Alexia Barbarossa | Medicinal chemistry | Young Scientist Award

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Dr. Alexia Barbarossa | Medicinal chemistry | Young Scientist Award

Researcher | Jadavpur University, India

Dr. Alexia Barbarossa, Ph.D. in Pharmaceutical Sciences, is an Italian researcher with expertise in microbiology, molecular biology, cell biology, and pharmaceutical chemistry. She currently serves as a Research Fellow at the University of Bari “Aldo Moro” and actively contributes to innovative drug repositioning, antimicrobial synergy, and bioactive compound research. Alongside her academic work, she engages in science communication, guest editing, and peer reviewing for several international journals. Dr. Barbarossa is known for her contributions to pharmaceutical microbiology, teaching, and thesis supervision.

Profile

Scopus

🎓 Education 

Alexia earned her Ph.D. in Pharmaceutical Sciences from the University of Bari “Aldo Moro” (2019–2023), focusing on drug repositioning in anticancer and antimicrobial therapy. She holds a Master’s degree in Pharmaceutical Chemistry and Technology from the University of Calabria, with a thesis on corticosurrenal carcinoma cell models. Her academic path is enriched by training in molecular biology, safety in labs, DNA forensic analysis, and research entrepreneurship, alongside certifications in English (B2 level) and interdisciplinary innovation workshops.

💼 Experience 

Dr. Barbarossa has worked as a Research Fellow, Scientific Communicator, and Thesis Co-supervisor. She participated in regional and national research programs on functional polymers and hybrid enzyme-material devices. She has provided teaching support and lectures at various academic levels including Master’s and PhD courses. With experience ranging from microbiological analysis to pharmaceutical innovation, her roles span peer tutoring, technical-teaching support, guest editing, and scientific writing. Her lab internships and pharmacy traineeship further enrich her hands-on pharmaceutical knowledge.

🏆 Awards & Honors 

Alexia received the Best Poster Presentation Award at Fun4Heritage 2019 for her work on fosfomycin analogues. She has also served as Guest Editor for journals like Antibiotics and Microorganisms, edited special issues on drug repositioning and antimicrobial synergy, and was appointed as an Expert in Microbiology for academic teaching. She co-supervised multiple award-worthy theses and actively participated in certified workshops related to entrepreneurship, sustainability, agrifood systems, and lab safety, showcasing her excellence in research and education.

🔬 Research Focus 

Dr. Barbarossa’s research centers on drug repositioning, antimicrobial synergy, biofilm studies, and the biological evaluation of natural/semi-synthetic substances. Her interdisciplinary work spans microbiology, cell biology, molecular diagnostics, and pharmaceutical innovation. She investigates essential oils and repurposed drugs (e.g., sertraline, melatonin) for antimicrobial and antitumor activity. She’s engaged in developing functional biomaterials and hybrid devices while exploring cosmetic microbiology and nutraceutical sciences, contributing to pharmaceutical sciences through publications, teaching, and international collaborations.

Conclusion

Dr. Alexia Barbarossa is a highly suitable and competitive candidate for the Young Scientist Award in Microbiology. Her combined expertise in microbial cultures, antimicrobial synergy, and drug repositioning, along with her scientific output and academic engagement, make her a promising young researcher. Strengthening international ties and developing independent research leadership would further elevate her candidacy.

Publication

Enhanced antibacterial efficacy of new benzothiazole phthalimide hybrid compounds/methyl-β-cyclodextrin inclusion complexes compared to the free forms: Insights into the possible mode of action

  • Authors: Alessia C. Carocci, Alexia Barbarossa, Antonio Rosato, Adriana Trapani, Antonio Carrieri

  • Journal: International Journal of Pharmaceutics

  • Year: 2025

Antibiofilm Effects of Plant Extracts Against Staphylococcus aureus

  • Authors: Alexia Barbarossa, Antonio Rosato, Roberta Tardugno, Giuseppe Fracchiolla, Alessia C. Carocci

  • Journal: Microorganisms

  • Year: 2025

Efficacy of Willow Herb (Epilobium angustifolium L. and E. parviflorum Schreb.) Crude and Purified Extracts and Oenothein B Against Prostatic Pathogens

  • Authors: Alexia Barbarossa, Antonio Rosato, Alessia C. Carocci, Filippo Maggi, Giovanni Caprioli

  • Journal: Antibiotics

  • Year: 2025

 

Nozuko Blasich | HIV and Mycology | Best Researcher Award

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Ms. Nozuko Blasich | HIV and Mycology | Best Researcher Award

Quality Control Technologist, National Health Laboratory Service South Africa

Nozuko Blasich is a Clinical Pathology Medical Technologist specializing in laboratory diagnostics, quality control, and biomedical research. She holds a Master of Science in Biomedical Technology and is currently pursuing a PhD in Biomedical Science, focusing on fungal pathogens and their public health impact. Her research on cryptococcal meningitis has influenced World Health Organization (WHO) policies. She has published in high-impact journals, presented at international conferences, and serves as a peer reviewer. Passionate about improving diagnostic accuracy, she explores point-of-care tests for infectious diseases.

Profile

Orcid

Education 🎓

Nozuko Blasich earned her Master of Science in Biomedical Technology, with research focusing on cryptococcal meningitis, significantly contributing to global health policies. She is currently a PhD candidate in Biomedical Science, investigating fungal pathogens and their environmental prevalence. Her academic journey emphasizes microbiology, clinical diagnostics, and public health.

Experience 🧑‍🏫

She serves as a Quality Control Technologist at the National Health Laboratory Service, ensuring diagnostic accuracy and laboratory efficiency. With expertise in mycology, she has worked extensively on cryptococcal antigen screening and HIV diagnostics.

 Awards & Honors 🏆

She has received recognition for her contributions to medical mycology, including best researcher awards and grants for her impactful studies on fungal pathogens and diagnostic advancements.

Research Interests 🔬

Her research explores fungal infections, laboratory diagnostics, and point-of-care testing to enhance public health interventions. She investigates diagnostic methodologies, antimicrobial resistance, and epidemiology to improve early detection and treatment outcomes.

Publications 📚

  1. Evaluating the Accuracy of Multiple Rapid Diagnostic Tests for HIV Detection in Serum Samples Analysed During Point-of-Care Proficiency Testing Assessments (2025) – Nozuko P. Blasich, Jerom Okot, Artur Ramos, Mduduzi B. Buthelezi, Dumisani F. Shabangu, Mahlatse M. Maleka, Sarvashni Moodliar, Nqobile Ngoma, Tendesayi Kufa

 

  1. Retrospective Assessment of a National Reflex Cryptococcal Antigen Screening Program in South Africa Through Interlaboratory Comparison of Lateral Flow Assay Results (2022) – Nozuko P. Blasich, Lindi M. Coetzee, Charlotte Sriruttan, Daniel DeSanto, Gregory S. Greene, Deborah K. Glencross, Nelesh P. Govender

 

  1. Association of Semi-Quantitative Cryptococcal Antigen Results in Plasma with Subclinical Cryptococcal Meningitis and Mortality Among Patients with Advanced HIV Disease (2021) – Nozuko P. Blasich, Rachel M. Wake, Ivy Rukasha, Yvonne Prince, Nelesh P. Govender

 

  1. Cryptococcus neoformans: Diagnostic Dilemmas, Electron Microscopy and Capsular Variants (2018) – Nozuko P. Blasich, Monica Birkhead, Serisha D. Naicker, Ivy Rukasha, Juno Thomas, Charlotte Sriruttan, Shareef Abrahams, Grisselda S. Mavuso, Nelesh P. Govender

 

Anastasia Kovrizhina | Medicinal chemistry | Women Researcher Award

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Dr. Anastasia Kovrizhina | Medicinal chemistry | Women Researcher Award

PhD Reseracher, Tomsk Polytechnic University Russia

Anastasia Kovrizhina is a Russian researcher specializing in organic chemistry and biotechnology. She holds a Ph.D. from National Research Tomsk Polytechnic University, where she focuses on molecular modeling and the synthesis of biologically active compounds. Currently, she is a researcher at Tomsk Polytechnic University and serves as a scientist secretary. Her work includes the development of novel kinase inhibitors and fluorocarbon aza-heterocycles for anticancer treatments. She has been actively involved in international collaborations, including research internships at Montana State University, USA, and Novosibirsk Institute of Organic Chemistry, Russia. With an h-index of 7, she has published extensively in high-impact journals and has presented at numerous international and national conferences. She has received multiple prestigious scholarships and awards, including the Baden-Württemberg State Scholarship and the Government Scholarship of the Russian Federation. Her expertise spans chemical synthesis, biological assays, computational chemistry, and quantum calculations.

Profile

Scopus

Education 🎓

Anastasia Kovrizhina earned her Ph.D. (2019-2023) in Organic Chemistry from National Research Tomsk Polytechnic University, specializing in molecular modeling and drug synthesis. She completed her Master’s degree (2017-2019) in Biotechnology at the same institution, where she studied organic and applied chemistry. During her studies, she participated in an academic exchange at Karlsruhe Institute of Technology, Germany, where she took courses in bioinformatics, bioprocessing, and enzymology. She obtained her Bachelor’s degree (2013-2017) in Biotechnology from National Research Tomsk Polytechnic University, with a strong foundation in chemistry, physics, and humanities. Her academic journey has been complemented by advanced training in computational chemistry, quantum calculations, and SAR/QSAR analysis. She has also gained international exposure through scholarships and research projects focused on innovative drug development. Her multidisciplinary education allows her to integrate experimental and computational approaches for pharmaceutical and medical applications.

Experience 🧑‍🏫

Anastasia Kovrizhina is currently a researcher at Tomsk Polytechnic University, specializing in the synthesis of biologically active compounds. She also serves as a scientist secretary at the School of Advanced Manufacturing Technologies and is an active member of the Council of Young Scientists. She has undertaken research internships at the Novosibirsk Institute of Organic Chemistry (2020) and Montana State University, USA (2019), where she collaborated on immunology and organic chemistry projects. Her work includes grant-funded research on kinase inhibitors, fluorocarbon aza-heterocycles, and polymer scaffolds for cardiovascular applications. She has supervised undergraduate and master’s students and has taught courses in professional English and organic chemistry. Her expertise includes molecular modeling, chemical synthesis, and computational chemistry. She has contributed to multiple research projects under the Russian Science Foundation and has been instrumental in developing innovative drug delivery systems for anticancer treatments.

 Awards & Honors 🏆

Anastasia Kovrizhina has received several prestigious awards, including the First Degree Diploma (2024) for her research on indenoquinoxalinone oxime (IQ-1). She won the 5th All-Russian Research Competition (2020) for her work on indenoquinoxaline derivatives. She was honored with the 3rd Degree Medal for “Achievements for Tomsk Polytechnic University” and the BAYHOST Scholarship for studying German (2020). She received the Baden-Württemberg State Scholarship (2018-2019) and the Russian Government Scholarship (2018-2019). Her participation in international conferences has been recognized with numerous accolades. She has also secured multiple research grants, including the Russian Science Foundation grants for developing kinase inhibitors and fluorocarbon aza-heterocycles as anticancer agents. Her scientific contributions to drug discovery and pharmaceutical chemistry have positioned her as a promising young researcher in her field.

Research Interests 🔬

Anastasia Kovrizhina’s research focuses on the synthesis and molecular modeling of biologically active compounds, particularly kinase inhibitors and fluorocarbon aza-heterocycles for anticancer treatments. She has pioneered the development of JNK kinase inhibitors based on indenoquinoxaline scaffolds, which have potential anti-inflammatory applications. Her work has demonstrated that IQ-1 salts enhance the efficacy of cerebral ischemia treatment. She has conducted pharmacokinetic studies on IQ-1 absorption in the gastrointestinal tract to optimize drug formulation. Her expertise extends to computational chemistry, quantum calculations, and structure-activity relationship (SAR) studies. She is also involved in developing supramolecular complexes for innovative drug delivery. Her interdisciplinary approach integrates synthetic chemistry, computational modeling, and biological assays to advance pharmaceutical research. She has contributed significantly to drug design, molecular docking studies, and the synthesis of novel heterocyclic compounds for targeted therapies.

Publications 📚

  1. Title: 6,8-Dibromo-11H-indeno[1,2-b]quinolin-11-one
    Year: 2024
    Author: Anastasia R. Kovrizhina, Dauren Tolegen, Dmitry I. Pavlov, Andrei S. Potapov, Andrei I. Khlebnikov
    Citations: Not available
    Article: Molbank

 

  1. Title: Evaluation of Nitric Oxide-Donating Properties of 11H-indeno[1,2-b]quinoxalin-11-one Oxime (IQ-1) by Electron Paramagnetic Resonance Spectroscopy
    Year: 2024
    Author: Viacheslav V. Andrianov, Igor A. Schepetkin, Leah V. Bazan, Khalil L. Gainutdinov, Anastasia R. Kovrizhina, Dmitriy N. Atochin, Andrei I. Khlebnikov
    Citations: Not available
    Article: Molecules

 

  1. Title: Dose proportionality and bioavailability of quinoxaline-based JNK inhibitor after single oral and intravenous administration in rats
    Year: 2024
    Author: Galina A. Frelikh, Elena A. Yanovskaya, Alexander P. Lakeev, Galina A. Chernysheva, Vera I. Smolyakova, Anastasia R. Kovrizhina
    Citations: Not available
    Article: Xenobiotica

 

  1. Title: Neuroprotective Effects of Tryptanthrin-6-Oxime in a Rat Model of Transient Focal Cerebral Ischemia
    Year: 2023
    Author: Mark Plotnikov, Galina A. Chernysheva, Vera I. Smol’yakova, Oleg I. Aliev, Anna M. Anishchenko, Olga A. Ulyakhina, Eugene S. Trofimova, Anastasia A. Ligacheva, Nina D. Anfinogenova, Anton Osipenko et al.
    Citations: Not available
    Article: Pharmaceuticals

 

  1. Title: Novel Tryptanthrin Derivatives with Selectivity as c–Jun N–Terminal Kinase (JNK) 3 Inhibitors
    Year: 2023
    Author: Igor A. Schepetkin, Oleksander S. Karpenko, Anastasia R. Kovrizhina, Liliya N. Kirpotina, Andrei I. Khlebnikov, Stepan I. Chekal, Alevtyna V. Radudik, Maryna O. Shybinska, Mark T. Quinn
    Citations: Not available
    Article: Molecules

 

  1. Title: Quantification of a promising JNK inhibitor and nitrovasodilator IQ-1 and its major metabolite in rat plasma by LC–MS/MS
    Year: 2022
    Author: Alexander P. Lakeev, Galina A. Frelikh, Elena A. Yanovskaya, Anastasia R. Kovrizhina, Vladimir V. Udut
    Citations: Not available
    Article: Bioanalysis

 

  1. Title: Poly(ϵ-caprolactone) Scaffolds Doped with c-Jun N-terminal Kinase Inhibitors Modulate Phagocyte Activation
    Year: 2019
    Author: K.S. Stankevich, I.A. Schepetkin, S.I. Goreninskii, A.K. Lavrinenko, E.N. Bolbasov, A.R. Kovrizhina, L.N. Kirpotina, V.D. Filimonov, A.I. Khlebnikov, S.I. Tverdokhlebov et al.
    Citations: Not available
    Article: ACS Biomaterials Science and Engineering

 

JAYAPRAKASH BEHERA| Medicinal chemistry | Young Scientist Award

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Mr. JAYAPRAKASH BEHERA| Medicinal chemistry | Young Scientist Award

Research scholar, CSIR-IIIM JAMMU, India

Jayaprakash Behera, an emerging researcher in Chemistry and Materials Science, holds a PhD from CSIR-IIIM Jammu under AcSIR. He is currently a Project Associate for CSIR Aroma Mission Phase-III. With a background in Polymer Chemistry and Organic Chemistry, he has worked on various research projects at prestigious institutions like IIT Guwahati and IIT Delhi. His innovative research has earned him multiple national and international accolades, including world records and recognition for contributions in scientific development.

Publication Profile

Scholar

🎓 Education 

PhD: CSIR – IIIM Jammu (continuing). M.Phil. Polymer Chemistry & Material Science, Veer Surendra Sai University of Technology (2020). M.Sc. Organic Chemistry, Galgotias University (2017). B.Sc. Chemistry, BJB Autonomous College, Utkal University (2013)

💼 Experience 

Jayaprakash has served as Project Associate for CSIR Aroma Mission Phase-III (2023–present) and Phase-II (2021–2023). He worked as JRF in a DST-funded project at Malaviya National Institute of Technology (2017-2019) and undertook major and minor projects at IIT Delhi and IIT Guwahati. He has also contributed significantly to national and international exhibitions and research projects on medicinal and nano-based products.

🏆 Awards & Honors 

Jayaprakash has received multiple prestigious awards, including the Dr. A.P.J. Abdul Kalam National Star Award, Young Scientist Award, City Excellence Award, Global Icon Award, and Rabindranath Tagore Hall of Fame Award. He is also a five-time world record holder, recognized by the London Book of World Records, USA Book of World Records, and more. Additionally, he has received accolades for his innovative ideas and contributions from CSIR and other organizations.

🔬 Research Focus 

Jayaprakash’s research revolves around Polymer Chemistry, Materials Science, and Nanotechnology, focusing on skin and hair-related solutions, nanoparticle seed coatings, and medicinal products. His work includes nano formulations for agricultural use, innovative medicinal soaps for skin issues, and skin and hair care solutions. He has authored multiple international articles and patents on his discoveries, contributing to the advancement of green chemistry and sustainable material science.

Publication Top Notes

  1. Nano boron nitride laminated poly (ethyl methacrylate)/poly (vinyl alcohol) composite films imprinted with silver nanoparticles as gas barrier and bacteria resistant packaging
    • Year: 2024
    • Authors: J Behera, S Patra, S Nazrul, SK Sharma, D Kumar, MK Verma, AK Katare, …
    • Citations: 2

 

  1. Bioassay-guided fractionations of Cannabis sativa extract and HPLC-assisted purifications of anti-proliferative active fractions lead to the isolation of 16 known and …
    • Year: 2024
    • Authors: Y Nalli, S Bharti, T Amin, R Singh, J Behera, SS Bhayye, YP Bharitkar, …
    • Citations: 2

 

  1. Correction: Bioassay-guided fractionations of Cannabis sativa extract and HPLC-assisted purifications of anti-proliferative active fractions lead to the isolation of 16 known …
    • Year: 2024
    • Authors: Y Nalli, S Bharti, T Amin, R Singh, J Behera, SS Bhayye, YP Bharitkar, …

 

  1. Phytochemical investigation of anti-proliferative active fractions of Cannabis sativa leads to isolate a new Compound Canniprene A and other bioactive compounds through …
    • Year: 2023
    • Authors: Y Nalli, S Bharti, T Amin, R Singh, J Behera, A Goswami, MK Verma

Snigdha Singh | Medicinal Chemistry | Best Researcher Award

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 Dr. Snigdha Singh | Medicinal Chemistry | Best Researcher Award

Dr at University of Delhi, India

I am an Assistant Professor in the Department of Chemistry at the University of Delhi and a Resident Tutor at Ambedkar Ganguly Students House for Women. My research focuses on the design and synthesis of novel compounds with biological applications, and I have substantial expertise in molecular dynamics, nanoparticle synthesis, and heterocyclic chemistry. I hold a Ph.D. from the University of Delhi, and my research has led to several peer-reviewed publications and collaborations with prestigious international institutions.

profile:

Scopus

Orcid

🏛️ Current Positions

Assistant Professor Department of Chemistry, University of Delhi, India June 2023 – Present. Resident Tutor Ambedkar Ganguly Students House for Women, Delhi, India September 2023 – Present

🎓 Academic Background

Postdoctoral Research Associate Rensselaer Polytechnic Institute, Department of Chemistry and Chemical Biology March 2023 – May 2023 Advisor: Prof. Christopher Cioffi Project: “Design and Synthesis of Neuropathic Inhibitors”. Research Associate-III University of Delhi, Department of Chemistry March 2021 – December 2023 Advisor: Prof. Ramesh Chandra Project: “Design and Synthesis of nanoparticles and their biomedical application”. Guest Scientist Humboldt Universität zu Berlin, Institute for Chemistry Sep. 2022 – Dec. 2022 & Sep. 2021 – Jan. 2022 Advisor: Prof. Christoph Arenz Project: “Synthesis of potential analogs for ACER3 activity”. Ph.D. in Chemistry University of Delhi Nov. 2017 – Feb. 2021 Advisor: Prof. Ramesh Chandra Thesis: “Synthesis and Development of Novel Heterocycles and their biological evaluation”. Ph.D. Exchange Student
University of Oxford, Department of Chemistry, U.K. Dec. 2020 – Feb. 2021 Advisor: Prof. Edward Anderson Project: “Towards new treatments for Leishmaniasis and Chagas disease through Natural Product chemistry”. Ph.D. Exchange Student University of Siena, Department of Chemistry, Italy Oct. 2018 – July 2019 Advisor: Prof. Maurizio Taddei Project: “Synthesis of 8-hydroxyquinoline molecules as Hedgehog Gli-Inhibitors”. M.Sc. in Chemistry (H) University of Delhi July 2013 – July 2015 Thesis: “Microwave-Assisted Synthesis of Piperidine/Piperazine based molecules”. B.Sc. in Chemistry (H) University of Delhi July 2010 – June 2013

🏅 Awards and Fellowships

Indo-UK Newton Bhabha Scholar British Council (U.K.) for research at the University of Oxford, U.K. Dec 2020 – Feb 2021. Indo-Italy Exchange Scholarship Ministry of Human Resource Development (MHRD), India & Italian Embassy Cultural Centre Oct 2018 – June 2019. Young Scientist Travel Award International Society for the study of Xenobiotics (ISSX) July 2019. Young Scientist Award University of Chemistry and Technology, Prague Sep 2019. Senior Research Fellowship (SRF) Indian Council of Medical Research (ICMR), India Dec 2018 – Dec 2020. UGC-CSIR-NET Examination 19th All India Rank Dec 2017. Merit Fellowship Hindu College, University of Delhi For 1st position in B.Sc Chemistry

🛠️ Skills

Multi-step organic reactions, heterocyclic synthesis. Handling inert-atmospheric conditions (Schlenk-line and glovebox). Binding studies of various blood proteins with anticancer drugs. Basic Cell culture, Maintenance of cancer cell lines, MTT assay, Apoptosis. Flash Chromatography, HPLC, NMR, IR, HRMS, UV-Vis, and fluorescence measurement analysis. Microsoft Office, Origin, Chem-draw, MestReNova, Joel Delta software analysis. Writing scientific reports, publications, and research projects

Publication:📝

 

  • Title: Precisely designed NIR based conjugated framework as a solid state emitter for selective recognition of cyanide ion in solid state and cancer cells
    • Journal: Journal of Photochemistry and Photobiology A: Chemistry
    • Year: 2024
    • DOI: 10.1016/j.jphotochem.2023.115373
    • EID: 2-s2.0-85178574911
    • ISSN: 10106030
    • Contributors: Kiran; Ranolia, A.; Rani, P.; Joshi, G.; Kumar, R.; Kumar, S.; Kumar, P.; Singh, S.; Sindhu, J.

 

  • Title: Synthesis and characterization of Fe3O4@SiO2@PDA@Ag core–shell nanoparticles and biological application on human lung cancer cell line and antibacterial strains
    • Journal: Artificial Cells, Nanomedicine, and Biotechnology
    • Year: 2024 (Published on 2024-12-31)
    • DOI: 10.1080/21691401.2023.2295534
    • Contributors: Snigdha Singh; Tanya Goel; Aarushi Singh; Heerak Chugh; Nayanika Chakraborty; Indrajit Roy; Manisha Tiwari; Ramesh Chandra

 

  • Title: Rationally designed dual channel reversible probe for cyanide recognition in aqueous medium with solid-state sensing abilities
    • Journal: Journal of Photochemistry and Photobiology A: Chemistry
    • Year: 2024 (Published on 2024-08)
    • DOI: 10.1016/j.jphotochem.2024.115650
    • Contributors: Kiran; Anju Ranolia; Priyanka; Indu Bala; Jyoti Jangir; Snigdha Singh; Jayant Sindhu; Parvin Kumar; Devender Singh

 

  • Title: Rationally designed C-3 sulfenylated 2-phenyl-4H-pyrido[1,2-a]pyrimidin-4-one based fluorescent probe for recognition of Fe3+
    • Journal: Journal of Molecular Structure
    • Year: 2024 (Published on 2024-04)
    • DOI: 10.1016/j.molstruc.2023.137456
    • Contributors: Priyanka; Payal Rani; Kiran; Ramesh Kataria; Parvin Kumar; Devender Singh; Anil Duhan; Snigdha Singh; Jayant Sindhu

 

  • Title: An expeditious on-water regioselective synthesis of novel arylidene-hydrazinyl-thiazoles as DNA targeting agents
    • Journal: Bioorganic Chemistry
    • Year: 2023
    • DOI: 10.1016/j.bioorg.2023.106524
    • EID: 2-s2.0-85152729436
    • ISSN: 10902120, 00452068
    • Contributors: Aggarwal, R.; Hooda, M.; Kumar, P.; Kumar, S.; Singh, S.; Chandra, R.

 

  • Title: Biological activity and structure-activity relationship of dehydrodieugenol B analogues against visceral leishmaniasis
    • Journal: RSC Medicinal Chemistry
    • Year: 2023
    • DOI: 10.1039/d3md00081h
    • EID: 2-s2.0-85162997205
    • ISSN: 26328682
    • Contributors: Amaral, M.; Asiki, H.; Sear, C.E.; Singh, S.; Pieper, P.; Haugland, M.M.; Anderson, E.A.; Tempone, A.G.

 

Antonios Kousaxidis | Medicinal Chemistry | Best Researcher Award

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 Mr. Antonios Kousaxidis | Medicinal Chemistry |Best Researcher Award

 Mr at School of Pharmacy, Aristotle University of Thessaloniki, Greece

A seasoned educator and researcher with extensive experience in physics, holding positions from Assistant to Associate Professor at IAU, Urmia, and Urmia University of Technology. Specialized in teaching a range of undergraduate to Ph.D. courses including Quantum Mechanics, Laser Physics, and Nonlinear Dynamical Systems. Proficient in Maple and Matlab programming with a strong background in finite element method analysis. Led impactful research projects in chaotic systems, cancer treatment, and national security, earning multiple awards including the Kharazmi Scientific Festival Second Prize. A recognized leader in academia with a commitment to advancing scientific knowledge and education.

Profile

  1. Scopus

🎓 Education:

Master’s Degree in Medicinal Chemistry: (9.85/10) from Departments of Chemistry, Medicine, Biological Applications and Technology, University of Ioannina, 45110, Ioannina, Greece. Bachelor’s Degree in Chemistry: (7.76/10) from Department of Chemistry, School of Sciences, University of Ioannina, 45110, Ioannina, Greece.

Personal Skills:

Synthetic Organic Chemistry and Biochemistry: Training in synthetic organic chemistry and biochemistry applied to drug design, with experience in several areas of synthetic methodology using retrosynthetic approaches. Metal-Based Coupling Reactions: Excellent knowledge and practice of metal-based coupling reactions in modern organic chemistry. Synthetic Routes Optimization: Training in synthetic routes optimization using one-pot reactions during master’s thesis. Analytical Methods: Proficient in NMR, IR, UV, and mass spectrometry for identifying organic compounds. Small Molecule Synthesis: Synthesis of small molecule organic compounds and isolation by recrystallization. Purification and Separation: Excellent knowledge and practice in chromatographic methods like column, preparative, and thin-layer chromatography for purifying and separating organic compounds. Biochemical Protocols: Good practice in using biochemical protocols for enzyme kinetics experiments. Drug Discovery Programs: Extensive experience in drug discovery programs, structure-based drug design, molecular docking, and SAR estimation models using in silico methods (Discovery Studio, Chimera, LigandScout, PyMOL, OpenBabel, ADMET). Scientific Manuscripts: Proficient in writing and preparing scientific manuscripts.

💻 Software Skills:

Office Suite (ECDL degree) – Word processing, spreadsheets, presentations, etc. Calculative and predictive programs like MestReNova, Topspin DataAnalysis, ChemDraw Ultra, MedChem Designer, and BioLoom.

Research Focus:

A. Kousaxidis primarily focuses on the design and synthesis of novel compounds with therapeutic potential, particularly targeting enzymes such as aldose reductase (ALR2) and protein tyrosine phosphatase 1B (PTP1B). The research also encompasses antimicrobial agents, lipoxygenase inhibitors, and therapeutic strategies for conditions like diabetes mellitus and sepsis.

Publications Top Notes 📝

  • A Molecular Hybridization Approach for the Design of Selective Aldose Reductase (ALR2) Inhibitors and Exploration of Their Activities Against Protein Tyrosine Phosphatase 1B (PTP1B)
    • Authors: Kousaxidis, A., Petrou, A., Rouvim, P., Nicolaou, I., Geronikaki, A.
    • Journal: Journal of Molecular Structure
    • Year: 2023
    • Volume: 1271
    • Article Number: 134116
    • Citations: 3
    • Summary: This study presents a hybridization approach to develop selective ALR2 inhibitors and investigates their potential activities against PTP1B, highlighting their dual therapeutic potential.

 

  • Design, Synthesis, and Pharmacological Evaluation of Indazole Carboxamides of N-Substituted Pyrrole Derivatives as Soybean Lipoxygenase Inhibitors
    • Authors: Lavrentaki, V., Kousaxidis, A., Theodosis-Nobelos, P., Koutsopoulos, K., Nicolaou, I.
    • Journal: Molecular Diversity
    • Year: 2023
    • Citations: 2
    • Summary: This paper discusses the synthesis and evaluation of novel indazole carboxamides, demonstrating significant inhibitory activity against soybean lipoxygenase.

 

  • N-Derivatives of (Z)-Methyl 3-(4-Oxo-2-thioxothiazolidin-5-ylidene)methyl)-1H-indole-2-carboxylates as Antimicrobial Agents—In Silico and In Vitro Evaluation
    • Authors: Petrou, A., Geronikaki, A., Kartsev, V., Nicolaou, I., Vizirianakis, I.S.
    • Journal: Pharmaceuticals
    • Year: 2023
    • Volume: 16
    • Issue: 1
    • Article Number: 131
    • Citations: 4
    • Summary: This open-access article evaluates the antimicrobial activity of new N-derivatives, supported by both in silico and in vitro methods.

 

  • Non-acidic Bifunctional Benzothiazole-Based Thiazolidinones with Antimicrobial and Aldose Reductase Inhibitory Activity as a Promising Therapeutic Strategy for Sepsis
    • Authors: Kousaxidis, A., Kovacikova, L., Nicolaou, I., Stefek, M., Geronikaki, A.
    • Journal: Medicinal Chemistry Research
    • Year: 2021
    • Volume: 30
    • Issue: 10
    • Pages: 1837-1848
    • Citations: 13
    • Summary: This research explores benzothiazole-based thiazolidinones with dual activity, suggesting a promising approach for treating sepsis.

 

  • Aldose Reductase and Protein Tyrosine Phosphatase 1B Inhibitors as a Promising Therapeutic Approach for Diabetes Mellitus
    • Authors: Kousaxidis, A., Petrou, A., Lavrentaki, V., Nicolaou, I., Geronikaki, A.
    • Journal: European Journal of Medicinal Chemistry
    • Year: 2020
    • Volume: 207
    • Article Number: 112742
    • Citations: 39
    • Summary: This review highlights the potential of targeting ALR2 and PTP1B as a therapeutic strategy for diabetes, emphasizing recent advances and future perspectives.

 

Monika Kopeć | medical chemistry | Young Scientist Award

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Dr. Monika Kopeć | medical chemistry | Young Scientist Award

👨‍🏫Profile Summary

In 2018, I earned a doctorate in chemical science from the Faculty of Chemistry at Lodz University of Technology, specializing in the study of biological systems using spectroscopic techniques. Additionally, I completed a master’s program in logistics with a focus on supply chain management. With nine years of experience in chemistry, including managing research projects, I have honed my skills in team collaboration and project management. I have also undertaken various courses and workshops to enhance my expertise, including those in self-motivation, effective learning, and commercializing research. Now, I aim to further expand my knowledge and skills in research techniques and seek opportunities in leading chemical or logistics companies.

🌐 Professional Profiles

 

Educational Qualifications 📚

Postgraduate Studies in Data Analysis and Data Mining University of Lodz, Faculty of Mathematics and Computer Science October 2021 – June 2022 PhD Studies in Chemistry Lodz University of Technology, Faculty of Chemistry October 2013 – September 2018 Dissertation awarded by the Council of the Chemical Faculty of Lodz University of Technology Postgraduate Studies in Forensic Biology University of Lodz, Faculty of Biology October 2014 – March 2016 Masters Studies in Logistics with Major in Supply Chain Management University of Lodz, Faculty of Management October 2012 – July 2014 Masters Studies in Chemistry with Major in Medical Chemistry Lodz University of Technology, Faculty of Chemistry March 2012 – July 2013 Engineering Studies in Chemistry with Major in Chemical Analysis in Environmental Control and Quality Engineering Lodz University of Technology, Faculty of Chemistry October 2008 – January 2012 Biologically-Chemical Profile High Comprehensive School S. Żeromskiego in Ozorków September 2005 – June 2008

Work Experience 💼

Lecturer Lodz University of Technology October 2019 – Present Responsibilities include experimental analysis, conducting classes, and research documentation. Postdoctoral Fellowship Jagiellonian University in Krakow January 2023 – February 2023 Engineering and Technical Specialist Lodz University of Technology May 2019 – December 2021 Duties involved equipment preparation, chemical reagent management, and ordering. Assistant Lodz University of Technology October 2018 – October 2019 Conducted experimental analysis, classes, and research documentation. Chemist Lodz University of Technology October 2015 – November 2018 Prepared reagents, conducted spectroscopy measurements, and provided technical support. PhD Student Lodz University of Technology October 2013 – September 2018 Conducted measurements using spectroscopy techniques. Apprenticeships Institute of Polymer and Dye Engineering in Zgierz District Police Headquarters in Zgierz July 2011 – August 2011 / July 2010 – August 2010 Hostess Cursor S.A. Sales & Marketing Services August 2009 – September 2009 Trainee District Police Headquarters in Zgierz June 2008 – September 2008

Trainings and Workshops 🎓

AFM Modes Training: Contact, tapping, ScanAsyst, Resonance Enhanced AFM-IR, Tapping AFM-IR, and Micro View Dates: 05.12.2022 – 09.12.2022 Laboratory Procedures Training: Operation and proper use of equipment such as the CO2 incubator Memmert ICO150med, laboratory centrifuge MPW 260R with cooling, and laminar chamber II safety class ESCO AIRSTREAM type AC2-4EB Dates: 4.10.2022 – 6.10.2022 Techniques Training: SDS-PAGE, Western Blot, and visualization of protein gels using Comassie and Stain-Free methods Usage of the Mini-Protean Tetra Cell, Trans-Blot Turbo, and ChemiDoc MP systems Dates: 4.10.2022 – 6.10.2022 Microscope and Imaging Software Training: Use of the Leica DMiL LED inverted microscope, Leica FLEXACAM C1 camera, and Leica LAS X software Quick Reading and Effective Learning Methods Course Commercialization of Research and Establishing Cooperation with Industry Workshop Team Coaching Workshop: Motivating Members to Achieve Common Goals Zetasizer and Nanosight Analyzers Training for Particle Size Measurements Training on the Use of Nanomaterials in Nanomedicine and Bionanotechnology Self-Motivation and Team Motivation Workshop

Projects 🚀

Raman Imaging of Human Cancerous Tissue and Cell Cultures (2016) Function: Project Manager Identification of Tumor Changes Based on Imaging and Raman Spectroscopy (2019) Function: Project Contractor Raman Imaging and Endospectroscopy in Oncological Omic Studies (2020 – 2022) Function: Project Contractor Analysis of Angiogenesis Process in Human Breast Tissue Using Raman Spectroscopy (2020 – 2021) Function: Project Manager Influence of Sugars on Metabolism of Lung Cancer Cells (2022) Function: Project Manager The Triangle: Carotenoids-Retinoids-Cytochromes in Cancer Progression (2022 – Present) Function: Project Contractor

Awards 🏆

  • Various Scholarships and Rector’s Scholarships during PhD Studies (2014 – 2018)
  • Platinum Medal at International Warsaw Invention Show (2019)
  • Award of the Rector of the Medical University of Lodz (2019)
  • Award for Scientific Achievements in Spectroscopic Identification of Cancer Changes (2019)
  • Award Supporting Scientific Excellence under the “Initiative of Excellence – Research University” Program (2020, 2021)

📚Top Noted Publication

  1. Title: Revision of Commonly Accepted Warburg Mechanism of Cancer Development: Redox-Sensitive Mitochondrial Cytochromes in Breast and Brain Cancers by Raman Imaging
    • Authors: H. Abramczyk, J. Surmacki, B. Brozek-Pluska, M. Kopec
    • Journal: Cancers
    • DOI: 10.3390/cancers13112599
    • Publication Date: Unknown

 

  1. Title: Raman imaging and statistical methods for analysis various type of human brain tumors and breast cancers
    • Authors: M. Kopec, J. Surmacki, M. Błaszczyk, M. Radek, H. Abramczyk
    • Journal: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
    • DOI: 10.1016/j.saa.2021.120091
    • Publication Date: 2021

 

  1. Title: The role of pro- and antiangiogenic factors in angiogenesis process by Raman spectroscopy
    • Authors: M. Kopec, H. Abramczyk
    • Journal: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
    • DOI: 10.1016/j.saa.2021.120667
    • Publication Date: 2021

 

  1. Title: Double face of cytochrome c in cancers by Raman imaging
    • Authors: H. Abramczyk, B. Brożek-Płuska, M. Kopeć
    • Journal: Scientific Reports
    • DOI: Link
    • Publication Date: 2022

 

  1. Title: Analysis of eggs depending on the hens’ breeding systems by Raman spectroscopy

 

  1. Title: Decoding Breast Cancer Metabolism: Hunting BRCA Mutations by Raman Spectroscopy
    • Authors: M. Kopec, B. Romanowska-Pietrasiak, H. Abramczyk
    • Journal: Photochem
    • DOI: 10.3390/photochem2030048
    • Publication Date: 2022

 

  1. Title: Hyperglycemia and cancer in human lung carcinoma by means of Raman spectroscopy and imaging
    • Authors: M. Kopec, K. Beton, K. Jarczewska, H. Abramczyk
    • Journal: Scientific Reports
    • DOI: 10.1038/s41598-022-21483-y
    • Publication Date: 2022

 

  1. Title: Hemoglobin and cytochrome c. reinterpreting the origins of oxygenation and oxidation in erythrocytes and in vivo cancer lung cells
    • Authors: H. Abramczyk, J.M. Surmacki, M. Kopeć, K. Jarczewska, B. Romanowska-Pietrasiak
    • Journal: Scientific Reports
    • DOI: 10.1038/s41598-023-41858-z
    • Publication Date: 2023

 

  1. Title: Raman imaging and chemometric methods in human normal bronchial and cancer lung cells: Raman biomarkers of lipid reprogramming

 

  1. Title: The role of glucose and fructose on lipid droplet metabolism in human normal bronchial and cancer lung cells by Raman spectroscopy

Simone Giovannuzzi | Medicinal chemistry | Young Scientist Award

Posted on by ScienceFather

 Dr . Simone Giovannuzzi | Medicinal chemistry | Young Scientist Award

👨‍🏫Profile Summary

Dedicated researcher with a strong academic background in Pharmaceutical Sciences, specializing in drug development and computational chemistry. Recently awarded a PhD in Advanced Materials and Data Science, with expertise in multi-scale modeling and simulation of composite materials. Proficient in implementing computational methods and artificial intelligence models to advance pharmaceutical research. Fluent in English, French, and Arabic.

🌐 Professional Profiles

  1. Scopus Profile

 

  1. Orcid Profile

 

🎓 Education

PhD cum laude in Area del Farmaco e Trattamenti Innovativi: Curriculum Scienze Farmaceutiche NEUROFARBA Department, University of Florence, Italy Nov 2020 – Oct 2023 Qualification to practise the profession of Pharmacist National exam for professional qualification Jul 2020 5-year single-cycle Master’s Degree in Pharmaceutical Chemistry and Technologies Faculty of Pharmacy, University of Florence, Italy
Oct 2015 – Jun 2020

🔬Work Experience

Post-Doctoral Researcher in Area del Farmaco NEUROFARBA Department, University of Florence, Italy Nov 2023 – Present Tutor Senior in Area del Farmaco PNRR Plan “Orientamento attivo nella transizione scuola-Università”, Next Generation EU programme (NGEU) Oct 2023 – Present Tutor In-itinere for Chemistry, Organic Chemistry and Spectroscopic Methods Scuola di Scienze della Salute Umana, Corso di Scienze Farmaceutiche Applicate – Controllo Qualità (SFA-CQ), University of Florence, Italy Mar 2021 – Dec 2023 Internship Centre National de la Recherche Scientifique (CNRS), Montpellier, Occitanie, France Feb 2022 – Jul 2022

🔬Reviewer

Reviewer for international peer-reviewed scientific journals with high impact factor: Expert opinion on Therapeutic Patent Journal of Enzyme Inhibition and Medicinal Chemistry Frontiers Molecules Future Medicinal Chemistry Journal of the Turkish Chemical Society, Section A

🤝Major Ongoing Collaborations

Prof. J.Y. Winum, CNRS Montpellier, France, Prof. C. Capasso, CNR Napoli, Italy, Prof. G. De Simone, CNR Napoli, Italy, Prof. A.B. Vermelho, U. di Rio de Janeiro, Brazil, Prof. A. Aspatwar, U. Di Tampere, Finland, Prof. M. Bucciantini, U. Di Firenze, Italy, Prof. A. Ligresti, ICB Napoli, Italy Prof. F. Borges, U. di Porto, Portugal, Prof. Daniel P. Flaherty, U. di Purdue, USA, Mohamed N. Seleem, U. della Virgina, USA, Prof. S. Carradori, U. di Chieti, Italy

🧠Personal Skills

Excellent collaboration and coaching skills within a team, Outstanding problem-solving abilities, Strong adaptability and flexibility, Excellent active listening skills, Excellent creativity, Strong inclination towards research, Excellent multitasking and time management skills

💻Technical Skills

NMR, IR Spectroscopy, UV-Vis and Fluorescence Absorption, Multi-Step synthesis, Structure-Activity Relationship (SAR) Studies, Stopped-Flow Technique, Literature Review and Patent Analysis

🖥️Digital Skills

ChemDraw, SciFinder, Reaxys, Topspin, Origin, MestReNova, MS Office, E-Learning Platform, AI tools (ChatGPT, Perplexity)

📚Top Noted Publication

  1. Year: 2022
    • Journal: Composite Structure Journal
    • Title: Multiparametric modeling of composite materials based on non-intrusive PGD informed by multiscale analyses: Application for real-time stiffness prediction of woven composites.

 

  1. Year: 2023
    • Journal: Journal of the Mechanics and Physics of Solids
    • Title: Multiscale Thermodynamics-Informed Neural Networks (MuTINN) towards Fast and Frugal Inelastic Computation of Woven Composite Structures.

 

  1. Year: 2023 (under process)
    • Journal: Composite Structure Journal
    • Title: Multiparametric modeling of composite materials based on non-intrusive PGD informed by multiscale analyses: Application for real-time virtual testing of woven composites.