Chandan Shivamalli | Life Sciences | Excellence in Research

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Assoc Prof Dr. Chandan Shivamalli | Life Sciences | Excellence in Research

 

Assoc Prof Dr at JSS Academy of Higher Education and Research India

Assoc Prof Dr Chandan S is an accomplished academic and researcher specializing in Biotechnology and Bioinformatics. He holds a Ph.D. from the University of Mysore and currently serves as an Assistant Professor and Coordinator at Jagadguru Sri Shivarathreeshwara University. Assoc Prof Dr. Chandan has extensive research experience, having worked on projects funded by prestigious agencies like DST-SERB and ICMR. He has led various projects, including studies on anti-mucosal inflammatory effects, Alzheimer’s disease therapy, and leptospiral peptidomimetics. Assoc Prof Dr. Chandan’s contributions to the field have earned him awards such as the DST-SERB Young Scientist Award and the ICMR Senior Research Fellowship.

profile

Scholar

šŸ“š Educational Qualification

Bachelor of Science (B.Sc) University / College: University of Mysore, JSS College, Mysore Period: 2002-2005. M.Sc University / College: University of Mysore, JSS College, Mysore Period: 2005-2007 . Master of Philosophy (M.Phil) University / College: Vinayaka Missions University (Deemed), Vinayaka Missions University Period: 2007-2008 . Ph.D University / College: University of Mysore, University of Mysore Period: 2010-2013

šŸ’¼ Work Experience

1. Project Directorate on Animal Disease Monitoring and Surveillance, ICAR Designation / Department: Post Graduate Research Assistant Period: June 02, 2007 – March 31, 2010 Duration: 2 Years 9 Months. 2. Department of Studies in Biotechnology Designation / Department: Project Fellow Period: May 17, 2010 – May 21, 2011 Duration: 1 Year 0 Months. 3. Indian Council for Medical Research Designation / Department: Senior Research Fellow Period: May 21, 2011 – December 13, 2013 Duration: 2 Years 7 Months. 4. Jagadguru Sri Shivarathreeshwara University Designation / Department: Lecturer, Biotechnology & Bioinformatics Period: December 13, 2013 – January 31, 2016 Duration: 2 Years 1 Month 5. Jagadguru Sri Shivarathreeshwara University Designation / Department: Assistant Professor & Coordinator, Biotechnology & Bioinformatics Period: February 01, 2016 – Till Date Duration: 5 Years 9 Months

šŸ† Awards

1. DST-SERB Young Scientist Awarding Agency: DST-SERB, Purpose of Award: Sanction of Project, Award Type: National, Award Date: June 1, 2016 2. Senior Research Fellow Awarding Agency: ICMR, Purpose of Award: To pursue PhD, Award Type: National, Award Date: May 21, 2011

šŸ”¬ Projects

1. Evaluation of anti-mucosal inflammatory effect of Acacia fernesiana using Zebra fish as model organism Principal Investigator: Dr. Chandan S Duration: 1 Year(s) Institute: School of Life Sciences – Mysuru Department: Biotechnology & Bioinformatics 2. A prospective study of synergistic effect of combination therapy of FDA approved drugs and in silico characterization against Alzheimer’s disease Principal Investigator: Dr. Chandan S Duration: 2 Year(s) Institute: School of Life Sciences – Mysuru Department: Biotechnology & Bioinformatics 3. Genomic and proteomic analysis of outer membrane vesicles from clinical isolates of Leptospira and development of antileptospiral peptidomimetics Principal Investigator: Dr. Chandan SDuration: 3 Year(s) Institute: Faculty of Life Sciences [FLS] Department: Bioinformatics [BIOINFO]

Publications Top NotesšŸ“

 

  • Title: A systematic review on ethnopharmacology, phytochemistry and pharmacological aspects of Thymus vulgaris Linn.
    Authors: SM Patil, R Ramu, PS Shirahatti, C Shivamallu, RG Amachawadi
    Year: 2021
    Journal: Heliyon
    Volume and Issue: 7(5)
    Article Number: 134

 

  • Title: Antiviral and immunomodulatory activity of curcumin: A case for prophylactic therapy for COVID-19
    Authors: RK Thimmulappa, KK Mudnakudu-Nagaraju, C Shivamallu, …
    Year: 2021
    Journal: Heliyon
    Volume and Issue: 7(2)
    Article Number: 133

 

  • Title: Bioactive compounds effective against type 2 diabetes mellitus: a systematic review
    Authors: C Egbuna, CG Awuchi, G Kushwaha, M Rudrapal, …
    Year: 2021
    Journal: Current Topics in Medicinal Chemistry
    Volume and Issue: 21(12)
    Pages: 1067-1095

 

  • Title: In silico evaluation of flavonoids as effective antiviral agents on the spike glycoprotein of SARS-CoV-2
    Authors: AS Jain, P Sushma, C Dharmashekar, MS Beelagi, SK Prasad, …
    Year: 2021
    Journal: Saudi Journal of Biological Sciences
    Volume and Issue: 28(1)
    Pages: 1040-1051

 

  • Title: Genetic typing of recent classical swine fever isolates from India
    Authors: SS Patil, D Hemadri, BP Shankar, AG Raghavendra, H Veeresh, …
    Year: 2010
    Journal: Veterinary Microbiology
    Volume and Issue: 141(3-4)
    Pages: 367-373

 

  • Title: Genistein: a potent anti-breast cancer agent
    Authors: SS Bhat, SK Prasad, C Shivamallu, KS Prasad, A Syed, P Reddy, CA Cull, …
    Year: 2021
    Journal: Current Issues in Molecular Biology
    Volume and Issue: 43(3)
    Pages: 1502-1517

 

  • Title: Palladium (II) complexes as biologically potent metallo-drugs: Synthesis, spectral characterization, DNA interaction studies and antibacterial activity
    Authors: KS Prasad, LS Kumar, S Chandan, RMN Kumar, HD Revanasiddappa
    Year: 2013
    Journal: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
    Volume: 107
    Pages: 108-116

 

  • Title: Aqueous Extract of Saraca indica Leaves in the Synthesis of Copper Oxide Nanoparticles: Finding a Way towards Going Green
    Authors: KS Prasad, A Patra, G Shruthi, S Chandan
    Year: 2017
    Journal: Journal of Nanotechnology
    Volume and Issue: 2017(1)
    Article Number: 7502610

 

  • Title: Quinazolinones linked amino acids derivatives as a new class of promising antimicrobial, antioxidant and anti-inflammatory agents
    Authors: KP Rakesh, S Ramesh, HMM Kumar, S Chandan, DC Gowda
    Year: 2015
    Journal: European Journal of Chemistry
    Volume and Issue: 6(3)
    Pages: 254-260

 

  • Title: Diorganotin(IV) complexes of biologically potent 4(3H)-quinazolinone derived Schiff bases: Synthesis, spectroscopic characterization, DNA interaction studies and …
    Authors: KS Prasad, LS Kumar, S Chandan, B Jayalakshmi, HD Revanasiddappa
    Year: 2011
    Journal: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
    Volume and Issue: 81(1)

 

Daniele Florio | Pharmaceutical science | Young Scientist Award

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Mr. Daniele Florio | Pharmaceutical science | Young Scientist Award

Daniele Florio is a dedicated researcher in pharmaceutical sciences, currently pursuing a Ph.D. at the University of Naples Federico II. His doctoral work focuses on integrated molecular approaches targeting mutated Nucleophosmin 1 in Acute Myeloid Leukemia, scheduled for completion in October 2024. Daniele brings extensive experience from his Marie Sklodowska-Curie secondment and voluntary internship, specializing in peptide synthesis, mass spectrometry, and spectroscopic techniques. With a strong publication record and active participation in international conferences, he contributes significantly to the fields of amyloid aggregation, chemical catalysis, and drug development, showcasing advanced skills in scientific research and analysis.

Profile

Scopus

šŸ‘Øā€šŸ«Professional Experience

Tutoring Activities (Grant Type B) 2023-2024, Naples, Italy, Department of Pharmacy, University of Naples Federico II, Provided supplementary teaching for Chemistry and Inorganic Chemistry courses for Pharmacy and CTF degree students. Ph.D. Candidate in Pharmaceutical Sciences (XXXVII Cycle) 2021 ā€“ Present, Naples, Italy, Department of Pharmacy, University of Naples Federico II, PhD Project: Integrated molecular approaches targeting mutated Nucleophosmin 1 in Acute Myeloid Leukemia., Scheduled PhD end: October 31, 2024. Secondee under Marie Skłodowska-Curie Research and Innovation Staff Exchange Action June 2022 ā€“ March 2023, Dublin, Ireland, Keladapharmachem, Participated in the GreenX4Drug (EU funded H2020 RISE project), focusing on developing novel asymmetric chemical catalysts for manufacturing high-value APIs and advanced intermediates.. Voluntary Internship Post-Degree 2018 ā€“ 2019, Naples, Italy, Department of Pharmacy, University of Naples Federico II, Designed, synthesized, and characterized peptides, peptidomimetics, and small molecules using solid-phase and solution methodologies. Utilized mass spectrometry (ESI) for identifying synthetic compounds and applied analytical and preparative methodologies (HPLC) for their purification and characterization. Conducted structural and functional characterization of biomolecules through spectroscopic techniques (CD, Fluorescence, SPR, UV-Vis). Supervisor: Prof. Daniela Marasco

šŸŽ“Education and Training

Biologist Board Examination February 7, 2022, University of Naples Federico II, Naples, Italy Masterā€™s Degree in Biological Science (Molecular Diagnostics Field) July 12, 2021, Naples, Italy Department of Pharmacy, University of Naples Federico II Experimental Thesis: “Protein fragments of Nucleophosmin 1 as models of amyloids”, Supervisor: Prof. Antonello Merlino, Co-Supervisor: Prof. Daniela Marasco,k Grade: 110/110. Bachelorā€™s Degree in Biological Science (Molecular Diagnostics Field) March 15, 2018, Naples, Italy Department of Pharmacy, University of Naples Federico II Experimental Thesis: “Amyloid-like aggregation of Nucleophosmin 1 regions related to Acute Myeloid Leukemia: spectroscopic studies” Supervisor: Prof. Daniela Marasco Grade: 106/110

šŸ“–Certifications

English TELSA C1, Grade B Language Certification ESAT, Malta Further & Higher Education Authority

Skills and Competencies

Organizational Skills

  • Efficient under pressure.
  • Adaptive to changes and new situations.
  • Strong independent work organization and goal achievement.

Job-related Skills

  • Solid-phase peptide synthesis and combinatorial peptide libraries using Fmoc/Boc chemistry.
  • Experience with various peptide synthesizers (BIOTAGE, Liberty Blue 2.0).
  • Proficient in analysis and purification using ESI mass spectrometry, HPLC, and flash purification systems.
  • Skilled in spectroscopic techniques (CD, Fluorescence, DLS, SPR, UV-Vis, FTIR, NMR).

Digital Skills

  • Proficient in Microsoft Office Suite.
  • Experienced with operating systems: MS-Windows, MacOS, LINUX.
  • Proficient in scientific data analysis software (GraphPad Prism).
  • Knowledgeable in databases (PubMed) and bibliographic management software (EndNote, Mendeley).
  • Proficient with video conferencing software (Teams, Skype, Zoom, Google Meet).
  • Excellent knowledge of major browsers (Edge, Chrome, Firefox, Safari, Opera).

šŸŒProjects

National Project Participation

  • BANDO-PRIN-2022. Research Project: Design, synthesis, and investigation of novel G-quadruplex aptamers against STAT3 and the interleukin-6 receptor (G4-APTASTAT).
  • Project Coordinator and Head of Research Unit: Prof. GALEONE Aldo

Bibliometric Parameters

  • H-index from Scopus: 11
  • Number of Publications: 24
  • Citations: 388

 

Publications Top Notes šŸ“

  • The effects of histidine substitution of aromatic residues on the amyloidogenic properties of the fragment 264ā€“277 of nucleophosmin 1
    • Authors: D. Florio, P. Luciano, C. Di Natale, D. Marasco
    • Journal: Bioorganic Chemistry
    • Volume: 147
    • Year: 2024
    • Pages: 107404

 

  • Could Targeting NPM1c+ Misfolding Be a Promising Strategy for Combating Acute Myeloid Leukemia?
    • Authors: D. Florio, D. Marasco
    • Journal: International Journal of Molecular Sciences
    • Volume: 25
    • Issue: 2
    • Year: 2024
    • Pages: 811

 

  • Modulation of hydrogel networks by metal ions
    • Authors: S. La Manna, D. Florio, C. Di Natale, D. Marasco
    • Journal: Journal of Peptide Science
    • Volume: 29
    • Issue: 8
    • Year: 2023
    • Article ID: e3474

 

  • Ruthenium complexes bearing glucosyl ligands are able to inhibit the amyloid aggregation of short histidine-peptides
    • Authors: D. Florio, S. La Manna, A. Annunziata, M. Monti, D. Marasco
    • Journal: Dalton Transactions
    • Volume: 52
    • Issue: 25
    • Year: 2023
    • Pages: 8549ā€“8557

 

  • Insights into Network of Hot Spots of Aggregation in Nucleophosmin 1
    • Authors: D. Florio, S. La Manna, C. Di Natale, A.M. Malfitano, D. Marasco
    • Journal: International Journal of Molecular Sciences
    • Volume: 23
    • Issue: 23
    • Year: 2022
    • Pages: 14704

 

  • Hydrogelation tunability of bioinspired short peptides
    • Authors: S. La Manna, D. Florio, V. Panzetta, C. Di Natale, D. Marasco
    • Journal: Soft Matter
    • Volume: 8
    • Year: 2022
    • Pages: 8

 

Antonios Kousaxidis | Medicinal Chemistry | Best Researcher Award

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Ā Mr. Antonios Kousaxidis | Medicinal Chemistry |Best Researcher Award

Ā Mr at School of Pharmacy, Aristotle University of Thessaloniki, Greece

A seasoned educator and researcher with extensive experience in physics, holding positions from Assistant to Associate Professor at IAU, Urmia, and Urmia University of Technology. Specialized in teaching a range of undergraduate to Ph.D. courses including Quantum Mechanics, Laser Physics, and Nonlinear Dynamical Systems. Proficient in Maple and Matlab programming with a strong background in finite element method analysis. Led impactful research projects in chaotic systems, cancer treatment, and national security, earning multiple awards including the Kharazmi Scientific Festival Second Prize. A recognized leader in academia with a commitment to advancing scientific knowledge and education.

Profile

  1. Scopus

šŸŽ“ Education:

Masterā€™s Degree in Medicinal Chemistry: (9.85/10) from Departments of Chemistry, Medicine, Biological Applications and Technology, University of Ioannina, 45110, Ioannina, Greece.Ā Bachelor’s Degree in Chemistry: (7.76/10) from Department of Chemistry, School of Sciences, University of Ioannina, 45110, Ioannina, Greece.

Personal Skills:

Synthetic Organic Chemistry and Biochemistry: Training in synthetic organic chemistry and biochemistry applied to drug design, with experience in several areas of synthetic methodology using retrosynthetic approaches. Metal-Based Coupling Reactions: Excellent knowledge and practice of metal-based coupling reactions in modern organic chemistry. Synthetic Routes Optimization: Training in synthetic routes optimization using one-pot reactions during masterā€™s thesis. Analytical Methods: Proficient in NMR, IR, UV, and mass spectrometry for identifying organic compounds. Small Molecule Synthesis: Synthesis of small molecule organic compounds and isolation by recrystallization. Purification and Separation: Excellent knowledge and practice in chromatographic methods like column, preparative, and thin-layer chromatography for purifying and separating organic compounds. Biochemical Protocols: Good practice in using biochemical protocols for enzyme kinetics experiments. Drug Discovery Programs: Extensive experience in drug discovery programs, structure-based drug design, molecular docking, and SAR estimation models using in silico methods (Discovery Studio, Chimera, LigandScout, PyMOL, OpenBabel, ADMET). Scientific Manuscripts: Proficient in writing and preparing scientific manuscripts.

šŸ’» Software Skills:

Office Suite (ECDL degree) – Word processing, spreadsheets, presentations, etc. Calculative and predictive programs like MestReNova, Topspin DataAnalysis, ChemDraw Ultra, MedChem Designer, and BioLoom.

Research Focus:

A. Kousaxidis primarily focuses on the design and synthesis of novel compounds with therapeutic potential, particularly targeting enzymes such as aldose reductase (ALR2) and protein tyrosine phosphatase 1B (PTP1B). The research also encompasses antimicrobial agents, lipoxygenase inhibitors, and therapeutic strategies for conditions like diabetes mellitus and sepsis.

Publications Top Notes šŸ“

  • A Molecular Hybridization Approach for the Design of Selective Aldose Reductase (ALR2) Inhibitors and Exploration of Their Activities Against Protein Tyrosine Phosphatase 1B (PTP1B)
    • Authors: Kousaxidis, A., Petrou, A., Rouvim, P., Nicolaou, I., Geronikaki, A.
    • Journal: Journal of Molecular Structure
    • Year: 2023
    • Volume: 1271
    • Article Number: 134116
    • Citations: 3
    • Summary: This study presents a hybridization approach to develop selective ALR2 inhibitors and investigates their potential activities against PTP1B, highlighting their dual therapeutic potential.

 

  • Design, Synthesis, and Pharmacological Evaluation of Indazole Carboxamides of N-Substituted Pyrrole Derivatives as Soybean Lipoxygenase Inhibitors
    • Authors: Lavrentaki, V., Kousaxidis, A., Theodosis-Nobelos, P., Koutsopoulos, K., Nicolaou, I.
    • Journal: Molecular Diversity
    • Year: 2023
    • Citations: 2
    • Summary: This paper discusses the synthesis and evaluation of novel indazole carboxamides, demonstrating significant inhibitory activity against soybean lipoxygenase.

 

  • N-Derivatives of (Z)-Methyl 3-(4-Oxo-2-thioxothiazolidin-5-ylidene)methyl)-1H-indole-2-carboxylates as Antimicrobial Agentsā€”In Silico and In Vitro Evaluation
    • Authors: Petrou, A., Geronikaki, A., Kartsev, V., Nicolaou, I., Vizirianakis, I.S.
    • Journal: Pharmaceuticals
    • Year: 2023
    • Volume: 16
    • Issue: 1
    • Article Number: 131
    • Citations: 4
    • Summary: This open-access article evaluates the antimicrobial activity of new N-derivatives, supported by both in silico and in vitro methods.

 

  • Non-acidic Bifunctional Benzothiazole-Based Thiazolidinones with Antimicrobial and Aldose Reductase Inhibitory Activity as a Promising Therapeutic Strategy for Sepsis
    • Authors: Kousaxidis, A., Kovacikova, L., Nicolaou, I., Stefek, M., Geronikaki, A.
    • Journal: Medicinal Chemistry Research
    • Year: 2021
    • Volume: 30
    • Issue: 10
    • Pages: 1837-1848
    • Citations: 13
    • Summary: This research explores benzothiazole-based thiazolidinones with dual activity, suggesting a promising approach for treating sepsis.

 

  • Aldose Reductase and Protein Tyrosine Phosphatase 1B Inhibitors as a Promising Therapeutic Approach for Diabetes Mellitus
    • Authors: Kousaxidis, A., Petrou, A., Lavrentaki, V., Nicolaou, I., Geronikaki, A.
    • Journal: European Journal of Medicinal Chemistry
    • Year: 2020
    • Volume: 207
    • Article Number: 112742
    • Citations: 39
    • Summary: This review highlights the potential of targeting ALR2 and PTP1B as a therapeutic strategy for diabetes, emphasizing recent advances and future perspectives.