🌐 🔬 Dr. Yonca Yüzügüllü Karakuş, an Assistant Professor at Kocaeli University, is a dedicated researcher in Microbial Biotechnology, Biochemistry, and Structural Biology. With a Ph.D. from the Middle East Technical University, her academic journey includes impactful research stints at the University of Leeds. As the Deputy Head of the Biology Department, she plays a crucial role in academia. Recognized with honors like the RCSB PDB Poster Prize and Kocaeli University Encouragement Award, she fosters the next generation of scientists through her supervision of Ph.D. and Master students. 🌱🧬
Ph.D., Molecular Genetics Tarbiat Modares University, Tehran, Iran Sep 23, 2009 – Jan 19, 2013 Thesis: Investigation of the effects of miR-326 overexpression on Hedgehog signaling pathway activation and induction of apoptosis in chronic myeloid leukemia CD34+ stem cells. M.Sc., Cell and Molecular Biology Science and research branch, Azad University, Tehran, Iran Sep 23, 2006 – Jun 27, 2009.B.Sc., Marine Biology University of Guilan, Guilan, Iran Sep 23, 2001 – Feb 19, 2006.
Research Training 🧪
Associate Research Scholar, Senior Scientist Tarbiat Modares University, Iran 2014 – 2018 Investigating the microRNA-mRNA regulatory network in human cancers Studying the roles of stem cell-derived exosomes in the regulation of the tumor microenvironment Studying the therapeutic effects of Curcumin on human cancers and malignancies Postdoc Research Fellow University of Michigan, MI, USA 2023 – present
Academic Appointments 👩🏫
Associate Professor Department of Molecular Genetics, Tarbiat Modares University, Iran 2022 – present. Assistant Professor Department of Molecular Genetics, Tarbiat Modares University, Iran 2018 – 2022.
Research Interests 🧬
Studying the contribution of tumor microenvironment components to cancer progression Investigating the role of regulatory RNAs in cancer biology and characterizing the significance of extracellular RNAs in the tumor microenvironment Understanding the functional roles of exosomes in regulating tumorigenesis and progression Investigating the ability of non-coding RNAs as diagnostic and prognostic biomarkers in cancer Developing novel cancer stem cell-directed treatments, reducing therapy resistance
Part-Time Activity as Teacher and/or Supervisor 📝
Azad University of Pishva (2012-2013) Azad University of Pharmaceutical Sciences Branch (2013-2019) Azad University of Medical Branch (2018-2019) Azad University, Science and Research Branch (2020-2022) Azad University, Tehran North Branch (2021-2022)
Awards and Honors 🏆
The country’s leading young researcher in the field of Biology, Abu-Reihan Award, 2021, Academy of Sciences of Iran
International prize winner of the 15th Khwarizmi International Youth Award, December 2013, Tehran, Iran
Teaching Experience 📖
Molecular Genetics for MSc students
Immunogenetics for MSc students
Bioinformatics for MSc students
Practical cell culture for MSc students
Special topics in Genetics for Ph.D. students
Cellular and molecular biology for Ph.D. students
Conference Presentations 🌐
More than 60 abstracts and 20 oral presentations in national and international conferences
📚Top Noted Publication
Colorectal cancer-secreted exosomal circ_001422
Journal: J Cancer Res Clin Oncol, 2023
Summary: Investigates the role of exosomal circ_001422 in regulating KDR expression and activating mTOR signaling in endothelial cells by targeting miR-195-5p.
The Promising Role of Non-Coding RNAs for Leukemia
Journal: Genes (Basel), 2023
Summary: Highlights the potential of non-coding RNAs as biomarkers and therapeutic targets for leukemia.
Characterization and Comparison of Mesenchymal Stem Cell-Derived Exosome Isolation Methods
Journal: Arch Razi Inst, 2022
Summary: Compares methods for isolating exosomes from mesenchymal stem cells.
Circulating exosomal microRNAs as Prognostic Biomarkers in Gastrointestinal Cancers
Journal: Cancer Cell Int, 2023
Summary: Systematic review and meta-analysis on exosomal microRNAs as potential prognostic biomarkers in gastrointestinal cancers.
Notch Signaling Pathway in Breast Cancer
Journal: BMC Cancer, 2022
Summary: Comprehensive analysis of the Notch signaling pathway as a prognostic and gene expression profile in breast cancer.
Monocytes Educated by Cancer-Associated Fibroblasts
Journal: J Translational Medicine, 2022
Summary: Explores the role of monocytes educated by cancer-associated fibroblasts in breast cancer.
The Role of CircRNA/miRNA/mRNA Axis in Breast Cancer Drug Resistance
Journal: Front Oncol, 2022
Summary: Reviews the role of CircRNA/miRNA/mRNA axis in breast cancer drug resistance.
Circular RNAs in Regulatory Networks of Cell Signaling Pathways in Human Cancers
Journal: Life Sci, 2022
Summary: Explores the roles of circular RNAs in regulatory networks of cell signaling pathways in human cancers.
A Critical Review on Induced Totipotent Stem Cells
Journal: Stem Cell Res, 2022
Summary: Provides a critical review of induced totipotent stem cells, discussing types and methods.
Strategies to Overcome the Side Effects of CAR T Cell Therapy
Journal: Ann N Y Acad Sci, 2022
Summary: Discusses strategies to overcome the side effects of chimeric antigen receptor T cell therapy
Sadegh Babashah | Molecular Medicine | Best Researcher Award