Dr. Angelika Długosz-Pokorska | Molecular biochemistry | Women Researcher Award

Dr at Medical University of Łódź, Poland

Angelika Długosz-Pokorska, born on January 15, 1990, in Łódź, Poland, is a Research Associate at the Medical University of Łódź, specializing in medicinal chemistry and cancer research. She leads projects on anticancer compounds, opioid analogs, and their pharmacological effects, contributing to multiple EU-funded research initiatives.

Profile

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Education 🎓

Angelika holds a Ph.D. in Medicinal Chemistry from the Medical University of Łódź, Poland, and has undergone research training at the University of Rouen, France, in neuropsychopharmacology.

Experience 🧑‍🏫

With over 7 years of research experience, Angelika has served as Principal Investigator and Co-investigator for numerous projects, including anticancer activity studies and pharmacological analysis of synthetic peptides and compounds. She has also supervised and mentored young researchers and students.

Awards and Honors 🏆

Angelika has received multiple accolades, including “Skuteczna Kobieta Roku 2021” (Effective Woman of the Year) in the Science category, Rector’s Awards for outstanding publications, and a First-level Special Award for Didactic Excellence.

Research Focus 🔍

Angelika’s research focuses on the development of new hybrid anticancer agents, including those with uracil skeletons and methylene groups. Her work also explores the role of endomorphin analogs in neuroprotection and cancer treatment.

Publications 📚

“Synthesis of New Chiral β-Carbonyl Selenides with Antioxidant and Anticancer Activity Evaluation—Part I”
- Journal: Materials
- Date: February 15, 2024
- DOI: 10.3390/ma17040899
- ISSN: 1996-1944
- Contributors: Anna Laskowska, Agata Pacuła-Miszewska, Magdalena Obieziurska-Fabisiak, Jastrzebska, Angelika Długosz-Pokorska, Katarzyna Gach-Janczak, Jacek Scianowski

“The Influence of Long Carbon Chains on the Antioxidant and Anticancer Properties of N-Substituted Benzisoselenazolones and Corresponding Diselenides”
- Journal: Pharmaceuticals
- Date: November 4, 2023
- DOI: 10.3390/ph16111560
- ISSN: 1424-8247
- Contributors: Agata Pacuła-Miszewska, Magdalena Obieziurska-Fabisiak, Jastrzebska, Angelika Długosz-Pokorska, Katarzyna Gach-Janczak, Jacek Scianowski

“New Uracil Analog with Exocyclic Methylidene Group Can Reverse Resistance to Taxol in MCF-7 Cancer Cells”
- Journal: Biologics: Targets and Therapy
- Date: May 2023
- DOI: 10.2147/btt.s405080
- ISSN: 1177-5491
- Contributors: Angelika Długosz-Pokorska, Renata Perlikowska, Tomasz Janecki, Anna Janecka

“Attachment of Chiral Functional Groups to Modify the Activity of New GPx Mimetics”
- Journal: Materials
- Date: March 11, 2022
- DOI: 10.3390/ma15062068
- ISSN: 1996-1944
- Contributors: Anna Laskowska, Agata Joanna Pacuła-Miszewska, Angelika Długosz-Pokorska, Anna Janecka, Andrzej Wojtczak, Jacek Scianowski

“A New Hybrid δ-Lactone Induces Apoptosis and Potentiates Anticancer Activity of Taxol in HL-60 Human Leukemia Cells”
- Journal: Molecules
- Date: 2020
- DOI: 10.3390/molecules25071479
- ISSN: 1420-3049
- Contributors: Katarzyna Gach-Janczak, Joanna Drogosz-Stachowicz, Angelika Długosz-Pokorska, Rafał Jakubowski, Tomasz Janecki, Jacek Szymański, Anna Janecka

“New Uracil Analog U-332 is an Inhibitor of NF-κB in 5-Fluorouracil-Resistant Human Leukemia HL-60 Cell Line”
- Journal: BMC Pharmacology & Toxicology
- Date: 2020
- DOI: 10.1186/s40360-020-0397-4
- ISSN: 1471-2210
- Contributors: Angelika Długosz-Pokorska, Marlena Pięta, Jacek Kędzia, Tomasz Janecki, Anna Janecka

“New Uracil Analogs with Exocyclic Methylidene Group as Potential Anticancer Agents”
- Journal: Anti-Cancer Agents in Medicinal Chemistry
- Date: 2020
- DOI: 10.2174/1871520619666191211104128
- ISSN: 1871-5206
- PMID: 31823706
- Contributors: Angelika Długosz-Pokorska, Joanna Drogosz-Stachowicz, Marlena Pięta, Tomasz Janecki, Urszula Krajewska, Marek Mirowski, Anna Janecka

“Seleninic Acid Potassium Salts as Water-Soluble Biocatalysts with Enhanced Bioavailability”
- Journal: Materials
- Date: 2020
- DOI: 10.3390/ma13030661
- ISSN: 1996-1944
- PMID: 32024274
- Contributors: Magdalena Obieziurska, Agata J. Pacuła, Anna Laskowska, Angelika Długosz-Pokorska, Anna Janecka, Jacek Ścianowski

“Molecular Mechanisms of Apoptosis Induced by a Novel Synthetic Quinolinone Derivative in HL-60 Human Leukemia Cells”
- Journal: Chemico-Biological Interactions
- Date: April 2020
- DOI: 10.1016/j.cbi.2020.109005
- ISSN: 0009-2797
- Contributors: Joanna Drogosz-Stachowicz, Angelika Długosz-Pokorska, Katarzyna Gach-Janczak, Agata Jaskulska, Tomasz Janecki, Anna Janecka

“Anticancer Activity of New α-Methylene-δ-Lactone DL-247 in Selected Cancer Cell Lines”
- Type: Conference Paper
- Date: 2019
- ISBN: 978-80-907442-0-2
- Contributors: Katarzyna Gach-Janczak, Angelika Długosz-Pokorska, Joanna Drogosz, R. Jakubowski, Jacek Szymański, Tomasz Janecki, Anna Janecka

Profile Summary

Efficient and detailed oriented post doctor researcher working in the field of natural products and food chemistry especially in bee products and medicinal plants. Owing to write reviews or original papers to be published in high impacted journals.

Professional Profiles

Orcid Profile

Qualifications 📚

Post-graduation PhD. in Biochemistry (Menoufia University) Date of graduation: 2024 Area of research: Drug discovery research, Functional Food. M.SC. in Biochemistry (Menoufia University) Date of graduation: Sep. 2019 Area of research: Drug discovery research, Functional Food Analytical Biochemistry Diploma (Menoufia University) Date of graduation: May 2014 Grade: Excellent. B.Sc. in Science, Chemistry and Botany Department (Menoufia University) Date of graduation: May 2006 Grade: Very Good (83%)

Scientific Experiences 🔬

Gas chromatography-Mass spectrometry analysis (GC-MS).
Liquid chromatography-Mass spectrometry analysis (LC-MS-MS).
GNPS interpretation.
Writing scientific papers.
Reviewing scientific papers.

Fields of Interest 🧪

Natural Product Chemistry
Biochemistry
Food Chemistry
Metabolomics

Conferences 🌐

Annual International Conference of THE EGYPTIAN FERTILITY AND STERILITY, 2023, International Association of Surgeons’ Gastroenterologists and Oncologists’ 5th Meeting of IASGO Egyptian Chapter, November 2021. Oral presenter in 3rd INTERNATIONAL JSPS AAE SYMPOSIUM, September 2021. Oral presenter in the 5th International Symposium on Phytochemicals in Medicine and Food conference, China, 2021. Menoufia Diabetes Conference, February 28, 2020. HGIDA 14th Scientific Event on Pitfalls in Diagnosis of Infectious Diseases, February 26, 2020. Training Course and Symposium on Apitherapy, December 4-5, 2019. Clinical Approach to Autoimmune Liver Diseases Postgraduate Course, November 27, 2019. IASGO Egyptian Chapter 2nd Annual Meeting, November 15-17, 2018.

Workshops 🛠️

American Society of Pharmacognosy webinars about most recent applications of natural products from April 2020 to November 2020. 1st GNPS User Meeting, August 2020. ‘Hands-on featuring a successful academic career’ workshop at Chemistry Department, American University of Cairo (AUC), July 2019.

Skills 🛠️

Good Command of English Intensive Course in English (Intermediate II Level, 36 Hours) Final Grade: Excellent (Minufia University) Conversation Course in English (Intermediate Level, 36 Hours) Final Grade: Excellent (Minufia University). Computer Skills Excellent Experience in Computer Software (Windows, Office, Internet) ICDL Certificate. Professional Development Pharma Mini-MBA (Certificate from ACC Group – American Canadian Center) Excellence in Negotiation Workshop (Scope Office) Advanced Presentation Skills Talent Pool Course Pharmacovigilance Basic Principles Leadership Skills and Management (Harvest Academy)

📚Top Noted Publication

Title: An updated multifaceted overview of sweet proteins and dipeptides as sugar substitutes; the chemistry, health benefits, gut interactions, and safety
- Authors: Farag, M. A., Rezk, M. M., Elashal, M. H., El-Araby, M., Khalifa, S. A., & El-Seedi, H. R.
- Journal: Food Research International
- Year: 2022
- DOI: 10.1016/j.foodres.2022.111853

Title: Bee pollen: Clinical trials and patent applications
- Authors: Algethami, J. S., El-Wahed, A. A. A., Elashal, M. H., Ahmed, H. R., Elshafiey, E. H., Omar, E. M., … & El-Seedi, H. R.
- Journal: Nutrients
- Year: 2022
- Volume: 14
- Issue: 14
- DOI: 10.3390/nu14142858

Title: Cosmetic applications of bee venom
- Authors: El-Wahed, A. A. A., Khalifa, S. A., Elashal, M. H., Musharraf, S. G., Saeed, A., Khatib, A., … & El-Seedi, H. R.
- Journal: Toxins
- Year: 2021
- Volume: 13
- Issue: 11
- DOI: 10.3390/toxins13110810

Title: Bee Pollen: Current Status and Therapeutic Potential
- Authors: Khalifa, S. A., Elashal, M. H., Yosri, N., Du, M., Musharraf, S. G., Nahar, L., & El-Seedi, H. R.
- Journal: Nutrients
- Year: 2021
- Volume: 13
- Issue: 6
- DOI: 10.3390/nu13061876

Title: Comprehensive overview on multiple strategies fighting COVID-19
- Authors: Khalifa, S. A., Mohamed, B. S., Elashal, M. H., Du, M., Guo, Z., Zhao, C., & El-Seedi, H. R.
- Journal: International Journal of Environmental Research and Public Health
- Year: 2020
- Volume: 17
- Issue: 16
- DOI: 10.3390/ijerph17165813

Title: Recent insights into chemical and pharmacological studies of bee bread
- Authors: Khalifa, S. A., Elashal, M., Kieliszek, M., Ghazala, N. E., Farag, M. A., Saeed, A., & El-Seedi, H. R.
- Journal: Trends in Food Science & Technology
- Year: 2020
- Volume: 97
- Pages: 300-316
- DOI: 10.1016/j.tifs.2019.08.021

Title: Apilarnil ameliorates Bisphenol A-induced testicular toxicity in adult male rats via improving antioxidant potency and PCNA expression
- Authors: Mohamed H. Elashal, Aida A. Abd El-Wahed, Mostafa Abdelgaber Mohamed, Rania Hamad, Mabrouk Attia Abd Eldaim, Shaden A. M. Khalifa, Hesham R. El-Seedi, Mohamed F. AlAjmi, Bishoy El-Aarag
- Journal: Reproductive Toxicology (accepted paper)
- Year: 2024

Angelika Długosz-Pokorska | Molecular biochemistry | Women Researcher Award