Thi Mong Diep Nguyen | Molecular Biology | Best Researcher Award

Assoc Prof Dr. Omvir Singh| Molecular Biology | Best Researcher Award

🔬🧬 Holding a Doctor of Science in Life Science (Cell Biotechnology) from the University of Tours, France, I’ve delved into diverse realms including cell biology, microbiology, and animal reproduction. As a Visiting Professor at the University of François-Rabelais and an Associate Professor at Quy Nhon University, I’ve led research projects exploring avian reproductive biotechnologies and the impact of AMPK protein kinase on male gonad functions. My contributions to grants investigating hCG glycoforms and fertility treatments showcase my dedication to advancing scientific understanding. 🌱👨‍🔬

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Training Background:

University of Tours, France Years: 4/2022 Major/ Specialty: Life Science (Cell biotechnology) Academic Degree: Doctor of Science University of François-Rabelais, Tours, France Years: 1/2020 – 3/2020 Major/ Specialty: Biotechnology Role: Visiting Professor Quy Nhon University Year: 1/2020 Major/ Specialty: Biotechnology Role: Associate Professor INRA _Institut national de la recherche agronomique (Nouzilly), France Years: 10/2018 – 2/2019, 11/2016 – 04/2017 Major/ Specialty: Animal Cell Biotechnology + Immunology + Gonadotropins Role: Postdoctoral Researcher François-Rabelais University, France Years: 11/2011 – 10/2015 Major/ Specialty: Life Science (Cell biotechnology) Academic Degree: Ph.D Quy Nhon University Years: 9/2005 – 6/2008 Major/ Specialty: Biology Academic Degree: Master Quy Nhon University Years: 9/2001 – 9/2005 Major/ Specialty: Biology Academic Degree: Bachelor

 

🔍Research Projects (Last 5 Years):

CRYOBIRD – Development of avian reproductive biotechnologies for the management of genetic diversity Years: 10/2010 – 10/2014 Funding Institution: France Role: Participant. Study on pathogenic microorganisms in Arachis Hypogaea L. in ecological condition of Hoai An district, Binh Dinh province Year: 2016 – 2017 Funding Institution: Quy Nhon University Role: Chairman Impact of AMPK protein kinase on male gonad and spermatozoa functions Years: 2018 – 2019 Funding Institution: Quy Nhon University Role: Chairman Characterization of new hCG glycoforms for implantation and early pregnancy diagnostic Years: 2017 – 2020 Funding Institution: France Role: Participant Investigation on the role of 5’-AMP activated protein kinase (AMPK) in adenylate cyclase gene expression using pharmacologicals activators and human Luteinizing Hormone (hLH) or Forskolin stimulators in Leydig MLTC-1 cells Years: 2018 – 2020 Funding Institution: NAFOSTED Role: Chairman Production of single-chain gonadotropins for fertility treatments Years: 2020 – 2023 Funding Institution: VINIF Role: Chairman

Publications Top Notes 📝

  1. Highly-Sensitive In Vitro Bioassays for FSH, TSH, PTH, Kp, and OT in Addition to LH in Mouse Leydig Tumor Cell
    • Authors: Klett, D., Pellissier, L., Lomet, D., Jean-Alphonse, F., Combarnous, Y.
    • Year: 2023

 

  1. Undissociable chemically cross-linked and single-chain gonadotropins
    • Authors: Nguyen, T.M.D., Klett, D., Combarnous, Y.
    • Year: 2023

 

  1. Impact of microwave synthesis time on the shape of silver nanostructures and their antibacterial activity
    • Authors: Hoang, N.H., Nguyen, V.N., Nguyen, T.T., Nguyen, T.M.D.
    • Year: 2023

 

  1. Natural and recombinant equine chorionic gonadotropins past and future in animal reproductive technology
    • Authors: Thach, D.T., Cuong, B.K., Van Tong, H., Combarnous, Y., Nguyen, T.M.D.
    • Year: 2022

 

  1. Effect of fluoxetine on cyclic adenosine monophosphate response to follicle-stimulating hormone in HEK cells
    • Authors: Nguyen, T.T., Nguyen, T.M.D.
    • Year: 2022

 

  1. Membrane Hormone Receptors and Their Signaling Pathways as Targets for Endocrine Disruptors
    • Authors: Combarnous, Y., Nguyen, T.M.D.
    • Year: 2022

 

  1. Roles of Soluble Adenylyl Cyclase in cAMP Synthesis in Animal Cells
    • Author: Nguyen, T.M.D.
    • Year: 2022

 

Hyun Suk Shin | Molecular Biology | Best Researcher Award

 Dr. Hyun Suk Shin | Molecular Biology | Best Researcher Award

 Dr. University of Las Palmas de Gran Canaria,  Spain

👩‍🔬 Hyun Suk Shin is a Marine Biotechnology expert with a rich academic background. She holds a B.Sc., M.Sc., and Ph.D. from Korea Maritime and Ocean University, where she delved into various aspects of aquaculture, molecular biology, and biochemistry. With extensive research experience, including international collaborations, she has contributed significantly to the field, resulting in numerous publications and patents. As a postdoctoral researcher, she continued her impactful work at institutions like the National Fisheries Research and Development Institute of Korea and the Fundación Canaria Parque Científico Tecnológico de la Universidad de Las Palmas de Gran Canaria. Recognized for her excellence, she received prestigious scholarships and awards, demonstrating her dedication to advancing aquaculture research.

 

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Education 📚

  1. Higher Degree
    • Name of Qualification: M.S. Science
    • Degree Awarding Entity: Korea Maritime and Ocean University
    • Date of Qualification: 28/02/2010
  2. Higher Degree
    • Name of Qualification: B.S. Science, Marine Biotechnology
    • Degree Awarding Entity: Korea Maritime and Ocean University
    • Date of Qualification: 28/02/2008

Doctorates

  • PhD Science
    • Degree Awarding Entity: Korea Maritime and Ocean University
    • Date of Degree: 28/02/2014

Teaching Experience📊

Experience Supervising Doctoral Theses and/or Final Year Projects: Project Title: Analysis of Skeletal Deformities in Gilthead Sea Bream Entity: Universidad de las Palmas de Gran Canaria Type of Entity: University Student: Alvaro Lorenzo Felipe Date of Reading: 05/07/2022Project Title: Programa Mejora Genética en Camarón Entity: Universidad de las Palmas de Gran Canaria Type of Entity: University

 

Scientific or Technological Activities 🔬

R&D Projects Funded Through Competitive Calls of Public or Private Entities

  1. Project Name: AquaIMPACT: Genomic and Nutritional Innovation for Genetically Superior Farmed Fish

Keywords: Molecular markers and recognition; Genetics transcription; Genetics expression of regulations; Epigenetics; Genetic drift; Population geneticsType of Project: Research and development, including transferGeographical Area: European UnionDegree of Contribution: ResearcherEntity: Universidad de las Palmas de Gran CanariaType of Entity: UniversityCity of Entity: Las Palmas de Gran Canaria, Canary Islands, SpainPrincipal Investigators: Daniel Montero Vítorres; Marisol Izquierdo Lopez; Juan Manuel Afonso Lopez; Maria Jesus Zamorano Serrano; Silvia Torrecillas Burriel; Hyun Suk Shin; Cathaysa Pérez GarcíaNumber of Researchers: 72Number of People/Year: 14Type of Participation: Team memberProgramme Name: Horizon 2020 Research and InnovationCode: 818367Start-End Date: 01/01/2018 – 02/01/2023Duration: 5 yearsParticipating Entities: [List of entities involved]Total Amount: €6,100,000Sub-Project Amount: €702,913Percentage as Grant: 100%Relevant Results: Determining the additive genetic components of immune system traits of sea bream and sea bass populations under genetic selection pressure for growth.Dedication Regime: Part-timeApplicant’s Contribution: In this project, my contribution is assigned within the WP2: Nutritional Innovation: Precision nutrition for superior genotypes, through the following tasks:Evaluation and divergent selection of sea bream breeders for growth and absence of skeletal deformities.Breeding, marking, fattening, and characterization of offspring and breeders using microsatellite markers “SMsa-1/ SMsa-2”.Study of genetic parameters of immune system traits.

Project Name: PerformFISH – Consumer Driven Production: Integrating Innovative Approaches for Competitive and Sustainable Performance across the Mediterranean Aquaculture Value Chain

Keywords: Genetics expression of regulations; Genetic drift; Population geneticsType of Project: Research and development, including transferGeographical Area: European Union[Include any additional information about the project here]

Publications Top Notes 📝

  • Effects of LED light spectra on oxidative stress and the protective role of melatonin in relation to the daily rhythm of the yellowtail clownfish, Amphiprion clarkii
    • Authors: HS Shin, J Lee, CY Choi
    • Journal: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology
    • Year: 2011

 

  • Effect of LED light spectra on starvation-induced oxidative stress in the cinnamon clownfish Amphiprion melanopus
    • Authors: CY Choi, HS Shin, YJ Choi, NN Kim, J Lee, GS Kil
    • Journal: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology
    • Year: 2012

 

  • Kisspeptin regulates the hypothalamus–pituitary–gonad axis gene expression during sexual maturation in the cinnamon clownfish, Amphiprion melanopus
    • Authors: NN Kim, HS Shin, YJ Choi, CY Choi
    • Journal: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology
    • Year: 2014

 

  • Effects of LED light spectra on the growth of the yellowtail clownfish Amphiprion clarkii
    • Authors: HS Shin, J Lee, CY Choi
    • Journal: Fisheries Science
    • Year: 2012

 

  • Profiles of antioxidant gene expression and physiological changes by thermal and hypoosmotic stresses in black porgy (Acanthopagrus schlegeli)
    • Authors: KW An, NN Kim, HS Shin, GS Kil, CY Choi
    • Journal: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology
    • Year: 2010

 

  • The effects of quercetin on physiological characteristics and oxidative stress resistance in olive flounder, Paralichthys olivaceus
    • Authors: HS Shin, JH Yoo, TS Min, KY Lee, CY Choi
    • Journal: Asian-Australasian Journal of Animal Sciences
    • Year: 2010

 

  • Selection for growth is associated in gilthead sea bream (Sparus aurata) with diet flexibility, changes in growth patterns and higher intestine plasticity
    • Authors: E Perera, P Simó-Mirabet, HS Shin, E Rosell-Moll, F Naya-Catalá, …
    • Journal: Aquaculture
    • Year: 2019

 

  • Quantitative mRNA expression of sox3 and DMRT1 during sex reversal, and expression profiles after GnRHa administration in black porgy, Acanthopagrus schlegeli
    • Authors: HS Shin, KW An, MS Park, MH Jeong, CY Choi
    • Journal: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology
    • Year: 2009

 

MOHAMED HAMDI EL ASHAL | Biochemistry Award | Best Researcher Award

 Mr . MOHAMED HAMDI EL ASHAL | Biochemistry Award | Best Researcher Award

👨‍🏫Profile Summary

Efficient and detailed oriented post doctor researcher working in the field of natural products and food chemistry especially in bee products and medicinal plants. Owing to write reviews or original papers to be published in high impacted journals.

🌐 Professional Profiles

 

 

Qualifications 📚

Post-graduation PhD. in Biochemistry (Menoufia University) Date of graduation: 2024 Area of research: Drug discovery research, Functional Food. M.SC. in Biochemistry (Menoufia University) Date of graduation: Sep. 2019 Area of research: Drug discovery research, Functional Food Analytical Biochemistry Diploma (Menoufia University) Date of graduation: May 2014 Grade: Excellent. B.Sc. in Science, Chemistry and Botany Department (Menoufia University) Date of graduation: May 2006 Grade: Very Good (83%)

Scientific Experiences 🔬

  • Gas chromatography-Mass spectrometry analysis (GC-MS).
  • Liquid chromatography-Mass spectrometry analysis (LC-MS-MS).
  • GNPS interpretation.
  • Writing scientific papers.
  • Reviewing scientific papers.

Fields of Interest 🧪

  • Natural Product Chemistry
  • Biochemistry
  • Food Chemistry
  • Metabolomics

Conferences 🌐

Annual International Conference of THE EGYPTIAN FERTILITY AND STERILITY, 2023, International Association of Surgeons’ Gastroenterologists and Oncologists’ 5th Meeting of IASGO Egyptian Chapter, November 2021. Oral presenter in 3rd INTERNATIONAL JSPS AAE SYMPOSIUM, September 2021. Oral presenter in the 5th International Symposium on Phytochemicals in Medicine and Food conference, China, 2021. Menoufia Diabetes Conference, February 28, 2020. HGIDA 14th Scientific Event on Pitfalls in Diagnosis of Infectious Diseases, February 26, 2020. Training Course and Symposium on Apitherapy, December 4-5, 2019. Clinical Approach to Autoimmune Liver Diseases Postgraduate Course, November 27, 2019. IASGO Egyptian Chapter 2nd Annual Meeting, November 15-17, 2018.

Workshops 🛠️

American Society of Pharmacognosy webinars about most recent applications of natural products from April 2020 to November 2020. 1st GNPS User Meeting, August 2020. ‘Hands-on featuring a successful academic career’ workshop at Chemistry Department, American University of Cairo (AUC), July 2019.

Skills 🛠️

Good Command of English Intensive Course in English (Intermediate II Level, 36 Hours) Final Grade: Excellent (Minufia University) Conversation Course in English (Intermediate Level, 36 Hours) Final Grade: Excellent (Minufia University). Computer Skills Excellent Experience in Computer Software (Windows, Office, Internet) ICDL Certificate. Professional Development Pharma Mini-MBA (Certificate from ACC Group – American Canadian Center) Excellence in Negotiation Workshop (Scope Office) Advanced Presentation Skills Talent Pool Course Pharmacovigilance Basic Principles Leadership Skills and Management (Harvest Academy)

 

📚Top Noted Publication

  1. Title: An updated multifaceted overview of sweet proteins and dipeptides as sugar substitutes; the chemistry, health benefits, gut interactions, and safety
    • Authors: Farag, M. A., Rezk, M. M., Elashal, M. H., El-Araby, M., Khalifa, S. A., & El-Seedi, H. R.
    • Journal: Food Research International
    • Year: 2022
    • DOI: 10.1016/j.foodres.2022.111853

 

  1. Title: Bee pollen: Clinical trials and patent applications
    • Authors: Algethami, J. S., El-Wahed, A. A. A., Elashal, M. H., Ahmed, H. R., Elshafiey, E. H., Omar, E. M., … & El-Seedi, H. R.
    • Journal: Nutrients
    • Year: 2022
    • Volume: 14
    • Issue: 14
    • DOI: 10.3390/nu14142858

 

  1. Title: Cosmetic applications of bee venom
    • Authors: El-Wahed, A. A. A., Khalifa, S. A., Elashal, M. H., Musharraf, S. G., Saeed, A., Khatib, A., … & El-Seedi, H. R.
    • Journal: Toxins
    • Year: 2021
    • Volume: 13
    • Issue: 11
    • DOI: 10.3390/toxins13110810

 

  1. Title: Bee Pollen: Current Status and Therapeutic Potential
    • Authors: Khalifa, S. A., Elashal, M. H., Yosri, N., Du, M., Musharraf, S. G., Nahar, L., & El-Seedi, H. R.
    • Journal: Nutrients
    • Year: 2021
    • Volume: 13
    • Issue: 6
    • DOI: 10.3390/nu13061876

 

  1. Title: Comprehensive overview on multiple strategies fighting COVID-19
    • Authors: Khalifa, S. A., Mohamed, B. S., Elashal, M. H., Du, M., Guo, Z., Zhao, C., & El-Seedi, H. R.
    • Journal: International Journal of Environmental Research and Public Health
    • Year: 2020
    • Volume: 17
    • Issue: 16
    • DOI: 10.3390/ijerph17165813

 

  1. Title: Recent insights into chemical and pharmacological studies of bee bread
    • Authors: Khalifa, S. A., Elashal, M., Kieliszek, M., Ghazala, N. E., Farag, M. A., Saeed, A., & El-Seedi, H. R.
    • Journal: Trends in Food Science & Technology
    • Year: 2020
    • Volume: 97
    • Pages: 300-316
    • DOI: 10.1016/j.tifs.2019.08.021

 

  1. Title: Apilarnil ameliorates Bisphenol A-induced testicular toxicity in adult male rats via improving antioxidant potency and PCNA expression
    • Authors: Mohamed H. Elashal, Aida A. Abd El-Wahed, Mostafa Abdelgaber Mohamed, Rania Hamad, Mabrouk Attia Abd Eldaim, Shaden A. M. Khalifa, Hesham R. El-Seedi, Mohamed F. AlAjmi, Bishoy El-Aarag
    • Journal: Reproductive Toxicology (accepted paper)
    • Year: 2024

 

 

Dana Laor | Molecular Biology, | Best Researcher Award

Dr. Dana Laor | Molecular Biology| Best Researcher Award

👨‍🏫Profile Summary

Dr. Dana Laor Bar-Yosef is a distinguished molecular biologist renowned for her groundbreaking research in metabolic disorders. She completed her undergraduate studies in biology at the Hebrew University of Jerusalem, followed by M.Sc. and Ph.D. training at Tel Aviv University under Prof. Martin Kupiec. Her Ph.D. research elucidated the roles of TOR protein kinase in cell signaling and amino acid homeostasis using yeast models. Joining Prof. Ehud Gazit’s lab in 2015, she established innovative in vivo models for studying inborn errors of metabolism (IEMs), leading to significant insights and potential therapeutics. Dr. Laor Bar-Yosef’s expertise spans over 15 years, guiding her leadership of the metabolic research group and pioneering the concept of “Metabolostasis.” Her contributions have been recognized with prestigious awards, including the 2020 Ziegler Award, affirming her exceptional impact on medical research in metabolic disorders.

🌐 Professional Profiles

Education🎓

Postdoctoral Researcher in Molecular Biology and Nanotechnology Tel Aviv University, Tel Aviv 2015-2018, Ph.D. in Molecular Biology
Tel Aviv University, Tel Aviv 2009-2014 Thesis title: “The role of TOR in rapamycin response in the fission yeast” Advisors: Prof. Martin Kupiec and Prof. Ronit Weisman. M.Sc. in Genetics Tel Aviv University, Tel Aviv 2007-2009 Thesis title: “The TOR pathway regulates cellular growth, gene silencing and telomere length maintenance in the fission yeast” Advisors: Prof. Martin Kupiec and Prof. Ronit Weisman. B.Sc. in Biology
The Hebrew University, Jerusalem 2003-2006

🔬 Researcher Experience

Head of the Metabolic Research Group Shmunis School of Biomedicine and Cancer Research, Tel Aviv University 2018-Present, Postdoctoral Research School of Molecular Cell Biology and Biotechnology, Tel Aviv University 2015-2018, Graduate Research Department of Microbiology and Biotechnology, Tel Aviv University 2007-2014

 Professional Development  📈

Women Executive Launchpad in HealthTech 8400 Health Network 2022-2023, Health Care Technological Innovation – From Idea to Commercialization Coller School of Management at Tel-Aviv University and Lahav Executive Education 2022

 Teaching Experience📚

Instructor, Introduction to Biology Course Tel Aviv University 2023-2024,  Instructor, “Commercializing University Research” Course
Coller School of Management, Tel Aviv University 2020, Instructor, “Graduate Record Examination Preparation Course”
Tel Aviv University 2014-2015, Teaching Assistant, “Introduction to Genetics” Course Tel Aviv University 2007-2013

Awards 🏆

The Late Breaking News Awards at the 2023 SSIEM Symposium 2023, The Ziegler Award for Research in the Field of Metabolic Disorders
2020, The Herbert and Sharon Glazer Fund Excellence Award 2017 And more…

Funding Acquired💰

The John Templeton Foundation Research Grant 2021-2024, Israel Science Foundation Research Grant 2019-2023, Momentum Fund Investment in Promising Breakthrough Technologies 2021-2023 And more…

 Patents🛠️

Laor, D., & Gazit, E (2018). Integrated drug discovery platform for inborn error of metabolism disorders.
US Provisional Patent Application No. 62/779,054. Pending. Laor, D., Sade, D., and Gazit, E (2021). Integrated drug discovery platform for protein misfolding disorders associated with metabolite accumulation.
Provisional.

 Conference and Scientific Meetings🌐

The first Metabolostasis conference, Israel (2023) Organizing Committee, ILASOL 36th Annual Meeting, Israel (2023)
Organizing Committee and Chair, Rare Connections 2022, Israel A conference dedicated for potential collaborations in the field of rare diseases. ISM 2022 Annual Meeting, Israel The first Israel Metabolomics Meeting, Israel (2022) And more…

 Community Involvement👥

Instructor, Jewish Community Center (JCC), Ohio, USA (2002, 2003) Guided Jewish-American youth about the Israeli Culture in a youth summer camp. Armor Instructor, Israel Defense Forces (2000-2002) Served as an armor guide for regular service and reserve duty soldiers at the Armored Corps School. Counselor, “Maccabi Tzair” Youth Movement, Israel (1996-2000) Served as a counselor and teaching coordinator, mentoring and advocating Israeli youth.

📚Top Noted Publication

  1. TOR complex 2 controls gene silencing, telomere length maintenance, and survival under DNA-damaging conditions
    • Authors: M Schonbrun, D Laor, L López-Maury, J Bähler, M Kupiec, R Weisman
    • Journal: Molecular and cellular biology
    • Volume: 29
    • Issue: 16
    • Pages: 4584-4594
    • Citations: 72
    • Year: 2009

 

  1. Two Decades of Studying Functional Amyloids in Microorganisms
    • Authors: SA Levkovich, E Gazit, D Laor Bar-Yosef
    • Journal: Trends in Microbiology
    • Citations: 68
    • Year: 2021

 

  1. Fibril formation and therapeutic targeting of amyloid-like structures in a yeast model of adenine accumulation
    • Authors: D Laor, D Sade, S Shaham-Niv, D Zaguri, M Gartner, V Basavalingappa, …
    • Journal: Nature communications
    • Volume: 10
    • Issue: 1
    • Pages: 62
    • Citations: 54
    • Year: 2019

 

  1. Yeast models for the study of amyloid-associated disorders and development of future therapy
    • Authors: S Rencus-Lazar, Y DeRowe, H Adsi, E Gazit, D Laor
    • Journal: Frontiers in Molecular Biosciences
    • Volume: 6
    • Pages: 15
    • Citations: 45
    • Year: 2019

 

  1. TORC1 regulates developmental responses to nitrogen stress via regulation of the GATA transcription factor Gaf1
    • Authors: D Laor, A Cohen, M Kupiec, R Weisman
    • Journal: MBio
    • Volume: 6
    • Issue: 4
    • Citations: 33
    • Year: 2015
  1. Engineered riboswitch nanocarriers as a possible disease-modifying treatment for metabolic disorders
    • Authors: S Zilberzwige-Tal, D Gazit, H Adsi, M Gartner, R Behl, D Bar-Yosef Laor, …
    • Journal: ACS nano
    • Volume: 16
    • Issue: 8
    • Pages: 11733-11741
    • Citations: 3
    • Year: 2022

 

  1. Integrated drug discovery platform for inborn error of metabolism disorders
    • Authors: E Gazit, L Dana
    • Patent: US Patent App. 17/345,248
    • Citations: 1
    • Year: 2021

 

  1. Mind your marker: the effect of common auxotrophic markers on complex traits in yeast
    • Authors: K Kaplan, SA Levkovich, Y DeRowe, E Gazit, D Laor Bar‐Yosef
    • Journal: The FEBS Journal
    • Year: 2024

 

  1. The von Hippel-Lindau protein forms fibrillar amyloid assemblies that are mitigated by the anti-amyloid molecule Purpurin
    • Authors: V Kumar, V Kaushik, S Kumar, SA Levkovich, P Gupta, DL Bar-Yosef, …
    • Journal: Biochemical and Biophysical Research Communications
    • Volume: 690
    • Pages: 149250
    • Year: 2024

 

  1. Branched-Chain Amino Acid Assembly into Amyloid-like Fibrils Provides a New Paradigm for Maple Syrup Urine Disease Pathology
    • Authors: T Kreiser, I Sogolovsky-Bard, D Zaguri, S Shaham-Niv, D Laor Bar-Yosef, …
    • Journal: International Journal of Molecular Sciences
    • Volume: 24
    • Issue: 21
    • Pages: 15999
    • Year: 2023

Flavia | Molecular Biology | Young Scientist Award

Dr. Flavia| Molecular Biology | Young Scientist Award

👨‍🏫Profile Summary

Flavia Scoyni is a highly accomplished researcher in molecular medicine, specializing in non-coding RNAs and their role in neurodegenerative diseases like Alzheimer’s and ischemic stroke. With a Ph.D. from the University of Eastern Finland under the Marie Skłodowska-Curie Programme, Flavia has extensive experience in experimental techniques such as scRNA-seq, FACS, and animal modeling. Their work has been published in prestigious journals and recognized with numerous grants and fellowships. Flavia’s expertise in molecular biology, cell culture, and animal work, coupled with a strong track record of securing research funding, positions them as a valuable asset in the field of translational medicine.

🌐 Professional Profiles

🎓Education:

Ph.D. in Molecular Medicine University of Eastern Finland, Kuopio, Finland Duration: Dec 2017 – Feb 2024 Marie Skłodowska-Curie Programme in Genetics and Mechanisms in Translational Medicine (GENOMMED) Advisor: Prof. Tarja Malm Dissertation: “Unlocking the potential of non-coding RNAs in regulating neurodegeneration – a glimpse into Alzheimer’s disease and ischemic stroke pathophysiology.” Ph.D. secondment Aarhus University, Aarhus, Denmark Duration: Sept 2018 – Feb 201 Advisor: Assoc. Prof. Thomas B. Hansen Funded by Saastamoinen Foundation travel grant FELASA accreditationUniversity of Eastern Finland, Kuopio, Finland May 2017 Federation of Laboratory Animal Science Associations (FELASA) Certificate in laboratory animal science for EU Functions A/D MSc in Molecular Biology “Sapienza” University of Rome, Rome, Italy Duration: Oct 2013 – Dec 2015 Master Degree in Molecular Biology Graduated magna cum laude (110/110 cum laude) Advisor: Prof. Alessandro Fatica Thesis title: “Identification of new transcriptional targets of p30 C/EBPα transcription factor isoform in acute myeloid leukemia” MSc in Genetics University Paris-Diderot VII, Paris, France Duration: Oct 2013 – June 2015 BSc in Biotechnology “Sapienza” University of Rome, Rome, Italy Duration: Oct 2010 – July 2013 Bachelor degree in Biotechnology Graduated magna cum laude (110/110 cum laude) Advisor: Prof. Carlo Presutti Thesis title: “The role of the mir-200 family in the regulation of the expression of AP1 transcriptional factor”

🔬Research Experience:

Early stage researcher Professor Tarja Malm University of Eastern Finland, A.I. Virtanen Institute for Molecular Sciences Jan 2017 – Dec 2017 Investigated the role of microRNAs in phagocytic microglia isolated from adult Alzheimer’s mice. Developed techniques including ex-vivo FACS, low input RNA extraction, cloning, qPCR, and protocol for transfection for hard-to-transfect cell lines. Conducted animal procedures to harvest brain samples or acutely isolate adult microglia. Erasmus traineeship Biotech Research & Innovation Centre, Copenhagen, Denmark Oct 2016 – June 2016 Developed a transgenic stable cell line for long non-coding RNAs. Applied techniques such as cloning of long inserts, lentiviral vector production, and stable cell line development. Master thesis Professor Alessandro Fatica “Sapienza” University of Rome, Rome, Italy June 2014 – Dec 2015 Investigated the regulation of the long non-coding RNA UCA1 mediated by C/EBPα transcription factor in the K562 lymphoblast cell line. Applied techniques including ChIP, cloning, RNA extraction, RT-qPCR, WB, transfection, CRISPR-Cas9, and stable cell line development. Master Internship Professor Giuseppe Macino “Sapienza” University of Rome, Rome, Italy Sept 2013 – March 2014 Studied microRNAs inducing epigenetic modifications in mammals.Applied techniques such as ChIP, cloning, mutagenesis, RNA extraction, RT-qPCR, WB, CRISPR-Cas9, and stable cell line development. Bachelor thesis Professor Carlo Presutti “Sapienza” University of Rome, Rome, Italy Oct 2012 – July 2013 Investigated the role of the miR-200a family in regulating c-JUN transcription factor expression. Utilized techniques including cloning, mutagenesis, bacterial transformation, and cell line culture.

💻 Technical Skills:

Molecular biology techniques such as scRNA-seq, RNA-seq, FACS, cloning, RT-qPCR, WB, lentiviral vectors generation. Cell culture techniques including neuronal culture, primary microglial culture, transduction, transfection, and stable cell line development. Animal work including FELASA A/D certification, maintenance, and breeding of transgenic mouse models, animal procedures, and tamoxifen-induced recombination. Statistical analysis, basic Python, and R.

🏆Fellowships, Awards, and Honors:

  • Secured total grants of 99.000€ during Ph.D., including grants from Pavo Nuermen Foundation, Finnish Cultural Foundation, Kuopio University Foundation, and others.

👩‍🏫 Teaching Experience:

  • Mentored a Ph.D. student and post-graduate student, and supervised five master’s thesis students during the Ph.D. program.

📚Top Noted Publication

  1. ciRS-7 and miR-7 regulate ischemia-induced neuronal death via glutamatergic signaling
    • Journal: Cell Reports
    • Year: 2024-03
    • DOI: 10.1016/j.celrep.2024.113862
    • Contributors: Flavia Scoyni; Valeriia Sitnikova; Luca Giudice; Paula Korhonen; Davide M. Trevisan; Ana Hernandez de Sande; Mireia Gomez-Budia; Raisa Giniatullina; Irene F. Ugidos; Hiramani Dhungana et al.

 

  1. Alzheimer’s disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs
    • Journal: Alzheimer’s & Dementia
    • Year: 2024-02
    • DOI: 10.1002/alz.13502
    • Contributors: Flavia Scoyni; Luca Giudice; Mari-Anna Väänänen; Nicholas Downes; Paula Korhonen; Xin Yi Choo; Nelli-Noora Välimäki; Petri Mäkinen; Nea Korvenlaita; Annemieke J Rozemuller et al.

 

  1. ciRS-7 and miR-7 regulate ischemia induced neuronal death via glutamatergic signaling
    • Journal: Preprint
    • Year: 2023-01-24
    • DOI: 10.1101/2023.01.24.525136
    • Contributors: Flavia Scoyni; Valeriia Sitnikova; Luca Giudice; Paula Korhonen; Davide M Trevisan; Ana Hernandez de Sande; Mireia Gomez-Budia; Raisa Giniatullina; Irene F Ugidos; Hiramani Dhungana et al.

 

  1. Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation
    • Journal: Journal of Neuroinflammation
    • Year: 2020
    • DOI: 10.1186/s12974-020-01870-w
    • Contributors: Kolosowska, N.; Gotkiewicz, M.; Dhungana, H.; Giudice, L.; Giugno, R.; Box, D.; Huuskonen, M.T.; Korhonen, P.; Scoyni, F.; Kanninen, K.M. et al.

 

  1. PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia
    • Journal: Stem Cell Reports
    • Year: 2019
    • DOI: 10.1016/j.stemcr.2019.08.004
    • Contributors: Konttinen, H.; Cabral-da-Silva, M.E.C.; Ohtonen, S.; Wojciechowski, S.; Shakirzyanova, A.; Caligola, S.; Giugno, R.; Ishchenko, Y.; Hernández, D.; Fazaludeen, M.F. et al.