Snigdha Singh | Medicinal Chemistry | Best Researcher Award

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Ā Dr. Snigdha Singh | Medicinal Chemistry | Best Researcher Award

Dr at University of Delhi, India

I am an Assistant Professor in the Department of Chemistry at the University of Delhi and a Resident Tutor at Ambedkar Ganguly Students House for Women. My research focuses on the design and synthesis of novel compounds with biological applications, and I have substantial expertise in molecular dynamics, nanoparticle synthesis, and heterocyclic chemistry. I hold a Ph.D. from the University of Delhi, and my research has led to several peer-reviewed publications and collaborations with prestigious international institutions.

profile:

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šŸ›ļø Current Positions

Assistant Professor Department of Chemistry, University of Delhi, India June 2023 ā€“ Present. Resident Tutor Ambedkar Ganguly Students House for Women, Delhi, India September 2023 ā€“ Present

šŸŽ“ Academic Background

Postdoctoral Research Associate Rensselaer Polytechnic Institute, Department of Chemistry and Chemical Biology March 2023 ā€“ May 2023 Advisor: Prof. Christopher Cioffi Project: ā€œDesign and Synthesis of Neuropathic Inhibitorsā€. Research Associate-III University of Delhi, Department of Chemistry March 2021 ā€“ December 2023 Advisor: Prof. Ramesh Chandra Project: ā€œDesign and Synthesis of nanoparticles and their biomedical applicationā€. Guest Scientist Humboldt UniversitƤt zu Berlin, Institute for Chemistry Sep. 2022 ā€“ Dec. 2022 & Sep. 2021 ā€“ Jan. 2022 Advisor: Prof. Christoph Arenz Project: ā€œSynthesis of potential analogs for ACER3 activityā€. Ph.D. in Chemistry University of Delhi Nov. 2017 ā€“ Feb. 2021 Advisor: Prof. Ramesh Chandra Thesis: ā€œSynthesis and Development of Novel Heterocycles and their biological evaluationā€. Ph.D. Exchange Student
University of Oxford, Department of Chemistry, U.K. Dec. 2020 ā€“ Feb. 2021 Advisor: Prof. Edward Anderson Project: ā€œTowards new treatments for Leishmaniasis and Chagas disease through Natural Product chemistryā€. Ph.D. Exchange Student University of Siena, Department of Chemistry, Italy Oct. 2018 ā€“ July 2019 Advisor: Prof. Maurizio Taddei Project: ā€œSynthesis of 8-hydroxyquinoline molecules as Hedgehog Gli-Inhibitorsā€. M.Sc. in Chemistry (H) University of Delhi July 2013 ā€“ July 2015 Thesis: ā€œMicrowave-Assisted Synthesis of Piperidine/Piperazine based moleculesā€. B.Sc. in Chemistry (H) University of Delhi July 2010 ā€“ June 2013

šŸ… Awards and Fellowships

Indo-UK Newton Bhabha Scholar British Council (U.K.) for research at the University of Oxford, U.K. Dec 2020 ā€“ Feb 2021. Indo-Italy Exchange Scholarship Ministry of Human Resource Development (MHRD), India & Italian Embassy Cultural Centre Oct 2018 ā€“ June 2019. Young Scientist Travel Award International Society for the study of Xenobiotics (ISSX) July 2019. Young Scientist Award University of Chemistry and Technology, Prague Sep 2019. Senior Research Fellowship (SRF) Indian Council of Medical Research (ICMR), India Dec 2018 ā€“ Dec 2020. UGC-CSIR-NET Examination 19th All India Rank Dec 2017. Merit Fellowship Hindu College, University of Delhi For 1st position in B.Sc Chemistry

šŸ› ļø Skills

Multi-step organic reactions, heterocyclic synthesis. Handling inert-atmospheric conditions (Schlenk-line and glovebox). Binding studies of various blood proteins with anticancer drugs. Basic Cell culture, Maintenance of cancer cell lines, MTT assay, Apoptosis. Flash Chromatography, HPLC, NMR, IR, HRMS, UV-Vis, and fluorescence measurement analysis. Microsoft Office, Origin, Chem-draw, MestReNova, Joel Delta software analysis. Writing scientific reports, publications, and research projects

Publication:šŸ“

 

  • Title: Precisely designed NIR based conjugated framework as a solid state emitter for selective recognition of cyanide ion in solid state and cancer cells
    • Journal: Journal of Photochemistry and Photobiology A: Chemistry
    • Year: 2024
    • DOI: 10.1016/j.jphotochem.2023.115373
    • EID: 2-s2.0-85178574911
    • ISSN: 10106030
    • Contributors: Kiran; Ranolia, A.; Rani, P.; Joshi, G.; Kumar, R.; Kumar, S.; Kumar, P.; Singh, S.; Sindhu, J.

 

  • Title: Synthesis and characterization of Fe3O4@SiO2@PDA@Ag coreā€“shell nanoparticles and biological application on human lung cancer cell line and antibacterial strains
    • Journal: Artificial Cells, Nanomedicine, and Biotechnology
    • Year: 2024 (Published on 2024-12-31)
    • DOI: 10.1080/21691401.2023.2295534
    • Contributors: Snigdha Singh; Tanya Goel; Aarushi Singh; Heerak Chugh; Nayanika Chakraborty; Indrajit Roy; Manisha Tiwari; Ramesh Chandra

 

  • Title: Rationally designed dual channel reversible probe for cyanide recognition in aqueous medium with solid-state sensing abilities
    • Journal: Journal of Photochemistry and Photobiology A: Chemistry
    • Year: 2024 (Published on 2024-08)
    • DOI: 10.1016/j.jphotochem.2024.115650
    • Contributors: Kiran; Anju Ranolia; Priyanka; Indu Bala; Jyoti Jangir; Snigdha Singh; Jayant Sindhu; Parvin Kumar; Devender Singh

 

  • Title: Rationally designed C-3 sulfenylated 2-phenyl-4H-pyrido[1,2-a]pyrimidin-4-one based fluorescent probe for recognition of Fe3+
    • Journal: Journal of Molecular Structure
    • Year: 2024 (Published on 2024-04)
    • DOI: 10.1016/j.molstruc.2023.137456
    • Contributors: Priyanka; Payal Rani; Kiran; Ramesh Kataria; Parvin Kumar; Devender Singh; Anil Duhan; Snigdha Singh; Jayant Sindhu

 

  • Title: An expeditious on-water regioselective synthesis of novel arylidene-hydrazinyl-thiazoles as DNA targeting agents
    • Journal: Bioorganic Chemistry
    • Year: 2023
    • DOI: 10.1016/j.bioorg.2023.106524
    • EID: 2-s2.0-85152729436
    • ISSN: 10902120, 00452068
    • Contributors: Aggarwal, R.; Hooda, M.; Kumar, P.; Kumar, S.; Singh, S.; Chandra, R.

 

  • Title: Biological activity and structure-activity relationship of dehydrodieugenol B analogues against visceral leishmaniasis
    • Journal: RSC Medicinal Chemistry
    • Year: 2023
    • DOI: 10.1039/d3md00081h
    • EID: 2-s2.0-85162997205
    • ISSN: 26328682
    • Contributors: Amaral, M.; Asiki, H.; Sear, C.E.; Singh, S.; Pieper, P.; Haugland, M.M.; Anderson, E.A.; Tempone, A.G.

 

Antonios Kousaxidis | Medicinal Chemistry | Best Researcher Award

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Ā Mr. Antonios Kousaxidis | Medicinal Chemistry |Best Researcher Award

Ā Mr at School of Pharmacy, Aristotle University of Thessaloniki, Greece

A seasoned educator and researcher with extensive experience in physics, holding positions from Assistant to Associate Professor at IAU, Urmia, and Urmia University of Technology. Specialized in teaching a range of undergraduate to Ph.D. courses including Quantum Mechanics, Laser Physics, and Nonlinear Dynamical Systems. Proficient in Maple and Matlab programming with a strong background in finite element method analysis. Led impactful research projects in chaotic systems, cancer treatment, and national security, earning multiple awards including the Kharazmi Scientific Festival Second Prize. A recognized leader in academia with a commitment to advancing scientific knowledge and education.

Profile

  1. Scopus

šŸŽ“ Education:

Masterā€™s Degree in Medicinal Chemistry: (9.85/10) from Departments of Chemistry, Medicine, Biological Applications and Technology, University of Ioannina, 45110, Ioannina, Greece.Ā Bachelor’s Degree in Chemistry: (7.76/10) from Department of Chemistry, School of Sciences, University of Ioannina, 45110, Ioannina, Greece.

Personal Skills:

Synthetic Organic Chemistry and Biochemistry: Training in synthetic organic chemistry and biochemistry applied to drug design, with experience in several areas of synthetic methodology using retrosynthetic approaches. Metal-Based Coupling Reactions: Excellent knowledge and practice of metal-based coupling reactions in modern organic chemistry. Synthetic Routes Optimization: Training in synthetic routes optimization using one-pot reactions during masterā€™s thesis. Analytical Methods: Proficient in NMR, IR, UV, and mass spectrometry for identifying organic compounds. Small Molecule Synthesis: Synthesis of small molecule organic compounds and isolation by recrystallization. Purification and Separation: Excellent knowledge and practice in chromatographic methods like column, preparative, and thin-layer chromatography for purifying and separating organic compounds. Biochemical Protocols: Good practice in using biochemical protocols for enzyme kinetics experiments. Drug Discovery Programs: Extensive experience in drug discovery programs, structure-based drug design, molecular docking, and SAR estimation models using in silico methods (Discovery Studio, Chimera, LigandScout, PyMOL, OpenBabel, ADMET). Scientific Manuscripts: Proficient in writing and preparing scientific manuscripts.

šŸ’» Software Skills:

Office Suite (ECDL degree) – Word processing, spreadsheets, presentations, etc. Calculative and predictive programs like MestReNova, Topspin DataAnalysis, ChemDraw Ultra, MedChem Designer, and BioLoom.

Research Focus:

A. Kousaxidis primarily focuses on the design and synthesis of novel compounds with therapeutic potential, particularly targeting enzymes such as aldose reductase (ALR2) and protein tyrosine phosphatase 1B (PTP1B). The research also encompasses antimicrobial agents, lipoxygenase inhibitors, and therapeutic strategies for conditions like diabetes mellitus and sepsis.

Publications Top Notes šŸ“

  • A Molecular Hybridization Approach for the Design of Selective Aldose Reductase (ALR2) Inhibitors and Exploration of Their Activities Against Protein Tyrosine Phosphatase 1B (PTP1B)
    • Authors: Kousaxidis, A., Petrou, A., Rouvim, P., Nicolaou, I., Geronikaki, A.
    • Journal: Journal of Molecular Structure
    • Year: 2023
    • Volume: 1271
    • Article Number: 134116
    • Citations: 3
    • Summary: This study presents a hybridization approach to develop selective ALR2 inhibitors and investigates their potential activities against PTP1B, highlighting their dual therapeutic potential.

 

  • Design, Synthesis, and Pharmacological Evaluation of Indazole Carboxamides of N-Substituted Pyrrole Derivatives as Soybean Lipoxygenase Inhibitors
    • Authors: Lavrentaki, V., Kousaxidis, A., Theodosis-Nobelos, P., Koutsopoulos, K., Nicolaou, I.
    • Journal: Molecular Diversity
    • Year: 2023
    • Citations: 2
    • Summary: This paper discusses the synthesis and evaluation of novel indazole carboxamides, demonstrating significant inhibitory activity against soybean lipoxygenase.

 

  • N-Derivatives of (Z)-Methyl 3-(4-Oxo-2-thioxothiazolidin-5-ylidene)methyl)-1H-indole-2-carboxylates as Antimicrobial Agentsā€”In Silico and In Vitro Evaluation
    • Authors: Petrou, A., Geronikaki, A., Kartsev, V., Nicolaou, I., Vizirianakis, I.S.
    • Journal: Pharmaceuticals
    • Year: 2023
    • Volume: 16
    • Issue: 1
    • Article Number: 131
    • Citations: 4
    • Summary: This open-access article evaluates the antimicrobial activity of new N-derivatives, supported by both in silico and in vitro methods.

 

  • Non-acidic Bifunctional Benzothiazole-Based Thiazolidinones with Antimicrobial and Aldose Reductase Inhibitory Activity as a Promising Therapeutic Strategy for Sepsis
    • Authors: Kousaxidis, A., Kovacikova, L., Nicolaou, I., Stefek, M., Geronikaki, A.
    • Journal: Medicinal Chemistry Research
    • Year: 2021
    • Volume: 30
    • Issue: 10
    • Pages: 1837-1848
    • Citations: 13
    • Summary: This research explores benzothiazole-based thiazolidinones with dual activity, suggesting a promising approach for treating sepsis.

 

  • Aldose Reductase and Protein Tyrosine Phosphatase 1B Inhibitors as a Promising Therapeutic Approach for Diabetes Mellitus
    • Authors: Kousaxidis, A., Petrou, A., Lavrentaki, V., Nicolaou, I., Geronikaki, A.
    • Journal: European Journal of Medicinal Chemistry
    • Year: 2020
    • Volume: 207
    • Article Number: 112742
    • Citations: 39
    • Summary: This review highlights the potential of targeting ALR2 and PTP1B as a therapeutic strategy for diabetes, emphasizing recent advances and future perspectives.

 

Simone Giovannuzzi | Medicinal chemistry | Young Scientist Award

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Ā Dr . Simone Giovannuzzi | Medicinal chemistry | Young Scientist Award

šŸ‘Øā€šŸ«Profile Summary

Dedicated researcher with a strong academic background in Pharmaceutical Sciences, specializing in drug development and computational chemistry. Recently awarded a PhD in Advanced Materials and Data Science, with expertise in multi-scale modeling and simulation of composite materials. Proficient in implementing computational methods and artificial intelligence models to advance pharmaceutical research. Fluent in English, French, and Arabic.

šŸŒ Professional Profiles

  1. Scopus Profile

 

  1. Orcid Profile

 

šŸŽ“ Education

PhD cum laude in Area del Farmaco e Trattamenti Innovativi: Curriculum Scienze Farmaceutiche NEUROFARBA Department, University of Florence, Italy Nov 2020 – Oct 2023 Qualification to practise the profession of Pharmacist National exam for professional qualification Jul 2020 5-year single-cycle Master’s Degree in Pharmaceutical Chemistry and Technologies Faculty of Pharmacy, University of Florence, Italy
Oct 2015 – Jun 2020

šŸ”¬Work Experience

Post-Doctoral Researcher in Area del Farmaco NEUROFARBA Department, University of Florence, Italy Nov 2023 – Present Tutor Senior in Area del Farmaco PNRR Plan “Orientamento attivo nella transizione scuola-UniversitĆ ”, Next Generation EU programme (NGEU) Oct 2023 – Present Tutor In-itinere for Chemistry, Organic Chemistry and Spectroscopic Methods Scuola di Scienze della Salute Umana, Corso di Scienze Farmaceutiche Applicate – Controllo QualitĆ  (SFA-CQ), University of Florence, Italy Mar 2021 – Dec 2023 Internship Centre National de la Recherche Scientifique (CNRS), Montpellier, Occitanie, France Feb 2022 – Jul 2022

šŸ”¬Reviewer

Reviewer for international peer-reviewed scientific journals with high impact factor: Expert opinion on Therapeutic Patent Journal of Enzyme Inhibition and Medicinal Chemistry Frontiers Molecules Future Medicinal Chemistry Journal of the Turkish Chemical Society, Section A

šŸ¤Major Ongoing Collaborations

Prof. J.Y. Winum, CNRS Montpellier, France, Prof. C. Capasso, CNR Napoli, Italy, Prof. G. De Simone, CNR Napoli, Italy, Prof. A.B. Vermelho, U. di Rio de Janeiro, Brazil, Prof. A. Aspatwar, U. Di Tampere, Finland, Prof. M. Bucciantini, U. Di Firenze, Italy, Prof. A. Ligresti, ICB Napoli, Italy Prof. F. Borges, U. di Porto, Portugal, Prof. Daniel P. Flaherty, U. di Purdue, USA, Mohamed N. Seleem, U. della Virgina, USA, Prof. S. Carradori, U. di Chieti, Italy

šŸ§ Personal Skills

Excellent collaboration and coaching skills within a team, Outstanding problem-solving abilities, Strong adaptability and flexibility, Excellent active listening skills, Excellent creativity, Strong inclination towards research, Excellent multitasking and time management skills

šŸ’»Technical Skills

NMR, IR Spectroscopy, UV-Vis and Fluorescence Absorption, Multi-Step synthesis, Structure-Activity Relationship (SAR) Studies, Stopped-Flow Technique, Literature Review and Patent Analysis

šŸ–„ļøDigital Skills

ChemDraw, SciFinder, Reaxys, Topspin, Origin, MestReNova, MS Office, E-Learning Platform, AI tools (ChatGPT, Perplexity)

šŸ“šTop Noted Publication

  1. Year: 2022
    • Journal: Composite Structure Journal
    • Title: Multiparametric modeling of composite materials based on non-intrusive PGD informed by multiscale analyses: Application for real-time stiffness prediction of woven composites.

 

  1. Year: 2023
    • Journal: Journal of the Mechanics and Physics of Solids
    • Title: Multiscale Thermodynamics-Informed Neural Networks (MuTINN) towards Fast and Frugal Inelastic Computation of Woven Composite Structures.

 

  1. Year: 2023 (under process)
    • Journal: Composite Structure Journal
    • Title: Multiparametric modeling of composite materials based on non-intrusive PGD informed by multiscale analyses: Application for real-time virtual testing of woven composites.