Dr.Julien Olivet | Epigenetics | Young Scientist Award

Dr Julien Olivet Rega Institute/KU Leuven Belgium

Julien Olivet is an exceptional candidate for the Young Scientist Award due to his innovative research in structural and chemical biology, leadership in managing research projects, and significant international recognition. His technical expertise, particularly in cryo-EM and drug discovery, stands out. Additionally, his commitment to teaching and science outreach is commendable. To strengthen his candidacy, he could emphasize the real-world impact of his research and diversify his research topics and publications. Overall, Julien’s achievements and contributions make him a highly deserving nominee for the award.

Publication profile

🎓 Education

PhD in Biochemistry, Molecular and Cellular Biology, Bioinformatics and ModelingUniversité de Liège, Belgium (2015-2021)Thesis: Selective disruption of histone deacetylase complexes by small-molecule inhibitors.MSc in Chemistry of Life and NanomaterialsUniversité de Namur, Belgium (2013-2015)Thesis: Synthesis of alginate/SiO2-TiO2 hybrid material for cell encapsulation.BSc in ChemistryFacultés Universitaires Notre-Dame de la Paix, Namur, Belgium (2009-2013).High School Diploma in Mathematics, Sciences Institut Notre-Dame de Loverval, Belgium (2003-2009).

🔬 Research Experience

Postdoctoral Fellow, KU Leuven (09/2021-present),Focus: Cryo-EM structures of SIN3 histone deacetylase (HDAC) complexes, managing collaborations, drug design.Visiting Senior Scientist, Université de Liège (09/2021-present)Focus: Inhibitors of SIN3 protein in HDAC complexes, drug screening, spin-off development.PhD Research Fellow, Université de Liège (01/2021-06/2021)Focus: Small molecule screening pipelines, virus-host interactions.Visiting FRS-FNRS/WBI PhD Research Fellow, Harvard Medical School (11/2015-12/2020)
Focus: Chemical genetic selections, protein interaction assays.

🏆 Honours and Awards

NSFC-FWO Collaboration Project Award (2024-2025),Research Foundation Flanders (FWO), Belgium.McKinsey & Company Scientific Award (2022)EUR 5000.Marie Skłodowska-Curie Actions (MSCA) European Postdoctoral Fellowship (2022-2024),EUR 191760.Best Oral Presentation Award (2019)Dana-Farber Cancer Institute, USA.

Publication

Maximizing binary interactome mapping with a minimal number of assays

Authors: SG Choi, J Olivet, P Cassonnet, PO Vidalain, K Luck, L Lambourne, …
Year: 2019

The HTLV-1 viral oncoproteins Tax and HBZ reprogram the cellular mRNA splicing landscape

Authors: C Vandermeulen, T O’Grady, J Wayet, B Galvan, S Maseko, M Cherkaoui, …
Year: 2021

Alternative glycosylation controls endoplasmic reticulum dynamics and tubular extension in mammalian cells

Authors: D Kerselidou, BS Dohai, DR Nelson, S Daakour, N De Cock, …
Year: 2021

A systematic approach to identify host targets and rapidly deliver broad-spectrum antivirals

Authors: J Olivet, SB Maseko, AN Volkov, K Salehi-Ashtiani, K Das, …
Year: 2022

AI-guided pipeline for protein–protein interaction drug discovery identifies a SARS-CoV-2 inhibitor

Authors: P Trepte, C Secker, J Olivet, J Blavier, S Kostova, SB Maseko, I Minia, …
Year: 2024

Identification of small molecule antivirals against HTLV-1 by targeting the hDLG1-Tax-1 protein-protein interaction

Authors: SB Maseko, Y Brammerloo, I Van Molle, A Sogues, C Martin, C Gorgulla, …
Year: 2023

A quantitative mapping approach to identify direct interactions within complexomes

Authors: P Trepte, C Secker, SG Choi, J Olivet, ES Ramos, P Cassonnet, S Golusik, …
Year: 2021

Expanding the HDAC druggable landscape beyond enzymatic activity

Authors: J Olivet, SG Choi, S Sierra, TM O’Grady, M de la Fuente Revenga, F Laval, …
Year: 2023

Interactome and structural basis for targeting the human T-cell leukemia virus Tax oncoprotein

Authors: SB Maseko, I Van Molle, K Blibek, C Gorgulla, J Olivet, J Blavier, …
Year: 2021

The viral oncoproteins Tax and HBZ reprogram the cellular mRNA splicing landscape

Authors: C Vandermeulen, T O’Grady, B Galvan, M Cherkaoui, A Desbuleux, …
Year: 2021

Structural basis for targeting the human T-cell leukemia virus Tax oncoprotein and syntenin-1 interaction using a small molecule

Authors: SB Maseko, I Van Molle, K Blibek, C Gorgulla, J Olivet, J Blavier, …
Year: 2021

Selective disruption of histone deacetylase complexes by small-molecule inhibitors of protein interactions

Author: J Olivet
Year: 2021

🏅 Conclusion

Julien Olivet is a strong candidate for the Young Scientist Award due to his outstanding research achievements, leadership skills, and contributions to the scientific community. His innovative work in cryo-EM and drug discovery, combined with his active role in mentoring and outreach, aligns well with the criteria for the award. Addressing the areas for improvement, particularly in demonstrating the broader impact of his research and expanding his publication portfolio, could further solidify his candidacy.

Dr. Dana Laor | Molecular Biology| Best Researcher Award

Profile Summary

Dr. Dana Laor Bar-Yosef is a distinguished molecular biologist renowned for her groundbreaking research in metabolic disorders. She completed her undergraduate studies in biology at the Hebrew University of Jerusalem, followed by M.Sc. and Ph.D. training at Tel Aviv University under Prof. Martin Kupiec. Her Ph.D. research elucidated the roles of TOR protein kinase in cell signaling and amino acid homeostasis using yeast models. Joining Prof. Ehud Gazit’s lab in 2015, she established innovative in vivo models for studying inborn errors of metabolism (IEMs), leading to significant insights and potential therapeutics. Dr. Laor Bar-Yosef’s expertise spans over 15 years, guiding her leadership of the metabolic research group and pioneering the concept of “Metabolostasis.” Her contributions have been recognized with prestigious awards, including the 2020 Ziegler Award, affirming her exceptional impact on medical research in metabolic disorders.

Professional Profiles

Scholar Profile

Education🎓

Postdoctoral Researcher in Molecular Biology and Nanotechnology Tel Aviv University, Tel Aviv 2015-2018, Ph.D. in Molecular Biology
Tel Aviv University, Tel Aviv 2009-2014 Thesis title: “The role of TOR in rapamycin response in the fission yeast” Advisors: Prof. Martin Kupiec and Prof. Ronit Weisman. M.Sc. in Genetics Tel Aviv University, Tel Aviv 2007-2009 Thesis title: “The TOR pathway regulates cellular growth, gene silencing and telomere length maintenance in the fission yeast” Advisors: Prof. Martin Kupiec and Prof. Ronit Weisman. B.Sc. in Biology
The Hebrew University, Jerusalem 2003-2006

🔬 Researcher Experience

Head of the Metabolic Research Group Shmunis School of Biomedicine and Cancer Research, Tel Aviv University 2018-Present, Postdoctoral Research School of Molecular Cell Biology and Biotechnology, Tel Aviv University 2015-2018, Graduate Research Department of Microbiology and Biotechnology, Tel Aviv University 2007-2014

Professional Development 📈

Women Executive Launchpad in HealthTech 8400 Health Network 2022-2023, Health Care Technological Innovation – From Idea to Commercialization Coller School of Management at Tel-Aviv University and Lahav Executive Education 2022

Teaching Experience📚

Instructor, Introduction to Biology Course Tel Aviv University 2023-2024, Instructor, “Commercializing University Research” Course
Coller School of Management, Tel Aviv University 2020, Instructor, “Graduate Record Examination Preparation Course”
Tel Aviv University 2014-2015, Teaching Assistant, “Introduction to Genetics” Course Tel Aviv University 2007-2013

Awards 🏆

The Late Breaking News Awards at the 2023 SSIEM Symposium 2023, The Ziegler Award for Research in the Field of Metabolic Disorders
2020, The Herbert and Sharon Glazer Fund Excellence Award 2017 And more…

Funding Acquired💰

The John Templeton Foundation Research Grant 2021-2024, Israel Science Foundation Research Grant 2019-2023, Momentum Fund Investment in Promising Breakthrough Technologies 2021-2023 And more…

Patents🛠️

Laor, D., & Gazit, E (2018). Integrated drug discovery platform for inborn error of metabolism disorders.
US Provisional Patent Application No. 62/779,054. Pending. Laor, D., Sade, D., and Gazit, E (2021). Integrated drug discovery platform for protein misfolding disorders associated with metabolite accumulation.
Provisional.

Conference and Scientific Meetings🌐

The first Metabolostasis conference, Israel (2023) Organizing Committee, ILASOL 36th Annual Meeting, Israel (2023)
Organizing Committee and Chair, Rare Connections 2022, Israel A conference dedicated for potential collaborations in the field of rare diseases. ISM 2022 Annual Meeting, Israel The first Israel Metabolomics Meeting, Israel (2022) And more…

Community Involvement👥

Instructor, Jewish Community Center (JCC), Ohio, USA (2002, 2003) Guided Jewish-American youth about the Israeli Culture in a youth summer camp. Armor Instructor, Israel Defense Forces (2000-2002) Served as an armor guide for regular service and reserve duty soldiers at the Armored Corps School. Counselor, “Maccabi Tzair” Youth Movement, Israel (1996-2000) Served as a counselor and teaching coordinator, mentoring and advocating Israeli youth.

📚Top Noted Publication

TOR complex 2 controls gene silencing, telomere length maintenance, and survival under DNA-damaging conditions
- Authors: M Schonbrun, D Laor, L López-Maury, J Bähler, M Kupiec, R Weisman
- Journal: Molecular and cellular biology
- Volume: 29
- Issue: 16
- Pages: 4584-4594
- Citations: 72
- Year: 2009

Two Decades of Studying Functional Amyloids in Microorganisms
- Authors: SA Levkovich, E Gazit, D Laor Bar-Yosef
- Journal: Trends in Microbiology
- Citations: 68
- Year: 2021

Fibril formation and therapeutic targeting of amyloid-like structures in a yeast model of adenine accumulation
- Authors: D Laor, D Sade, S Shaham-Niv, D Zaguri, M Gartner, V Basavalingappa, …
- Journal: Nature communications
- Volume: 10
- Issue: 1
- Pages: 62
- Citations: 54
- Year: 2019

Yeast models for the study of amyloid-associated disorders and development of future therapy
- Authors: S Rencus-Lazar, Y DeRowe, H Adsi, E Gazit, D Laor
- Journal: Frontiers in Molecular Biosciences
- Volume: 6
- Pages: 15
- Citations: 45
- Year: 2019

TORC1 regulates developmental responses to nitrogen stress via regulation of the GATA transcription factor Gaf1
- Authors: D Laor, A Cohen, M Kupiec, R Weisman
- Journal: MBio
- Volume: 6
- Issue: 4
- Citations: 33
- Year: 2015

Engineered riboswitch nanocarriers as a possible disease-modifying treatment for metabolic disorders
- Authors: S Zilberzwige-Tal, D Gazit, H Adsi, M Gartner, R Behl, D Bar-Yosef Laor, …
- Journal: ACS nano
- Volume: 16
- Issue: 8
- Pages: 11733-11741
- Citations: 3
- Year: 2022

Integrated drug discovery platform for inborn error of metabolism disorders
- Authors: E Gazit, L Dana
- Patent: US Patent App. 17/345,248
- Citations: 1
- Year: 2021

Mind your marker: the effect of common auxotrophic markers on complex traits in yeast
- Authors: K Kaplan, SA Levkovich, Y DeRowe, E Gazit, D Laor Bar‐Yosef
- Journal: The FEBS Journal
- Year: 2024

The von Hippel-Lindau protein forms fibrillar amyloid assemblies that are mitigated by the anti-amyloid molecule Purpurin
- Authors: V Kumar, V Kaushik, S Kumar, SA Levkovich, P Gupta, DL Bar-Yosef, …
- Journal: Biochemical and Biophysical Research Communications
- Volume: 690
- Pages: 149250
- Year: 2024

Branched-Chain Amino Acid Assembly into Amyloid-like Fibrils Provides a New Paradigm for Maple Syrup Urine Disease Pathology
- Authors: T Kreiser, I Sogolovsky-Bard, D Zaguri, S Shaham-Niv, D Laor Bar-Yosef, …
- Journal: International Journal of Molecular Sciences
- Volume: 24
- Issue: 21
- Pages: 15999
- Year: 2023

Julien Olivet | Epigenetics | Young Scientist Award

Dr.Julien Olivet | Epigenetics | Young Scientist Award

Dr Julien Olivet Rega Institute/KU Leuven Belgium

🎓 Education

🔬 Research Experience

🏆 Honours and Awards

Publication

🏅 Conclusion

Dana Laor | Molecular Biology, | Best Researcher Award