Julien Olivet | Epigenetics | Young Scientist Award

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Dr.Julien Olivet | Epigenetics | Young Scientist Award

Dr Julien Olivet Rega Institute/KU Leuven Belgium

Julien Olivet is an exceptional candidate for the Young Scientist Award due to his innovative research in structural and chemical biology, leadership in managing research projects, and significant international recognition. His technical expertise, particularly in cryo-EM and drug discovery, stands out. Additionally, his commitment to teaching and science outreach is commendable. To strengthen his candidacy, he could emphasize the real-world impact of his research and diversify his research topics and publications. Overall, Julienā€™s achievements and contributions make him a highly deserving nominee for the award.

Publication profile

scholar

šŸŽ“ Education

PhD in Biochemistry, Molecular and Cellular Biology, Bioinformatics and ModelingUniversitĆ© de LiĆØge, Belgium (2015-2021)Thesis: Selective disruption of histone deacetylase complexes by small-molecule inhibitors.MSc in Chemistry of Life and NanomaterialsUniversitĆ© de Namur, Belgium (2013-2015)Thesis: Synthesis of alginate/SiO2-TiO2 hybrid material for cell encapsulation.BSc in ChemistryFacultĆ©s Universitaires Notre-Dame de la Paix, Namur, Belgium (2009-2013).High School Diploma in Mathematics, Sciences Institut Notre-Dame de Loverval, Belgium (2003-2009).

šŸ”¬ Research Experience

Postdoctoral Fellow, KU Leuven (09/2021-present),Focus: Cryo-EM structures of SIN3 histone deacetylase (HDAC) complexes, managing collaborations, drug design.Visiting Senior Scientist, UniversitĆ© de LiĆØge (09/2021-present)Focus: Inhibitors of SIN3 protein in HDAC complexes, drug screening, spin-off development.PhD Research Fellow, UniversitĆ© de LiĆØge (01/2021-06/2021)Focus: Small molecule screening pipelines, virus-host interactions.Visiting FRS-FNRS/WBI PhD Research Fellow, Harvard Medical School (11/2015-12/2020)
Focus: Chemical genetic selections, protein interaction assays.

šŸ† Honours and Awards

NSFC-FWO Collaboration Project Award (2024-2025),Research Foundation Flanders (FWO), Belgium.McKinsey & Company Scientific Award (2022)EUR 5000.Marie Skłodowska-Curie Actions (MSCA) European Postdoctoral Fellowship (2022-2024),EUR 191760.Best Oral Presentation Award (2019)Dana-Farber Cancer Institute, USA.

Publication

  • Maximizing binary interactome mapping with a minimal number of assays
    • Authors: SG Choi, J Olivet, P Cassonnet, PO Vidalain, K Luck, L Lambourne, …
    • Year: 2019
  • The HTLV-1 viral oncoproteins Tax and HBZ reprogram the cellular mRNA splicing landscape
    • Authors: C Vandermeulen, T Oā€™Grady, J Wayet, B Galvan, S Maseko, M Cherkaoui, …
    • Year: 2021
  • Alternative glycosylation controls endoplasmic reticulum dynamics and tubular extension in mammalian cells
    • Authors: D Kerselidou, BS Dohai, DR Nelson, S Daakour, N De Cock, …
    • Year: 2021
  • A systematic approach to identify host targets and rapidly deliver broad-spectrum antivirals
    • Authors: J Olivet, SB Maseko, AN Volkov, K Salehi-Ashtiani, K Das, …
    • Year: 2022
  • AI-guided pipeline for proteinā€“protein interaction drug discovery identifies a SARS-CoV-2 inhibitor
    • Authors: P Trepte, C Secker, J Olivet, J Blavier, S Kostova, SB Maseko, I Minia, …
    • Year: 2024
  • Identification of small molecule antivirals against HTLV-1 by targeting the hDLG1-Tax-1 protein-protein interaction
    • Authors: SB Maseko, Y Brammerloo, I Van Molle, A Sogues, C Martin, C Gorgulla, …
    • Year: 2023
  • A quantitative mapping approach to identify direct interactions within complexomes
    • Authors: P Trepte, C Secker, SG Choi, J Olivet, ES Ramos, P Cassonnet, S Golusik, …
    • Year: 2021
  • Expanding the HDAC druggable landscape beyond enzymatic activity
    • Authors: J Olivet, SG Choi, S Sierra, TM O’Grady, M de la Fuente Revenga, F Laval, …
    • Year: 2023
  • Interactome and structural basis for targeting the human T-cell leukemia virus Tax oncoprotein
    • Authors: SB Maseko, I Van Molle, K Blibek, C Gorgulla, J Olivet, J Blavier, …
    • Year: 2021
  • The viral oncoproteins Tax and HBZ reprogram the cellular mRNA splicing landscape
    • Authors: C Vandermeulen, T Oā€™Grady, B Galvan, M Cherkaoui, A Desbuleux, …
    • Year: 2021
  • Structural basis for targeting the human T-cell leukemia virus Tax oncoprotein and syntenin-1 interaction using a small molecule
    • Authors: SB Maseko, I Van Molle, K Blibek, C Gorgulla, J Olivet, J Blavier, …
    • Year: 2021
  • Selective disruption of histone deacetylase complexes by small-molecule inhibitors of protein interactions
    • Author: J Olivet
    • Year: 2021

 

šŸ… Conclusion

Julien Olivet is a strong candidate for the Young Scientist Award due to his outstanding research achievements, leadership skills, and contributions to the scientific community. His innovative work in cryo-EM and drug discovery, combined with his active role in mentoring and outreach, aligns well with the criteria for the award. Addressing the areas for improvement, particularly in demonstrating the broader impact of his research and expanding his publication portfolio, could further solidify his candidacy.

Dhurjhoti Saha | Chromatin remodeler | Best Researcher Award

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Ā Dr. Dhurjhoti Saha | Chromatin remodeler | Best Researcher Award

Dr. MD Anderson Cancer Center, United States

šŸ‘©ā€šŸ”¬ Dhurjhoti Saha, Ph.D., is an accomplished researcher with expertise in high-throughput Next-Generation Sequencing (NGS) techniques and bioinformatics analysis. With a background in chromatin biology and cancer research, Dr. Saha has made significant contributions to understanding the role of chromatin remodelers in genome organization and cancer progression. Experienced in programming languages like Python and R, she has developed analysis pipelines and tools for genomic data interpretation. Dr. Saha’s strong project management skills have been demonstrated through her leadership in managing research teams and securing NIH grants. With a track record of peer-reviewed publications and scientific presentations, she continues to drive innovation in the field of epigenetics and cancer biology.šŸŒŸ

Profile

Scopus

 

Orcid

 

Scholar

 

 

Research Summary šŸ§¬šŸ”¬

Proficient in high-throughput Next-Generation Sequencing (NGS) techniques such as ChIP-seq, RNA-seq, PRO-seq, CUT&RUN, Hi-ChIP, and gene editing tools like CRISPR/Cas9.Skilled in NGS data analysis, including ChIP-seq, RIP-seq, ATAC-seq, CUT&RUN, RNA-seq, with established analysis pipelines and genomic analysis tools. Experienced in programming languages Python and R. Expertise in mammalian cell culture, including cancer cell lines, mouse embryonic stem cells, stable cell line generation, and drug/small molecule screening. Demonstrated excellent project management skills, including team management, protocol development, and manuscript writing for publication. Strong track record of research publications in peer-reviewed journals and presentations at international conferences and seminars. Assisted in securing NIH R01 grant.

Employment History šŸ’¼

Associate Data Scientist at The University of Texas MD Anderson Cancer Center (June 2023-present)Research Scientist at The University of Texas MD Anderson Cancer Center (August 2021-May 2023)Post-doctoral Fellow at The University of Texas MD Anderson Cancer Center (August 2017-August 2021)Postdoctoral Fellow at CSIR-Institute of Genomics and Integrative Biology (March 2016-June 2017)Senior Research Fellow at CSIR-Institute of Genomics and Integrative Biology (August 2012-February 2016)Research Assistant at CSIR-Institute of Genomics and Integrative Biology (January 2009-July 2012)

Education šŸŽ“

Ph.D. in Life Science from CSIR-Institute of Genomics and Integrative Biology, New Delhi, India (February 2016)M.Sc. in Zoology from University of Kolkata, India (June 2007)B.Sc. in Zoology from [University Name], India (June 2005)

Mentoring and Outreach Activities šŸŒŸ

Graduate School

  • Mentored 8 graduate students and project assistants (3 males, 5 females).

Research Scientist and Postdoctoral Fellow

  • Mentored 3 postdoctoral fellows, graduate students, and project assistants.
  • Advised mentees on selecting and planning manageable research topics.
  • Evaluated and monitored research progress, providing guidance and encouragement.
  • Fostered intellectual and scholarly development, offering advice on career opportunities.
  • Mentored a female project assistant to secure a Ph.D. position based on her research interests.
  • Guided an international female Ph.D. student from China in completing research work at MDACC.

Outreach

  • Served as elected Chairperson of the Postdoctoral Association (PDAEC) at MDACC for three years (2018-2021).
  • Led outreach programs including Career Development, Internal Communications, Responsible Conduct of Research, Teaching Opportunities, and Policy Making.

Honors and Other Scientific Recognitions šŸ†

Received travel awards from MD Anderson Cancer Center to present at Keystone Conference Center, Epigenetics Meeting in Denver (January 2020), and Penn State Conference, Epigenetics Meeting in Pennsylvania (August 2019).Awarded the Center of Cancer Epigenetics (CCE) postdoctoral fellowship (2019-20).Recognized with a poster award at Genome Meet Conference, New Delhi, India (December 2012).Nationally recognized for scientific work in India by The Hindu newspaper.Awarded Senior Research Fellowship by CSIR, Dept. of Life Science, Govt. Of India (2012).Acknowledged for Best Performance in M.Sc. (Zoology) by Rishi Bankim Chandra College, Kolkata University, India (2005).

 

Publications Top Notes šŸ“

  1. Title: Zinc-finger transcription factors are associated with guanine quadruplex motifs in human, chimpanzee, mouse and rat promoters genome-wide
    • Authors: P Kumar, VK Yadav, A Baral, P Kumar, D Saha, S Chowdhury
    • Journal: Nucleic acids research
    • Volume: 39
    • Issue: 18
    • Pages: 8005-8016
    • Year: 2011
    • Citations: 71

 

  1. Title: MRN complex-dependent recruitment of ubiquitylated BLM helicase to DSBs negatively regulates DNA repair pathways
    • Authors: V Tripathi, H Agarwal, S Priya, H Batra, P Modi, M Pandey, D Saha, …
    • Journal: Nature communications
    • Volume: 9
    • Issue: 1
    • Pages: 1016
    • Year: 2018
    • Citations: 64

 

  1. Title: Epigenetic suppression of human telomerase (hTERT) is mediated by the metastasis suppressor NME2 in a G-quadruplexā€“dependent fashion
    • Authors: D Saha, A Singh, T Hussain, V Srivastava, S Sengupta, A Kar, P Dhapola, …
    • Journal: Journal of Biological Chemistry
    • Volume: 292
    • Issue: 37
    • Pages: 15205-15215
    • Year: 2017
    • Citations: 61

 

  1. Title: Telomere length-dependent transcription and epigenetic modifications in promoters remote from telomere ends
    • Authors: AK Mukherjee, S Sharma, S Sengupta, D Saha, P Kumar, T Hussain, …
    • Journal: PLoS genetics
    • Volume: 14
    • Issue: 11
    • Pages: e1007782
    • Year: 2018
    • Citations: 57

 

  1. Title: Transcription regulation of CDKN1A (p21/CIP1/WAF1) by TRF2 is epigenetically controlled through the REST repressor complex
    • Authors: T Hussain, D Saha, G Purohit, A Kar, A Kishore Mukherjee, S Sharma, …
    • Journal: Scientific reports
    • Volume: 7
    • Issue: 1
    • Pages: 11541
    • Year: 2017
    • Citations: 52

 

  1. Title: Non-metastatic 2 (NME2)-mediated suppression of lung cancer metastasis involves transcriptional regulation of key cell adhesion factor vinculin
    • Authors: RK Thakur, VK Yadav, A Kumar, A Singh, K Pal, L Hoeppner, D Saha, …
    • Journal: Nucleic acids research
    • Volume: 42
    • Issue: 18
    • Pages: 11589-11600
    • Year: 2014
    • Citations: 48

 

  1. Title: Telomere repeatā€“binding factor 2 binds extensively to extra-telomeric G-quadruplexes and regulates the epigenetic status of several gene promoters
    • Authors: AK Mukherjee, S Sharma, S Bagri, R Kutum, P Kumar, A Hussain, P Singh, …
    • Journal: Journal of Biological Chemistry
    • Volume: 294
    • Issue: 47
    • Pages: 17709-17722
    • Year: 2019
    • Citations: 38

 

  1. Title: Metastases suppressor NME2 associates with telomere ends and telomerase and reduces telomerase activity within cells
    • Authors: A Kar, D Saha, G Purohit, A Singh, P Kumar, VK Yadav, P Kumar, …
    • Journal: Nucleic acids research
    • Volume: 40
    • Issue: 6
    • Pages: 2554-2565
    • Year: 2012
    • Citations: 34

 

  1. Title: ATF3 negatively regulates cellular antiviral signaling and autophagy in the absence of type I interferons
    • Authors: V Sood, KB Sharma, V Gupta, D Saha, P Dhapola, M Sharma, U Sen, …
    • Journal: Scientific reports
    • Volume: 7
    • Issue: 1
    • Pages: 8789
    • Year: 2017
    • Citations: 30

 

  1. Title: Fluorescent Dansylā€Guanosine Conjugates that Bind cā€MYC Promoter Gā€Quadruplex and Downregulate cā€MYC Expression
    • Authors: Y Pavan Kumar, P Saha, D Saha, I Bessi, H Schwalbe, S Chowdhury, …
    • Journal: ChemBioChem
    • Volume: 17
    • Issue: 5
    • Pages: 388-393
    • Year: 2016
    • Citations: 22