Nune Manasa | Tissue engineering | Best Researcher Award

Assoc Prof Dr. Nune Manasa | Tissue engineering | Best Researcher Award

Assoc Prof Dr at Manipal Institute of Regenerative Medicine India

With a Ph.D. in Medical Nanotechnology and extensive research and teaching experience, this professional has made significant contributions to the field of biotechnology and biomaterials. They have held positions such as Assistant Professor and Research Associate, showcasing expertise in stem cell research, tissue engineering, and nanotechnology. Their achievements include numerous awards, memberships, and editorial roles in esteemed journals. Additionally, they actively participate in academic committees and serve as a reviewer for prestigious journals and grant proposals. With a commitment to excellence in research and education, they continue to drive innovation in the biomedical field.

Profile

 

Scholar

 📚🎓Academic Profile

  • Ph.D. in Medical Nanotechnology (2016) from Centre for Nanotechnology & Advanced Biomaterials, SASTRA University, Thanjavur, India
  • M.Sc. Biotechnology (2009) (80%) from Jawaharlal Nehru Technological University (J.N.T.U), Hyderabad, India
  • B.Sc. Biotechnology, Botany & Chemistry (2007) (81%) from Nizam College, Osmania University, Hyderabad, India.

 🔬👩‍🏫 Research & Teaching Experience 

Assistant Professor at Manipal Institute of Regenerative Medicine, Manipal Academy of Higher Education, Bengaluru from July 2017 – July 2022. Research Associate in the Chemistry of Physics & Materials Unit of Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India from February 2016 – November 2016. CSIR-Senior Research Fellow in the Centre for Nanotechnology & Advanced Biomaterials (CeNTAB) of SASTRA University, Thanjavur, Tamil Nadu, India from October 2014 – November 2015. ICMR-Junior Research Fellow in the Centre for Nanotechnology & Advanced Biomaterials (CeNTAB) of SASTRA University, Thanjavur, Tamil Nadu, India from April 2011- September 2014. Teaching Assistant in the Centre for Nanotechnology & Advanced Biomaterials (CeNTAB) of SASTRA University, Thanjavur, Tamil Nadu, India from January 2010 – March 2011. Research Intern of Biotech Consortium of India Ltd (BCIL) at Indian Immunologicals Limited, Gachibowli, Hyderabad from November 2009 – December 2009. Project Trainee at Indian Immunologicals Limited, Gachibowli, Hyderabad from January 2009 – October 2009

Honors/ Awards🏆🎖️

Invited to the ASEAN-INDIA Women Scientists Conclave (AIWSC), 24-26 April 2024 Singapore, co-organized by Singapore’s Agency of Science, Technology and Research (A*Star) with India’s Department of Science & Technology and Anushandhan National Research Foundation (ANRF) with the support of the ASEAN Secretariat.American Chemical Society (ACS) complimentary membership as an appreciation in recognition for being an ACS peer-reviewer in March 2024.Best poster award at the National Symposium on Recent Trends in Biomedical Engineering (NSRTBME 2023) organized by MIT Manipal from 31st March – 1st April 2023.Second place in the Science poster presentation during the National Science day programme held at Manipal Institute of Regenerative Medicine on 24/02/2023.SBAOI-MAHE Young Scientist Award and first prize for the oral presentation titled ‘Polycaprolactone Nanofibers Coated with Cell-Derived Matrix for Uterine Tissue Engineering’ at the International Conference on Biomaterials, Regenerative Medicine and Devices (BIO-Remedi 22) held at IIT Guwahati, December 15-18, 2022.Life member (Awardee) of the Society for Biomaterials & Artificial Organs India (SBAOI) since March 2023.Life member of the Society for Tissue Engineering & Regenerative Medicine India (STERMI) since October 2022.Certificate of Appreciation awarded for being the resource person for the faculty development program titled “Institutional Committee for Stem Cell Research: Guidelines and Screening Procedures for Protocols” organized by Manipal College of Dental Sciences, Mangalore on January 28th 2022 & July 2nd 2021.Second prize for oral presentation at the 4th International Conference on Recent Trends in Bioengineering (ICRTB 2021), organized by MIT School of Bioengineering Sciences & Research, Pune (MITBIO) from February 12-13, 2021Best poster award at the 5th Indian Peptide Symposium organized by Indian Peptide Society on September 24-25, 2015, at JNCASR, Bangalore, IndiaSenior Research Fellowship (CSIR-SRF) award from Council of Scientific and Industrial Research (CSIR), Human Resource and Development Group in 2014.Selected as Project trainee for DBT-Biotech Industrial Training Programme (BITP) by the Department of Biotechnology & Biotech Consortium of India Ltd (BCIL) at Indian Immunologicals Limited, Gachibowli, Hyderabad in 2009.GATE (Graduate Aptitude Test in Engineering) – Biotechnology qualified in 2010.GRE (Graduate Record Examination) – Obtained 1210/1600 – 75.6% in 2008.

 🔍📝 Reviewer & Examiner

‘Ph.D. Coordinator’ of MIRM from February 2023.’IQAC Coordinator’ of MIRM from October 2022-March 2023.Member Secretary for the Institutional Committee for Stem Cell Research (IC-SCR) of MIRM, MAHE since November 2020.Stem cell expert of the IEC committee of SDM University, Dharwad in December 2023.Guest topic editor for ‘Frontiers in Neuroscience’ (IF-5.152) in the section ‘Translational Neuroscience’ for a research topic on ‘Combinatorial Neural Engineering Approaches for Neurotrauma and Neurological Disorders’ in February 2023.Guest editor for ‘JoVE’ (IF-1.4); editing a special issue in methods collection on “Designing of ECM-based biomimetic scaffolds for nerve tissue engineering applications” since September 2022.Peer-reviewed an Israel Science Foundation grant in March 2024.Peer-reviewed for various prestigious journals including ‘Biotechnology Journal’, ‘Journal of Polymer Science’, ‘Journal of Tissue Engineering’, ‘ACS Nano’, ‘Journal of Nanobiotechnology’, ‘Small’, ‘Neuroscience Bulletin’, and many more.Invited to be part of a screening committee of the National Post Doc Symposium (NPDS) 2022 jointly organized by BLiSC and IISER Thiruvananthapuram, July 20-22, 2022, in March 2022.Appointed as external question paper setter for Yenepoya University, Mangalore for setting Ph.D. entrance test questions in July 2020.Doctoral Advisory Committee member, protocol panel member, thesis examiner invitation for internal and external Ph.D. candidates since 2021.

Publications Top Notes 📝

  • Self-assembling peptide nanofibrous scaffolds for tissue engineering: novel approaches and strategies for effective functional regeneration
    • Authors: M Nune, P Kumaraswamy, U Maheswari Krishnan, S Sethuraman
    • Journal: Current Protein and Peptide Science
    • Volume: 14
    • Issue: 1
    • Pages: 70-84
    • Year: 2013
    • Citations: 102

 

  • Melanin incorporated electroactive and antioxidant silk fibroin nanofibrous scaffolds for nerve tissue engineering
    • Authors: M Nune, S Manchineella, T Govindaraju, KS Narayan
    • Journal: Materials Science and Engineering: C
    • Volume: 94
    • Pages: 17-25
    • Year: 2019
    • Citations: 91

 

  • Silica-based bioactive glasses and their applications in hard tissue regeneration: A review
    • Authors: N Al-Harbi, H Mohammed, Y Al-Hadeethi, AS Bakry, A Umar, MA Hussein, …
    • Journal: Pharmaceuticals
    • Volume: 14
    • Issue: 2
    • Pages: 75
    • Year: 2021
    • Citations: 77

 

  • PLGA nanofibers blended with designer self-assembling peptides for peripheral neural regeneration
    • Authors: M Nune, UM Krishnan, S Sethuraman
    • Journal: Materials Science and Engineering: C
    • Volume: 62
    • Pages: 329-337
    • Year: 2016
    • Citations: 69

 

  • Self-assembling peptide nanostructures on aligned poly (lactide-co-glycolide) nanofibers for the functional regeneration of sciatic nerve
    • Authors: M Nune, A Subramanian, UM Krishnan, SS Kaimal, S Sethuraman
    • Journal: Nanomedicine
    • Volume: 12
    • Issue: 3
    • Pages: 219-235
    • Year: 2017
    • Citations: 31

Somayeh Hashemi Sheikhshabani | Human Genetics | Best Researcher Award

Dr. Somayeh Hashemi Sheikhshabani | Human Genetics | Best Researcher Award

👨‍🏫Profile Summary

I am a highly skilled researcher specializing in Medical Genetics with a focus on Cancer Biology, Cancer Drug Resistance, Noncoding RNAs, Computational Biology, and Genetics of Rare Diseases. With a Ph.D. from Shahid Beheshti University of Medical Sciences, Tehran, Iran, and a strong background in Cellular and Molecular Biology, I’ve conducted extensive research on genetic analysis of male infertility, identification of genes involved in various cancers, and prediction of regulatory networks using bioinformatics tools. Proficient in a wide range of experimental techniques and software applications, I am dedicated to advancing knowledge in genetics and contributing to the development of innovative therapies.

 

🌐 Professional Profiles

Education 📚

PhD in Medical Genetics Shahid Beheshti University of Medical Sciences, Tehran, Iran September 23, 2019 – October 7, 2023 PhD Thesis: Genetic investigation of non-obstructive azoospermia families with cytogenetic and molecular genetic tests, and determining the relationship between genetic and clinical findings of patients.M.Sc. in Cellular and Molecular Biology National Institute of Genetic Engineering and Biotechnology, Tehran, Iran September 23, 2010 – October 27, 2012 Master Thesis: Alkaloid extract of Peganum harmala L. seed on the expression of Bax and Bcl-2 genes involved in mitochondrial apoptosis pathway in cancer cells.B.Sc. in Molecular Genetics Shahrekord University, Shahrekord, Iran September 23, 2005 – October 7, 2009

Research Interests 🔬

  • Cancer Biology
  • Cancer Drug Resistance
  • Noncoding RNAs
  • Computational Biology
  • Genetics of Rare Diseases

Research Projects 🧬

Genetic analysis of male infertility in a family using Whole Exome Sequencing. (Student Research Committee, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2024)In silico prediction of non-coding RNA-gene regulatory network in primary gonad failure defects. (Student Research Committee, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2024)In silico identification of functional single nucleotide polymorphisms of azoospermia genes. (Student Research Committee, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2024)In silico prediction of coagulation system functional polymorphisms. (Student Research Committee, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2024)Identification of genes involved in Imatinib resistance in chronic myeloid leukemia (CML). (Student Research Committee, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2024)Genetic analysis of families with non-obstructive azoospermia by Whole Exome Sequencing. (Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2024)Genetic investigation of infertility in an Iranian family with infertility in both sexes. (Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2023)Prediction of tissue-specific inflammatory LncRNAs in COVID-19 patients. (Student Research Committee, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2021-2024)Identification of inflammatory miRNAs associated with COVID-19 and determination of their potential target genes using bioinformatics tools. (Student Research Committee, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2021-2023)Identification of genes involved in the development of chemotherapy resistance in lung cancer. (Student Research Committee, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2021-2024)Identification of common polymorphisms in the host antioxidant pathway against viruses and prediction of their effects. (Student Research Committee, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2021-2024)Identification of genes involved in the development of chemotherapy resistance in ovarian cancer. (Student Research Committee, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2021-2023)Investigation of the effect of oleuropein on miR-125b and miR-34a expression in ovarian cancer cell lines. (Cellular and Molecular Research Center, Shahrekord University of Medical Sciences; 2019-2020)Investigation of the effect of oleuropein on miR-181b and miR-21 expression in breast cancer cell line. (Cellular and Molecular Research Center, Shahrekord University of Medical Sciences; 2019-2020)Investigation of the effect of oleuropein on the expression of genes involved in apoptosis in cisplatin-resistant ovarian cell line. (Cellular and Molecular Research Center, Shahrekord University of Medical Sciences; 2019-2020)Study of the effect of nanoparticles containing altretiamine and arstin on ferroptosis in ovarian cancer cell line. (Cellular and Molecular Research Center, Shahrekord University of Medical Sciences; 2016-2020)Study of the effect of nanoparticles containing altretamine on ferroptosis-apoptosis in ovarian cancer cell line. (Cellular and Molecular Research Center, Shahrekord University of Medical Sciences; 2018-2019)Genetic etiology determination of non-syndromic hearing loss families using Whole Exome Sequencing. (Cellular and Molecular Research Center, Shahrekord University of Medical Sciences; 2018-2019)

Skills 🛠️

A. Experimental Techniques:Human cell cultureMTT assay (Drugs, Natural products, Nanoparticles)DNA and RNA extractionApoptosis assayROS assayElectrophoresisQuantitative PCRConventional PCRSonicationNanodropKaryotypingSanger sequencingWhole exome sequencingB. Software Ability:Various microRNA databases (TargetScan, miRBase, miRWalk, etc.)Various lncRNA databases (starBase, LncBase, etc.)Pathway databases (KEGG, WikiPathways, Reactome)Variant prediction tools (SIFT, Mutation Taster, Polyphen, CADD, etc.)Genome browsers (NCBI, Ensembl, UCSC)Primer design software and tools (AlleleID, Primer3, Oligo 7, etc.)Sequence analysis software (QIAGEN CLC Genomics Workbench, Mutation Surveyor, FinchTV, etc.)STRINGDBCytoscapeGene RunnerGenome expression databases (GEO, GTEx, etc.)

Workshops 📚

 

  • Various workshops covering topics such as predicting LncRNAs, the role of biological systems in cancer, electronic resource investigation, Next Generation sequencing, molecular techniques, article writing, PCR, and bioinformatics.

📚Top Noted Publication

  1. Title: The effect of oleuropein on apoptotic pathway regulators in breast cancer cells
    • Journal: European Journal of Pharmacology
    • Year: 2020
    • Volume: 886
    • Pages: 173509
    • Citations: 43

 

  1. Title: Peganum harmala L.’s anti-growth effect on a breast cancer cell line
    • Journal: Biotechnology reports
    • Year: 2015
    • Volume: 8
    • Pages: 138-143
    • Citations: 39

 

  1. Title: Oleuropein reduces cisplatin resistance in ovarian cancer by targeting apoptotic pathway regulators
    • Journal: Life Sciences
    • Year: 2021
    • Volume: 278
    • Pages: 119525
    • Citations: 26

 

  1. Title: Growth inhibitory impact of Peganum harmala L. on two breast cancer cell lines
    • Journal: Iranian journal of biotechnology
    • Year: 2014
    • Volume: 12
    • Issue: 1
    • Pages: 8-14
    • Citations: 23

 

  1. Title: The impact of oleuropein on miRNAs regulating cell death signaling pathway in human cervical cancer cells
    • Journal: Biotechnology and Applied Biochemistry
    • Year: 2024
    • Volume: 71
    • Issue: 1
    • Pages: 61-71
    • Citations: 1

 

  1. Title: In Silico Prediction of Functional SNPs Interrupting Antioxidant Defense Genes in Relation to COVID-19 Progression
    • Journal: Biochemical Genetics
    • Year: 2024
    • Pages: 1-27

 

  1. Title: Meta-analysis of microarray data to determine gene indicators involved in the cisplatin resistance in ovarian cancer
    • Journal: Cancer Reports
    • Year: 2023
    • Volume: 6
    • Issue: 12
    • Pages: e1884

Flavia | Molecular Biology | Young Scientist Award

Dr. Flavia| Molecular Biology | Young Scientist Award

👨‍🏫Profile Summary

Flavia Scoyni is a highly accomplished researcher in molecular medicine, specializing in non-coding RNAs and their role in neurodegenerative diseases like Alzheimer’s and ischemic stroke. With a Ph.D. from the University of Eastern Finland under the Marie Skłodowska-Curie Programme, Flavia has extensive experience in experimental techniques such as scRNA-seq, FACS, and animal modeling. Their work has been published in prestigious journals and recognized with numerous grants and fellowships. Flavia’s expertise in molecular biology, cell culture, and animal work, coupled with a strong track record of securing research funding, positions them as a valuable asset in the field of translational medicine.

🌐 Professional Profiles

🎓Education:

Ph.D. in Molecular Medicine University of Eastern Finland, Kuopio, Finland Duration: Dec 2017 – Feb 2024 Marie Skłodowska-Curie Programme in Genetics and Mechanisms in Translational Medicine (GENOMMED) Advisor: Prof. Tarja Malm Dissertation: “Unlocking the potential of non-coding RNAs in regulating neurodegeneration – a glimpse into Alzheimer’s disease and ischemic stroke pathophysiology.” Ph.D. secondment Aarhus University, Aarhus, Denmark Duration: Sept 2018 – Feb 201 Advisor: Assoc. Prof. Thomas B. Hansen Funded by Saastamoinen Foundation travel grant FELASA accreditationUniversity of Eastern Finland, Kuopio, Finland May 2017 Federation of Laboratory Animal Science Associations (FELASA) Certificate in laboratory animal science for EU Functions A/D MSc in Molecular Biology “Sapienza” University of Rome, Rome, Italy Duration: Oct 2013 – Dec 2015 Master Degree in Molecular Biology Graduated magna cum laude (110/110 cum laude) Advisor: Prof. Alessandro Fatica Thesis title: “Identification of new transcriptional targets of p30 C/EBPα transcription factor isoform in acute myeloid leukemia” MSc in Genetics University Paris-Diderot VII, Paris, France Duration: Oct 2013 – June 2015 BSc in Biotechnology “Sapienza” University of Rome, Rome, Italy Duration: Oct 2010 – July 2013 Bachelor degree in Biotechnology Graduated magna cum laude (110/110 cum laude) Advisor: Prof. Carlo Presutti Thesis title: “The role of the mir-200 family in the regulation of the expression of AP1 transcriptional factor”

🔬Research Experience:

Early stage researcher Professor Tarja Malm University of Eastern Finland, A.I. Virtanen Institute for Molecular Sciences Jan 2017 – Dec 2017 Investigated the role of microRNAs in phagocytic microglia isolated from adult Alzheimer’s mice. Developed techniques including ex-vivo FACS, low input RNA extraction, cloning, qPCR, and protocol for transfection for hard-to-transfect cell lines. Conducted animal procedures to harvest brain samples or acutely isolate adult microglia. Erasmus traineeship Biotech Research & Innovation Centre, Copenhagen, Denmark Oct 2016 – June 2016 Developed a transgenic stable cell line for long non-coding RNAs. Applied techniques such as cloning of long inserts, lentiviral vector production, and stable cell line development. Master thesis Professor Alessandro Fatica “Sapienza” University of Rome, Rome, Italy June 2014 – Dec 2015 Investigated the regulation of the long non-coding RNA UCA1 mediated by C/EBPα transcription factor in the K562 lymphoblast cell line. Applied techniques including ChIP, cloning, RNA extraction, RT-qPCR, WB, transfection, CRISPR-Cas9, and stable cell line development. Master Internship Professor Giuseppe Macino “Sapienza” University of Rome, Rome, Italy Sept 2013 – March 2014 Studied microRNAs inducing epigenetic modifications in mammals.Applied techniques such as ChIP, cloning, mutagenesis, RNA extraction, RT-qPCR, WB, CRISPR-Cas9, and stable cell line development. Bachelor thesis Professor Carlo Presutti “Sapienza” University of Rome, Rome, Italy Oct 2012 – July 2013 Investigated the role of the miR-200a family in regulating c-JUN transcription factor expression. Utilized techniques including cloning, mutagenesis, bacterial transformation, and cell line culture.

💻 Technical Skills:

Molecular biology techniques such as scRNA-seq, RNA-seq, FACS, cloning, RT-qPCR, WB, lentiviral vectors generation. Cell culture techniques including neuronal culture, primary microglial culture, transduction, transfection, and stable cell line development. Animal work including FELASA A/D certification, maintenance, and breeding of transgenic mouse models, animal procedures, and tamoxifen-induced recombination. Statistical analysis, basic Python, and R.

🏆Fellowships, Awards, and Honors:

  • Secured total grants of 99.000€ during Ph.D., including grants from Pavo Nuermen Foundation, Finnish Cultural Foundation, Kuopio University Foundation, and others.

👩‍🏫 Teaching Experience:

  • Mentored a Ph.D. student and post-graduate student, and supervised five master’s thesis students during the Ph.D. program.

📚Top Noted Publication

  1. ciRS-7 and miR-7 regulate ischemia-induced neuronal death via glutamatergic signaling
    • Journal: Cell Reports
    • Year: 2024-03
    • DOI: 10.1016/j.celrep.2024.113862
    • Contributors: Flavia Scoyni; Valeriia Sitnikova; Luca Giudice; Paula Korhonen; Davide M. Trevisan; Ana Hernandez de Sande; Mireia Gomez-Budia; Raisa Giniatullina; Irene F. Ugidos; Hiramani Dhungana et al.

 

  1. Alzheimer’s disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs
    • Journal: Alzheimer’s & Dementia
    • Year: 2024-02
    • DOI: 10.1002/alz.13502
    • Contributors: Flavia Scoyni; Luca Giudice; Mari-Anna Väänänen; Nicholas Downes; Paula Korhonen; Xin Yi Choo; Nelli-Noora Välimäki; Petri Mäkinen; Nea Korvenlaita; Annemieke J Rozemuller et al.

 

  1. ciRS-7 and miR-7 regulate ischemia induced neuronal death via glutamatergic signaling
    • Journal: Preprint
    • Year: 2023-01-24
    • DOI: 10.1101/2023.01.24.525136
    • Contributors: Flavia Scoyni; Valeriia Sitnikova; Luca Giudice; Paula Korhonen; Davide M Trevisan; Ana Hernandez de Sande; Mireia Gomez-Budia; Raisa Giniatullina; Irene F Ugidos; Hiramani Dhungana et al.

 

  1. Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation
    • Journal: Journal of Neuroinflammation
    • Year: 2020
    • DOI: 10.1186/s12974-020-01870-w
    • Contributors: Kolosowska, N.; Gotkiewicz, M.; Dhungana, H.; Giudice, L.; Giugno, R.; Box, D.; Huuskonen, M.T.; Korhonen, P.; Scoyni, F.; Kanninen, K.M. et al.

 

  1. PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia
    • Journal: Stem Cell Reports
    • Year: 2019
    • DOI: 10.1016/j.stemcr.2019.08.004
    • Contributors: Konttinen, H.; Cabral-da-Silva, M.E.C.; Ohtonen, S.; Wojciechowski, S.; Shakirzyanova, A.; Caligola, S.; Giugno, R.; Ishchenko, Y.; Hernández, D.; Fazaludeen, M.F. et al.