Scientist, Stanford University United States
Weili Miao is a postdoctoral researcher at Stanford University, specializing in the functional exploration of biomolecular interactions, particularly involving proteins, RNAs, and DNAs. With a robust background in targeted proteomics and molecular biology, Miao has developed numerous mass spectrometry-based methods to analyze kinase signaling, RNA-protein binding, and protein post-translational modifications. She completed her Ph.D. in Chemistry from the University of California, Riverside in 2019 and a B.S. from Fudan University. Miao has published extensively in high-impact journals such as Cell, Nature Communications, and Nucleic Acids Research, and has co-authored over 20 scientific articles and one book chapter. Her current research has unveiled novel roles of glucose in regulating protein and RNA function in epidermal differentiation. Recognized with prestigious awards like the NIH K01 Award, Miao is emerging as a leader in functional proteomics and epigenetic regulation.
Profile
Scholar
🎓 Education
Weili Miao earned her Ph.D. in Chemistry from the University of California, Riverside in May 2019, where she focused on proteome-wide analysis of protein expression, sequence variations, and post-translational modifications (PTMs). During her doctoral training, she also developed PRM-based approaches for targeted analysis of the human kinome and protein interactomes. Prior to that, she completed her Bachelor of Science degree in Chemistry from Fudan University in June 2014, one of China’s top-ranked institutions. At Fudan, she conducted undergraduate research in the development of novel TiO₂ and functionalized mesoporous materials for phosphopeptide and glycopeptide enrichment. Her education trajectory has combined rigorous theoretical training with cutting-edge research experience in proteomics, analytical chemistry, and molecular biology. This educational foundation has empowered her to drive impactful innovations in systems biology and molecular regulation throughout her postdoctoral work and beyond.
💼 Experience
Weili Miao has accumulated significant research experience across premier institutions. Since September 2019, she has been a postdoctoral researcher at Stanford University, investigating biomolecular interactions—especially involving glucose-binding proteins like DDX21, DDX50, and NSUN2—and their roles in epidermal differentiation. She utilizes cutting-edge techniques including MST, PROBER, and easy-CLIP to dissect protein-DNA/RNA interactions. Prior to Stanford, she conducted postdoctoral and graduate research at UC Riverside, developing proteomic approaches to analyze ATP-binding proteins and kinome signaling during cancer progression. At Novartis Shanghai, she briefly participated in Alzheimer’s drug discovery through the Young Explorer Program. Her early research at Fudan University included novel techniques for glycopeptide enrichment. In total, Miao’s experience spans nearly a decade in proteomics, molecular biology, and biomedical research, blending method development with biological discovery. She also managed labs and instrumentation setups, reflecting her strong technical leadership in experimental research.
🏆 Awards and Honors
Weili Miao is a recipient of several prestigious awards recognizing her research excellence and innovation. Most notably, she received the NIH K01 Mentored Research Scientist Development Award (2024–2029), a highly competitive grant supporting early-career scientists with promise for independent research careers. She was awarded the Dissertation Year Program Fellowship at UC Riverside (2018–2019), acknowledging her outstanding doctoral work in targeted proteomics and functional analysis. In 2019, she was honored with the Award for Outstanding Self-Financed Students Abroad, sponsored by the Chinese government to recognize high-achieving scholars studying overseas. These honors underscore her scientific impact, research leadership, and potential for advancing molecular biology and proteomics. Her sustained publication record in Cell, Nature Communications, and J. Proteome Res., as both first and corresponding author, further solidifies her reputation as a rising star in biomedical research.
🔬 Research Focus
Weili Miao’s research centers on understanding the dynamic interactions of proteins with DNA, RNA, and small molecules, particularly glucose, using advanced proteomic and biochemical tools. Her current work at Stanford focuses on how glucose modulates RNA-binding proteins like NSUN2, DDX21, and DDX50, thereby influencing mRNA splicing and epidermal differentiation. She incorporates innovative methods such as MST, PROBER, and easy-CLIP to study protein interactions at high resolution. During her doctoral studies, she focused on ATP-binding proteins, kinases, and heat shock proteins, and developed mass spectrometry-based assays for comprehensive proteome profiling. Her research also extends into disease contexts, including cancer metastasis and drug resistance. Broadly, her focus lies in functional proteomics, epigenetic regulation, and molecular signal transduction, with an emphasis on identifying novel biological mechanisms and therapeutic targets. Her integrative approach merges analytical chemistry with molecular biology to drive insights in cellular regulation and disease mechanisms.
Conclusion
Dr. Weili Miao is an exceptionally qualified and highly deserving candidate for a Best Researcher Award, especially in the early-to-mid career stage. Her research productivity, technical innovation, and impact on biomedical science are outstanding. While she could further boost her candidacy by assuming more independent leadership roles and enhancing broader engagement, her current accomplishments already place her in the top tier of postdoctoral researchers.
Publication
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Title: RNA-binding proteins contribute to small RNA loading in plant extracellular vesicles
Year: 2021
Authors: B He, Q Cai, L Qiao, CY Huang, S Wang, W Miao, T Ha, Y Wang, H Jin
Citations: 269
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Title: SARS-CoV-2 B.1.1.7 and B.1.351 spike variants bind human ACE2 with increased affinity
Year: 2021
Authors: M Ramanathan*, ID Ferguson*, W Miao*, PA Khavari
Citations: 244
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Title: CPT1A/2-mediated FAO enhancement—a metabolic target in radioresistant breast cancer
Year: 2019
Authors: S Han, R Wei, X Zhang, N Jiang, M Fan, JH Huang, B Xie, L Zhang, …
Citations: 141
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Title: YY1 interacts with guanine quadruplexes to regulate DNA looping and gene expression
Year: 2021
Authors: L Li, P Williams, W Ren, MY Wang, Z Gao, W Miao, M Huang, J Song, …
Citations: 117
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Title: YTHDF2 binds to 5-methylcytosine in RNA and modulates the maturation of ribosomal RNA
Year: 2019
Authors: X Dai, G Gonzalez, L Li, J Li, C You, W Miao, J Hu, L Fu, Y Zhao, R Li, L Li, …
Citations: 81
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Title: Adenylate kinase 4 modulates the resistance of breast cancer cells to tamoxifen through an m6A-based epitranscriptomic mechanism
Year: 2020
Authors: X Liu, G Gonzalez, X Dai, W Miao, J Yuan, M Huang, D Bade, L Li, Y Sun, …
Citations: 78
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Title: Pyruvate kinase M2 regulates homologous recombination-mediated DNA double-strand break repair
Year: 2018
Authors: ST Sizemore, M Zhang, JH Cho, GM Sizemore, B Hurwitz, B Kaur, …
Citations: 73
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Title: The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance
Year: 2022
Authors: ID Ferguson, B Patiño-Escobar, ST Tuomivaara, YHT Lin, MA Nix, …
Citations: 72
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Title: Elevated hexokinase II expression confers acquired resistance to 4-hydroxytamoxifen in breast cancer cells
Year: 2019
Authors: X Liu, W Miao, M Huang, L Li, X Dai, Y Wang
Citations: 54
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Title: Glucose dissociates DDX21 dimers to regulate mRNA splicing and tissue differentiation
Year: 2023
Authors: W Miao, DF Porter, V Lopez-Pajares, Z Siprashvili, RM Meyers, Y Bai, …
Citations: 45
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Title: Dual regulation of Arabidopsis AGO2 by arginine methylation
Year: 2019
Authors: P Hu, H Zhao, P Zhu, Y Xiao, W Miao, Y Wang, H Jin
Citations: 45
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Title: easyCLIP analysis of RNA-protein interactions incorporating absolute quantification
Year: 2021
Authors: DF Porter, W Miao, X Yang, GA Goda, AL Ji, LKH Donohue, MM Aleman, …
Citations: 44