Thi Mong Diep Nguyen | Molecular Biology | Best Researcher Award

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Assoc Prof Dr. Omvir Singh| Molecular Biology | Best Researcher Award

šŸ”¬šŸ§¬ Holding a Doctor of Science in Life Science (Cell Biotechnology) from the University of Tours, France, I’ve delved into diverse realms including cell biology, microbiology, and animal reproduction. As a Visiting Professor at the University of FranƧois-Rabelais and an Associate Professor at Quy Nhon University, I’ve led research projects exploring avian reproductive biotechnologies and the impact of AMPK protein kinase on male gonad functions. My contributions to grants investigating hCG glycoforms and fertility treatments showcase my dedication to advancing scientific understanding. šŸŒ±šŸ‘Øā€šŸ”¬

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Training Background:

University of Tours, France Years: 4/2022 Major/ Specialty: Life Science (Cell biotechnology) Academic Degree: Doctor of Science University of FranƧois-Rabelais, Tours, France Years: 1/2020 – 3/2020 Major/ Specialty: Biotechnology Role: Visiting Professor Quy Nhon University Year: 1/2020 Major/ Specialty: Biotechnology Role: Associate Professor INRA _Institut national de la recherche agronomique (Nouzilly), France Years: 10/2018 – 2/2019, 11/2016 – 04/2017 Major/ Specialty: Animal Cell Biotechnology + Immunology + Gonadotropins Role: Postdoctoral Researcher FranƧois-Rabelais University, France Years: 11/2011 – 10/2015 Major/ Specialty: Life Science (Cell biotechnology) Academic Degree: Ph.D Quy Nhon University Years: 9/2005 – 6/2008 Major/ Specialty: Biology Academic Degree: Master Quy Nhon University Years: 9/2001 – 9/2005 Major/ Specialty: Biology Academic Degree: Bachelor

 

šŸ”Research Projects (Last 5 Years):

CRYOBIRD – Development of avian reproductive biotechnologies for the management of genetic diversity Years: 10/2010 – 10/2014 Funding Institution: France Role: Participant. Study on pathogenic microorganisms in Arachis Hypogaea L. in ecological condition of Hoai An district, Binh Dinh province Year: 2016 – 2017 Funding Institution: Quy Nhon University Role: Chairman Impact of AMPK protein kinase on male gonad and spermatozoa functions Years: 2018 – 2019 Funding Institution: Quy Nhon University Role: Chairman Characterization of new hCG glycoforms for implantation and early pregnancy diagnostic Years: 2017 – 2020 Funding Institution: France Role: Participant Investigation on the role of 5ā€™-AMP activated protein kinase (AMPK) in adenylate cyclase gene expression using pharmacologicals activators and human Luteinizing Hormone (hLH) or Forskolin stimulators in Leydig MLTC-1 cells Years: 2018 – 2020 Funding Institution: NAFOSTED Role: Chairman Production of single-chain gonadotropins for fertility treatments Years: 2020 – 2023 Funding Institution: VINIF Role: Chairman

Publications Top Notes šŸ“

  1. Highly-Sensitive In Vitro Bioassays for FSH, TSH, PTH, Kp, and OT in Addition to LH in Mouse Leydig Tumor Cell
    • Authors: Klett, D., Pellissier, L., Lomet, D., Jean-Alphonse, F., Combarnous, Y.
    • Year: 2023

 

  1. Undissociable chemically cross-linked and single-chain gonadotropins
    • Authors: Nguyen, T.M.D., Klett, D., Combarnous, Y.
    • Year: 2023

 

  1. Impact of microwave synthesis time on the shape of silver nanostructures and their antibacterial activity
    • Authors: Hoang, N.H., Nguyen, V.N., Nguyen, T.T., Nguyen, T.M.D.
    • Year: 2023

 

  1. Natural and recombinant equine chorionic gonadotropins past and future in animal reproductive technology
    • Authors: Thach, D.T., Cuong, B.K., Van Tong, H., Combarnous, Y., Nguyen, T.M.D.
    • Year: 2022

 

  1. Effect of fluoxetine on cyclic adenosine monophosphate response to follicle-stimulating hormone in HEK cells
    • Authors: Nguyen, T.T., Nguyen, T.M.D.
    • Year: 2022

 

  1. Membrane Hormone Receptors and Their Signaling Pathways as Targets for Endocrine Disruptors
    • Authors: Combarnous, Y., Nguyen, T.M.D.
    • Year: 2022

 

  1. Roles of Soluble Adenylyl Cyclase in cAMP Synthesis in Animal Cells
    • Author: Nguyen, T.M.D.
    • Year: 2022

 

Hyun Suk Shin | Molecular Biology | Best Researcher Award

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Ā Dr. Hyun Suk Shin | Molecular Biology | Best Researcher Award

Ā Dr. University of Las Palmas de Gran Canaria,Ā  Spain

šŸ‘©ā€šŸ”¬ Hyun Suk Shin is a Marine Biotechnology expert with a rich academic background. She holds a B.Sc., M.Sc., and Ph.D. from Korea Maritime and Ocean University, where she delved into various aspects of aquaculture, molecular biology, and biochemistry. With extensive research experience, including international collaborations, she has contributed significantly to the field, resulting in numerous publications and patents. As a postdoctoral researcher, she continued her impactful work at institutions like the National Fisheries Research and Development Institute of Korea and the FundaciĆ³n Canaria Parque CientĆ­fico TecnolĆ³gico de la Universidad de Las Palmas de Gran Canaria. Recognized for her excellence, she received prestigious scholarships and awards, demonstrating her dedication to advancing aquaculture research.

 

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Education šŸ“š

  1. Higher Degree
    • Name of Qualification: M.S. Science
    • Degree Awarding Entity: Korea Maritime and Ocean University
    • Date of Qualification: 28/02/2010
  2. Higher Degree
    • Name of Qualification: B.S. Science, Marine Biotechnology
    • Degree Awarding Entity: Korea Maritime and Ocean University
    • Date of Qualification: 28/02/2008

Doctorates

  • PhD Science
    • Degree Awarding Entity: Korea Maritime and Ocean University
    • Date of Degree: 28/02/2014

Teaching ExperiencešŸ“Š

Experience Supervising Doctoral Theses and/or Final Year Projects: Project Title: Analysis of Skeletal Deformities in Gilthead Sea Bream Entity: Universidad de las Palmas de Gran Canaria Type of Entity: University Student: Alvaro Lorenzo Felipe Date of Reading: 05/07/2022Project Title: Programa Mejora GenĆ©tica en CamarĆ³n Entity: Universidad de las Palmas de Gran Canaria Type of Entity: University

 

Scientific or Technological Activities šŸ”¬

R&D Projects Funded Through Competitive Calls of Public or Private Entities

  1. Project Name: AquaIMPACT: Genomic and Nutritional Innovation for Genetically Superior Farmed Fish

Keywords: Molecular markers and recognition; Genetics transcription; Genetics expression of regulations; Epigenetics; Genetic drift; Population geneticsType of Project: Research and development, including transferGeographical Area: European UnionDegree of Contribution: ResearcherEntity: Universidad de las Palmas de Gran CanariaType of Entity: UniversityCity of Entity: Las Palmas de Gran Canaria, Canary Islands, SpainPrincipal Investigators: Daniel Montero VĆ­torres; Marisol Izquierdo Lopez; Juan Manuel Afonso Lopez; Maria Jesus Zamorano Serrano; Silvia Torrecillas Burriel; Hyun Suk Shin; Cathaysa PĆ©rez GarcĆ­aNumber of Researchers: 72Number of People/Year: 14Type of Participation: Team memberProgramme Name: Horizon 2020 Research and InnovationCode: 818367Start-End Date: 01/01/2018 – 02/01/2023Duration: 5 yearsParticipating Entities: [List of entities involved]Total Amount: ā‚¬6,100,000Sub-Project Amount: ā‚¬702,913Percentage as Grant: 100%Relevant Results: Determining the additive genetic components of immune system traits of sea bream and sea bass populations under genetic selection pressure for growth.Dedication Regime: Part-timeApplicant’s Contribution: In this project, my contribution is assigned within the WP2: Nutritional Innovation: Precision nutrition for superior genotypes, through the following tasks:Evaluation and divergent selection of sea bream breeders for growth and absence of skeletal deformities.Breeding, marking, fattening, and characterization of offspring and breeders using microsatellite markers “SMsa-1/ SMsa-2”.Study of genetic parameters of immune system traits.

Project Name: PerformFISH – Consumer Driven Production: Integrating Innovative Approaches for Competitive and Sustainable Performance across the Mediterranean Aquaculture Value Chain

Keywords: Genetics expression of regulations; Genetic drift; Population geneticsType of Project: Research and development, including transferGeographical Area: European Union[Include any additional information about the project here]

Publications Top Notes šŸ“

  • Effects of LED light spectra on oxidative stress and the protective role of melatonin in relation to the daily rhythm of the yellowtail clownfish, Amphiprion clarkii
    • Authors: HS Shin, J Lee, CY Choi
    • Journal: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology
    • Year: 2011

 

  • Effect of LED light spectra on starvation-induced oxidative stress in the cinnamon clownfish Amphiprion melanopus
    • Authors: CY Choi, HS Shin, YJ Choi, NN Kim, J Lee, GS Kil
    • Journal: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology
    • Year: 2012

 

  • Kisspeptin regulates the hypothalamusā€“pituitaryā€“gonad axis gene expression during sexual maturation in the cinnamon clownfish, Amphiprion melanopus
    • Authors: NN Kim, HS Shin, YJ Choi, CY Choi
    • Journal: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology
    • Year: 2014

 

  • Effects of LED light spectra on the growth of the yellowtail clownfish Amphiprion clarkii
    • Authors: HS Shin, J Lee, CY Choi
    • Journal: Fisheries Science
    • Year: 2012

 

  • Profiles of antioxidant gene expression and physiological changes by thermal and hypoosmotic stresses in black porgy (Acanthopagrus schlegeli)
    • Authors: KW An, NN Kim, HS Shin, GS Kil, CY Choi
    • Journal: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology
    • Year: 2010

 

  • The effects of quercetin on physiological characteristics and oxidative stress resistance in olive flounder, Paralichthys olivaceus
    • Authors: HS Shin, JH Yoo, TS Min, KY Lee, CY Choi
    • Journal: Asian-Australasian Journal of Animal Sciences
    • Year: 2010

 

  • Selection for growth is associated in gilthead sea bream (Sparus aurata) with diet flexibility, changes in growth patterns and higher intestine plasticity
    • Authors: E Perera, P SimĆ³-Mirabet, HS Shin, E Rosell-Moll, F Naya-CatalĆ”, …
    • Journal: Aquaculture
    • Year: 2019

 

  • Quantitative mRNA expression of sox3 and DMRT1 during sex reversal, and expression profiles after GnRHa administration in black porgy, Acanthopagrus schlegeli
    • Authors: HS Shin, KW An, MS Park, MH Jeong, CY Choi
    • Journal: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology
    • Year: 2009

 

Annesha Chakraborty| Bioinformatics | Women Researcher Award

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Ā Dr. Annesha Chakraborty | Bioinformatics | Women Researcher Award

Ā Dr. SASTRA DEEMED UNIVERSITY

šŸ‘©ā€šŸ”¬ A highly motivated Ph.D. candidate at SASTRA Deemed University, specializing in Bioinformatics and Biomolecular Crystallography, with hands-on experience in molecular docking, dynamics, and laboratory techniques. Possessing an M.Sc. in Microbiology and B.Sc. (Hons.) in Microbiology, Chemistry, and Botany, I excel in research and academic achievements. As a Research Intern at MEAB LAB and Lab Tech. Intern at Suraksha Diagnostic Pvt. Ltd., I contributed to multiple publications and gained expertise in DNA/RNA extraction and PCR. Currently engaged in molecular dynamics studies on COVID Mpro, biomass production, and A.baumanniiā€™s efflux pump research. Passionate about advancing scientific knowledge and addressing real-world challenges.šŸŒŸ

 

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šŸŽ“ Education

Doctor of Philosophy (2023-Ongoing) SASTRA Deemed University, India Bioinformatics Center and Biomolecular Crystallography Lab, under the supervision of Dr. S. Thamotharan and co-supervision of Dr. Vigneshwer R. Currently pursuing research funded by DBT-govt. of India. M.Sc in Microbiology (2020-2022) Grade: A+ (80%) [Ranked 4th] B.Sc (Hons.) in Microbiology (2017-2020) Optional subjects: Chemistry and Botany Grade: B+ 12th (High School) (2015-2017) Science stream

šŸ”¬ Key Skills

  • Molecular Docking
  • Molecular Dynamics
  • Schrodinger
  • Pymol
  • MegaAUTODOCK
  • Agarose Gel Electrophoresis
  • ELISA
  • qPCR
  • RT-PCR
  • Flow Cytometry
  • Online tools for nucleic acid or protein sequence-based analysis (Expasy, Clustal Omega, NCBI)

šŸ’¼ Work Experience

Research Intern at MEAB LAB (08/2021-09/2022) JIS University (Hybrid mode) Responsibilities: Worked on current research projects with PhD scholars as a Project Associate Intern. Co-authored 3 review articles and 1 book chapter, and contributed to 3 research projects. Previously worked here for Master’s thesis paper. Lab Tech Intern at Suraksha Diagnostic Pvt. Ltd. (12.08.2022-24.08.2022) Responsibilities: Conducted DNA and RNA extraction for PCR to detect HLA, hepatitis B, hepatitis C, and Covid-19 virus. Performed RT-PCR and real-time PCR to detect RNA and DNA viruses.

Publications Top Notes šŸ“

  1. Title: Lignocellulolytic Microbial Systems and its Importance in Dye Decolourization: A Review

 

  1. Title: Microbial electrolysis cells for effective biohydrogen biogenesis from biowastes

 

  1. Title: Algae educed industrial enzymes production: a sustainable way forward?
    • Book: Industrial Microbiology
    • ISBN: 978-93-5461-997-7
    • Publisher: Astral International Pvt. Ltd. (Scopus)

Somayeh Hashemi Sheikhshabani | Human Genetics | Best Researcher Award

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Dr. Somayeh Hashemi Sheikhshabani | Human Genetics | Best Researcher Award

šŸ‘Øā€šŸ«Profile Summary

I am a highly skilled researcher specializing in Medical Genetics with a focus on Cancer Biology, Cancer Drug Resistance, Noncoding RNAs, Computational Biology, and Genetics of Rare Diseases. With a Ph.D. from Shahid Beheshti University of Medical Sciences, Tehran, Iran, and a strong background in Cellular and Molecular Biology, I’ve conducted extensive research on genetic analysis of male infertility, identification of genes involved in various cancers, and prediction of regulatory networks using bioinformatics tools. Proficient in a wide range of experimental techniques and software applications, I am dedicated to advancing knowledge in genetics and contributing to the development of innovative therapies.

 

šŸŒ Professional Profiles

Education šŸ“š

PhD in Medical Genetics Shahid Beheshti University of Medical Sciences, Tehran, Iran September 23, 2019 ā€“ October 7, 2023 PhD Thesis: Genetic investigation of non-obstructive azoospermia families with cytogenetic and molecular genetic tests, and determining the relationship between genetic and clinical findings of patients.M.Sc. in Cellular and Molecular Biology National Institute of Genetic Engineering and Biotechnology, Tehran, Iran September 23, 2010 ā€“ October 27, 2012 Master Thesis: Alkaloid extract of Peganum harmala L. seed on the expression of Bax and Bcl-2 genes involved in mitochondrial apoptosis pathway in cancer cells.B.Sc. in Molecular Genetics Shahrekord University, Shahrekord, Iran September 23, 2005 ā€“ October 7, 2009

Research Interests šŸ”¬

  • Cancer Biology
  • Cancer Drug Resistance
  • Noncoding RNAs
  • Computational Biology
  • Genetics of Rare Diseases

Research Projects šŸ§¬

Genetic analysis of male infertility in a family using Whole Exome Sequencing. (Student Research Committee, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2024)In silico prediction of non-coding RNA-gene regulatory network in primary gonad failure defects. (Student Research Committee, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2024)In silico identification of functional single nucleotide polymorphisms of azoospermia genes. (Student Research Committee, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2024)In silico prediction of coagulation system functional polymorphisms. (Student Research Committee, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2024)Identification of genes involved in Imatinib resistance in chronic myeloid leukemia (CML). (Student Research Committee, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2024)Genetic analysis of families with non-obstructive azoospermia by Whole Exome Sequencing. (Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2024)Genetic investigation of infertility in an Iranian family with infertility in both sexes. (Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2023)Prediction of tissue-specific inflammatory LncRNAs in COVID-19 patients. (Student Research Committee, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2021-2024)Identification of inflammatory miRNAs associated with COVID-19 and determination of their potential target genes using bioinformatics tools. (Student Research Committee, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2021-2023)Identification of genes involved in the development of chemotherapy resistance in lung cancer. (Student Research Committee, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2021-2024)Identification of common polymorphisms in the host antioxidant pathway against viruses and prediction of their effects. (Student Research Committee, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2021-2024)Identification of genes involved in the development of chemotherapy resistance in ovarian cancer. (Student Research Committee, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2021-2023)Investigation of the effect of oleuropein on miR-125b and miR-34a expression in ovarian cancer cell lines. (Cellular and Molecular Research Center, Shahrekord University of Medical Sciences; 2019-2020)Investigation of the effect of oleuropein on miR-181b and miR-21 expression in breast cancer cell line. (Cellular and Molecular Research Center, Shahrekord University of Medical Sciences; 2019-2020)Investigation of the effect of oleuropein on the expression of genes involved in apoptosis in cisplatin-resistant ovarian cell line. (Cellular and Molecular Research Center, Shahrekord University of Medical Sciences; 2019-2020)Study of the effect of nanoparticles containing altretiamine and arstin on ferroptosis in ovarian cancer cell line. (Cellular and Molecular Research Center, Shahrekord University of Medical Sciences; 2016-2020)Study of the effect of nanoparticles containing altretamine on ferroptosis-apoptosis in ovarian cancer cell line. (Cellular and Molecular Research Center, Shahrekord University of Medical Sciences; 2018-2019)Genetic etiology determination of non-syndromic hearing loss families using Whole Exome Sequencing. (Cellular and Molecular Research Center, Shahrekord University of Medical Sciences; 2018-2019)

Skills šŸ› ļø

A. Experimental Techniques:Human cell cultureMTT assay (Drugs, Natural products, Nanoparticles)DNA and RNA extractionApoptosis assayROS assayElectrophoresisQuantitative PCRConventional PCRSonicationNanodropKaryotypingSanger sequencingWhole exome sequencingB. Software Ability:Various microRNA databases (TargetScan, miRBase, miRWalk, etc.)Various lncRNA databases (starBase, LncBase, etc.)Pathway databases (KEGG, WikiPathways, Reactome)Variant prediction tools (SIFT, Mutation Taster, Polyphen, CADD, etc.)Genome browsers (NCBI, Ensembl, UCSC)Primer design software and tools (AlleleID, Primer3, Oligo 7, etc.)Sequence analysis software (QIAGEN CLC Genomics Workbench, Mutation Surveyor, FinchTV, etc.)STRINGDBCytoscapeGene RunnerGenome expression databases (GEO, GTEx, etc.)

Workshops šŸ“š

 

  • Various workshops covering topics such as predicting LncRNAs, the role of biological systems in cancer, electronic resource investigation, Next Generation sequencing, molecular techniques, article writing, PCR, and bioinformatics.

šŸ“šTop Noted Publication

  1. Title: The effect of oleuropein on apoptotic pathway regulators in breast cancer cells
    • Journal: European Journal of Pharmacology
    • Year: 2020
    • Volume: 886
    • Pages: 173509
    • Citations: 43

 

  1. Title: Peganum harmala L.ā€™s anti-growth effect on a breast cancer cell line
    • Journal: Biotechnology reports
    • Year: 2015
    • Volume: 8
    • Pages: 138-143
    • Citations: 39

 

  1. Title: Oleuropein reduces cisplatin resistance in ovarian cancer by targeting apoptotic pathway regulators
    • Journal: Life Sciences
    • Year: 2021
    • Volume: 278
    • Pages: 119525
    • Citations: 26

 

  1. Title: Growth inhibitory impact of Peganum harmala L. on two breast cancer cell lines
    • Journal: Iranian journal of biotechnology
    • Year: 2014
    • Volume: 12
    • Issue: 1
    • Pages: 8-14
    • Citations: 23

 

  1. Title: The impact of oleuropein on miRNAs regulating cell death signaling pathway in human cervical cancer cells
    • Journal: Biotechnology and Applied Biochemistry
    • Year: 2024
    • Volume: 71
    • Issue: 1
    • Pages: 61-71
    • Citations: 1

 

  1. Title: In Silico Prediction of Functional SNPs Interrupting Antioxidant Defense Genes in Relation to COVID-19 Progression
    • Journal: Biochemical Genetics
    • Year: 2024
    • Pages: 1-27

 

  1. Title: Meta-analysis of microarray data to determine gene indicators involved in the cisplatin resistance in ovarian cancer
    • Journal: Cancer Reports
    • Year: 2023
    • Volume: 6
    • Issue: 12
    • Pages: e1884

Flavia | Molecular Biology | Young Scientist Award

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Dr. Flavia| Molecular Biology | Young Scientist Award

šŸ‘Øā€šŸ«Profile Summary

Flavia Scoyni is a highly accomplished researcher in molecular medicine, specializing in non-coding RNAs and their role in neurodegenerative diseases like Alzheimer’s and ischemic stroke. With a Ph.D. from the University of Eastern Finland under the Marie Skłodowska-Curie Programme, Flavia has extensive experience in experimental techniques such as scRNA-seq, FACS, and animal modeling. Their work has been published in prestigious journals and recognized with numerous grants and fellowships. Flavia’s expertise in molecular biology, cell culture, and animal work, coupled with a strong track record of securing research funding, positions them as a valuable asset in the field of translational medicine.

šŸŒ Professional Profiles

šŸŽ“Education:

Ph.D. in Molecular Medicine University of Eastern Finland, Kuopio, Finland Duration: Dec 2017 – Feb 2024 Marie Skłodowska-Curie Programme in Genetics and Mechanisms in Translational Medicine (GENOMMED) Advisor: Prof. Tarja Malm Dissertation: “Unlocking the potential of non-coding RNAs in regulating neurodegeneration – a glimpse into Alzheimerā€™s disease and ischemic stroke pathophysiology.” Ph.D. secondment Aarhus University, Aarhus, Denmark Duration: Sept 2018 – Feb 201 Advisor: Assoc. Prof. Thomas B. Hansen Funded by Saastamoinen Foundation travel grant FELASA accreditationUniversity of Eastern Finland, Kuopio, Finland May 2017 Federation of Laboratory Animal Science Associations (FELASA) Certificate in laboratory animal science for EU Functions A/D MSc in Molecular Biology “Sapienza” University of Rome, Rome, Italy Duration: Oct 2013 – Dec 2015 Master Degree in Molecular Biology Graduated magna cum laude (110/110 cum laude) Advisor: Prof. Alessandro Fatica Thesis title: “Identification of new transcriptional targets of p30 C/EBPĪ± transcription factor isoform in acute myeloid leukemia” MSc in Genetics University Paris-Diderot VII, Paris, France Duration: Oct 2013 – June 2015 BSc in Biotechnology “Sapienza” University of Rome, Rome, Italy Duration: Oct 2010 – July 2013 Bachelor degree in Biotechnology Graduated magna cum laude (110/110 cum laude) Advisor: Prof. Carlo Presutti Thesis title: “The role of the mir-200 family in the regulation of the expression of AP1 transcriptional factor”

šŸ”¬Research Experience:

Early stage researcher Professor Tarja Malm University of Eastern Finland, A.I. Virtanen Institute for Molecular Sciences Jan 2017 ā€“ Dec 2017 Investigated the role of microRNAs in phagocytic microglia isolated from adult Alzheimerā€™s mice. Developed techniques including ex-vivo FACS, low input RNA extraction, cloning, qPCR, and protocol for transfection for hard-to-transfect cell lines. Conducted animal procedures to harvest brain samples or acutely isolate adult microglia. Erasmus traineeship Biotech Research & Innovation Centre, Copenhagen, Denmark Oct 2016 – June 2016 Developed a transgenic stable cell line for long non-coding RNAs. Applied techniques such as cloning of long inserts, lentiviral vector production, and stable cell line development. Master thesis Professor Alessandro Fatica “Sapienza” University of Rome, Rome, Italy June 2014 – Dec 2015 Investigated the regulation of the long non-coding RNA UCA1 mediated by C/EBPĪ± transcription factor in the K562 lymphoblast cell line. Applied techniques including ChIP, cloning, RNA extraction, RT-qPCR, WB, transfection, CRISPR-Cas9, and stable cell line development. Master Internship Professor Giuseppe Macino “Sapienza” University of Rome, Rome, Italy Sept 2013 – March 2014 Studied microRNAs inducing epigenetic modifications in mammals.Applied techniques such as ChIP, cloning, mutagenesis, RNA extraction, RT-qPCR, WB, CRISPR-Cas9, and stable cell line development. Bachelor thesis Professor Carlo Presutti “Sapienza” University of Rome, Rome, Italy Oct 2012 – July 2013 Investigated the role of the miR-200a family in regulating c-JUN transcription factor expression. Utilized techniques including cloning, mutagenesis, bacterial transformation, and cell line culture.

šŸ’» Technical Skills:

Molecular biology techniques such as scRNA-seq, RNA-seq, FACS, cloning, RT-qPCR, WB, lentiviral vectors generation. Cell culture techniques including neuronal culture, primary microglial culture, transduction, transfection, and stable cell line development. Animal work including FELASA A/D certification, maintenance, and breeding of transgenic mouse models, animal procedures, and tamoxifen-induced recombination. Statistical analysis, basic Python, and R.

šŸ†Fellowships, Awards, and Honors:

  • Secured total grants of 99.000ā‚¬ during Ph.D., including grants from Pavo Nuermen Foundation, Finnish Cultural Foundation, Kuopio University Foundation, and others.

šŸ‘©ā€šŸ« Teaching Experience:

  • Mentored a Ph.D. student and post-graduate student, and supervised five master’s thesis students during the Ph.D. program.

šŸ“šTop Noted Publication

  1. ciRS-7 and miR-7 regulate ischemia-induced neuronal death via glutamatergic signaling
    • Journal: Cell Reports
    • Year: 2024-03
    • DOI: 10.1016/j.celrep.2024.113862
    • Contributors: Flavia Scoyni; Valeriia Sitnikova; Luca Giudice; Paula Korhonen; Davide M. Trevisan; Ana Hernandez de Sande; Mireia Gomez-Budia; Raisa Giniatullina; Irene F. Ugidos; Hiramani Dhungana et al.

 

  1. Alzheimer’s disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs
    • Journal: Alzheimer’s & Dementia
    • Year: 2024-02
    • DOI: 10.1002/alz.13502
    • Contributors: Flavia Scoyni; Luca Giudice; Mari-Anna VƤƤnƤnen; Nicholas Downes; Paula Korhonen; Xin Yi Choo; Nelli-Noora VƤlimƤki; Petri MƤkinen; Nea Korvenlaita; Annemieke J Rozemuller et al.

 

  1. ciRS-7 and miR-7 regulate ischemia induced neuronal death via glutamatergic signaling
    • Journal: Preprint
    • Year: 2023-01-24
    • DOI: 10.1101/2023.01.24.525136
    • Contributors: Flavia Scoyni; Valeriia Sitnikova; Luca Giudice; Paula Korhonen; Davide M Trevisan; Ana Hernandez de Sande; Mireia Gomez-Budia; Raisa Giniatullina; Irene F Ugidos; Hiramani Dhungana et al.

 

  1. Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation
    • Journal: Journal of Neuroinflammation
    • Year: 2020
    • DOI: 10.1186/s12974-020-01870-w
    • Contributors: Kolosowska, N.; Gotkiewicz, M.; Dhungana, H.; Giudice, L.; Giugno, R.; Box, D.; Huuskonen, M.T.; Korhonen, P.; Scoyni, F.; Kanninen, K.M. et al.

 

  1. PSEN1Ī”E9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia
    • Journal: Stem Cell Reports
    • Year: 2019
    • DOI: 10.1016/j.stemcr.2019.08.004
    • Contributors: Konttinen, H.; Cabral-da-Silva, M.E.C.; Ohtonen, S.; Wojciechowski, S.; Shakirzyanova, A.; Caligola, S.; Giugno, R.; Ishchenko, Y.; HernĆ”ndez, D.; Fazaludeen, M.F. et al.