadorian Ministry of Public Health, where she played a key role in drafting nine research and bioethics regulations and developing strategic guidelines for national health management. She is currently an associate researcher at the Center for Research on Health in Latin America (CISeAL) at Pontificia Universidad Católica del Ecuador (PUCE).

Research Interests:

Katherine Simbaña Rivera’s research interests encompass a broad spectrum, including the Ecuadorian pharmaceutical market, COVID-19, translational cancer research, and applied health sciences. Her work focuses on advancing public health through innovative research methodologies and strategic health interventions.

Publications Top Notes 📝:

1. Clinical, molecular, and epidemiological characterization of the SARS-CoV-2 virus and the Coronavirus Disease 2019 (COVID-19), a comprehensive literature review

  • Authors: Ortiz-Prado, E., Simbaña-Rivera, K., Gómez-Barreno, L., Rubio-Neira, M., …
  • Journal: Diagnostic Microbiology and Infectious Disease
  • Volume: 98
  • Issue: 1
  • Year: 2020
  • Article Number: 115094
  • Citations: 543

2. Epidemiological, socio-demographic and clinical features of the early phase of the COVID-19 epidemic in Ecuador

  • Authors: Ortiz-Prado, E., Simbaña-Rivera, K., Barreno, L.G., Diaz, A.M., Barreto, A., …
  • Journal: PLoS Neglected Tropical Diseases
  • Volume: 15
  • Issue: 1
  • Year: 2021
  • Article Number: e0008958
  • Citations: 171

3. Anxiety and depression in patients with confirmed and suspected COVID-19 in Ecuador

  • Authors: Paz, C., Mascialino, G., Adana Díaz, L., Rodríguez Lorenzana, A., …
  • Journal: Psychiatry and Clinical Neurosciences
  • Volume: 74
  • Issue: 10
  • Year: 2020
  • Pages: 554-555
  • Citations: 109

4. Behavioral and sociodemographic predictors of anxiety and depression in patients under epidemiological surveillance for COVID-19 in Ecuador

  • Authors: Paz, C., Mascialino, G., Adana-Díaz, L., Rodríguez-Lorenzana, A., …
  • Journal: PLoS One
  • Volume: 15
  • Issue: 9
  • Year: 2020
  • Article Number: e0240008
  • Citations: 80

5. The disease burden of suicide in Ecuador, a 15 years’ geodemographic cross-sectional study (2001–2015)

  • Authors: Ortiz-Prado, E., Simbaña, K., Gómez, L., Henriquez-Trujillo, A.R., …
  • Journal: BMC Psychiatry
  • Volume: 17
  • Issue: 1
  • Year: 2017
  • Pages: 1-11
  • Citations: 56

 

Hyun Suk Shin | Molecular Biology | Best Researcher Award

 Dr. Hyun Suk Shin | Molecular Biology | Best Researcher Award

 Dr. University of Las Palmas de Gran Canaria,  Spain

👩‍🔬 Hyun Suk Shin is a Marine Biotechnology expert with a rich academic background. She holds a B.Sc., M.Sc., and Ph.D. from Korea Maritime and Ocean University, where she delved into various aspects of aquaculture, molecular biology, and biochemistry. With extensive research experience, including international collaborations, she has contributed significantly to the field, resulting in numerous publications and patents. As a postdoctoral researcher, she continued her impactful work at institutions like the National Fisheries Research and Development Institute of Korea and the Fundación Canaria Parque Científico Tecnológico de la Universidad de Las Palmas de Gran Canaria. Recognized for her excellence, she received prestigious scholarships and awards, demonstrating her dedication to advancing aquaculture research.

 

Profile

Scopus

Scholar

Education 📚

  1. Higher Degree
    • Name of Qualification: M.S. Science
    • Degree Awarding Entity: Korea Maritime and Ocean University
    • Date of Qualification: 28/02/2010
  2. Higher Degree
    • Name of Qualification: B.S. Science, Marine Biotechnology
    • Degree Awarding Entity: Korea Maritime and Ocean University
    • Date of Qualification: 28/02/2008

Doctorates

  • PhD Science
    • Degree Awarding Entity: Korea Maritime and Ocean University
    • Date of Degree: 28/02/2014

Teaching Experience📊

Experience Supervising Doctoral Theses and/or Final Year Projects: Project Title: Analysis of Skeletal Deformities in Gilthead Sea Bream Entity: Universidad de las Palmas de Gran Canaria Type of Entity: University Student: Alvaro Lorenzo Felipe Date of Reading: 05/07/2022Project Title: Programa Mejora Genética en Camarón Entity: Universidad de las Palmas de Gran Canaria Type of Entity: University

 

Scientific or Technological Activities 🔬

R&D Projects Funded Through Competitive Calls of Public or Private Entities

  1. Project Name: AquaIMPACT: Genomic and Nutritional Innovation for Genetically Superior Farmed Fish

Keywords: Molecular markers and recognition; Genetics transcription; Genetics expression of regulations; Epigenetics; Genetic drift; Population geneticsType of Project: Research and development, including transferGeographical Area: European UnionDegree of Contribution: ResearcherEntity: Universidad de las Palmas de Gran CanariaType of Entity: UniversityCity of Entity: Las Palmas de Gran Canaria, Canary Islands, SpainPrincipal Investigators: Daniel Montero Vítorres; Marisol Izquierdo Lopez; Juan Manuel Afonso Lopez; Maria Jesus Zamorano Serrano; Silvia Torrecillas Burriel; Hyun Suk Shin; Cathaysa Pérez GarcíaNumber of Researchers: 72Number of People/Year: 14Type of Participation: Team memberProgramme Name: Horizon 2020 Research and InnovationCode: 818367Start-End Date: 01/01/2018 – 02/01/2023Duration: 5 yearsParticipating Entities: [List of entities involved]Total Amount: €6,100,000Sub-Project Amount: €702,913Percentage as Grant: 100%Relevant Results: Determining the additive genetic components of immune system traits of sea bream and sea bass populations under genetic selection pressure for growth.Dedication Regime: Part-timeApplicant’s Contribution: In this project, my contribution is assigned within the WP2: Nutritional Innovation: Precision nutrition for superior genotypes, through the following tasks:Evaluation and divergent selection of sea bream breeders for growth and absence of skeletal deformities.Breeding, marking, fattening, and characterization of offspring and breeders using microsatellite markers “SMsa-1/ SMsa-2”.Study of genetic parameters of immune system traits.

Project Name: PerformFISH – Consumer Driven Production: Integrating Innovative Approaches for Competitive and Sustainable Performance across the Mediterranean Aquaculture Value Chain

Keywords: Genetics expression of regulations; Genetic drift; Population geneticsType of Project: Research and development, including transferGeographical Area: European Union[Include any additional information about the project here]

Publications Top Notes 📝

  • Effects of LED light spectra on oxidative stress and the protective role of melatonin in relation to the daily rhythm of the yellowtail clownfish, Amphiprion clarkii
    • Authors: HS Shin, J Lee, CY Choi
    • Journal: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology
    • Year: 2011

 

  • Effect of LED light spectra on starvation-induced oxidative stress in the cinnamon clownfish Amphiprion melanopus
    • Authors: CY Choi, HS Shin, YJ Choi, NN Kim, J Lee, GS Kil
    • Journal: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology
    • Year: 2012

 

  • Kisspeptin regulates the hypothalamus–pituitary–gonad axis gene expression during sexual maturation in the cinnamon clownfish, Amphiprion melanopus
    • Authors: NN Kim, HS Shin, YJ Choi, CY Choi
    • Journal: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology
    • Year: 2014

 

  • Effects of LED light spectra on the growth of the yellowtail clownfish Amphiprion clarkii
    • Authors: HS Shin, J Lee, CY Choi
    • Journal: Fisheries Science
    • Year: 2012

 

  • Profiles of antioxidant gene expression and physiological changes by thermal and hypoosmotic stresses in black porgy (Acanthopagrus schlegeli)
    • Authors: KW An, NN Kim, HS Shin, GS Kil, CY Choi
    • Journal: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology
    • Year: 2010

 

  • The effects of quercetin on physiological characteristics and oxidative stress resistance in olive flounder, Paralichthys olivaceus
    • Authors: HS Shin, JH Yoo, TS Min, KY Lee, CY Choi
    • Journal: Asian-Australasian Journal of Animal Sciences
    • Year: 2010

 

  • Selection for growth is associated in gilthead sea bream (Sparus aurata) with diet flexibility, changes in growth patterns and higher intestine plasticity
    • Authors: E Perera, P Simó-Mirabet, HS Shin, E Rosell-Moll, F Naya-Catalá, …
    • Journal: Aquaculture
    • Year: 2019

 

  • Quantitative mRNA expression of sox3 and DMRT1 during sex reversal, and expression profiles after GnRHa administration in black porgy, Acanthopagrus schlegeli
    • Authors: HS Shin, KW An, MS Park, MH Jeong, CY Choi
    • Journal: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology
    • Year: 2009

 

MOHAMED HAMDI EL ASHAL | Biochemistry Award | Best Researcher Award

 Mr . MOHAMED HAMDI EL ASHAL | Biochemistry Award | Best Researcher Award

👨‍🏫Profile Summary

Efficient and detailed oriented post doctor researcher working in the field of natural products and food chemistry especially in bee products and medicinal plants. Owing to write reviews or original papers to be published in high impacted journals.

🌐 Professional Profiles

 

 

Qualifications 📚

Post-graduation PhD. in Biochemistry (Menoufia University) Date of graduation: 2024 Area of research: Drug discovery research, Functional Food. M.SC. in Biochemistry (Menoufia University) Date of graduation: Sep. 2019 Area of research: Drug discovery research, Functional Food Analytical Biochemistry Diploma (Menoufia University) Date of graduation: May 2014 Grade: Excellent. B.Sc. in Science, Chemistry and Botany Department (Menoufia University) Date of graduation: May 2006 Grade: Very Good (83%)

Scientific Experiences 🔬

  • Gas chromatography-Mass spectrometry analysis (GC-MS).
  • Liquid chromatography-Mass spectrometry analysis (LC-MS-MS).
  • GNPS interpretation.
  • Writing scientific papers.
  • Reviewing scientific papers.

Fields of Interest 🧪

  • Natural Product Chemistry
  • Biochemistry
  • Food Chemistry
  • Metabolomics

Conferences 🌐

Annual International Conference of THE EGYPTIAN FERTILITY AND STERILITY, 2023, International Association of Surgeons’ Gastroenterologists and Oncologists’ 5th Meeting of IASGO Egyptian Chapter, November 2021. Oral presenter in 3rd INTERNATIONAL JSPS AAE SYMPOSIUM, September 2021. Oral presenter in the 5th International Symposium on Phytochemicals in Medicine and Food conference, China, 2021. Menoufia Diabetes Conference, February 28, 2020. HGIDA 14th Scientific Event on Pitfalls in Diagnosis of Infectious Diseases, February 26, 2020. Training Course and Symposium on Apitherapy, December 4-5, 2019. Clinical Approach to Autoimmune Liver Diseases Postgraduate Course, November 27, 2019. IASGO Egyptian Chapter 2nd Annual Meeting, November 15-17, 2018.

Workshops 🛠️

American Society of Pharmacognosy webinars about most recent applications of natural products from April 2020 to November 2020. 1st GNPS User Meeting, August 2020. ‘Hands-on featuring a successful academic career’ workshop at Chemistry Department, American University of Cairo (AUC), July 2019.

Skills 🛠️

Good Command of English Intensive Course in English (Intermediate II Level, 36 Hours) Final Grade: Excellent (Minufia University) Conversation Course in English (Intermediate Level, 36 Hours) Final Grade: Excellent (Minufia University). Computer Skills Excellent Experience in Computer Software (Windows, Office, Internet) ICDL Certificate. Professional Development Pharma Mini-MBA (Certificate from ACC Group – American Canadian Center) Excellence in Negotiation Workshop (Scope Office) Advanced Presentation Skills Talent Pool Course Pharmacovigilance Basic Principles Leadership Skills and Management (Harvest Academy)

 

📚Top Noted Publication

  1. Title: An updated multifaceted overview of sweet proteins and dipeptides as sugar substitutes; the chemistry, health benefits, gut interactions, and safety
    • Authors: Farag, M. A., Rezk, M. M., Elashal, M. H., El-Araby, M., Khalifa, S. A., & El-Seedi, H. R.
    • Journal: Food Research International
    • Year: 2022
    • DOI: 10.1016/j.foodres.2022.111853

 

  1. Title: Bee pollen: Clinical trials and patent applications
    • Authors: Algethami, J. S., El-Wahed, A. A. A., Elashal, M. H., Ahmed, H. R., Elshafiey, E. H., Omar, E. M., … & El-Seedi, H. R.
    • Journal: Nutrients
    • Year: 2022
    • Volume: 14
    • Issue: 14
    • DOI: 10.3390/nu14142858

 

  1. Title: Cosmetic applications of bee venom
    • Authors: El-Wahed, A. A. A., Khalifa, S. A., Elashal, M. H., Musharraf, S. G., Saeed, A., Khatib, A., … & El-Seedi, H. R.
    • Journal: Toxins
    • Year: 2021
    • Volume: 13
    • Issue: 11
    • DOI: 10.3390/toxins13110810

 

  1. Title: Bee Pollen: Current Status and Therapeutic Potential
    • Authors: Khalifa, S. A., Elashal, M. H., Yosri, N., Du, M., Musharraf, S. G., Nahar, L., & El-Seedi, H. R.
    • Journal: Nutrients
    • Year: 2021
    • Volume: 13
    • Issue: 6
    • DOI: 10.3390/nu13061876

 

  1. Title: Comprehensive overview on multiple strategies fighting COVID-19
    • Authors: Khalifa, S. A., Mohamed, B. S., Elashal, M. H., Du, M., Guo, Z., Zhao, C., & El-Seedi, H. R.
    • Journal: International Journal of Environmental Research and Public Health
    • Year: 2020
    • Volume: 17
    • Issue: 16
    • DOI: 10.3390/ijerph17165813

 

  1. Title: Recent insights into chemical and pharmacological studies of bee bread
    • Authors: Khalifa, S. A., Elashal, M., Kieliszek, M., Ghazala, N. E., Farag, M. A., Saeed, A., & El-Seedi, H. R.
    • Journal: Trends in Food Science & Technology
    • Year: 2020
    • Volume: 97
    • Pages: 300-316
    • DOI: 10.1016/j.tifs.2019.08.021

 

  1. Title: Apilarnil ameliorates Bisphenol A-induced testicular toxicity in adult male rats via improving antioxidant potency and PCNA expression
    • Authors: Mohamed H. Elashal, Aida A. Abd El-Wahed, Mostafa Abdelgaber Mohamed, Rania Hamad, Mabrouk Attia Abd Eldaim, Shaden A. M. Khalifa, Hesham R. El-Seedi, Mohamed F. AlAjmi, Bishoy El-Aarag
    • Journal: Reproductive Toxicology (accepted paper)
    • Year: 2024

 

 

Dana Laor | Molecular Biology, | Best Researcher Award

Dr. Dana Laor | Molecular Biology| Best Researcher Award

👨‍🏫Profile Summary

Dr. Dana Laor Bar-Yosef is a distinguished molecular biologist renowned for her groundbreaking research in metabolic disorders. She completed her undergraduate studies in biology at the Hebrew University of Jerusalem, followed by M.Sc. and Ph.D. training at Tel Aviv University under Prof. Martin Kupiec. Her Ph.D. research elucidated the roles of TOR protein kinase in cell signaling and amino acid homeostasis using yeast models. Joining Prof. Ehud Gazit’s lab in 2015, she established innovative in vivo models for studying inborn errors of metabolism (IEMs), leading to significant insights and potential therapeutics. Dr. Laor Bar-Yosef’s expertise spans over 15 years, guiding her leadership of the metabolic research group and pioneering the concept of “Metabolostasis.” Her contributions have been recognized with prestigious awards, including the 2020 Ziegler Award, affirming her exceptional impact on medical research in metabolic disorders.

🌐 Professional Profiles

Education🎓

Postdoctoral Researcher in Molecular Biology and Nanotechnology Tel Aviv University, Tel Aviv 2015-2018, Ph.D. in Molecular Biology
Tel Aviv University, Tel Aviv 2009-2014 Thesis title: “The role of TOR in rapamycin response in the fission yeast” Advisors: Prof. Martin Kupiec and Prof. Ronit Weisman. M.Sc. in Genetics Tel Aviv University, Tel Aviv 2007-2009 Thesis title: “The TOR pathway regulates cellular growth, gene silencing and telomere length maintenance in the fission yeast” Advisors: Prof. Martin Kupiec and Prof. Ronit Weisman. B.Sc. in Biology
The Hebrew University, Jerusalem 2003-2006

🔬 Researcher Experience

Head of the Metabolic Research Group Shmunis School of Biomedicine and Cancer Research, Tel Aviv University 2018-Present, Postdoctoral Research School of Molecular Cell Biology and Biotechnology, Tel Aviv University 2015-2018, Graduate Research Department of Microbiology and Biotechnology, Tel Aviv University 2007-2014

 Professional Development  📈

Women Executive Launchpad in HealthTech 8400 Health Network 2022-2023, Health Care Technological Innovation – From Idea to Commercialization Coller School of Management at Tel-Aviv University and Lahav Executive Education 2022

 Teaching Experience📚

Instructor, Introduction to Biology Course Tel Aviv University 2023-2024,  Instructor, “Commercializing University Research” Course
Coller School of Management, Tel Aviv University 2020, Instructor, “Graduate Record Examination Preparation Course”
Tel Aviv University 2014-2015, Teaching Assistant, “Introduction to Genetics” Course Tel Aviv University 2007-2013

Awards 🏆

The Late Breaking News Awards at the 2023 SSIEM Symposium 2023, The Ziegler Award for Research in the Field of Metabolic Disorders
2020, The Herbert and Sharon Glazer Fund Excellence Award 2017 And more…

Funding Acquired💰

The John Templeton Foundation Research Grant 2021-2024, Israel Science Foundation Research Grant 2019-2023, Momentum Fund Investment in Promising Breakthrough Technologies 2021-2023 And more…

 Patents🛠️

Laor, D., & Gazit, E (2018). Integrated drug discovery platform for inborn error of metabolism disorders.
US Provisional Patent Application No. 62/779,054. Pending. Laor, D., Sade, D., and Gazit, E (2021). Integrated drug discovery platform for protein misfolding disorders associated with metabolite accumulation.
Provisional.

 Conference and Scientific Meetings🌐

The first Metabolostasis conference, Israel (2023) Organizing Committee, ILASOL 36th Annual Meeting, Israel (2023)
Organizing Committee and Chair, Rare Connections 2022, Israel A conference dedicated for potential collaborations in the field of rare diseases. ISM 2022 Annual Meeting, Israel The first Israel Metabolomics Meeting, Israel (2022) And more…

 Community Involvement👥

Instructor, Jewish Community Center (JCC), Ohio, USA (2002, 2003) Guided Jewish-American youth about the Israeli Culture in a youth summer camp. Armor Instructor, Israel Defense Forces (2000-2002) Served as an armor guide for regular service and reserve duty soldiers at the Armored Corps School. Counselor, “Maccabi Tzair” Youth Movement, Israel (1996-2000) Served as a counselor and teaching coordinator, mentoring and advocating Israeli youth.

📚Top Noted Publication

  1. TOR complex 2 controls gene silencing, telomere length maintenance, and survival under DNA-damaging conditions
    • Authors: M Schonbrun, D Laor, L López-Maury, J Bähler, M Kupiec, R Weisman
    • Journal: Molecular and cellular biology
    • Volume: 29
    • Issue: 16
    • Pages: 4584-4594
    • Citations: 72
    • Year: 2009

 

  1. Two Decades of Studying Functional Amyloids in Microorganisms
    • Authors: SA Levkovich, E Gazit, D Laor Bar-Yosef
    • Journal: Trends in Microbiology
    • Citations: 68
    • Year: 2021

 

  1. Fibril formation and therapeutic targeting of amyloid-like structures in a yeast model of adenine accumulation
    • Authors: D Laor, D Sade, S Shaham-Niv, D Zaguri, M Gartner, V Basavalingappa, …
    • Journal: Nature communications
    • Volume: 10
    • Issue: 1
    • Pages: 62
    • Citations: 54
    • Year: 2019

 

  1. Yeast models for the study of amyloid-associated disorders and development of future therapy
    • Authors: S Rencus-Lazar, Y DeRowe, H Adsi, E Gazit, D Laor
    • Journal: Frontiers in Molecular Biosciences
    • Volume: 6
    • Pages: 15
    • Citations: 45
    • Year: 2019

 

  1. TORC1 regulates developmental responses to nitrogen stress via regulation of the GATA transcription factor Gaf1
    • Authors: D Laor, A Cohen, M Kupiec, R Weisman
    • Journal: MBio
    • Volume: 6
    • Issue: 4
    • Citations: 33
    • Year: 2015
  1. Engineered riboswitch nanocarriers as a possible disease-modifying treatment for metabolic disorders
    • Authors: S Zilberzwige-Tal, D Gazit, H Adsi, M Gartner, R Behl, D Bar-Yosef Laor, …
    • Journal: ACS nano
    • Volume: 16
    • Issue: 8
    • Pages: 11733-11741
    • Citations: 3
    • Year: 2022

 

  1. Integrated drug discovery platform for inborn error of metabolism disorders
    • Authors: E Gazit, L Dana
    • Patent: US Patent App. 17/345,248
    • Citations: 1
    • Year: 2021

 

  1. Mind your marker: the effect of common auxotrophic markers on complex traits in yeast
    • Authors: K Kaplan, SA Levkovich, Y DeRowe, E Gazit, D Laor Bar‐Yosef
    • Journal: The FEBS Journal
    • Year: 2024

 

  1. The von Hippel-Lindau protein forms fibrillar amyloid assemblies that are mitigated by the anti-amyloid molecule Purpurin
    • Authors: V Kumar, V Kaushik, S Kumar, SA Levkovich, P Gupta, DL Bar-Yosef, …
    • Journal: Biochemical and Biophysical Research Communications
    • Volume: 690
    • Pages: 149250
    • Year: 2024

 

  1. Branched-Chain Amino Acid Assembly into Amyloid-like Fibrils Provides a New Paradigm for Maple Syrup Urine Disease Pathology
    • Authors: T Kreiser, I Sogolovsky-Bard, D Zaguri, S Shaham-Niv, D Laor Bar-Yosef, …
    • Journal: International Journal of Molecular Sciences
    • Volume: 24
    • Issue: 21
    • Pages: 15999
    • Year: 2023

Flavia | Molecular Biology | Young Scientist Award

Dr. Flavia| Molecular Biology | Young Scientist Award

👨‍🏫Profile Summary

Flavia Scoyni is a highly accomplished researcher in molecular medicine, specializing in non-coding RNAs and their role in neurodegenerative diseases like Alzheimer’s and ischemic stroke. With a Ph.D. from the University of Eastern Finland under the Marie Skłodowska-Curie Programme, Flavia has extensive experience in experimental techniques such as scRNA-seq, FACS, and animal modeling. Their work has been published in prestigious journals and recognized with numerous grants and fellowships. Flavia’s expertise in molecular biology, cell culture, and animal work, coupled with a strong track record of securing research funding, positions them as a valuable asset in the field of translational medicine.

🌐 Professional Profiles

🎓Education:

Ph.D. in Molecular Medicine University of Eastern Finland, Kuopio, Finland Duration: Dec 2017 – Feb 2024 Marie Skłodowska-Curie Programme in Genetics and Mechanisms in Translational Medicine (GENOMMED) Advisor: Prof. Tarja Malm Dissertation: “Unlocking the potential of non-coding RNAs in regulating neurodegeneration – a glimpse into Alzheimer’s disease and ischemic stroke pathophysiology.” Ph.D. secondment Aarhus University, Aarhus, Denmark Duration: Sept 2018 – Feb 201 Advisor: Assoc. Prof. Thomas B. Hansen Funded by Saastamoinen Foundation travel grant FELASA accreditationUniversity of Eastern Finland, Kuopio, Finland May 2017 Federation of Laboratory Animal Science Associations (FELASA) Certificate in laboratory animal science for EU Functions A/D MSc in Molecular Biology “Sapienza” University of Rome, Rome, Italy Duration: Oct 2013 – Dec 2015 Master Degree in Molecular Biology Graduated magna cum laude (110/110 cum laude) Advisor: Prof. Alessandro Fatica Thesis title: “Identification of new transcriptional targets of p30 C/EBPα transcription factor isoform in acute myeloid leukemia” MSc in Genetics University Paris-Diderot VII, Paris, France Duration: Oct 2013 – June 2015 BSc in Biotechnology “Sapienza” University of Rome, Rome, Italy Duration: Oct 2010 – July 2013 Bachelor degree in Biotechnology Graduated magna cum laude (110/110 cum laude) Advisor: Prof. Carlo Presutti Thesis title: “The role of the mir-200 family in the regulation of the expression of AP1 transcriptional factor”

🔬Research Experience:

Early stage researcher Professor Tarja Malm University of Eastern Finland, A.I. Virtanen Institute for Molecular Sciences Jan 2017 – Dec 2017 Investigated the role of microRNAs in phagocytic microglia isolated from adult Alzheimer’s mice. Developed techniques including ex-vivo FACS, low input RNA extraction, cloning, qPCR, and protocol for transfection for hard-to-transfect cell lines. Conducted animal procedures to harvest brain samples or acutely isolate adult microglia. Erasmus traineeship Biotech Research & Innovation Centre, Copenhagen, Denmark Oct 2016 – June 2016 Developed a transgenic stable cell line for long non-coding RNAs. Applied techniques such as cloning of long inserts, lentiviral vector production, and stable cell line development. Master thesis Professor Alessandro Fatica “Sapienza” University of Rome, Rome, Italy June 2014 – Dec 2015 Investigated the regulation of the long non-coding RNA UCA1 mediated by C/EBPα transcription factor in the K562 lymphoblast cell line. Applied techniques including ChIP, cloning, RNA extraction, RT-qPCR, WB, transfection, CRISPR-Cas9, and stable cell line development. Master Internship Professor Giuseppe Macino “Sapienza” University of Rome, Rome, Italy Sept 2013 – March 2014 Studied microRNAs inducing epigenetic modifications in mammals.Applied techniques such as ChIP, cloning, mutagenesis, RNA extraction, RT-qPCR, WB, CRISPR-Cas9, and stable cell line development. Bachelor thesis Professor Carlo Presutti “Sapienza” University of Rome, Rome, Italy Oct 2012 – July 2013 Investigated the role of the miR-200a family in regulating c-JUN transcription factor expression. Utilized techniques including cloning, mutagenesis, bacterial transformation, and cell line culture.

💻 Technical Skills:

Molecular biology techniques such as scRNA-seq, RNA-seq, FACS, cloning, RT-qPCR, WB, lentiviral vectors generation. Cell culture techniques including neuronal culture, primary microglial culture, transduction, transfection, and stable cell line development. Animal work including FELASA A/D certification, maintenance, and breeding of transgenic mouse models, animal procedures, and tamoxifen-induced recombination. Statistical analysis, basic Python, and R.

🏆Fellowships, Awards, and Honors:

  • Secured total grants of 99.000€ during Ph.D., including grants from Pavo Nuermen Foundation, Finnish Cultural Foundation, Kuopio University Foundation, and others.

👩‍🏫 Teaching Experience:

  • Mentored a Ph.D. student and post-graduate student, and supervised five master’s thesis students during the Ph.D. program.

📚Top Noted Publication

  1. ciRS-7 and miR-7 regulate ischemia-induced neuronal death via glutamatergic signaling
    • Journal: Cell Reports
    • Year: 2024-03
    • DOI: 10.1016/j.celrep.2024.113862
    • Contributors: Flavia Scoyni; Valeriia Sitnikova; Luca Giudice; Paula Korhonen; Davide M. Trevisan; Ana Hernandez de Sande; Mireia Gomez-Budia; Raisa Giniatullina; Irene F. Ugidos; Hiramani Dhungana et al.

 

  1. Alzheimer’s disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs
    • Journal: Alzheimer’s & Dementia
    • Year: 2024-02
    • DOI: 10.1002/alz.13502
    • Contributors: Flavia Scoyni; Luca Giudice; Mari-Anna Väänänen; Nicholas Downes; Paula Korhonen; Xin Yi Choo; Nelli-Noora Välimäki; Petri Mäkinen; Nea Korvenlaita; Annemieke J Rozemuller et al.

 

  1. ciRS-7 and miR-7 regulate ischemia induced neuronal death via glutamatergic signaling
    • Journal: Preprint
    • Year: 2023-01-24
    • DOI: 10.1101/2023.01.24.525136
    • Contributors: Flavia Scoyni; Valeriia Sitnikova; Luca Giudice; Paula Korhonen; Davide M Trevisan; Ana Hernandez de Sande; Mireia Gomez-Budia; Raisa Giniatullina; Irene F Ugidos; Hiramani Dhungana et al.

 

  1. Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation
    • Journal: Journal of Neuroinflammation
    • Year: 2020
    • DOI: 10.1186/s12974-020-01870-w
    • Contributors: Kolosowska, N.; Gotkiewicz, M.; Dhungana, H.; Giudice, L.; Giugno, R.; Box, D.; Huuskonen, M.T.; Korhonen, P.; Scoyni, F.; Kanninen, K.M. et al.

 

  1. PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia
    • Journal: Stem Cell Reports
    • Year: 2019
    • DOI: 10.1016/j.stemcr.2019.08.004
    • Contributors: Konttinen, H.; Cabral-da-Silva, M.E.C.; Ohtonen, S.; Wojciechowski, S.; Shakirzyanova, A.; Caligola, S.; Giugno, R.; Ishchenko, Y.; Hernández, D.; Fazaludeen, M.F. et al.