Mohammadsadeq Mottaqi | Computational biology | Young Scientist Award

Mr. Mohammadsadeq Mottaqi | Computational biology | Young Scientist Award

MohammadSadeq Mottaqi is a dedicated Ph.D. candidate in Biochemistry at the City University of New York, with a strong foundation in Biotechnology from the University of Tehran. He possesses a robust skill set in Python, R, and various bioinformatics tools. His research focuses on machine learning-based drug action prediction, molecular dynamics simulations, and protein-ligand interactions. He has contributed significantly to research projects at Hunter College and Weill Cornell Medicine, and has industry experience as an R&D intern. MohammadSadeq is a published author, with works in journals like the Journal of Environmental Management and Informatics in Medicine Unlocked.

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Education🎓

City University of New York, the Graduate Center, New York, NY PhD in Biochemistry, Computer Science Department
Aug 2022 – Present. University of Tehran, Tehran, Iran B.Sc. in Biotechnology, GPA: 3.8 (top 15%) Sep 2017 – March 2022

 Technical Skills💻

Programming Languages: Python, R, Bioinformatics Tools and Libraries: PyMol, MOE, Gromacs, Spss, Unity, Scikit-learn, Data Analysis: Transcriptomics data analysis, Statistical analysis, Data Visualization, Operating Systems: Linux, Unix, Others: High-performance computing

 Relevant Experience 🌟

Machine learning-based prediction methods for drug actions
Prof. Lei Xie lab, Hunter College and Weill Cornell Medicine
June 2023 – Present
Thesis: Deep learning models for chemical-induced differential gene expression and cell viability predictions for de novo drugs and cell lines

  • Resolve challenges in predictive modeling using algorithmic approaches
  • Design pre-processing pipelines for Transcriptomics datasets
  • Integrate disparate Transcriptomics datasets (80 cell-lines) using Python
  • Incorporate multiple diverse labeled and unlabeled OMICS data
  • Contribute to writing manuscript

Molecular dynamics simulations of mutated HER2 protein
Research assistant – Dr. Mateusz Marianski lab, Hunter College
April 2023 – June 2023

  • Investigated coupling reactions and residue interactions in several mutated HER2 proteins
  • Performed molecular dynamics (MD) simulations employing Gromacs
  • Analyzed the data of the MD simulations
  • Presented the interpreted results

Protein-Ligand interactions in docking
Research assistant – Prof. Tom Kurtzman lab, Lehman College
Nov 2022 – Jan 2023

  • Identified the potential molecular interactions between protein pharmacophores and ligands
  • Wrote Python scripts in PyMOL for detection of potential H-bonds and Van der Waals forces

Aral Teb CO. Ltd., Tehran, Iran
R&D Intern
May 2020 – Oct 2020

  • Designed and executed experiments for a bacterial diagnostic kit
  • Converted 3D MRI data into a format compatible with 3D bioprinter
  • Served as a key researcher in the clean room

Virtual reality (VR) project, Iran’s National Elites Foundation
Nov 2020 – Aug 2021

  • Devised 7 biotechnological experiments in VR environments employing Unity software
  • Collaborated with 9 computer scientists and 4 biologists

Publications Top Notes 📝

  • Iman Kianian, Mohammad Sadeq Mottaqi, et al. Automated identification of toxigenic cyanobacterial genera for water quality control purposes, Journal of Environmental Management

 

  • Mohammad Sadeq Mottaqi, et al. Contribution of machine learning approaches in response to SARS-CoV-2 infection, Informatics in Medicine Unlocked, 2021

Thi Mong Diep Nguyen | Molecular Biology | Best Researcher Award

Assoc Prof Dr. Omvir Singh| Molecular Biology | Best Researcher Award

🔬🧬 Holding a Doctor of Science in Life Science (Cell Biotechnology) from the University of Tours, France, I’ve delved into diverse realms including cell biology, microbiology, and animal reproduction. As a Visiting Professor at the University of François-Rabelais and an Associate Professor at Quy Nhon University, I’ve led research projects exploring avian reproductive biotechnologies and the impact of AMPK protein kinase on male gonad functions. My contributions to grants investigating hCG glycoforms and fertility treatments showcase my dedication to advancing scientific understanding. 🌱👨‍🔬

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Scholar

Training Background:

University of Tours, France Years: 4/2022 Major/ Specialty: Life Science (Cell biotechnology) Academic Degree: Doctor of Science University of François-Rabelais, Tours, France Years: 1/2020 – 3/2020 Major/ Specialty: Biotechnology Role: Visiting Professor Quy Nhon University Year: 1/2020 Major/ Specialty: Biotechnology Role: Associate Professor INRA _Institut national de la recherche agronomique (Nouzilly), France Years: 10/2018 – 2/2019, 11/2016 – 04/2017 Major/ Specialty: Animal Cell Biotechnology + Immunology + Gonadotropins Role: Postdoctoral Researcher François-Rabelais University, France Years: 11/2011 – 10/2015 Major/ Specialty: Life Science (Cell biotechnology) Academic Degree: Ph.D Quy Nhon University Years: 9/2005 – 6/2008 Major/ Specialty: Biology Academic Degree: Master Quy Nhon University Years: 9/2001 – 9/2005 Major/ Specialty: Biology Academic Degree: Bachelor

 

🔍Research Projects (Last 5 Years):

CRYOBIRD – Development of avian reproductive biotechnologies for the management of genetic diversity Years: 10/2010 – 10/2014 Funding Institution: France Role: Participant. Study on pathogenic microorganisms in Arachis Hypogaea L. in ecological condition of Hoai An district, Binh Dinh province Year: 2016 – 2017 Funding Institution: Quy Nhon University Role: Chairman Impact of AMPK protein kinase on male gonad and spermatozoa functions Years: 2018 – 2019 Funding Institution: Quy Nhon University Role: Chairman Characterization of new hCG glycoforms for implantation and early pregnancy diagnostic Years: 2017 – 2020 Funding Institution: France Role: Participant Investigation on the role of 5’-AMP activated protein kinase (AMPK) in adenylate cyclase gene expression using pharmacologicals activators and human Luteinizing Hormone (hLH) or Forskolin stimulators in Leydig MLTC-1 cells Years: 2018 – 2020 Funding Institution: NAFOSTED Role: Chairman Production of single-chain gonadotropins for fertility treatments Years: 2020 – 2023 Funding Institution: VINIF Role: Chairman

Publications Top Notes 📝

  1. Highly-Sensitive In Vitro Bioassays for FSH, TSH, PTH, Kp, and OT in Addition to LH in Mouse Leydig Tumor Cell
    • Authors: Klett, D., Pellissier, L., Lomet, D., Jean-Alphonse, F., Combarnous, Y.
    • Year: 2023

 

  1. Undissociable chemically cross-linked and single-chain gonadotropins
    • Authors: Nguyen, T.M.D., Klett, D., Combarnous, Y.
    • Year: 2023

 

  1. Impact of microwave synthesis time on the shape of silver nanostructures and their antibacterial activity
    • Authors: Hoang, N.H., Nguyen, V.N., Nguyen, T.T., Nguyen, T.M.D.
    • Year: 2023

 

  1. Natural and recombinant equine chorionic gonadotropins past and future in animal reproductive technology
    • Authors: Thach, D.T., Cuong, B.K., Van Tong, H., Combarnous, Y., Nguyen, T.M.D.
    • Year: 2022

 

  1. Effect of fluoxetine on cyclic adenosine monophosphate response to follicle-stimulating hormone in HEK cells
    • Authors: Nguyen, T.T., Nguyen, T.M.D.
    • Year: 2022

 

  1. Membrane Hormone Receptors and Their Signaling Pathways as Targets for Endocrine Disruptors
    • Authors: Combarnous, Y., Nguyen, T.M.D.
    • Year: 2022

 

  1. Roles of Soluble Adenylyl Cyclase in cAMP Synthesis in Animal Cells
    • Author: Nguyen, T.M.D.
    • Year: 2022

 

Diana Samodova| Proteomics

Dr Diana Samodova: Leading Researcher in Proteomics

👨‍🏫  Diana Samodova, an Dr at the University of Copenhagen, Novo Nordisk Foundation Center for Basic Metabolic Research, Denmark. stands as a distinguished academic and researcher in the Biochemistry.

Diana Samodova, a dedicated researcher, has traversed the intricate landscapes of molecular biology and proteomics to unravel the mysteries held within ancient proteins. Her academic odyssey commenced at the University of Latvia, where she earned a Bachelor’s in Natural Sciences and delved into the photostability of nitrofurazone.

Driven by curiosity, Diana pursued a Master of Sciences in Chemistry, investigating antiradical activity kinetics in antibacterial plant extracts. This academic foundation laid the groundwork for her Ph.D. journey at the University of Copenhagen, focusing on “Mass spectrometry technology for palaeoproteomics.

🌐 Professional Profiles:

 

🎓 Educational Pursuits:

  • Ph.D. Thesis: Mastery of mass spectrometry techniques for palaeoproteomics.
  • Master’s Thesis: Probing antiradical activities in diverse antibacterial plant extracts.

🔍 Research & Expertise: Diana’s expertise spans bottom-up proteomics, peptidomics, metaproteomics, and multi-enzymatic digestion. Her postdoctoral role at the University of Copenhagen expanded her horizons into scientific project management, LC-MS/MS analysis, and exploring various software applications.

📚 Noteworthy Contributions: Her contributions extend beyond the lab bench; Diana’s research has graced prestigious journals. Notable publications include elucidating the oral microbiota in type-2-diabetes, muscle fiber heterogeneity, and even ancient enamel proteome sequences, shedding light on early primate species.

🏆 Scholarly Achievements: Recipient of esteemed scholarships like the Marie Curie ETN and EEA/Norway Grants, Diana has furthered her research while fostering international cooperation and knowledge transfer.

🌐 Outreach & Engagement: Beyond academia, Diana co-organized scientific symposiums, engaging with diverse audiences through laboratory experiments, hands-on activities, and scientific micro-talks, inspiring the next generation of scientists.

🔬🌟 Future Exploration: Armed with a rich tapestry of proteomic expertise, Diana Samodova continues her scientific journey, unraveling the secrets held within ancient proteins, and advancing the frontiers of molecular research.

Top Noted Publication:

Early Pleistocene enamel proteome from Dmanisi resolves Stephanorhinus phylogeny Published on 2019/10/3 Cited by 138

Enamel proteome shows that Gigantopithecus was an early diverging pongine Published on 2019/12/12 Cited by 98

Palaeoproteomic profiling of conservation layers on a 14th century Italian wall painting Published on 2018/6/18 Cited by 93

Chemical composition analysis, antimicrobial activity and cytotoxicity screening of moss extracts (moss phytochemistry) Published on 2015/9/18 Cited by 87

ProAlanase is an effective alternative to trypsin for proteomics applications and disulfide bond mapping Published on 2020/12/1 Cited by 24

Multi-technique approach for qualitative and quantitative characterization of furazidin degradation kinetics under alkaline conditions Published on Cited by 9

Anti-Bacterial Activity and Online HPLC-DPPH Based Antiradical Kinetics of Medicinal Plant Extracts of High Relevance for Cosmetics Production Published on 2018/3/5 Cited by 7

Structure and stability of racemic and enantiopure pimobendan monohydrates: on the phenomenon of unusually high stability Published on 2017/4/5 Cited by 7

Chemical characterization and in vitro evaluation of birch sap and a complex of plant extracts for potential use in cosmetic anti-ageing products. Published on 2017/1/1 Cited by 3

Rugged large volume injection for sensitive capillary LC-MS environmental monitoring Published on 2017/8/28 Cited by 2