Antonios Kousaxidis | Medicinal Chemistry | Best Researcher Award

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Ā Mr. Antonios Kousaxidis | Medicinal Chemistry |Best Researcher Award

Ā Mr at School of Pharmacy, Aristotle University of Thessaloniki, Greece

A seasoned educator and researcher with extensive experience in physics, holding positions from Assistant to Associate Professor at IAU, Urmia, and Urmia University of Technology. Specialized in teaching a range of undergraduate to Ph.D. courses including Quantum Mechanics, Laser Physics, and Nonlinear Dynamical Systems. Proficient in Maple and Matlab programming with a strong background in finite element method analysis. Led impactful research projects in chaotic systems, cancer treatment, and national security, earning multiple awards including the Kharazmi Scientific Festival Second Prize. A recognized leader in academia with a commitment to advancing scientific knowledge and education.

Profile

  1. Scopus

šŸŽ“ Education:

Masterā€™s Degree in Medicinal Chemistry: (9.85/10) from Departments of Chemistry, Medicine, Biological Applications and Technology, University of Ioannina, 45110, Ioannina, Greece.Ā Bachelor’s Degree in Chemistry: (7.76/10) from Department of Chemistry, School of Sciences, University of Ioannina, 45110, Ioannina, Greece.

Personal Skills:

Synthetic Organic Chemistry and Biochemistry: Training in synthetic organic chemistry and biochemistry applied to drug design, with experience in several areas of synthetic methodology using retrosynthetic approaches. Metal-Based Coupling Reactions: Excellent knowledge and practice of metal-based coupling reactions in modern organic chemistry. Synthetic Routes Optimization: Training in synthetic routes optimization using one-pot reactions during masterā€™s thesis. Analytical Methods: Proficient in NMR, IR, UV, and mass spectrometry for identifying organic compounds. Small Molecule Synthesis: Synthesis of small molecule organic compounds and isolation by recrystallization. Purification and Separation: Excellent knowledge and practice in chromatographic methods like column, preparative, and thin-layer chromatography for purifying and separating organic compounds. Biochemical Protocols: Good practice in using biochemical protocols for enzyme kinetics experiments. Drug Discovery Programs: Extensive experience in drug discovery programs, structure-based drug design, molecular docking, and SAR estimation models using in silico methods (Discovery Studio, Chimera, LigandScout, PyMOL, OpenBabel, ADMET). Scientific Manuscripts: Proficient in writing and preparing scientific manuscripts.

šŸ’» Software Skills:

Office Suite (ECDL degree) – Word processing, spreadsheets, presentations, etc. Calculative and predictive programs like MestReNova, Topspin DataAnalysis, ChemDraw Ultra, MedChem Designer, and BioLoom.

Research Focus:

A. Kousaxidis primarily focuses on the design and synthesis of novel compounds with therapeutic potential, particularly targeting enzymes such as aldose reductase (ALR2) and protein tyrosine phosphatase 1B (PTP1B). The research also encompasses antimicrobial agents, lipoxygenase inhibitors, and therapeutic strategies for conditions like diabetes mellitus and sepsis.

Publications Top Notes šŸ“

  • A Molecular Hybridization Approach for the Design of Selective Aldose Reductase (ALR2) Inhibitors and Exploration of Their Activities Against Protein Tyrosine Phosphatase 1B (PTP1B)
    • Authors: Kousaxidis, A., Petrou, A., Rouvim, P., Nicolaou, I., Geronikaki, A.
    • Journal: Journal of Molecular Structure
    • Year: 2023
    • Volume: 1271
    • Article Number: 134116
    • Citations: 3
    • Summary: This study presents a hybridization approach to develop selective ALR2 inhibitors and investigates their potential activities against PTP1B, highlighting their dual therapeutic potential.

 

  • Design, Synthesis, and Pharmacological Evaluation of Indazole Carboxamides of N-Substituted Pyrrole Derivatives as Soybean Lipoxygenase Inhibitors
    • Authors: Lavrentaki, V., Kousaxidis, A., Theodosis-Nobelos, P., Koutsopoulos, K., Nicolaou, I.
    • Journal: Molecular Diversity
    • Year: 2023
    • Citations: 2
    • Summary: This paper discusses the synthesis and evaluation of novel indazole carboxamides, demonstrating significant inhibitory activity against soybean lipoxygenase.

 

  • N-Derivatives of (Z)-Methyl 3-(4-Oxo-2-thioxothiazolidin-5-ylidene)methyl)-1H-indole-2-carboxylates as Antimicrobial Agentsā€”In Silico and In Vitro Evaluation
    • Authors: Petrou, A., Geronikaki, A., Kartsev, V., Nicolaou, I., Vizirianakis, I.S.
    • Journal: Pharmaceuticals
    • Year: 2023
    • Volume: 16
    • Issue: 1
    • Article Number: 131
    • Citations: 4
    • Summary: This open-access article evaluates the antimicrobial activity of new N-derivatives, supported by both in silico and in vitro methods.

 

  • Non-acidic Bifunctional Benzothiazole-Based Thiazolidinones with Antimicrobial and Aldose Reductase Inhibitory Activity as a Promising Therapeutic Strategy for Sepsis
    • Authors: Kousaxidis, A., Kovacikova, L., Nicolaou, I., Stefek, M., Geronikaki, A.
    • Journal: Medicinal Chemistry Research
    • Year: 2021
    • Volume: 30
    • Issue: 10
    • Pages: 1837-1848
    • Citations: 13
    • Summary: This research explores benzothiazole-based thiazolidinones with dual activity, suggesting a promising approach for treating sepsis.

 

  • Aldose Reductase and Protein Tyrosine Phosphatase 1B Inhibitors as a Promising Therapeutic Approach for Diabetes Mellitus
    • Authors: Kousaxidis, A., Petrou, A., Lavrentaki, V., Nicolaou, I., Geronikaki, A.
    • Journal: European Journal of Medicinal Chemistry
    • Year: 2020
    • Volume: 207
    • Article Number: 112742
    • Citations: 39
    • Summary: This review highlights the potential of targeting ALR2 and PTP1B as a therapeutic strategy for diabetes, emphasizing recent advances and future perspectives.

 

Faiyaz Shakeel |Pharmaceutical sciences | Best Researcher Award

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Ā Prof Dr. Faiyaz Shakeel | Pharmaceutical sciences |Best Researcher Award

Prof Dr. King Saud University, Saudi Arabia

šŸ‘©ā€šŸ”¬Highly accomplished in pharmaceutics, holds a Ph.D. and M. Pharm. from Jamia Hamdard University, India. With extensive experience as a Professor and Associate Professor at King Saud University, Riyadh, Saudi Arabia, and previous roles in academia and research, he excels in formulation research and development. His expertise spans nanoemulsions and transdermal dosage forms, contributing significantly to the field. Driven by a passion for innovation, he led groundbreaking projects, optimizing drug delivery systems for enhanced therapeutic outcomes. Eager to leverage his skills and knowledge, he seeks to join a renowned research organization, fostering growth and advancement in pharmaceutical sciences.šŸŒŸ

 

Profile

 

Scholar

 

šŸŽ“ Ā Objectives

Seeking association with a renowned research organization in formulation research and development to upgrade knowledge, research, and management skills in line with the latest trends. Eager to be part of a dynamic team contributing to organizational growth.

šŸ“š Ā Qualification Overview

Doctor of Philosophy (Ph.D.) in Pharmaceutics, Jamia Hamdard University, New Delhi, India, 2004-2007. Master of Pharmacy (M. Pharm.) in Pharmaceutics, Jamia Hamdard University, New Delhi, India, 2002-2004. Bachelor of Pharmacy (B. Pharm.), Jamia Hamdard University, New Delhi, India, 1998-2002.

šŸ‘Øā€šŸ« Professional Experience

Professor, King Saud University, Riyadh, Saudi Arabia (Feb 2022 – Present) Associate Professor, King Saud University, Riyadh, Saudi Arabia (Mar 2016 – Feb 2022) Assistant Professor, King Saud University, Riyadh, Saudi Arabia (Nov 2011 – Mar 2016) Lecturer, Garyounis University, Benghazi, Libya (Nov 2007 – Nov 2011) Senior Lecturer, Bhawani Shankar Anangpuria Institute of Pharmacy, Faridabad, India (Aug 2006 – Oct 2007) Guest Lecturer, Shri Gopichand College of Pharmacy, Baghpat, India (Jul 2004 – Jun 2006)

šŸ… Ā Professional Qualification

Ph.D. Title: Formulation and development of transdermal dosage form (Nanoemulsions) for antirheumatoid drug, Jamia Hamdard University, New Delhi, India, 2004-2007. M. Pharm. Title: Development and evaluation of bioadhesive transdermal gels of diclofenac diethylamine, Jamia Hamdard University, New Delhi, India, 2002-2004. B. Pharm., Jamia Hamdard University, New Delhi, India, 1998-2002.

šŸ”¬Ā Practical Experience

Master’s Research Project: Developed bioadhesive transdermal gels for diclofenac diethylamine. Ph.D. Thesis: Developed nanoemulsion and nanoemulsion gel formulations of celecoxib and aceclofenac for arthritis.

šŸ”Conclusion of Research Projects

Master’s Project: Optimized gel showed controlled drug release and significant anti-inflammatory effects. Ph.D. Thesis: Developed nanoemulsion formulations with controlled release, higher absorption, and significant pharmacodynamic effects.

Publications Top Notes šŸ“

  • Development and bioavailability assessment of ramipril nanoemulsion formulation
    • Authors: S Shafiq, F Shakeel, S Talegaonkar, FJ Ahmad, RK Khar, M Ali
    • Journal: European journal of pharmaceutics and biopharmaceutics
    • Year: 2007
    • Volume: 66
    • Issue: 2
    • Pages: 227-243
    • Citations: 1006

 

  • Nanoemulsions as vehicles for transdermal delivery of aceclofenac
    • Authors: F Shakeel, S Baboota, A Ahuja, J Ali, M Aqil, S Shafiq
    • Journal: Aaps Pharmscitech
    • Year: 2007
    • Volume: 8
    • Pages: 191-199
    • Citations: 427

 

  • Formulation development and optimization using nanoemulsion technique: a technical note
    • Authors: S Shafiq-un-Nabi, F Shakeel, S Talegaonkar, J Ali, S Baboota, A Ahuja, …
    • Journal: AAPS pharmscitech
    • Year: 2007
    • Volume: 8
    • Pages: E12-E17
    • Citations: 420

 

  • Design, development and evaluation of novel nanoemulsion formulations for transdermal potential of celecoxib
    • Authors: S Baboota, F Shakeel, A Ahuja, J Ali, S Shafiq
    • Journal: Acta pharmaceutica
    • Year: 2007
    • Volume: 57
    • Issue: 3
    • Pages: 315-332
    • Citations: 397

 

  • A review on the strategies for oral delivery of proteins and peptides and their clinical perspectives
    • Authors: A Muheem, F Shakeel, MA Jahangir, M Anwar, N Mallick, GK Jain, …
    • Journal: Saudi Pharmaceutical Journal
    • Year: 2016
    • Volume: 24
    • Issue: 4
    • Pages: 413-428
    • Citations: 384