Daniele Florio | Pharmaceutical science | Young Scientist Award

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Mr. Daniele Florio | Pharmaceutical science | Young Scientist Award

Daniele Florio is a dedicated researcher in pharmaceutical sciences, currently pursuing a Ph.D. at the University of Naples Federico II. His doctoral work focuses on integrated molecular approaches targeting mutated Nucleophosmin 1 in Acute Myeloid Leukemia, scheduled for completion in October 2024. Daniele brings extensive experience from his Marie Sklodowska-Curie secondment and voluntary internship, specializing in peptide synthesis, mass spectrometry, and spectroscopic techniques. With a strong publication record and active participation in international conferences, he contributes significantly to the fields of amyloid aggregation, chemical catalysis, and drug development, showcasing advanced skills in scientific research and analysis.

Profile

Scopus

šŸ‘Øā€šŸ«Professional Experience

Tutoring Activities (Grant Type B) 2023-2024, Naples, Italy, Department of Pharmacy, University of Naples Federico II, Provided supplementary teaching for Chemistry and Inorganic Chemistry courses for Pharmacy and CTF degree students. Ph.D. Candidate in Pharmaceutical Sciences (XXXVII Cycle) 2021 ā€“ Present, Naples, Italy, Department of Pharmacy, University of Naples Federico II, PhD Project: Integrated molecular approaches targeting mutated Nucleophosmin 1 in Acute Myeloid Leukemia., Scheduled PhD end: October 31, 2024. Secondee under Marie Skłodowska-Curie Research and Innovation Staff Exchange Action June 2022 ā€“ March 2023, Dublin, Ireland, Keladapharmachem, Participated in the GreenX4Drug (EU funded H2020 RISE project), focusing on developing novel asymmetric chemical catalysts for manufacturing high-value APIs and advanced intermediates.. Voluntary Internship Post-Degree 2018 ā€“ 2019, Naples, Italy, Department of Pharmacy, University of Naples Federico II, Designed, synthesized, and characterized peptides, peptidomimetics, and small molecules using solid-phase and solution methodologies. Utilized mass spectrometry (ESI) for identifying synthetic compounds and applied analytical and preparative methodologies (HPLC) for their purification and characterization. Conducted structural and functional characterization of biomolecules through spectroscopic techniques (CD, Fluorescence, SPR, UV-Vis). Supervisor: Prof. Daniela Marasco

šŸŽ“Education and Training

Biologist Board Examination February 7, 2022, University of Naples Federico II, Naples, Italy Masterā€™s Degree in Biological Science (Molecular Diagnostics Field) July 12, 2021, Naples, Italy Department of Pharmacy, University of Naples Federico II Experimental Thesis: “Protein fragments of Nucleophosmin 1 as models of amyloids”, Supervisor: Prof. Antonello Merlino, Co-Supervisor: Prof. Daniela Marasco,k Grade: 110/110. Bachelorā€™s Degree in Biological Science (Molecular Diagnostics Field) March 15, 2018, Naples, Italy Department of Pharmacy, University of Naples Federico II Experimental Thesis: “Amyloid-like aggregation of Nucleophosmin 1 regions related to Acute Myeloid Leukemia: spectroscopic studies” Supervisor: Prof. Daniela Marasco Grade: 106/110

šŸ“–Certifications

English TELSA C1, Grade B Language Certification ESAT, Malta Further & Higher Education Authority

Skills and Competencies

Organizational Skills

  • Efficient under pressure.
  • Adaptive to changes and new situations.
  • Strong independent work organization and goal achievement.

Job-related Skills

  • Solid-phase peptide synthesis and combinatorial peptide libraries using Fmoc/Boc chemistry.
  • Experience with various peptide synthesizers (BIOTAGE, Liberty Blue 2.0).
  • Proficient in analysis and purification using ESI mass spectrometry, HPLC, and flash purification systems.
  • Skilled in spectroscopic techniques (CD, Fluorescence, DLS, SPR, UV-Vis, FTIR, NMR).

Digital Skills

  • Proficient in Microsoft Office Suite.
  • Experienced with operating systems: MS-Windows, MacOS, LINUX.
  • Proficient in scientific data analysis software (GraphPad Prism).
  • Knowledgeable in databases (PubMed) and bibliographic management software (EndNote, Mendeley).
  • Proficient with video conferencing software (Teams, Skype, Zoom, Google Meet).
  • Excellent knowledge of major browsers (Edge, Chrome, Firefox, Safari, Opera).

šŸŒProjects

National Project Participation

  • BANDO-PRIN-2022. Research Project: Design, synthesis, and investigation of novel G-quadruplex aptamers against STAT3 and the interleukin-6 receptor (G4-APTASTAT).
  • Project Coordinator and Head of Research Unit: Prof. GALEONE Aldo

Bibliometric Parameters

  • H-index from Scopus: 11
  • Number of Publications: 24
  • Citations: 388

 

Publications Top Notes šŸ“

  • The effects of histidine substitution of aromatic residues on the amyloidogenic properties of the fragment 264ā€“277 of nucleophosmin 1
    • Authors: D. Florio, P. Luciano, C. Di Natale, D. Marasco
    • Journal: Bioorganic Chemistry
    • Volume: 147
    • Year: 2024
    • Pages: 107404

 

  • Could Targeting NPM1c+ Misfolding Be a Promising Strategy for Combating Acute Myeloid Leukemia?
    • Authors: D. Florio, D. Marasco
    • Journal: International Journal of Molecular Sciences
    • Volume: 25
    • Issue: 2
    • Year: 2024
    • Pages: 811

 

  • Modulation of hydrogel networks by metal ions
    • Authors: S. La Manna, D. Florio, C. Di Natale, D. Marasco
    • Journal: Journal of Peptide Science
    • Volume: 29
    • Issue: 8
    • Year: 2023
    • Article ID: e3474

 

  • Ruthenium complexes bearing glucosyl ligands are able to inhibit the amyloid aggregation of short histidine-peptides
    • Authors: D. Florio, S. La Manna, A. Annunziata, M. Monti, D. Marasco
    • Journal: Dalton Transactions
    • Volume: 52
    • Issue: 25
    • Year: 2023
    • Pages: 8549ā€“8557

 

  • Insights into Network of Hot Spots of Aggregation in Nucleophosmin 1
    • Authors: D. Florio, S. La Manna, C. Di Natale, A.M. Malfitano, D. Marasco
    • Journal: International Journal of Molecular Sciences
    • Volume: 23
    • Issue: 23
    • Year: 2022
    • Pages: 14704

 

  • Hydrogelation tunability of bioinspired short peptides
    • Authors: S. La Manna, D. Florio, V. Panzetta, C. Di Natale, D. Marasco
    • Journal: Soft Matter
    • Volume: 8
    • Year: 2022
    • Pages: 8

 

Faiyaz Shakeel |Pharmaceutical sciences | Best Researcher Award

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Ā Prof Dr. Faiyaz Shakeel | Pharmaceutical sciences |Best Researcher Award

Prof Dr. King Saud University, Saudi Arabia

šŸ‘©ā€šŸ”¬Highly accomplished in pharmaceutics, holds a Ph.D. and M. Pharm. from Jamia Hamdard University, India. With extensive experience as a Professor and Associate Professor at King Saud University, Riyadh, Saudi Arabia, and previous roles in academia and research, he excels in formulation research and development. His expertise spans nanoemulsions and transdermal dosage forms, contributing significantly to the field. Driven by a passion for innovation, he led groundbreaking projects, optimizing drug delivery systems for enhanced therapeutic outcomes. Eager to leverage his skills and knowledge, he seeks to join a renowned research organization, fostering growth and advancement in pharmaceutical sciences.šŸŒŸ

 

Profile

 

Scholar

 

šŸŽ“ Ā Objectives

Seeking association with a renowned research organization in formulation research and development to upgrade knowledge, research, and management skills in line with the latest trends. Eager to be part of a dynamic team contributing to organizational growth.

šŸ“š Ā Qualification Overview

Doctor of Philosophy (Ph.D.) in Pharmaceutics, Jamia Hamdard University, New Delhi, India, 2004-2007. Master of Pharmacy (M. Pharm.) in Pharmaceutics, Jamia Hamdard University, New Delhi, India, 2002-2004. Bachelor of Pharmacy (B. Pharm.), Jamia Hamdard University, New Delhi, India, 1998-2002.

šŸ‘Øā€šŸ« Professional Experience

Professor, King Saud University, Riyadh, Saudi Arabia (Feb 2022 – Present) Associate Professor, King Saud University, Riyadh, Saudi Arabia (Mar 2016 – Feb 2022) Assistant Professor, King Saud University, Riyadh, Saudi Arabia (Nov 2011 – Mar 2016) Lecturer, Garyounis University, Benghazi, Libya (Nov 2007 – Nov 2011) Senior Lecturer, Bhawani Shankar Anangpuria Institute of Pharmacy, Faridabad, India (Aug 2006 – Oct 2007) Guest Lecturer, Shri Gopichand College of Pharmacy, Baghpat, India (Jul 2004 – Jun 2006)

šŸ… Ā Professional Qualification

Ph.D. Title: Formulation and development of transdermal dosage form (Nanoemulsions) for antirheumatoid drug, Jamia Hamdard University, New Delhi, India, 2004-2007. M. Pharm. Title: Development and evaluation of bioadhesive transdermal gels of diclofenac diethylamine, Jamia Hamdard University, New Delhi, India, 2002-2004. B. Pharm., Jamia Hamdard University, New Delhi, India, 1998-2002.

šŸ”¬Ā Practical Experience

Master’s Research Project: Developed bioadhesive transdermal gels for diclofenac diethylamine. Ph.D. Thesis: Developed nanoemulsion and nanoemulsion gel formulations of celecoxib and aceclofenac for arthritis.

šŸ”Conclusion of Research Projects

Master’s Project: Optimized gel showed controlled drug release and significant anti-inflammatory effects. Ph.D. Thesis: Developed nanoemulsion formulations with controlled release, higher absorption, and significant pharmacodynamic effects.

Publications Top Notes šŸ“

  • Development and bioavailability assessment of ramipril nanoemulsion formulation
    • Authors: S Shafiq, F Shakeel, S Talegaonkar, FJ Ahmad, RK Khar, M Ali
    • Journal: European journal of pharmaceutics and biopharmaceutics
    • Year: 2007
    • Volume: 66
    • Issue: 2
    • Pages: 227-243
    • Citations: 1006

 

  • Nanoemulsions as vehicles for transdermal delivery of aceclofenac
    • Authors: F Shakeel, S Baboota, A Ahuja, J Ali, M Aqil, S Shafiq
    • Journal: Aaps Pharmscitech
    • Year: 2007
    • Volume: 8
    • Pages: 191-199
    • Citations: 427

 

  • Formulation development and optimization using nanoemulsion technique: a technical note
    • Authors: S Shafiq-un-Nabi, F Shakeel, S Talegaonkar, J Ali, S Baboota, A Ahuja, …
    • Journal: AAPS pharmscitech
    • Year: 2007
    • Volume: 8
    • Pages: E12-E17
    • Citations: 420

 

  • Design, development and evaluation of novel nanoemulsion formulations for transdermal potential of celecoxib
    • Authors: S Baboota, F Shakeel, A Ahuja, J Ali, S Shafiq
    • Journal: Acta pharmaceutica
    • Year: 2007
    • Volume: 57
    • Issue: 3
    • Pages: 315-332
    • Citations: 397

 

  • A review on the strategies for oral delivery of proteins and peptides and their clinical perspectives
    • Authors: A Muheem, F Shakeel, MA Jahangir, M Anwar, N Mallick, GK Jain, …
    • Journal: Saudi Pharmaceutical Journal
    • Year: 2016
    • Volume: 24
    • Issue: 4
    • Pages: 413-428
    • Citations: 384

 

hrishti Singh | Biomedical Engineering | Women Researcher Award

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Ā Dr. hrishti Singh | Biomedical Engineering | Women Researcher Award

Ā Dr. George Mason University, United States

šŸ‘©ā€šŸ”¬ With 5 years of experience as a biomedical engineer, scientist, and entrepreneur, I specialize in developing translational contrast agent platforms for enhancing early-stage tumor diagnosis. Additionally, I possess 1 year of healthcare product management experience as a Co-Founder of a biotech start-up. My expertise lies in problem-solving, stakeholder relationship management, and project planning, with a strong passion for innovation and improving patient outcomes through healthcare product development and leadership.

 

Profile

Scholar

Education šŸ“š

PhD in Bioengineering, George Mason University, Fairfax, VA (Aug. 2017 ā€“ Dec. 2022)Masters in Biomedical Engineering, University of Bridgeport, Bridgeport, CT (Aug. 2015 ā€“ Aug. 2017)Bachelors in Engineering (B.E) in Biotechnology, Ramaiah Institute of Technology, Bangalore, Karnataka (Aug. 2011 ā€“ Aug. 2015)

Technical Skills šŸ› ļø

Languages: Python, Matlab, Perl

Software Skills: Nanoscale Molecular Dynamics (NAMD), Adobe Illustrator

Experimental Skills: Gel Electrophoresis, Western Blotting, Flow Cytometry, Cell Culture, Biomaterial Design, Synthesis and Characterization, Lipid Nanoparticle Synthesis, Rheology of Soft Materials, Cyclic Voltammetry, Electroimpedance Spectroscopy, Scanning Electron Microscopy (SEM), Polymerase Chain Reaction (PCR), In-vitro Tissue Models, DNA Extraction, Cell Transfection, Enzyme-Linked Immunosorbent Assay (ELISA), In-vivo Ultrasound and Photoacoustic Imaging

Research Awards šŸ…

WeSci Women in STEM Crowdfunding Campaign Winner, 2023George Mason University Outstanding PhD Dissertation Award, 2023Biomedical Engineering Society Advanced Biomanufacturing (AbioM) Best Graduate Work Award, 2023George Mason University Office of Provost and Executive Vice-President Award, 2018University of Bridgeport School of Engineering Academic Accomplishment, 2017University of Bridgeport Faculty Research Day, Winner of Best Graduate Poster, 2017ASEE Northeast Conference, Honorable Mention in Best Graduate Poster, 2016IEEE CT-IETA, Third Place in Best Graduate Poster, 2016IEEE CT-IETA, Honorable Mention in Best Graduate Poster, 2016Ramaiah Institute of Technology Alumni Association, Best B.E Project, 2015

Highlighted Presentation šŸŽ¤

  • Gordon Imaging Institute and MGH, Harvard University (Invite) Aug. 2023
    • Oral: Non-invasive Whole Body PA Imaging of Small Animals using ICG dye constructs. Cambridge, MA

Presentations šŸ“Š

Biomedical Engineering Society Annual Meeting Oct. 2022Virginia Catalyst Conference Sept. 2022George Mason University ā€Mason Graduate Interdisciplinary Conferenceā€ Mar. 2022Biomedical Engineering Society Annual Meeting Oct. 2020Materials Research Society Annual Meeting Dec. 2019

Leadership and Volunteer Experience šŸ¤

President of Graduate Association for Bioengineering Students at George Mason University.Member of International Student Advisory Board at George Mason University.Responsible for mentoring undergraduate students.Part of Letters to Pre-Scientist Program exchanging letters with middle and high school female students to demonstrate the importance of women in STEM.

Relevant Skills šŸ§Ŗ

  • Nanomedicine
  • Biomaterials
  • Contrast Agents
  • Drug Delivery
  • Photoacoustic Imaging
  • Rational Design of Solutions to Health Problems
  • Grant Writing
  • Transformational Leadership
  • Strong Communication

Entrepreneurial Experience šŸ’¼

NIRView Biosciences Inc. (March 2023 – Present)Co-Founder and CEO, Fairfax, VA Responsible for identifying customer needs, conducting product-market fit analysis, and building sustainable business and revenue models. Define the vision of the product and communicate it to the product development team and stakeholders. Proposal writing to secure non-dilutive funding from different government agencies. National Science Foundation I-Corps Entrepreneurial Program (May 2023 – July 2023)Entrepreneurial Lead, NSF I-Corps Bay Area Node, UC Berkley Determined business plans, mission statements, and visions for public health products. Conducted extensive customer discovery interviews to determine product-market fit.

Relevant Media and Websites šŸ“°

Relevant Awards šŸ†

Key Personnel and Investigator on NSF Grant Award Number 2325234.1st place winner and Masonā€™s Choice Winner of Patriot Pitch Competition (2023).2nd place winner of Accelerate Investor Conference (2023) pitch competition.Principal Investigator on NSF Small Business Innovation and Research Grant.Contrast agent technology selected as STAT News Best 64 technologies in the United States, 2023.

Research Experience šŸ“Š

George Mason UniversityPostdoctoral Research Fellow (March 2023 – Present)Graduate Research Assistant (August 2019 – December 2022)Graduate Research Assistant (August 2017 – August 2018)

Publications Top Notes šŸ“

  • Title: Synthesis of DNA origami scaffolds: current and emerging strategies
  • Authors: J Bush, S Singh, M Vargas, E Oktay, CH Hu, R Veneziano
  • Journal: Molecules
  • Year: 2020

 

  • Title: Solar cells with PbS quantum dot sensitized TiO2ā€“multiwalled carbon nanotube composites, sulfide-titania gel and tin sulfide coated C-fabric
  • Authors: RK Kokal, M Deepa, A Kalluri, S Singh, I Macwan, PK Patra, J Gilarde
  • Journal: Physical Chemistry Chemical Physics
  • Year: 2017

 

 

  • Title: Interactions between avidin and graphene for development of a biosensing platform
  • Authors: I Macwan, MDH Khan, A Aphale, S Singh, J Liu, M Hingorani, P Patra
  • Journal: Biosensors and Bioelectronics
  • Year: 2017

 

 

  • Title: Size-tunable ICG-based contrast agent platform for targeted near-infrared photoacoustic imaging.
  • Authors: S Singh, G Giammanco, CH Hu, J Bush, LS Cordova, DJ Lawrence, …
  • Journal: Photoacoustics
  • Year: 2023

 

 

  • Title: A Computational Approach for Understanding the Interactions between Graphene Oxide and Nucleoside Diphosphate Kinase with Implications for Heart Failure
  • Authors: A Ray, I Macwan, S Singh, S Silwal, P Patra
  • Journal: Nanomaterials
  • Year: 2018

 

 

  • Title: Versatile encapsulation and synthesis of potent liposomes by thermal equilibration
  • Authors: SA Roberts, C Lee, S Singh, N Agrawal
  • Journal: Membranes
  • Year: 2022

 

 

  • Title: Increasing Vaccine Production using Pulsed Ultrasound Waves
  • Authors: J Xing, S Singh, Y Zhao, Y Duan, H Guo, C Hu, A Ma, R George, JZ Xing, …
  • Journal: PLOS One
  • Year: 2017

 

 

  • Title: Autonomously Propelled Colloids for Penetration and Payload Delivery in Complex Extracellular Matrices
  • Authors: S Singh, J Moran
  • Journal: Micromachines
  • Year: 2022

 

 

  • Title: Rational design of ICG-based contrast agents for near-infrared photoacoustic imaging
  • Authors: M Hanafi, N Such, G Giammanco, S Singh, D Wegierak, E Abenojar, …
  • Journal: Photons Plus Ultrasound: Imaging and Sensing
  • Year: 2024

 

  • Title: Transcranial photoacoustic imaging with ICG J-aggregates for imaging blood-brain barrier leak following LPS-induced neuroinflammation
  • Authors: FJ Bodera, S Singh, R Veneziano, PV Chitnis, MJ McVey, MC Kolios
  • Journal: Photons Plus Ultrasound: Imaging and Sensing
  • Year: 2024

 

 

  • Title: Modified j-aggregates and conjugates thereof
  • Authors: R Veneziano, PV Chitnis, S Singh
  • Journal: US Patent App.
  • Year: 2023

 

  • Title: Indocyanine green-based in-vivo photoacoustic imaging contrast agent platform (Conference Presentation)
  • Authors: S Singh, G Giammanco, C Hu, J Bush, LS Cordova, DJ Lawrence, …
  • Journal: Photons Plus Ultrasound: Imaging and Sensing
  • Year: 2023

 

  • Title: Computational Investigation of Chirality-Based Separation of Carbon Nanotubes Using Tripeptide Library
  • Authors: S Singh, HR Divecha, A Ayoola, M Xavierselvan, J Devlin, I Macwan
  • Journal: Biomolecules
  • Year: 2023

 

 

 

Marina Dimitrijevic | Physical Chemistry | Young Scientist Award

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Ā Ms. Marina Dimitrijevic | Plant Pathology | Young Scientist Award

Ms. University of Kragujevac, Faculty of Science Serbia

šŸ‘©ā€šŸ”¬ I am deeply passionate about chemistry and pharmaceutical research, with a focus on synthesis and pharmacological evaluation of bioactive compounds. My academic journey has been marked by significant contributions to the field, including the publication of research work in prestigious SCI-listed journals.šŸŒŸ

 

Profile

Orcid

 

EducationšŸŽ“

  • PhD Studies, Chemistry Faculty of Sciences, University of Kragujevac (Serbia) Specialization: Organic Chemistry Commenced: 2021. Master of Chemistry Department for Research and Development Faculty of Science, University of Kragujevac (Serbia) Duration: 2020-2021. Bachelor of Chemistry Department for Research and Development Faculty of Science, University of Kragujevac (Serbia) Duration: 2016-2020

šŸ’¼Work Experience

Research Trainee
University of Kragujevac, Faculty of Science, Department of Chemistry
2022 – Present

Conducting scientific research focused on the synthesis of heterocyclic compounds, with a specific emphasis on developing small molecules as potential inhibitors of the enzyme dihydroorotate dehydrogenase (hDHODH).Engaged in teaching Organic Chemistry courses, imparting knowledge and expertise to students.Acting as a mentor at the Regional Center for Talented Children in Kragujevac, guiding and supporting the development of young talents.

Ā Expertise

My areas of expertise include:

  • Synthesis of organic compounds
  • Spectroscopic analysis techniques
  • Chromatographic methods
  • Pharmacological properties and evaluation of compounds

Publications Top Notes šŸ“

  1. Title: Rapid access to pyrrolo[3,4-c]quinoline-1,3-diones: An improved synthetic protocol using a precursor prepared by Pfitzinger reaction
    • Journal: Tetrahedron
    • Volume: 132
    • Year: 2023
    • Pages: 133236

 

  1. Title: Discovery of a new class of potent pyrrolo[3,4-c]quinoline-1,3-diones based inhibitors of human dihydroorotate dehydrogenase: Synthesis, pharmacological and toxicological evaluation
    • Journal: Bioorganic chemistry
    • Volume: 147
    • Year: 2024
    • Pages: 107359