Ms. Prarthana Sharma l Agricultural and Biological Sciences
| Best Researcher Award
University of Warmia and Mazury in Olsztyn | Poland
Dr. Prarthana Sharma’s research focuses on molecular mechanisms regulating hepatic function, gene expression, and hepatoprotection using animal models. Her work integrates cell culture, molecular biology, and pharmacological approaches to understand the interaction between dietary compounds and cellular signaling in liver physiology. She has contributed to advanced investigations on the hepatoprotective effects of medicinal plant extracts such as Silybum marianum (silymarin) and Curcuma longa (turmeric) in mitigating aflatoxin B1-induced liver toxicity, employing both in vivo porcine models and in vitro hepatocyte culture systems. Her research involves microRNA profiling, transcriptomic analysis, and molecular pathway mapping to identify gene regulatory networks responsible for liver protection and regeneration. With expertise in gene expression studies, RNA and DNA isolation, cDNA synthesis, PCR, and real-time PCR, she explores molecular responses to dietary interventions at cellular and systemic levels. Her scientific contributions also include comparative gene expression studies in granulosa cells, linking molecular genetics to reproductive physiology. She actively participates in preclinical research, focusing on toxicokinetics, pharmacokinetics, and drug delivery, contributing to translational approaches in veterinary and biomedical sciences. Through multidisciplinary collaborations, her research aims to advance understanding of nutrigenomics, toxicogenomics, and molecular pharmacology for improving animal and human health.
Featured Publication
Sharma, P., Asediya, V., Kalra, G., Sultana, S., Purohit, N., Kibitlewska, K., Kozera, W., Czarnik, U., Karpiesiuk, K., & Lecewicz, M. (2025). Hepatoprotective effect of Silymarin herb in prevention of liver dysfunction using pig as animal model. Nutrients, 17(20), 3278. https://doi.org/10.3390/nu17203278