Shen Zhang | Proteomics | Best Researcher Award

Assoc Prof Dr. Shen Zhang | Proteomics | Best Researcher Award

Shen Zhang is an Associate Professor and Director of the Mass Spectrometry Platform at the Reproductive and Genetic Hospital of CITIC-XIANGYA, Changsha, China. He earned his B.Sc. in Chemistry from Hunan University and his Ph.D. in Analytical Chemistry from Dalian Institute of Chemical Physics, Chinese Academy of Sciences. Zhang’s research focuses on advanced mass spectrometry techniques and proteomics. His notable achievements include the Hundred Youth Talents Program of Hunan Province award and the ASMS Post-Doctoral Career Development Award. He has held prestigious positions at the Lunenfeld-Tanenbaum Research Institute and the University of Toronto. Zhang has published extensively in high-impact journals and serves as a reviewer and guest editor for various scientific publications.

Publication Profile

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šŸŽ“ Academic and Training Background

Hunan University B.Sc. in Chemistry, 2006-2010. Dalian Institute of Chemical Physics, Chinese Academy of Sciences
Ph.D. in Analytical Chemistry, 2010-2015 (Supervised by Yukui Zhang and Lihua Zhang)

šŸ’¼ Work Experience

Reproductive and Genetic Hospital of CITIC-XIANGYA Associate Professor & Director of the Mass Spectrometry Platform
August 2021 – Present. Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Canada Research Fellow May 2016 – May 2021. University of Toronto and SCIEX Global LCMS R&D Center, Canada Mitacs Elevate Postdoctoral Fellow December 2017 – December 2019

šŸ† Selected Accomplishments and Honors

April 2022: Hundred Youth Talents Program of Hunan Province. June 2018: ASMS Post-Doctoral Career Development Award. November 2017: CSMS Travel Award. June 2017: Mitacs Elevate Postdoctoral Fellowship. February 2017: Travel Award from Lunenfeld-Tanenbaum Research Institute. November 2016: 2016-2017 Trainees Innovation Grant. May 2015: Excellent Students in Chinese Academy of Sciences. April 2015: Student Travel Grant for MSB 2015. June 2010: Outstanding Dissertation, Hunan University

 

šŸ† Strengths for the Award

  1. Outstanding Academic Background:
    • Shen Zhang holds a B.Sc. in Chemistry from Hunan University and a Ph.D. in Analytical Chemistry from the Dalian Institute of Chemical Physics, showcasing a strong academic foundation in his field.
  2. Significant Research Contributions:
    • Zhang’s publications in high-impact journals like Analytical Chemistry, Journal of Proteome Research, and Frontiers in Molecular Biosciences reflect his substantial contributions to the field of mass spectrometry and proteomics.
  3. Prestigious Fellowships and Awards:
    • He has received notable awards including the ASMS Post-Doctoral Career Development Award and the Mitacs Elevate Postdoctoral Fellowship, recognizing his exceptional research achievements.
  4. Leadership and Innovation:
    • As the Director of the Mass Spectrometry Platform at the Reproductive and Genetic Hospital of CITIC-XIANGYA, Zhang demonstrates leadership and innovation in applying advanced mass spectrometry techniques.
  5. Editorial and Reviewing Roles:
    • His roles as Guest Editor and Reviewer for several esteemed journals highlight his expertise and influence in the scientific community.
  6. Successful Collaborative Projects:
    • Zhang’s successful collaborations with international researchers and institutions underscore his ability to work effectively in multidisciplinary teams.

šŸ” Areas for Improvement

  1. Broader Research Impact:
    • While Zhang has a strong publication record, expanding research into broader applications or emerging areas of proteomics could enhance the impact of his work.
  2. Increased Public Engagement:
    • Greater efforts in public engagement and science communication could help in translating his research findings to a wider audience, increasing the societal impact of his work.
  3. Diversified Funding Sources:
    • Seeking diverse funding opportunities beyond traditional fellowships might support further innovative research and expansion of his research platform.

Publications:

  1. Title: High-resolution quadrupole improves spectral purity and reduces interference from non-target ions in isobaric multiplexed quantitative proteomics
    Year: 2024
    Author: Shen Zhang; J.C. Yves Le Blanc; Brett Larsen; Karen Colwill; Lyle Burton; Mircea Guna; Anne-Claude Gingras; Stephen Tate

 

  1. Title: Homozygous ACTL9 mutations cause irregular mitochondrial sheath arrangement and abnormal flagellum assembly in spermatozoa and male infertility
    Year: 2024
    Author: Qi Li; Yilian Huang; Shen Zhang; Fei Gong; Guangxiu Lu; Ge Lin; Jing Dai

 

  1. Title: In-Depth Endogenous Phosphopeptidomics of Serum with Zirconium(IV)-Grafted Mesoporous Silica Enrichment
    Year: 2024
    Author: Ci Wu; Shen Zhang; Chunyan Hou; Stephen Byers; Junfeng Ma

 

  1. Title: All-in-One digital microfluidics pipeline for proteomic sample preparation and analysis
    Year: 2023
    Author: Jiaxi Peng; Calvin Chan; Shuailong Zhang; Alexandros A. Sklavounos; Maxwell E. Olson; Erica Y. Scott; Yechen Hu; Vigneshwar Rajesh; Bingyu B. Li; M. Dean Chamberlain et al.

 

  1. Title: On-capillary alkylation micro-reactor: a facile strategy for proteo-metabolome profiling in the same single cells
    Year: 2023
    Author: Yingyun He; Huiming Yuan; Yu Liang; Xinxin Liu; Xiaozhe Zhang; Yahui Ji; Baofeng Zhao; Kaiguang Yang; Jue Zhang; Shen Zhang et al.

 

  1. Title: Trace Sample Proteome Quantification by Data-Dependent Acquisition without Dynamic Exclusion
    Year: 2023
    Author: Ci Wu; Jiao Lei; Fei Meng; Xingyao Wang; Cassandra J. Wong; Jiaxi Peng; Ge Lin; Anne-Claude Gingras; Junfeng Ma; Shen Zhang

šŸ… Conclusion

Shen Zhang is a highly qualified candidate for the Research for Best Researcher Award. His impressive academic achievements, significant research contributions, prestigious awards, and leadership in mass spectrometry research demonstrate his excellence and potential. By addressing areas for improvement such as expanding research impact and increasing public engagement, Zhang could further enhance his contributions to the field and make a strong case for the award.

Mohammadsadeq Mottaqi | Computational biology | Young Scientist Award

Mr. Mohammadsadeq Mottaqi | Computational biology | Young Scientist Award

MohammadSadeq Mottaqi is a dedicated Ph.D. candidate in Biochemistry at the City University of New York, with a strong foundation in Biotechnology from the University of Tehran. He possesses a robust skill set in Python, R, and various bioinformatics tools. His research focuses on machine learning-based drug action prediction, molecular dynamics simulations, and protein-ligand interactions. He has contributed significantly to research projects at Hunter College and Weill Cornell Medicine, and has industry experience as an R&D intern. MohammadSadeq is a published author, with works in journals like the Journal of Environmental Management and Informatics in Medicine Unlocked.

Profile

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EducationšŸŽ“

City University of New York, the Graduate Center, New York, NY PhD in Biochemistry, Computer Science Department
Aug 2022 – Present. University of Tehran, Tehran, Iran B.Sc. in Biotechnology, GPA: 3.8 (top 15%) Sep 2017 – March 2022

Ā Technical SkillsšŸ’»

Programming Languages: Python, R, Bioinformatics Tools and Libraries: PyMol, MOE, Gromacs, Spss, Unity, Scikit-learn, Data Analysis: Transcriptomics data analysis, Statistical analysis, Data Visualization, Operating Systems: Linux, Unix, Others: High-performance computing

Ā Relevant Experience šŸŒŸ

Machine learning-based prediction methods for drug actions
Prof. Lei Xie lab, Hunter College and Weill Cornell Medicine
June 2023 – Present
Thesis: Deep learning models for chemical-induced differential gene expression and cell viability predictions for de novo drugs and cell lines

  • Resolve challenges in predictive modeling using algorithmic approaches
  • Design pre-processing pipelines for Transcriptomics datasets
  • Integrate disparate Transcriptomics datasets (80 cell-lines) using Python
  • Incorporate multiple diverse labeled and unlabeled OMICS data
  • Contribute to writing manuscript

Molecular dynamics simulations of mutated HER2 protein
Research assistant – Dr. Mateusz Marianski lab, Hunter College
April 2023 – June 2023

  • Investigated coupling reactions and residue interactions in several mutated HER2 proteins
  • Performed molecular dynamics (MD) simulations employing Gromacs
  • Analyzed the data of the MD simulations
  • Presented the interpreted results

Protein-Ligand interactions in docking
Research assistant – Prof. Tom Kurtzman lab, Lehman College
Nov 2022 – Jan 2023

  • Identified the potential molecular interactions between protein pharmacophores and ligands
  • Wrote Python scripts in PyMOL for detection of potential H-bonds and Van der Waals forces

Aral Teb CO. Ltd., Tehran, Iran
R&D Intern
May 2020 – Oct 2020

  • Designed and executed experiments for a bacterial diagnostic kit
  • Converted 3D MRI data into a format compatible with 3D bioprinter
  • Served as a key researcher in the clean room

Virtual reality (VR) project, Iranā€™s National Elites Foundation
Nov 2020 – Aug 2021

  • Devised 7 biotechnological experiments in VR environments employing Unity software
  • Collaborated with 9 computer scientists and 4 biologists

Publications Top Notes šŸ“

  • Iman Kianian, Mohammad Sadeq Mottaqi, et al. Automated identification of toxigenic cyanobacterial genera for water quality control purposes, Journal of Environmental Management

 

  • Mohammad Sadeq Mottaqi, et al. Contribution of machine learning approaches in response to SARS-CoV-2 infection, Informatics in Medicine Unlocked, 2021