Ameneh Jafari | Genetics Award | Women Researcher Award

Dr. Ameneh Jafari | Genetics Award | Women Researcher Award

👨‍🏫Profile Summary

With a Ph.D. in Applied Proteomics from Shahid Beheshti University of Medical Sciences and extensive research experience at institutions like Motamed Cancer Institute, I specialize in identifying anti-cancer agents using proteomics approaches. As a Bioinformatician at Pars Silico Bioinformatics Laboratory, I leverage my expertise in molecular methods, cell culture, and cytotoxicity assays. Recognized with awards such as the first rank in Clinical Biochemistry and achievements like editorial board membership for Technology in Cancer Research & Treatment, I am dedicated to advancing biochemistry and cancer research through innovative methodologies and academic contributions.

🌐 Professional Profiles

📚Educational Background:

Ph.D. in Applied Proteomics, Shahid Beheshti University of Medical Sciences Supervisor: Prof. Mostafa Rezaei-Tavirani Thesis Title: Identifying the nature of the anti-cancer agents in conditioned media of human amniotic epithelial cells by proteomics approach.  M.Sc. in Clinical Biochemistry, Yazd University of Medical Sciences Supervisor: Prof. Bemanali Jalali-Khaniabadi Thesis Title: Relationship between plasma lipoprotein (a) concentration and oxidizability in healthy adult men B.Sc. Biology, Shahid Beheshti University

professional experience 💼

Researcher: Motamed Cancer Institute, Tehran, Iran. (2021-2023), Bioinformatician: Pars Silico Bioinformatics Laboratory, Tehran, Iran (2019-Present), Faculty member: Zabol University of Medical Sciences, Zabol, Iran (2007-2011)

Research experiences 🔬

Shahid Beheshti University of Medical Sciences, Tehran, Iran: List of research projects conducted… Motamed Cancer Institute, Tehran, Iran: List of research projects conducted…

Technical skills 💻

Human and animal cell/tissue culture and isolation, Molecular methods (PCR, Real-time PCR), Colorimetric assays, Flow cytometry analysis Cytotoxicity assays, Colony assay, Spheroid assay, Scratch assay, 2D-PAGE, Cell Proliferation Assays, Animal handling, Application Software: Office, Prism, Endnote, Cytoscape, AutoDock Vina

Awards 🏆

First rank, among graduates in Clinical Biochemistry (MSc), 2008, The second rank of country entrance for Ph.D., 2012, First ranking award in Tehran Climathon International Event, 2023

Teaching experiences 📖

Zabol University of Medical Sciences, Zabol (2008-2011), List of subjects taught… Islamic Azad University (2011-2014) List of subjects taught…

Editorial responsibilities 📝

  • Editorial Review Board member: Technology in Cancer Research & Treatment
  • Ad hoc reviewer for various journals

Conference presentations 🎙️

  • List of conference presentations…

Book & book chapter publications 📖

  • Part of the Methods in Molecular Biology book series, 2023.

📚Top Noted Publication

  1. Potential therapeutic options for COVID-19: an update on current evidence
    • Authors: Z Niknam, A Jafari, A Golchin, F Danesh Pouya, M Nemati, …
    • Journal: European journal of medical research
    • Volume: 27
    • Pages: 1-15
    • Citations: 123
    • Year: 2022

 

  1. Amniotic membrane and its epithelial and mesenchymal stem cells as an appropriate source for skin tissue engineering and regenerative medicine
    • Authors: B Farhadihosseinabadi, M Farahani, T Tayebi, A Jafari, F Biniazan, …
    • Journal: Artificial cells, nanomedicine, and biotechnology
    • Volume: 46
    • Issue: sup2
    • Pages: 431-440
    • Citations: 120
    • Year: 2018

 

  1. Human urine proteomics: analytical techniques and clinical applications in renal diseases
    • Authors: S Kalantari, A Jafari, R Moradpoor, E Ghasemi, E Khalkhal
    • Journal: International journal of proteomics
    • Citations: 90
    • Year: 2015
  2. Exosomes and cancer: from molecular mechanisms to clinical applications
    • Authors: A Jafari, A Babajani, M Abdollahpour-Alitappeh, N Ahmadi, …
    • Journal: Medical Oncology
    • Volume: 38
    • Issue: 4
    • Pages: 45
    • Citations: 51
    • Year: 2021

 

  1. Clinical applications and anticancer effects of antimicrobial peptides: from bench to bedside
    • Authors: A Jafari, A Babajani, R Sarrami Forooshani, M Yazdani, …
    • Journal: Frontiers in oncology
    • Volume: 12
    • Pages: 819563
    • Citations: 45
    • Year: 2022

 

  1. HSP90 and Co-chaperones: Impact on Tumor Progression and Prospects for Molecular-Targeted Cancer Therapy
    • Authors: A Jafari, M Rezaei-Tavirani, B Farhadihosseinabadi, S Taranejoo, H Zali
    • Journal: Cancer Investigation
    • Volume: 38
    • Issue: 5
    • Pages: 310-328
    • Citations: 41
    • Year: 2020

 

  1. Evidence for the Benefits of Melatonin in Cardiovascular Disease
    • Authors: M Tobeiha, A Jafari, S Fadaei, SMA Mirazimi, F Dashti, A Amiri, H Khan, …
    • Journal: Frontiers in cardiovascular medicine
    • Volume: 9
    • Pages: 888319
    • Citations: 40
    • Year: 2022

 

  1. Human amniotic mesenchymal stem cells to promote/suppress cancer: two sides of the same coin
    • Authors: A Jafari, M Rezaei-Tavirani, B Farhadihosseinabadi, H Zali, H Niknejad
    • Journal: Stem Cell Research & Therapy
    • Volume: 12
    • Issue: 1
    • Pages: 126
    • Citations: 37
    • Year: 2021

 

  1. Current advances and challenges in COVID-19 vaccine development: from conventional vaccines to next-generation vaccine platforms
    • Authors: A Jafari, F Danesh Pouya, Z Niknam, M Abdollahpour‑Alitappeh, …
    • Journal: Molecular biology reports
    • Volume: 49
    • Issue: 6
    • Pages: 4943-4957
    • Citations: 33
    • Year: 2022

 

  1. Multiple sclerosis biomarker discoveries by proteomics and metabolomics approaches
    • Authors: A Jafari, A Babajani, M Rezaei-Tavirani
    • Journal: Biomarker Insights
    • Volume: 16
    • Pages: 11772719211013352
    • Citations: 27
    • Year: 2021

 

Flavia | Molecular Biology | Young Scientist Award

Dr. Flavia| Molecular Biology | Young Scientist Award

👨‍🏫Profile Summary

Flavia Scoyni is a highly accomplished researcher in molecular medicine, specializing in non-coding RNAs and their role in neurodegenerative diseases like Alzheimer’s and ischemic stroke. With a Ph.D. from the University of Eastern Finland under the Marie Skłodowska-Curie Programme, Flavia has extensive experience in experimental techniques such as scRNA-seq, FACS, and animal modeling. Their work has been published in prestigious journals and recognized with numerous grants and fellowships. Flavia’s expertise in molecular biology, cell culture, and animal work, coupled with a strong track record of securing research funding, positions them as a valuable asset in the field of translational medicine.

🌐 Professional Profiles

🎓Education:

Ph.D. in Molecular Medicine University of Eastern Finland, Kuopio, Finland Duration: Dec 2017 – Feb 2024 Marie Skłodowska-Curie Programme in Genetics and Mechanisms in Translational Medicine (GENOMMED) Advisor: Prof. Tarja Malm Dissertation: “Unlocking the potential of non-coding RNAs in regulating neurodegeneration – a glimpse into Alzheimer’s disease and ischemic stroke pathophysiology.” Ph.D. secondment Aarhus University, Aarhus, Denmark Duration: Sept 2018 – Feb 201 Advisor: Assoc. Prof. Thomas B. Hansen Funded by Saastamoinen Foundation travel grant FELASA accreditationUniversity of Eastern Finland, Kuopio, Finland May 2017 Federation of Laboratory Animal Science Associations (FELASA) Certificate in laboratory animal science for EU Functions A/D MSc in Molecular Biology “Sapienza” University of Rome, Rome, Italy Duration: Oct 2013 – Dec 2015 Master Degree in Molecular Biology Graduated magna cum laude (110/110 cum laude) Advisor: Prof. Alessandro Fatica Thesis title: “Identification of new transcriptional targets of p30 C/EBPα transcription factor isoform in acute myeloid leukemia” MSc in Genetics University Paris-Diderot VII, Paris, France Duration: Oct 2013 – June 2015 BSc in Biotechnology “Sapienza” University of Rome, Rome, Italy Duration: Oct 2010 – July 2013 Bachelor degree in Biotechnology Graduated magna cum laude (110/110 cum laude) Advisor: Prof. Carlo Presutti Thesis title: “The role of the mir-200 family in the regulation of the expression of AP1 transcriptional factor”

🔬Research Experience:

Early stage researcher Professor Tarja Malm University of Eastern Finland, A.I. Virtanen Institute for Molecular Sciences Jan 2017 – Dec 2017 Investigated the role of microRNAs in phagocytic microglia isolated from adult Alzheimer’s mice. Developed techniques including ex-vivo FACS, low input RNA extraction, cloning, qPCR, and protocol for transfection for hard-to-transfect cell lines. Conducted animal procedures to harvest brain samples or acutely isolate adult microglia. Erasmus traineeship Biotech Research & Innovation Centre, Copenhagen, Denmark Oct 2016 – June 2016 Developed a transgenic stable cell line for long non-coding RNAs. Applied techniques such as cloning of long inserts, lentiviral vector production, and stable cell line development. Master thesis Professor Alessandro Fatica “Sapienza” University of Rome, Rome, Italy June 2014 – Dec 2015 Investigated the regulation of the long non-coding RNA UCA1 mediated by C/EBPα transcription factor in the K562 lymphoblast cell line. Applied techniques including ChIP, cloning, RNA extraction, RT-qPCR, WB, transfection, CRISPR-Cas9, and stable cell line development. Master Internship Professor Giuseppe Macino “Sapienza” University of Rome, Rome, Italy Sept 2013 – March 2014 Studied microRNAs inducing epigenetic modifications in mammals.Applied techniques such as ChIP, cloning, mutagenesis, RNA extraction, RT-qPCR, WB, CRISPR-Cas9, and stable cell line development. Bachelor thesis Professor Carlo Presutti “Sapienza” University of Rome, Rome, Italy Oct 2012 – July 2013 Investigated the role of the miR-200a family in regulating c-JUN transcription factor expression. Utilized techniques including cloning, mutagenesis, bacterial transformation, and cell line culture.

💻 Technical Skills:

Molecular biology techniques such as scRNA-seq, RNA-seq, FACS, cloning, RT-qPCR, WB, lentiviral vectors generation. Cell culture techniques including neuronal culture, primary microglial culture, transduction, transfection, and stable cell line development. Animal work including FELASA A/D certification, maintenance, and breeding of transgenic mouse models, animal procedures, and tamoxifen-induced recombination. Statistical analysis, basic Python, and R.

🏆Fellowships, Awards, and Honors:

  • Secured total grants of 99.000€ during Ph.D., including grants from Pavo Nuermen Foundation, Finnish Cultural Foundation, Kuopio University Foundation, and others.

👩‍🏫 Teaching Experience:

  • Mentored a Ph.D. student and post-graduate student, and supervised five master’s thesis students during the Ph.D. program.

📚Top Noted Publication

  1. ciRS-7 and miR-7 regulate ischemia-induced neuronal death via glutamatergic signaling
    • Journal: Cell Reports
    • Year: 2024-03
    • DOI: 10.1016/j.celrep.2024.113862
    • Contributors: Flavia Scoyni; Valeriia Sitnikova; Luca Giudice; Paula Korhonen; Davide M. Trevisan; Ana Hernandez de Sande; Mireia Gomez-Budia; Raisa Giniatullina; Irene F. Ugidos; Hiramani Dhungana et al.

 

  1. Alzheimer’s disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs
    • Journal: Alzheimer’s & Dementia
    • Year: 2024-02
    • DOI: 10.1002/alz.13502
    • Contributors: Flavia Scoyni; Luca Giudice; Mari-Anna Väänänen; Nicholas Downes; Paula Korhonen; Xin Yi Choo; Nelli-Noora Välimäki; Petri Mäkinen; Nea Korvenlaita; Annemieke J Rozemuller et al.

 

  1. ciRS-7 and miR-7 regulate ischemia induced neuronal death via glutamatergic signaling
    • Journal: Preprint
    • Year: 2023-01-24
    • DOI: 10.1101/2023.01.24.525136
    • Contributors: Flavia Scoyni; Valeriia Sitnikova; Luca Giudice; Paula Korhonen; Davide M Trevisan; Ana Hernandez de Sande; Mireia Gomez-Budia; Raisa Giniatullina; Irene F Ugidos; Hiramani Dhungana et al.

 

  1. Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation
    • Journal: Journal of Neuroinflammation
    • Year: 2020
    • DOI: 10.1186/s12974-020-01870-w
    • Contributors: Kolosowska, N.; Gotkiewicz, M.; Dhungana, H.; Giudice, L.; Giugno, R.; Box, D.; Huuskonen, M.T.; Korhonen, P.; Scoyni, F.; Kanninen, K.M. et al.

 

  1. PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia
    • Journal: Stem Cell Reports
    • Year: 2019
    • DOI: 10.1016/j.stemcr.2019.08.004
    • Contributors: Konttinen, H.; Cabral-da-Silva, M.E.C.; Ohtonen, S.; Wojciechowski, S.; Shakirzyanova, A.; Caligola, S.; Giugno, R.; Ishchenko, Y.; Hernández, D.; Fazaludeen, M.F. et al.

Agricultural and Biological Sciences

Introduction of Agricultural and Biological Sciences

Introduction of Agricultural and Biological Sciences research plays a pivotal role in addressing global challenges related to food security, environmental sustainability, and human health. This multifaceted field encompasses the study of living organisms, their interactions, and the development of innovative solutions to enhance agricultural productivity and biodiversity conservation.

Here are five suitable subtopics in Agricultural and Biological Sciences:

Crop Genetics and Breeding

This subfield focuses on improving crop varieties through genetic manipulation and selective breeding techniques to enhance yield, disease resistance, and nutritional content, contributing to sustainable agriculture.

Eco-friendly Pest Management

Research in this area explores alternative and environmentally friendly methods for controlling pests and diseases in agriculture, reducing the reliance on chemical pesticides.

Biotechnology and Genetic Engineering

This subtopic involves the application of biotechnology tools to modify and improve plants and animals for various agricultural purposes, such as developing drought-resistant crops or disease-resistant livestock.

Biodiversity Conservation

Conservation biology studies aim to protect and sustain the planet’s rich biodiversity, addressing issues like habitat loss, species extinction, and the preservation of ecosystems critical for agriculture and life on Earth.

Soil Health and Nutrient Management

This area delves into maintaining and enhancing soil fertility, minimizing soil erosion, and optimizing nutrient management practices to ensure sustainable agricultural production while preserving soil ecosystems.

These subtopics represent just a fraction of the diverse and dynamic field of Agricultural and Biological Sciences, highlighting the importance of research in addressing pressing global challenges related to agriculture, ecology, and human well-being.

Agricultural and Biological Sciences

Introduction of Agricultural and Biological Sciences

Introduction of Agricultural and Biological Sciences research plays a pivotal role in addressing global challenges related to food security, environmental sustainability, and human health. This multifaceted field encompasses the study of living organisms, their interactions, and the development of innovative solutions to enhance agricultural productivity and biodiversity conservation.

Here are five suitable subtopics in Agricultural and Biological Sciences:

Crop Genetics and Breeding

This subfield focuses on improving crop varieties through genetic manipulation and selective breeding techniques to enhance yield, disease resistance, and nutritional content, contributing to sustainable agriculture.

Eco-friendly Pest Management

Research in this area explores alternative and environmentally friendly methods for controlling pests and diseases in agriculture, reducing the reliance on chemical pesticides.

Biotechnology and Genetic Engineering

This subtopic involves the application of biotechnology tools to modify and improve plants and animals for various agricultural purposes, such as developing drought-resistant crops or disease-resistant livestock.

Biodiversity Conservation

Conservation biology studies aim to protect and sustain the planet's rich biodiversity, addressing issues like habitat loss, species extinction, and the preservation of ecosystems critical for agriculture and life on Earth.

Soil Health and Nutrient Management

This area delves into maintaining and enhancing soil fertility, minimizing soil erosion, and optimizing nutrient management practices to ensure sustainable agricultural production while preserving soil ecosystems.

These subtopics represent just a fraction of the diverse and dynamic field of Agricultural and Biological Sciences, highlighting the importance of research in addressing pressing global challenges related to agriculture, ecology, and human well-being.