PhD Reseracher, Tomsk Polytechnic University Russia
Anastasia Kovrizhina is a Russian researcher specializing in organic chemistry and biotechnology. She holds a Ph.D. from National Research Tomsk Polytechnic University, where she focuses on molecular modeling and the synthesis of biologically active compounds. Currently, she is a researcher at Tomsk Polytechnic University and serves as a scientist secretary. Her work includes the development of novel kinase inhibitors and fluorocarbon aza-heterocycles for anticancer treatments. She has been actively involved in international collaborations, including research internships at Montana State University, USA, and Novosibirsk Institute of Organic Chemistry, Russia. With an h-index of 7, she has published extensively in high-impact journals and has presented at numerous international and national conferences. She has received multiple prestigious scholarships and awards, including the Baden-WΓΌrttemberg State Scholarship and the Government Scholarship of the Russian Federation. Her expertise spans chemical synthesis, biological assays, computational chemistry, and quantum calculations.
Profile
Scopus
Education π
Anastasia Kovrizhina earned her Ph.D. (2019-2023) in Organic Chemistry from National Research Tomsk Polytechnic University, specializing in molecular modeling and drug synthesis. She completed her Masterβs degree (2017-2019) in Biotechnology at the same institution, where she studied organic and applied chemistry. During her studies, she participated in an academic exchange at Karlsruhe Institute of Technology, Germany, where she took courses in bioinformatics, bioprocessing, and enzymology. She obtained her Bachelorβs degree (2013-2017) in Biotechnology from National Research Tomsk Polytechnic University, with a strong foundation in chemistry, physics, and humanities. Her academic journey has been complemented by advanced training in computational chemistry, quantum calculations, and SAR/QSAR analysis. She has also gained international exposure through scholarships and research projects focused on innovative drug development. Her multidisciplinary education allows her to integrate experimental and computational approaches for pharmaceutical and medical applications.
Experience π§βπ«
Anastasia Kovrizhina is currently a researcher at Tomsk Polytechnic University, specializing in the synthesis of biologically active compounds. She also serves as a scientist secretary at the School of Advanced Manufacturing Technologies and is an active member of the Council of Young Scientists. She has undertaken research internships at the Novosibirsk Institute of Organic Chemistry (2020) and Montana State University, USA (2019), where she collaborated on immunology and organic chemistry projects. Her work includes grant-funded research on kinase inhibitors, fluorocarbon aza-heterocycles, and polymer scaffolds for cardiovascular applications. She has supervised undergraduate and masterβs students and has taught courses in professional English and organic chemistry. Her expertise includes molecular modeling, chemical synthesis, and computational chemistry. She has contributed to multiple research projects under the Russian Science Foundation and has been instrumental in developing innovative drug delivery systems for anticancer treatments.
Awards & Honors π
Anastasia Kovrizhina has received several prestigious awards, including the First Degree Diploma (2024) for her research on indenoquinoxalinone oxime (IQ-1). She won the 5th All-Russian Research Competition (2020) for her work on indenoquinoxaline derivatives. She was honored with the 3rd Degree Medal for βAchievements for Tomsk Polytechnic Universityβ and the BAYHOST Scholarship for studying German (2020). She received the Baden-WΓΌrttemberg State Scholarship (2018-2019) and the Russian Government Scholarship (2018-2019). Her participation in international conferences has been recognized with numerous accolades. She has also secured multiple research grants, including the Russian Science Foundation grants for developing kinase inhibitors and fluorocarbon aza-heterocycles as anticancer agents. Her scientific contributions to drug discovery and pharmaceutical chemistry have positioned her as a promising young researcher in her field.
Research Interests π¬
Anastasia Kovrizhinaβs research focuses on the synthesis and molecular modeling of biologically active compounds, particularly kinase inhibitors and fluorocarbon aza-heterocycles for anticancer treatments. She has pioneered the development of JNK kinase inhibitors based on indenoquinoxaline scaffolds, which have potential anti-inflammatory applications. Her work has demonstrated that IQ-1 salts enhance the efficacy of cerebral ischemia treatment. She has conducted pharmacokinetic studies on IQ-1 absorption in the gastrointestinal tract to optimize drug formulation. Her expertise extends to computational chemistry, quantum calculations, and structure-activity relationship (SAR) studies. She is also involved in developing supramolecular complexes for innovative drug delivery. Her interdisciplinary approach integrates synthetic chemistry, computational modeling, and biological assays to advance pharmaceutical research. She has contributed significantly to drug design, molecular docking studies, and the synthesis of novel heterocyclic compounds for targeted therapies.
Publications π
- Title: 6,8-Dibromo-11H-indeno[1,2-b]quinolin-11-one
Year: 2024
Author: Anastasia R. Kovrizhina, Dauren Tolegen, Dmitry I. Pavlov, Andrei S. Potapov, Andrei I. Khlebnikov
Citations: Not available
Article: Molbank
- Title: Evaluation of Nitric Oxide-Donating Properties of 11H-indeno[1,2-b]quinoxalin-11-one Oxime (IQ-1) by Electron Paramagnetic Resonance Spectroscopy
Year: 2024
Author: Viacheslav V. Andrianov, Igor A. Schepetkin, Leah V. Bazan, Khalil L. Gainutdinov, Anastasia R. Kovrizhina, Dmitriy N. Atochin, Andrei I. Khlebnikov
Citations: Not available
Article: Molecules
- Title: Dose proportionality and bioavailability of quinoxaline-based JNK inhibitor after single oral and intravenous administration in rats
Year: 2024
Author: Galina A. Frelikh, Elena A. Yanovskaya, Alexander P. Lakeev, Galina A. Chernysheva, Vera I. Smolyakova, Anastasia R. Kovrizhina
Citations: Not available
Article: Xenobiotica
- Title: Neuroprotective Effects of Tryptanthrin-6-Oxime in a Rat Model of Transient Focal Cerebral Ischemia
Year: 2023
Author: Mark Plotnikov, Galina A. Chernysheva, Vera I. Smolβyakova, Oleg I. Aliev, Anna M. Anishchenko, Olga A. Ulyakhina, Eugene S. Trofimova, Anastasia A. Ligacheva, Nina D. Anfinogenova, Anton Osipenko et al.
Citations: Not available
Article: Pharmaceuticals
- Title: Novel Tryptanthrin Derivatives with Selectivity as cβJun NβTerminal Kinase (JNK) 3 Inhibitors
Year: 2023
Author: Igor A. Schepetkin, Oleksander S. Karpenko, Anastasia R. Kovrizhina, Liliya N. Kirpotina, Andrei I. Khlebnikov, Stepan I. Chekal, Alevtyna V. Radudik, Maryna O. Shybinska, Mark T. Quinn
Citations: Not available
Article: Molecules
- Title: Quantification of a promising JNK inhibitor and nitrovasodilator IQ-1 and its major metabolite in rat plasma by LCβMS/MS
Year: 2022
Author: Alexander P. Lakeev, Galina A. Frelikh, Elena A. Yanovskaya, Anastasia R. Kovrizhina, Vladimir V. Udut
Citations: Not available
Article: Bioanalysis
- Title: Poly(Ο΅-caprolactone) Scaffolds Doped with c-Jun N-terminal Kinase Inhibitors Modulate Phagocyte Activation
Year: 2019
Author: K.S. Stankevich, I.A. Schepetkin, S.I. Goreninskii, A.K. Lavrinenko, E.N. Bolbasov, A.R. Kovrizhina, L.N. Kirpotina, V.D. Filimonov, A.I. Khlebnikov, S.I. Tverdokhlebov et al.
Citations: Not available
Article: ACS Biomaterials Science and Engineering