Abdulwasiu Ibrahim | Drug Discovery | Young Scientist Award

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Mr. Abdulwasiu Ibrahim | Drug Discovery | Young Scientist Award

Research Fellow, Drosophila Research and Training Centre Nigeria

Abdulwasiu Ibrahim is a biochemist specializing in cancer biology, molecular biology, and bioinformatics. He is affiliated with the Department of Biochemistry, University of Ibadan, Nigeria. His expertise spans drug discovery, precision medicine, pharmacogenomics, and toxicogenomics. Proficient in computational biology, he applies computer-aided drug design, immunoinformatics, and biochemical analytics to research. His technical skills include gel electrophoresis, ELISA, PCR, and spectroscopy. He has a strong background in statistical analysis using GraphPad Prism and Microsoft Excel, with foundational knowledge of Python. He has extensive research experience in genetic profiling and biological drug delivery. Currently, he is a Research Fellow at the Drosophila Research and Training Centre and a Research Associate at the Institute of Bioinformatics and Molecular Therapeutics. He has received multiple conference fellowships and published several high-impact research papers. His work contributes to advancing cancer treatment and precision medicine using bioinformatics and molecular biology approaches.

Publication Profile

Oricd

🎓 Education

Master of Science in Biochemistry (Cancer Research and Molecular Biology) – University of Ibadan, Nigeria (2022–2024) Thesis: Interactive Toxicity of 2-Acetylaminoflourene and Diethylnitrosamine in Drosophila melanogaster. Bachelor of Science in Biochemistry (Second Class Upper-Honours) – Usmanu Danfodiyo University, Sokoto, Nigeria (2015–2019)
Thesis: Analgesic Activity of n-Hexane Extract of Castor Seed on Formalin-Induced Pain in Albino Rats.

💼 Experience

Research Fellow – Drosophila Research and Training Centre (2022–Present) Designed and conducted Drosophila experiments, supervised students, and managed lab operations.. Research Associate (Volunteer) – Institute of Bioinformatics and Molecular Therapeutics (2022–Present) Developed computational models for drug discovery, performed molecular docking, and trained interns. Post-Graduate Research Assistant – University of Ibadan (2022–2024) Conducted molecular analysis of cancer markers and supervised undergraduate projects. Research Assistant – Drosophila Laboratory, University of Ibadan (2021–2022) Taught students Drosophila research techniques and performed oxidative stress biomarker analysis. Undergraduate Research Assistant – Usmanu Danfodiyo University (2019–2020) Conducted phytochemical screening, biochemical analysis, and systematic reviews. Tutorial Teacher – Nigerian Society of Biochemistry Students (2019) Taught biochemistry, pharmacology, and molecular biology to undergraduate students.

🏆 Awards & Honors

Conference Fellowships: 11th & 10th Conference of the Nigerian Institute of Medical Research (NIMR) (2022, 2021) 2nd Drug Discovery Africa International Conference (DDA) (2022) 2nd Conference of Nigerian Bioinformatics and Genomics Network (NBGN) (2021) 7th Unibadan Conference of Basic Medical Sciences (2021). Virtual Chair Award – Midwest Drosophila Conference (2022). Pre-Conference Workshops: Genotyping with TaqMan and Real-Time PCR Bioinformatics and Genome-Wide Association Studies Summer School: Hands-on training in bioinformatics and drug discovery. Best Paper Presentation: Nigerian Society of Biochemistry and Molecular Biology Conference (2021) Recognized for contributions to Drosophila biomedical research and computational drug design.

🔍 Research Focus

Cancer Biology & Genomics: Investigating genetic markers and molecular pathways in cancer progression. Molecular Biology & Bioinformatics: Computational modeling of biomolecules and genome-wide association studies. Drug Discovery & Design: Using in silico techniques to identify potential drug candidates for cancer and neurodegenerative diseases. Precision Medicine & Genetic Profiling: Exploring personalized treatment approaches through pharmacogenomics. Pharmacogenomics & Toxicogenomics: Studying drug responses and toxic effects at the genetic level. Biological Drug Delivery: Developing targeted therapies using nanoformulations and bioactive compounds. Computational Biology: Expertise in homology modeling, molecular docking, virtual screening, and molecular dynamics simulations. Laboratory Techniques: Skilled in gel electrophoresis, ELISA, PCR, spectrophotometry, and tissue imaging.

Publication Top Notes

  • Computational Investigation of Polo-like Kinase 1 (PLK1): Inhibitive Potential of Benzimidazole-Carbonamide Derivatives for Cancer Treatment
    • Year: 2024
    • Authors: Ipinloju, N.; Balogun, T.A.; Ibrahim, A.; Adeyemo, M.A.; Esan, T.O.; Emmanuel, A.V.; Bello, K.A.; Omiyeniyi, G.D.; Oyeneyin, O.E.
    • Citation: Physical Chemistry Research
    • Link: DOI: 10.22036/pcr.2023.377616.2331

 

  • Identification of Phytochemicals with Inhibitory Potential Against Beta-lactamase Enzymes via Computer-aided Approach
    • Year: 2024
    • Authors: Nwokebu, G.C.; Adesina, A.B.; Isibor, C.N.; Aigbepue, S.A.; Egbo, C.C.; Pureaziba, N.; Isaac, O.O.; Owolade, A.J.-J.; Alabere, H.O.; Iwuagwu, M.O.
    • Citation: Bioorganic Chemistry
    • Link: DOI: 10.1016/j.bioorg.2024.107238

 

  • Insight into the Corrosion Inhibiting Potential and Anticancer Activity of 1-(4-methoxyphenyl)-5-methyl-N’-(2-oxoindolin-3-ylidene)-1H-1,2,3-triazole-4-carbohydrazide via Computational Approaches
    • Year: 2024
    • Authors: Oluwatoba Emmanuel Oyeneyin; Abdulwasiu Ibrahim; Nureni Ipinloju; Adeniyi John Ademoyegun; Nathanael Damilare Ojo
    • Citation: Journal of Biomolecular Structure and Dynamics
    • Link: DOI: 10.1080/07391102.2023.2260491

 

  • Plant-derived Extracellular Vesicles as Potential Smart Nano Drug Delivery Systems for Antioxidant Vitamins C and E in Alzheimer’s Disease
    • Year: 2024
    • Authors: Amina Jiyah; Suleiman Alhaji Muhammad; Abdulwasiu Ibrahim; Ibrahim Bulama; Abdullahi Ibrahim; Abdullahi Yahya Abbas; Mustapha Umar Imam; Yusuf Saidu; Lawal Suleiman Bilbis
    • Citation: Journal of Drug Delivery Science and Technology
    • Link: DOI: 10.1016/j.jddst.2024.105618

 

  • Identification of Potential Acetylcholinesterase (AChE) Inhibitors from Vitis Vinifera: A Case Study of Alzheimer’s Disease (AD)
    • Year: 2023
    • Authors: Sofela, S.O.; Ibrahim, A.; Bodun, D.S.; Nwankwo, D.O.; Mafimisebi, M.; Abdulrasheed, B.; Balogun, T.; Opeyemi, I.
    • Citation: Research Square
    • Link: DOI: 10.21203/rs.3.rs-3342491/v1

 

  • Quantum Evaluation and Therapeutic Activity of (E)-N-(4-methoxyphenyl)-2-(4-(3-oxo-3-phenylprop-1-en-1-yl) phenoxy)acetamide and Its Modified Derivatives Against EGFR and VEGFR-2 in the Treatment of Triple-negative Cancer via In Silico Approach
    • Year: 2023
    • Authors: Ipinloju, N.; Ibrahim, A.; da Costa, R.A.; Adigun, T.B.; Olubode, S.O.; Abayomi, K.J.; Aiyelabegan, A.O.; Esan, T.O.; Muhammad, S.A.; Oyeneyin, O.E.
    • Citation: Journal of Molecular Modeling
    • Link: DOI: 10.1007/s00894-023-05543-2

 

  • Discovery of Potential Phytochemicals from Carica Papaya Targeting BRCA-1 in Breast Cancer Treatment
    • Year: 2023
    • Authors: Abdulwasiu Ibrahim; Nureni Ipinloju; Abdulsamad Omotayo Aiyelabegan; Abdulbaki Adio Alfa-Ibrahim; Suleiman Alhaji Muhammad; Oluwatoba Emmanuel Oyeneyin
    • Citation: Applied Biochemistry and Biotechnology
    • Link: DOI: 10.1007/s12010-023-04473-2

 

  • Discovery of Small Molecule PARKIN Activator from Antipsychotic/Anti-neuropsychiatric Drugs as Therapeutics for PD: An In Silico Repurposing Approach
    • Year: 2023
    • Authors: Abdulwasiu Ibrahim; Nureni Ipinloju; Nkechi Hope Atasie; Rahmotallah Mosunmola Babalola; Suleiman Alhaji Muhammad; Oluwatoba Emmanuel Oyeneyin
    • Citation: Applied Biochemistry and Biotechnology
    • Link: DOI: 10.1007/s12010-023-04376-2

 

  • Computational Evaluation of Azadirachta Indica-Derived Bioactive Compounds as Potential Inhibitors of NLRP3 in the Treatment of Alzheimer’s Disease
    • Year: 2023
    • Authors: Ishabiyi FO; Ogidi J; Olukade BA; Amorha CC; El-Sharkawy LY; Okolo CC; Adeniyi TM; Atasie NH; Ibrahim A.; Balogun TA
    • Citation: Journal of Alzheimer’s Disease (JAD)
    • Link: DOI: 10.3233/jad-221020

 

  • Discovery of Small Molecule PARKIN Activator as Therapeutics for PD: An In-silico Repurposing Approach
    • Year: 2022
    • Authors: Abdulwasiu Ibrahim; Nureni Ipinloju; Suleiman Alhaji Muhammad; Oluwatoba Emmanuel Oyeneyin; Nkechi Hope Atasie
    • Citation: Preprint
    • Link: DOI: 10.21203/rs.3.rs-2035291/v1

 

  • Antioxidant-Rich Nutraceutical as a Therapeutic Strategy for Sickle Cell Disease

 

Chen Wai Wong | Biotechnology | Best Researcher Award

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Assoc. Prof. Dr. Chen Wai Wong | Biotechnology | Best Researcher Award

Lecturer, UCSI University Malaysia

Dr. Wong Chen Wai is an Associate Professor at the Faculty of Applied Sciences, UCSI University, Malaysia. With a background in Biotechnology, he specializes in enzyme and food biotechnology, teaching subjects related to biochemistry, biotechnology, and biosensors. He has made significant contributions to both academia and industry through research and teaching. He has supervised numerous Ph.D. and MSc students, leading various cutting-edge research projects. 🌱👨‍🏫

Publication Profile

Scopus

Orcid

Scholar

🎓 Education

Dr. Wong holds a Postgraduate Diploma in Tertiary Teaching (2021), a Ph.D. in Enzyme and Food Biotechnology (2009), and a Bachelor of Science in Biotechnology (2001), all from esteemed Malaysian institutions. His academic journey has honed his expertise in biotechnology and applied sciences.

💼 Experience

Dr. Wong has held key academic positions at UCSI University, including Associate Professor (2019–present) and Head of Biotechnology (2019–2022). He has also worked as an Application Chemist and Engineer in the industry before pursuing his academic career. His teaching spans various subjects in biotechnology, and he has supervised many graduate and postgraduate students.

🏆 Awards & Honors

Dr. Wong’s achievements include recognition for excellence in research and teaching, with a strong focus on biotechnological innovations. He has been awarded various fellowships and honors for his contributions to education and research.

🔬 Research Focus

Dr. Wong’s research focuses on the development of bioplastics, biofuels, enzyme technology, and the use of natural extracts in biotechnology. His current research includes the sustainable use of agricultural waste and biorefinery technologies.

Conclusion

Dr. Wong’s distinguished academic and research career, marked by his leadership in biotechnology and contributions to sustainable biotechnological solutions, makes him highly deserving of the Best Researcher Award. While opportunities for expanding his interdisciplinary collaborations exist, his current body of work and mentorship in shaping future leaders in biotechnology makes him a standout researcher in his field.

Publication Top Notes

  • Title: Effect of enzymatic processing, inlet temperature, and maltodextrin concentration on the rheological and physicochemical properties of spray‐dried banana (Musa acuminata) powder
    Year: 2018
    Authors: CW Wong, CY Teoh, CE Putri
    Citation: Journal of Food Processing and Preservation, 18

 

  • Title: Inhibitory effect of Malaysian coastal plants on banana (Musa acuminata Colla “Lakatan”), ginger (Zingiber officinale Roscoe), and sweet potato (Ipomoea batatas) polyphenol oxidase
    Year: 2021
    Authors: WY Lim, YW Cheng, LB Lian, EWC Chan, CW Wong
    Citation: Journal of Food Science and Technology, 58, 4178-4184

 

  • Title: Ceiba pentandra (L.) Gaertn.: An overview of its botany, uses, reproductive biology, pharmacological properties, and industrial potentials
    Year: 2022
    Authors: EWC Chan, SW Yeong, CW Wong, OYM Soo, ACY Phua, YK Ng
    Citation: Journal of Applied Biology and Biotechnology, 10(20), 1-7

 

  • Title: Inhibitory Effect of Onion Extract on Cassava Leaf (Manihot esculenta Crantz) Polyphenol Oxidase
    Year: 2014
    Authors: CW Wong, PLA Lee
    Citation: International Food Research Journal, 21(2), 755-758

 

  • Title: Hydrophobic bioactive constituents of cinnamon bark as inhibitors of polyphenol oxidase from Musa acuminata ‘Mas’ peel
    Year: 2022
    Authors: ZZ Siew, EWC Chan, CW Wong
    Citation: Biocatalysis and Agricultural Biotechnology, 45, 102504

 

  • Title: Effects of inlet temperature and carrier concentration on spray-dried ‘cempedak’ (Artocarpus integer) fruit powder and its reconstitution properties
    Year: 2021
    Authors: LP Pui, R Karim, YA Yusof, CW Wong, HM Ghazali
    Citation: Acta Scientiarum Polonorum, Technologia Alimentaria, 20(2), 135-148

 

  • Title: Tyrosinase inhibiting extracts from coastal plants as potential additives in skin whitening formulations
    Year: 2021
    Authors: WY Lim, EWC Chan, CW Phan, CW Wong
    Citation: Current Applied Science and Technology, 21, 481-494

 

  • Title: Role of scutellarin in human cancer—A review
    Year: 2019
    Authors: EWC Chan, CSS Lim, WY Lim, ZJ Loong, CW Wong
    Citation: Journal of Applied Pharmaceutical Science, 9(1), 142-146

 

  • Title: Deep eutectic solvents for batteries and fuel cells: biosubstitution, advantages, challenges, and future directions
    Year: 2023
    Authors: Y Hariyanto, YK Ng, ZZ Siew, CY Soon, AC Fisher, L Kloyer, CW Wong, et al.
    Citation: Energy & Fuels, 37(23), 18395-18407

 

  • Title: Pomolic acid: A short review on its chemistry, plant sources, pharmacological properties, and patents
    Year: 2023
    Authors: EWC Chan, YK Ng, CSS Lim, VS Anggraeni, ZZ Siew, CW Wong, et al.
    Citation: Journal of Applied Pharmaceutical Science, 13(5), 058-065

 

  • Title: Anti-quorum sensing and antibiotic enhancement of allylpyrocatechol and methyl gallate
    Year: 2021
    Authors: CSS Lim, EWC Chan, CW Wong, JBL Tan, VS Anggraeni, ZJ Loong, et al.
    Citation: Jurnal Teknologi, 83(3), 101-106

 

  • Title: Thermostable Deep Eutectic Solvents for Thermochemical Reactions: Novel Stability Indicators
    Year: 2024
    Authors: Y Hariyanto, CW Wong, AC Fisher, L Kloyer, EWC Chan
    Citation: ACS Sustainable Chemistry & Engineering, 12(17), 6774-6785

 

  • Title: Swelling behavior and methylene blue absorption of carboxymethyl cellulose hydrogels prepared from Malaysian agricultural wastes by electron beam irradiation
    Year: 2020
    Authors: EWC Chan, CMY Huang, P CHIA, CSS Lim, ZJ Loong, M Talib, CW Wong, et al.
    Citation: Cell Chem Technol, 54(5-6), 421-428

 

Larisa Dunai | biotechnology | Best Researcher Award

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Prof. Larisa Dunai | biotechnology | Best Researcher Award

Professor, Universitat Politècnica de València Spain

Prof. Larisa Dunai is a renowned academic at the Universitat Politècnica de València, specializing in graphical engineering. She has been a Professor Titular (Associate Professor) since 2006. Her academic journey began at the Universitatea Tehnică a Moldovei, where she earned degrees in Radioelectronics and Telecommunications. With a passion for advancing the field, Prof. Dunai has made significant contributions to education and research in engineering. Her work spans various aspects of graphical engineering, and she is an active member of IEEE. She has consistently engaged in academic leadership, focusing on innovative approaches in her field.

Publication Profile

Scopus

Orcid

Google Scholar

🎓 Education

Prof. Larisa Dunai holds a Doctorate in Graphic Engineering from the Universitat Politècnica de València (2010). She earned a Master’s degree in Radioelectronics and Telecommunications from the Universitatea Tehnică a Moldovei (2004), following her undergraduate degree in the same field (2003). Her academic foundations in telecommunications and graphic engineering have led to an exceptional career dedicated to teaching, research, and technological advancement in these domains.

💼 Experience

Prof. Dunai has been a Professor Titular (Associate Professor) in the Department of Graphic Engineering at the Universitat Politècnica de València since 2006. Her expertise encompasses radioelectronics, telecommunications, and graphical engineering. She has made significant contributions through her research and teaching, focusing on innovative techniques in engineering design and graphic visualization. Prof. Dunai is also a prominent member of IEEE, contributing to the academic community and working to advance the field of engineering through education, publications, and professional involvement.

🏆 Awards & Honors

Throughout her career, Prof. Larisa Dunai has been recognized for her excellence in teaching and research. She has received numerous academic awards and honors, including recognition for her contributions to the field of graphic engineering. As an active member of IEEE, she is respected for her leadership in the engineering community. Prof. Dunai’s dedication to education and research has had a lasting impact on her students and the broader scientific community.

🔬 Research Focus

Prof. Dunai’s research is centered on the integration of graphic engineering, telecommunications, and radioelectronics. She is particularly interested in the application of graphic techniques to solve complex engineering problems and enhance technological advancements. Her research explores innovative methods in graphical visualization, as well as the development of new systems and applications in telecommunications. Prof. Dunai’s work has been instrumental in advancing the practical application of engineering principles in various industries.

Conclusion

Professor Larisa Dunai is a highly accomplished and influential researcher whose expertise in engineering, particularly graphic engineering and telecommunications, positions her as a strong contender for the Best Researcher Award. Her academic achievements, professional experience, and involvement in global research networks make her an outstanding candidate. By expanding her collaborative efforts and enhancing her international profile, Professor Dunai has the potential to make even greater strides in her field, contributing to the advancement of technology and engineering on a global scale.

Publication Top Notes

  • Dispositivo de navegación para personas invidentes basado en la tecnología time of flight
    • Year: 2013
    • Authors: I Lengua, L Dunai, G Peris Fajarnés, B Defez
    • Citation: 21*
  • Automatic classification of winding asymmetries in wound rotor induction motors based on bicoherence and fuzzy C-means algorithms of stray flux signals
    • Year: 2021
    • Authors: MEI Martínez, JA Antonino-Daviu, PF de Córdoba, JA Conejero, L Dunai
    • Citation: 19
  • Virtual sound localization by blind people
    • Year: 2015
    • Authors: L Dunai, I Lengua, G Peris-Fajarnés, F Brusola
    • Citation: 16
  • E-learning in industrial electronics during covid-19
    • Year: 2021
    • Authors: L Dunai, J Martins, K Umetani, O Lucia, Y Ibrahim, GK Appuhamillage
    • Citation: 15
  • Data fusion system for electric motors condition monitoring: an innovative solution
    • Year: 2023
    • Authors: RA Osornio-Rios, I Zamudio-Ramírez, AY Jaen-Cuellar, J Antonino-Daviu, …
    • Citation: 13
  • Face detection and recognition application for Android
    • Year: 2015
    • Authors: M Chillaron, L Dunai, GP Fajarnes, IL Lengua
    • Citation: 13
  • Velocity vector (3D) measurement for spherical objects using an electro-optical device
    • Year: 2011
    • Authors: E Lluna, V Santiago, B Defez, L Dunai, G Peris-Fajarnes
    • Citation: 12
  • Diseño de un exoesqueleto de extremidades inferiores
    • Year: 2019
    • Authors: L Dunai, I Lengua, G Peris Fajarnes, B Defez Garcia
    • Citation: 10
  • Interaural time difference thresholds as a function of frequency
    • Year: 2013
    • Authors: WM Hartmann, L Dunai, T Qu
    • Citation: 10
  • Detection of uniform gearbox wear in induction motors based on the analysis of stray flux signals through statistical time-domain features and dimensionality reduction techniques
    • Year: 2022
    • Authors: I Zamudio-Ramirez, JJ Saucedo-Dorantes, J Antonino-Daviu, …
    • Citation: 9
  • Tracking of high-order stray-flux harmonics under starting for the detection of winding asymmetries in wound-rotor induction motors
    • Year: 2021
    • Authors: I Zamudio-Ramirez, JA Antonino-Daviu, RA Osornio-Rios, L Dunai
    • Citation: 9
  • Sound map generation for a prototype blind mobility system using multiple sensors
    • Year: 2008
    • Authors: NO Araque, L Dunai, F Rossetti, L Listi, M Mirmehdi, JLG Mora, …
    • Citation: 9
  • Stray flux analysis for the detection of rotor failures in wound rotor induction motors
    • Year: 2019
    • Authors: J Antonino-Daviu, I Zamudio-Ramírez, RA Osornio-Ríos, V Fuster-Roig, …
    • Citation: 8
  • Electronic travel aid systems for visually impaired people
    • Year: 2011
    • Authors: L Dunai, G Peris Fajarnes, S Praderas
    • Citation: 8
  • Cognitive aid system for blind people (CASBliP)
    • Year: 2009
    • Authors: VS Praderas, N Ortigosa, L Dunai, GP Fajarnes
    • Citation: 8
  • Automatic Classification of Field Winding Faults in Synchronous Motors based on Bicoherence Image Segmentation and Higher Order Statistics of Stray Flux Signals
    • Year: 2023
    • Authors: MEI Martínez, JG Carmenate, J Antonino-Daviu, L Dunai, CA Platero, …
    • Citation: 7

 

Afif Ben Mahmoud | Genomics | Excellence in Research

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 Dr. Afif Ben Mahmoud | Genomics | Excellence in Research  

 Dr at Qatar Biomedical Research Institute,  Qatar

Afif Ben Mahmoud, Ph.D., is a Senior Research Associate at the Neurological Disorders Research Center, Qatar Biomedical Research Institute, Hamad Bin Khalifa University, in Doha, Qatar. A Tunisian national, Dr. Ben Mahmoud specializes in human molecular genetics and has dedicated over ten years to researching neurological disorders and genetic diseases. He holds a Ph.D. in Biological Sciences and has made significant contributions to understanding neurodevelopmental disorders through innovative research techniques and mentoring graduate students. His work emphasizes the identification of genetic factors in various disorders, making him a vital asset to the scientific community in Qatar and beyond.

Profile

Scopus

Scholar

Education 🎓

Dr. Ben Mahmoud earned his Ph.D. in Biological Sciences (Human Molecular Genetics) from the Faculty of Sciences of Sfax, University of Sfax, Tunisia, in 2015. Prior to this, he obtained a Master’s degree in Genetics and Biodiversity from the Higher Institute of Biotechnology of Monastir, Tunisia, in 2009. His academic journey began with an Engineering degree in Animal Production from the Higher School of Agronomy of Mateur, University of Carthage, Tunisia, in 2007. This solid educational foundation has equipped him with the necessary skills and knowledge to excel in his research endeavors.

Experience 💼

Since 2019, Dr. Ben Mahmoud has served as a Senior Research Associate at the Qatar Biomedical Research Institute, where he identifies and characterizes candidate genes for neurodevelopmental disorders by analyzing whole exome and whole genome sequencing data. Before this, he was a Postdoctoral Researcher at the College of Medicine and Health Sciences, University of UAE, from 2016 to 2018, focusing on genomic and cellular studies of autosomal recessive disorders. He has also taught cell biology and genetics at various higher education institutions in Tunisia, contributing to the academic development of future scientists.

Awards and Honors 🏆

Dr. Ben Mahmoud has received recognition for his contributions to genetic research and education. He participated in the development of cell lines using CRISPR-Cas9 technology at UAEU, which aims to better understand diseases. His work has been featured in multiple peer-reviewed publications, establishing him as an authority in his field. He has been actively involved in mentoring students, fostering the next generation of researchers, and enhancing the academic environment in which he works.

Research Focus 🔬

Dr. Ben Mahmoud’s research primarily focuses on neurological disorders and human genetic diseases, specifically identifying the genetic basis of neurodevelopmental disorders. He employs advanced techniques such as next-generation sequencing and molecular biology methods to analyze candidate genes. His recent studies aim to elucidate the cellular mechanisms behind disease-causing mutations, contributing to the broader understanding of genetic disorders. Dr. Ben Mahmoud’s work is instrumental in developing targeted therapeutic strategies, enhancing the potential for personalized medicine in treating complex genetic conditions.

Conclusion 📝

Dr. Afif Ben Mahmoud exemplifies excellence in research through his substantial contributions to the field of neurological disorders and human genetics. His extensive experience, technical expertise, and commitment to mentorship position him as a strong candidate for the Excellence in Research Award. By addressing potential areas for improvement, such as broadening his research focus and enhancing public engagement, Dr. Ben Mahmoud could further amplify his impact within the scientific community and beyond. His ongoing work promises to advance our understanding of complex genetic diseases, making him a valuable asset to the field.

Publications Top Notes

  • Antagonist effects of Bacillus spp. strains against Fusarium graminearum for protection of durum wheat (Triticum turgidum L. subsp. durum)
    • Authors: I Zalila-Kolsi, AB Mahmoud, H Ali, S Sellami, Z Nasfi, S Tounsi, …
    • Journal: Microbiological Research, 2016
    • Pages: 148-158

 

  • Mitochondrial DNA mutations and polymorphisms in asthenospermic infertile men
    • Authors: S Baklouti-Gargouri, M Ghorbel, A Ben Mahmoud, E Mkaouar-Rebai, …
    • Journal: Molecular Biology Reports, 2013
    • Volume/Pages: 40, 4705-4712

 

  • A novel mutation MT-COIII m.9267G>C and MT-COI m.5913G>A mutation in mitochondrial genes in a Tunisian family with maternally inherited diabetes and deafness (MIDD)
    • Authors: M Tabebi, E Mkaouar-Rebai, M Mnif, F Kallabi, AB Mahmoud, WB Saad, …
    • Journal: Biochemical and Biophysical Research Communications, 2015
    • Volume/Pages: 459(3), 353-360

 

  • Genetics of hypogonadotropic hypogonadism—Human and mouse genes, inheritance, oligogenicity, and genetic counseling
    • Authors: ED Louden, A Poch, HG Kim, A Ben-Mahmoud, SH Kim, LC Layman
    • Journal: Molecular and Cellular Endocrinology, 2021
    • Volume: 534, 111334

 

  • Identification of a novel m.9588G>A missense mutation in the mitochondrial COIII gene in asthenozoospermic Tunisian infertile men
    • Authors: S Baklouti-Gargouri, M Ghorbel, A Ben Mahmoud, E Mkaouar-Rebai, …
    • Journal: Journal of Assisted Reproduction and Genetics, 2014
    • Volume/Pages: 31, 595-600

 

  • A novel aberrant splice site mutation in COL27A1 is responsible for Steel syndrome and extension of the phenotype to include hearing loss
    • Authors: N Gariballa, A Ben-Mahoud, M Komara, AM Al-Shamsi, …
    • Journal: American Journal of Medical Genetics Part A, 2017
    • Volume/Pages: 173(5), 1257-1263

 

  • Whole mitochondrial genome screening of a family with maternally inherited diabetes and deafness (MIDD) associated with retinopathy: A putative haplotype associated to MIDD and its phenotypic implications
    • Authors: M Tabebi, N Charfi, F Kallabi, O Alila-Fersi, AB Mahmoud, A Tlili, …
    • Journal: Journal of Diabetes and its Complications, 2017
    • Volume/Pages: 31(1), 253-259

 

  • Two novel mutations in COII and tRNAHis mitochondrial genes in asthenozoospermic infertiles men
    • Authors: BG Siwar, G Myriam, BM Afif, MR Emna, C Nozha, S Afifa, F Faiza, …
    • Journal: Biochemical and Biophysical Research Communications, 2014
    • Volume/Pages: 450(1), 610-615

 

  • A novel m.6307A>G mutation in the mitochondrial COXI gene in asthenozoospermic infertile men
    • Authors: S Baklouti-Gargouri, M Ghorbel, A Ben Mahmoud, E Mkaouar-Rebai, …
    • Journal: Molecular Reproduction and Development, 2013
    • Volume/Pages: 80(7), 581-587

 

  • Bacillus amyloliquefaciens: Harnessing Its Potential for Industrial, Medical, and Agricultural Applications—A Comprehensive Review
    • Authors: I Zalila-Kolsi, A Ben-Mahmoud, R Al-Barazie
    • Journal: Microorganisms, 2023
    • Volume/Pages: 11(9), 2215

 

  • Novel cases of Tunisian patients with mutations in the gene encoding 17β-hydroxysteroid dehydrogenase type 3 and a founder effect
    • Authors: BB Rhouma, F Kallabi, N Mahfoudh, AB Mahmoud, RT Engeli, H Kamoun, …
    • Journal: The Journal of Steroid Biochemistry and Molecular Biology, 2017
    • Volume/Pages: 165, 86-94

 

  • Eif2b3 mutants recapitulate phenotypes of vanishing white matter disease and validate novel disease alleles in zebrafish
    • Authors: YR Lee, SH Kim, A Ben-Mahmoud, OH Kim, TI Choi, KH Lee, B Ku, J Eum, …
    • Journal: Human Molecular Genetics, 2021
    • Volume/Pages: 30(5), 331-342

 

Julien Olivet | Epigenetics | Young Scientist Award

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Dr.Julien Olivet | Epigenetics | Young Scientist Award

Dr Julien Olivet Rega Institute/KU Leuven Belgium

Julien Olivet is an exceptional candidate for the Young Scientist Award due to his innovative research in structural and chemical biology, leadership in managing research projects, and significant international recognition. His technical expertise, particularly in cryo-EM and drug discovery, stands out. Additionally, his commitment to teaching and science outreach is commendable. To strengthen his candidacy, he could emphasize the real-world impact of his research and diversify his research topics and publications. Overall, Julien’s achievements and contributions make him a highly deserving nominee for the award.

Publication profile

scholar

🎓 Education

PhD in Biochemistry, Molecular and Cellular Biology, Bioinformatics and ModelingUniversité de Liège, Belgium (2015-2021)Thesis: Selective disruption of histone deacetylase complexes by small-molecule inhibitors.MSc in Chemistry of Life and NanomaterialsUniversité de Namur, Belgium (2013-2015)Thesis: Synthesis of alginate/SiO2-TiO2 hybrid material for cell encapsulation.BSc in ChemistryFacultés Universitaires Notre-Dame de la Paix, Namur, Belgium (2009-2013).High School Diploma in Mathematics, Sciences Institut Notre-Dame de Loverval, Belgium (2003-2009).

🔬 Research Experience

Postdoctoral Fellow, KU Leuven (09/2021-present),Focus: Cryo-EM structures of SIN3 histone deacetylase (HDAC) complexes, managing collaborations, drug design.Visiting Senior Scientist, Université de Liège (09/2021-present)Focus: Inhibitors of SIN3 protein in HDAC complexes, drug screening, spin-off development.PhD Research Fellow, Université de Liège (01/2021-06/2021)Focus: Small molecule screening pipelines, virus-host interactions.Visiting FRS-FNRS/WBI PhD Research Fellow, Harvard Medical School (11/2015-12/2020)
Focus: Chemical genetic selections, protein interaction assays.

🏆 Honours and Awards

NSFC-FWO Collaboration Project Award (2024-2025),Research Foundation Flanders (FWO), Belgium.McKinsey & Company Scientific Award (2022)EUR 5000.Marie Skłodowska-Curie Actions (MSCA) European Postdoctoral Fellowship (2022-2024),EUR 191760.Best Oral Presentation Award (2019)Dana-Farber Cancer Institute, USA.

Publication

  • Maximizing binary interactome mapping with a minimal number of assays
    • Authors: SG Choi, J Olivet, P Cassonnet, PO Vidalain, K Luck, L Lambourne, …
    • Year: 2019
  • The HTLV-1 viral oncoproteins Tax and HBZ reprogram the cellular mRNA splicing landscape
    • Authors: C Vandermeulen, T O’Grady, J Wayet, B Galvan, S Maseko, M Cherkaoui, …
    • Year: 2021
  • Alternative glycosylation controls endoplasmic reticulum dynamics and tubular extension in mammalian cells
    • Authors: D Kerselidou, BS Dohai, DR Nelson, S Daakour, N De Cock, …
    • Year: 2021
  • A systematic approach to identify host targets and rapidly deliver broad-spectrum antivirals
    • Authors: J Olivet, SB Maseko, AN Volkov, K Salehi-Ashtiani, K Das, …
    • Year: 2022
  • AI-guided pipeline for protein–protein interaction drug discovery identifies a SARS-CoV-2 inhibitor
    • Authors: P Trepte, C Secker, J Olivet, J Blavier, S Kostova, SB Maseko, I Minia, …
    • Year: 2024
  • Identification of small molecule antivirals against HTLV-1 by targeting the hDLG1-Tax-1 protein-protein interaction
    • Authors: SB Maseko, Y Brammerloo, I Van Molle, A Sogues, C Martin, C Gorgulla, …
    • Year: 2023
  • A quantitative mapping approach to identify direct interactions within complexomes
    • Authors: P Trepte, C Secker, SG Choi, J Olivet, ES Ramos, P Cassonnet, S Golusik, …
    • Year: 2021
  • Expanding the HDAC druggable landscape beyond enzymatic activity
    • Authors: J Olivet, SG Choi, S Sierra, TM O’Grady, M de la Fuente Revenga, F Laval, …
    • Year: 2023
  • Interactome and structural basis for targeting the human T-cell leukemia virus Tax oncoprotein
    • Authors: SB Maseko, I Van Molle, K Blibek, C Gorgulla, J Olivet, J Blavier, …
    • Year: 2021
  • The viral oncoproteins Tax and HBZ reprogram the cellular mRNA splicing landscape
    • Authors: C Vandermeulen, T O’Grady, B Galvan, M Cherkaoui, A Desbuleux, …
    • Year: 2021
  • Structural basis for targeting the human T-cell leukemia virus Tax oncoprotein and syntenin-1 interaction using a small molecule
    • Authors: SB Maseko, I Van Molle, K Blibek, C Gorgulla, J Olivet, J Blavier, …
    • Year: 2021
  • Selective disruption of histone deacetylase complexes by small-molecule inhibitors of protein interactions
    • Author: J Olivet
    • Year: 2021

 

🏅 Conclusion

Julien Olivet is a strong candidate for the Young Scientist Award due to his outstanding research achievements, leadership skills, and contributions to the scientific community. His innovative work in cryo-EM and drug discovery, combined with his active role in mentoring and outreach, aligns well with the criteria for the award. Addressing the areas for improvement, particularly in demonstrating the broader impact of his research and expanding his publication portfolio, could further solidify his candidacy.

Nune Manasa | Tissue engineering | Best Researcher Award

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Assoc Prof Dr. Nune Manasa | Tissue engineering | Best Researcher Award

Assoc Prof Dr at Manipal Institute of Regenerative Medicine India

With a Ph.D. in Medical Nanotechnology and extensive research and teaching experience, this professional has made significant contributions to the field of biotechnology and biomaterials. They have held positions such as Assistant Professor and Research Associate, showcasing expertise in stem cell research, tissue engineering, and nanotechnology. Their achievements include numerous awards, memberships, and editorial roles in esteemed journals. Additionally, they actively participate in academic committees and serve as a reviewer for prestigious journals and grant proposals. With a commitment to excellence in research and education, they continue to drive innovation in the biomedical field.

Profile

 

Scholar

 📚🎓Academic Profile

  • Ph.D. in Medical Nanotechnology (2016) from Centre for Nanotechnology & Advanced Biomaterials, SASTRA University, Thanjavur, India
  • M.Sc. Biotechnology (2009) (80%) from Jawaharlal Nehru Technological University (J.N.T.U), Hyderabad, India
  • B.Sc. Biotechnology, Botany & Chemistry (2007) (81%) from Nizam College, Osmania University, Hyderabad, India.

 🔬👩‍🏫 Research & Teaching Experience 

Assistant Professor at Manipal Institute of Regenerative Medicine, Manipal Academy of Higher Education, Bengaluru from July 2017 – July 2022. Research Associate in the Chemistry of Physics & Materials Unit of Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India from February 2016 – November 2016. CSIR-Senior Research Fellow in the Centre for Nanotechnology & Advanced Biomaterials (CeNTAB) of SASTRA University, Thanjavur, Tamil Nadu, India from October 2014 – November 2015. ICMR-Junior Research Fellow in the Centre for Nanotechnology & Advanced Biomaterials (CeNTAB) of SASTRA University, Thanjavur, Tamil Nadu, India from April 2011- September 2014. Teaching Assistant in the Centre for Nanotechnology & Advanced Biomaterials (CeNTAB) of SASTRA University, Thanjavur, Tamil Nadu, India from January 2010 – March 2011. Research Intern of Biotech Consortium of India Ltd (BCIL) at Indian Immunologicals Limited, Gachibowli, Hyderabad from November 2009 – December 2009. Project Trainee at Indian Immunologicals Limited, Gachibowli, Hyderabad from January 2009 – October 2009

Honors/ Awards🏆🎖️

Invited to the ASEAN-INDIA Women Scientists Conclave (AIWSC), 24-26 April 2024 Singapore, co-organized by Singapore’s Agency of Science, Technology and Research (A*Star) with India’s Department of Science & Technology and Anushandhan National Research Foundation (ANRF) with the support of the ASEAN Secretariat.American Chemical Society (ACS) complimentary membership as an appreciation in recognition for being an ACS peer-reviewer in March 2024.Best poster award at the National Symposium on Recent Trends in Biomedical Engineering (NSRTBME 2023) organized by MIT Manipal from 31st March – 1st April 2023.Second place in the Science poster presentation during the National Science day programme held at Manipal Institute of Regenerative Medicine on 24/02/2023.SBAOI-MAHE Young Scientist Award and first prize for the oral presentation titled ‘Polycaprolactone Nanofibers Coated with Cell-Derived Matrix for Uterine Tissue Engineering’ at the International Conference on Biomaterials, Regenerative Medicine and Devices (BIO-Remedi 22) held at IIT Guwahati, December 15-18, 2022.Life member (Awardee) of the Society for Biomaterials & Artificial Organs India (SBAOI) since March 2023.Life member of the Society for Tissue Engineering & Regenerative Medicine India (STERMI) since October 2022.Certificate of Appreciation awarded for being the resource person for the faculty development program titled “Institutional Committee for Stem Cell Research: Guidelines and Screening Procedures for Protocols” organized by Manipal College of Dental Sciences, Mangalore on January 28th 2022 & July 2nd 2021.Second prize for oral presentation at the 4th International Conference on Recent Trends in Bioengineering (ICRTB 2021), organized by MIT School of Bioengineering Sciences & Research, Pune (MITBIO) from February 12-13, 2021Best poster award at the 5th Indian Peptide Symposium organized by Indian Peptide Society on September 24-25, 2015, at JNCASR, Bangalore, IndiaSenior Research Fellowship (CSIR-SRF) award from Council of Scientific and Industrial Research (CSIR), Human Resource and Development Group in 2014.Selected as Project trainee for DBT-Biotech Industrial Training Programme (BITP) by the Department of Biotechnology & Biotech Consortium of India Ltd (BCIL) at Indian Immunologicals Limited, Gachibowli, Hyderabad in 2009.GATE (Graduate Aptitude Test in Engineering) – Biotechnology qualified in 2010.GRE (Graduate Record Examination) – Obtained 1210/1600 – 75.6% in 2008.

 🔍📝 Reviewer & Examiner

‘Ph.D. Coordinator’ of MIRM from February 2023.’IQAC Coordinator’ of MIRM from October 2022-March 2023.Member Secretary for the Institutional Committee for Stem Cell Research (IC-SCR) of MIRM, MAHE since November 2020.Stem cell expert of the IEC committee of SDM University, Dharwad in December 2023.Guest topic editor for ‘Frontiers in Neuroscience’ (IF-5.152) in the section ‘Translational Neuroscience’ for a research topic on ‘Combinatorial Neural Engineering Approaches for Neurotrauma and Neurological Disorders’ in February 2023.Guest editor for ‘JoVE’ (IF-1.4); editing a special issue in methods collection on “Designing of ECM-based biomimetic scaffolds for nerve tissue engineering applications” since September 2022.Peer-reviewed an Israel Science Foundation grant in March 2024.Peer-reviewed for various prestigious journals including ‘Biotechnology Journal’, ‘Journal of Polymer Science’, ‘Journal of Tissue Engineering’, ‘ACS Nano’, ‘Journal of Nanobiotechnology’, ‘Small’, ‘Neuroscience Bulletin’, and many more.Invited to be part of a screening committee of the National Post Doc Symposium (NPDS) 2022 jointly organized by BLiSC and IISER Thiruvananthapuram, July 20-22, 2022, in March 2022.Appointed as external question paper setter for Yenepoya University, Mangalore for setting Ph.D. entrance test questions in July 2020.Doctoral Advisory Committee member, protocol panel member, thesis examiner invitation for internal and external Ph.D. candidates since 2021.

Publications Top Notes 📝

  • Self-assembling peptide nanofibrous scaffolds for tissue engineering: novel approaches and strategies for effective functional regeneration
    • Authors: M Nune, P Kumaraswamy, U Maheswari Krishnan, S Sethuraman
    • Journal: Current Protein and Peptide Science
    • Volume: 14
    • Issue: 1
    • Pages: 70-84
    • Year: 2013
    • Citations: 102

 

  • Melanin incorporated electroactive and antioxidant silk fibroin nanofibrous scaffolds for nerve tissue engineering
    • Authors: M Nune, S Manchineella, T Govindaraju, KS Narayan
    • Journal: Materials Science and Engineering: C
    • Volume: 94
    • Pages: 17-25
    • Year: 2019
    • Citations: 91

 

  • Silica-based bioactive glasses and their applications in hard tissue regeneration: A review
    • Authors: N Al-Harbi, H Mohammed, Y Al-Hadeethi, AS Bakry, A Umar, MA Hussein, …
    • Journal: Pharmaceuticals
    • Volume: 14
    • Issue: 2
    • Pages: 75
    • Year: 2021
    • Citations: 77

 

  • PLGA nanofibers blended with designer self-assembling peptides for peripheral neural regeneration
    • Authors: M Nune, UM Krishnan, S Sethuraman
    • Journal: Materials Science and Engineering: C
    • Volume: 62
    • Pages: 329-337
    • Year: 2016
    • Citations: 69

 

  • Self-assembling peptide nanostructures on aligned poly (lactide-co-glycolide) nanofibers for the functional regeneration of sciatic nerve
    • Authors: M Nune, A Subramanian, UM Krishnan, SS Kaimal, S Sethuraman
    • Journal: Nanomedicine
    • Volume: 12
    • Issue: 3
    • Pages: 219-235
    • Year: 2017
    • Citations: 31

Somayeh Hashemi Sheikhshabani | Human Genetics | Best Researcher Award

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Dr. Somayeh Hashemi Sheikhshabani | Human Genetics | Best Researcher Award

👨‍🏫Profile Summary

I am a highly skilled researcher specializing in Medical Genetics with a focus on Cancer Biology, Cancer Drug Resistance, Noncoding RNAs, Computational Biology, and Genetics of Rare Diseases. With a Ph.D. from Shahid Beheshti University of Medical Sciences, Tehran, Iran, and a strong background in Cellular and Molecular Biology, I’ve conducted extensive research on genetic analysis of male infertility, identification of genes involved in various cancers, and prediction of regulatory networks using bioinformatics tools. Proficient in a wide range of experimental techniques and software applications, I am dedicated to advancing knowledge in genetics and contributing to the development of innovative therapies.

 

🌐 Professional Profiles

Education 📚

PhD in Medical Genetics Shahid Beheshti University of Medical Sciences, Tehran, Iran September 23, 2019 – October 7, 2023 PhD Thesis: Genetic investigation of non-obstructive azoospermia families with cytogenetic and molecular genetic tests, and determining the relationship between genetic and clinical findings of patients.M.Sc. in Cellular and Molecular Biology National Institute of Genetic Engineering and Biotechnology, Tehran, Iran September 23, 2010 – October 27, 2012 Master Thesis: Alkaloid extract of Peganum harmala L. seed on the expression of Bax and Bcl-2 genes involved in mitochondrial apoptosis pathway in cancer cells.B.Sc. in Molecular Genetics Shahrekord University, Shahrekord, Iran September 23, 2005 – October 7, 2009

Research Interests 🔬

  • Cancer Biology
  • Cancer Drug Resistance
  • Noncoding RNAs
  • Computational Biology
  • Genetics of Rare Diseases

Research Projects 🧬

Genetic analysis of male infertility in a family using Whole Exome Sequencing. (Student Research Committee, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2024)In silico prediction of non-coding RNA-gene regulatory network in primary gonad failure defects. (Student Research Committee, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2024)In silico identification of functional single nucleotide polymorphisms of azoospermia genes. (Student Research Committee, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2024)In silico prediction of coagulation system functional polymorphisms. (Student Research Committee, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2024)Identification of genes involved in Imatinib resistance in chronic myeloid leukemia (CML). (Student Research Committee, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2024)Genetic analysis of families with non-obstructive azoospermia by Whole Exome Sequencing. (Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2024)Genetic investigation of infertility in an Iranian family with infertility in both sexes. (Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2023)Prediction of tissue-specific inflammatory LncRNAs in COVID-19 patients. (Student Research Committee, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2021-2024)Identification of inflammatory miRNAs associated with COVID-19 and determination of their potential target genes using bioinformatics tools. (Student Research Committee, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2021-2023)Identification of genes involved in the development of chemotherapy resistance in lung cancer. (Student Research Committee, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2021-2024)Identification of common polymorphisms in the host antioxidant pathway against viruses and prediction of their effects. (Student Research Committee, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2021-2024)Identification of genes involved in the development of chemotherapy resistance in ovarian cancer. (Student Research Committee, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2021-2023)Investigation of the effect of oleuropein on miR-125b and miR-34a expression in ovarian cancer cell lines. (Cellular and Molecular Research Center, Shahrekord University of Medical Sciences; 2019-2020)Investigation of the effect of oleuropein on miR-181b and miR-21 expression in breast cancer cell line. (Cellular and Molecular Research Center, Shahrekord University of Medical Sciences; 2019-2020)Investigation of the effect of oleuropein on the expression of genes involved in apoptosis in cisplatin-resistant ovarian cell line. (Cellular and Molecular Research Center, Shahrekord University of Medical Sciences; 2019-2020)Study of the effect of nanoparticles containing altretiamine and arstin on ferroptosis in ovarian cancer cell line. (Cellular and Molecular Research Center, Shahrekord University of Medical Sciences; 2016-2020)Study of the effect of nanoparticles containing altretamine on ferroptosis-apoptosis in ovarian cancer cell line. (Cellular and Molecular Research Center, Shahrekord University of Medical Sciences; 2018-2019)Genetic etiology determination of non-syndromic hearing loss families using Whole Exome Sequencing. (Cellular and Molecular Research Center, Shahrekord University of Medical Sciences; 2018-2019)

Skills 🛠️

A. Experimental Techniques:Human cell cultureMTT assay (Drugs, Natural products, Nanoparticles)DNA and RNA extractionApoptosis assayROS assayElectrophoresisQuantitative PCRConventional PCRSonicationNanodropKaryotypingSanger sequencingWhole exome sequencingB. Software Ability:Various microRNA databases (TargetScan, miRBase, miRWalk, etc.)Various lncRNA databases (starBase, LncBase, etc.)Pathway databases (KEGG, WikiPathways, Reactome)Variant prediction tools (SIFT, Mutation Taster, Polyphen, CADD, etc.)Genome browsers (NCBI, Ensembl, UCSC)Primer design software and tools (AlleleID, Primer3, Oligo 7, etc.)Sequence analysis software (QIAGEN CLC Genomics Workbench, Mutation Surveyor, FinchTV, etc.)STRINGDBCytoscapeGene RunnerGenome expression databases (GEO, GTEx, etc.)

Workshops 📚

 

  • Various workshops covering topics such as predicting LncRNAs, the role of biological systems in cancer, electronic resource investigation, Next Generation sequencing, molecular techniques, article writing, PCR, and bioinformatics.

📚Top Noted Publication

  1. Title: The effect of oleuropein on apoptotic pathway regulators in breast cancer cells
    • Journal: European Journal of Pharmacology
    • Year: 2020
    • Volume: 886
    • Pages: 173509
    • Citations: 43

 

  1. Title: Peganum harmala L.’s anti-growth effect on a breast cancer cell line
    • Journal: Biotechnology reports
    • Year: 2015
    • Volume: 8
    • Pages: 138-143
    • Citations: 39

 

  1. Title: Oleuropein reduces cisplatin resistance in ovarian cancer by targeting apoptotic pathway regulators
    • Journal: Life Sciences
    • Year: 2021
    • Volume: 278
    • Pages: 119525
    • Citations: 26

 

  1. Title: Growth inhibitory impact of Peganum harmala L. on two breast cancer cell lines
    • Journal: Iranian journal of biotechnology
    • Year: 2014
    • Volume: 12
    • Issue: 1
    • Pages: 8-14
    • Citations: 23

 

  1. Title: The impact of oleuropein on miRNAs regulating cell death signaling pathway in human cervical cancer cells
    • Journal: Biotechnology and Applied Biochemistry
    • Year: 2024
    • Volume: 71
    • Issue: 1
    • Pages: 61-71
    • Citations: 1

 

  1. Title: In Silico Prediction of Functional SNPs Interrupting Antioxidant Defense Genes in Relation to COVID-19 Progression
    • Journal: Biochemical Genetics
    • Year: 2024
    • Pages: 1-27

 

  1. Title: Meta-analysis of microarray data to determine gene indicators involved in the cisplatin resistance in ovarian cancer
    • Journal: Cancer Reports
    • Year: 2023
    • Volume: 6
    • Issue: 12
    • Pages: e1884

Flavia | Molecular Biology | Young Scientist Award

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Dr. Flavia| Molecular Biology | Young Scientist Award

👨‍🏫Profile Summary

Flavia Scoyni is a highly accomplished researcher in molecular medicine, specializing in non-coding RNAs and their role in neurodegenerative diseases like Alzheimer’s and ischemic stroke. With a Ph.D. from the University of Eastern Finland under the Marie Skłodowska-Curie Programme, Flavia has extensive experience in experimental techniques such as scRNA-seq, FACS, and animal modeling. Their work has been published in prestigious journals and recognized with numerous grants and fellowships. Flavia’s expertise in molecular biology, cell culture, and animal work, coupled with a strong track record of securing research funding, positions them as a valuable asset in the field of translational medicine.

🌐 Professional Profiles

🎓Education:

Ph.D. in Molecular Medicine University of Eastern Finland, Kuopio, Finland Duration: Dec 2017 – Feb 2024 Marie Skłodowska-Curie Programme in Genetics and Mechanisms in Translational Medicine (GENOMMED) Advisor: Prof. Tarja Malm Dissertation: “Unlocking the potential of non-coding RNAs in regulating neurodegeneration – a glimpse into Alzheimer’s disease and ischemic stroke pathophysiology.” Ph.D. secondment Aarhus University, Aarhus, Denmark Duration: Sept 2018 – Feb 201 Advisor: Assoc. Prof. Thomas B. Hansen Funded by Saastamoinen Foundation travel grant FELASA accreditationUniversity of Eastern Finland, Kuopio, Finland May 2017 Federation of Laboratory Animal Science Associations (FELASA) Certificate in laboratory animal science for EU Functions A/D MSc in Molecular Biology “Sapienza” University of Rome, Rome, Italy Duration: Oct 2013 – Dec 2015 Master Degree in Molecular Biology Graduated magna cum laude (110/110 cum laude) Advisor: Prof. Alessandro Fatica Thesis title: “Identification of new transcriptional targets of p30 C/EBPα transcription factor isoform in acute myeloid leukemia” MSc in Genetics University Paris-Diderot VII, Paris, France Duration: Oct 2013 – June 2015 BSc in Biotechnology “Sapienza” University of Rome, Rome, Italy Duration: Oct 2010 – July 2013 Bachelor degree in Biotechnology Graduated magna cum laude (110/110 cum laude) Advisor: Prof. Carlo Presutti Thesis title: “The role of the mir-200 family in the regulation of the expression of AP1 transcriptional factor”

🔬Research Experience:

Early stage researcher Professor Tarja Malm University of Eastern Finland, A.I. Virtanen Institute for Molecular Sciences Jan 2017 – Dec 2017 Investigated the role of microRNAs in phagocytic microglia isolated from adult Alzheimer’s mice. Developed techniques including ex-vivo FACS, low input RNA extraction, cloning, qPCR, and protocol for transfection for hard-to-transfect cell lines. Conducted animal procedures to harvest brain samples or acutely isolate adult microglia. Erasmus traineeship Biotech Research & Innovation Centre, Copenhagen, Denmark Oct 2016 – June 2016 Developed a transgenic stable cell line for long non-coding RNAs. Applied techniques such as cloning of long inserts, lentiviral vector production, and stable cell line development. Master thesis Professor Alessandro Fatica “Sapienza” University of Rome, Rome, Italy June 2014 – Dec 2015 Investigated the regulation of the long non-coding RNA UCA1 mediated by C/EBPα transcription factor in the K562 lymphoblast cell line. Applied techniques including ChIP, cloning, RNA extraction, RT-qPCR, WB, transfection, CRISPR-Cas9, and stable cell line development. Master Internship Professor Giuseppe Macino “Sapienza” University of Rome, Rome, Italy Sept 2013 – March 2014 Studied microRNAs inducing epigenetic modifications in mammals.Applied techniques such as ChIP, cloning, mutagenesis, RNA extraction, RT-qPCR, WB, CRISPR-Cas9, and stable cell line development. Bachelor thesis Professor Carlo Presutti “Sapienza” University of Rome, Rome, Italy Oct 2012 – July 2013 Investigated the role of the miR-200a family in regulating c-JUN transcription factor expression. Utilized techniques including cloning, mutagenesis, bacterial transformation, and cell line culture.

💻 Technical Skills:

Molecular biology techniques such as scRNA-seq, RNA-seq, FACS, cloning, RT-qPCR, WB, lentiviral vectors generation. Cell culture techniques including neuronal culture, primary microglial culture, transduction, transfection, and stable cell line development. Animal work including FELASA A/D certification, maintenance, and breeding of transgenic mouse models, animal procedures, and tamoxifen-induced recombination. Statistical analysis, basic Python, and R.

🏆Fellowships, Awards, and Honors:

  • Secured total grants of 99.000€ during Ph.D., including grants from Pavo Nuermen Foundation, Finnish Cultural Foundation, Kuopio University Foundation, and others.

👩‍🏫 Teaching Experience:

  • Mentored a Ph.D. student and post-graduate student, and supervised five master’s thesis students during the Ph.D. program.

📚Top Noted Publication

  1. ciRS-7 and miR-7 regulate ischemia-induced neuronal death via glutamatergic signaling
    • Journal: Cell Reports
    • Year: 2024-03
    • DOI: 10.1016/j.celrep.2024.113862
    • Contributors: Flavia Scoyni; Valeriia Sitnikova; Luca Giudice; Paula Korhonen; Davide M. Trevisan; Ana Hernandez de Sande; Mireia Gomez-Budia; Raisa Giniatullina; Irene F. Ugidos; Hiramani Dhungana et al.

 

  1. Alzheimer’s disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs
    • Journal: Alzheimer’s & Dementia
    • Year: 2024-02
    • DOI: 10.1002/alz.13502
    • Contributors: Flavia Scoyni; Luca Giudice; Mari-Anna Väänänen; Nicholas Downes; Paula Korhonen; Xin Yi Choo; Nelli-Noora Välimäki; Petri Mäkinen; Nea Korvenlaita; Annemieke J Rozemuller et al.

 

  1. ciRS-7 and miR-7 regulate ischemia induced neuronal death via glutamatergic signaling
    • Journal: Preprint
    • Year: 2023-01-24
    • DOI: 10.1101/2023.01.24.525136
    • Contributors: Flavia Scoyni; Valeriia Sitnikova; Luca Giudice; Paula Korhonen; Davide M Trevisan; Ana Hernandez de Sande; Mireia Gomez-Budia; Raisa Giniatullina; Irene F Ugidos; Hiramani Dhungana et al.

 

  1. Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation
    • Journal: Journal of Neuroinflammation
    • Year: 2020
    • DOI: 10.1186/s12974-020-01870-w
    • Contributors: Kolosowska, N.; Gotkiewicz, M.; Dhungana, H.; Giudice, L.; Giugno, R.; Box, D.; Huuskonen, M.T.; Korhonen, P.; Scoyni, F.; Kanninen, K.M. et al.

 

  1. PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia
    • Journal: Stem Cell Reports
    • Year: 2019
    • DOI: 10.1016/j.stemcr.2019.08.004
    • Contributors: Konttinen, H.; Cabral-da-Silva, M.E.C.; Ohtonen, S.; Wojciechowski, S.; Shakirzyanova, A.; Caligola, S.; Giugno, R.; Ishchenko, Y.; Hernández, D.; Fazaludeen, M.F. et al.